Development Level

Tbio 60 | 11,445
Tclin 20 | 613
Tchem 18 | 1,598
Tdark 1 | 6,588

Collection

Ion Channel: IDG Consortium (T... 3 | 99
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 9 | 979
decreased body weight 4 | 161
decreased total body fat amoun... 4 | 207
abnormal bone structure 3 | 187
decreased bone mineral content 3 | 151
embryonic lethality prior to t... 3 | 278
increased circulating triglyce... 3 | 42
abnormal behavior 2 | 298
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased grip strength 2 | 116
embryonic lethality prior to o... 2 | 239
hypoactivity 2 | 132
preweaning lethality, incomple... 2 | 499
tremors 2 | 39
abnormal anxiety-related respo... 1 | 1
abnormal cecum morphology 1 | 7
abnormal embryo size 1 | 220
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal heart shape 1 | 5
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal social-conspecific in... 1 | 3
absent pinna reflex 1 | 23
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased exploration in new e... 1 | 11
decreased heart left ventricle... 1 | 28
decreased lactate dehydrogenas... 1 | 16
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
enlarged cecum 1 | 5
enlarged heart 1 | 210
enlarged seminal vesicle 1 | 10
female infertility 1 | 60
hydrometra 1 | 53
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased circulating chloride... 1 | 41
increased circulating free fat... 1 | 20
increased circulating sodium l... 1 | 71
increased exploration in new e... 1 | 8
increased fasted circulating g... 1 | 76
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased startle reflex 1 | 112
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small superior vagus ganglion 1 | 74
thin ventricular wall 1 | 24

Disease

Carcinoma 89 | 11,493
glioblastoma 59 | 5,792
ovarian cancer 58 | 8,520
atypical teratoid / rhabdoid tumor 52 | 5,112
ependymoma 51 | 4,679
osteosarcoma 51 | 7,950
medulloblastoma, large-cell 49 | 6,241
Kidney cancer 46 | 2,613
psoriasis 43 | 6,694
lung cancer 42 | 4,740
Astrocytoma, Pilocytic 41 | 3,081
adult high grade glioma 41 | 3,801
Breast cancer 40 | 3,578
group 3 medulloblastoma 39 | 4,104
oligodendroglioma 39 | 2,850
primitive neuroectodermal tumor 35 | 3,035
subependymal giant cell astrocytoma 33 | 2,287
Cancer 32 | 2,499
malignant mesothelioma 31 | 3,232
astrocytic glioma 30 | 2,597
lung carcinoma 30 | 2,843
Pick disease 28 | 1,894
Epilepsy 26 | 792
intraductal papillary-mucinous neoplasm (IPMN) 26 | 3,291
invasive ductal carcinoma 26 | 2,951
pancreatic cancer 25 | 2,398
non-small cell lung cancer 24 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,955
pituitary cancer 23 | 1,972
Intellectual disability 21 | 1,016
Schizophrenia 21 | 1,160
lung adenocarcinoma 21 | 2,716
Liver cancer 19 | 604
Muscle hypotonia 19 | 571
Seizures 19 | 596
colon cancer 19 | 1,478
Melanoma 18 | 711
ductal carcinoma in situ 18 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,989
interstitial cystitis 17 | 2,312
Bipolar Disorder 16 | 666
Skin cancer 16 | 469
tuberculosis 16 | 2,010
Autosomal recessive predisposition 15 | 1,442
Dull intelligence 15 | 645
Low intelligence 15 | 645
Mental Retardation 15 | 645
Mental deficiency 15 | 645
Poor school performance 15 | 645
breast carcinoma 15 | 1,638
cystic fibrosis 15 | 1,696
Cognitive delay 13 | 608
Global developmental delay 13 | 608
Mental and motor retardation 13 | 608
diabetes mellitus 12 | 1,728
group 4 medulloblastoma 12 | 1,855
primary pancreatic ductal adenocarcinoma 12 | 1,109
Alzheimer's disease 11 | 658
Autistic Disorder 11 | 364
Lennox-Gastaut syndrome 11 | 34
Neuropathy 11 | 261
acute quadriplegic myopathy 11 | 1,158
adrenocortical carcinoma 11 | 1,428
Carcinoma, Squamous Cell 10 | 110
Cough 10 | 23
Dysuria 10 | 26
Epilepsy characterized by intractable complex partial seizures 10 | 28
Itching of skin 10 | 18
Life-Threatening Ventricular Tachycardia 10 | 15
Local anesthesia 10 | 40
Localization-related epilepsy 10 | 13
Minor Skin Wound Pain 10 | 12
Motor cortex epilepsy 10 | 10
Mouth Irritation 10 | 12
Multiple myeloma 10 | 1,332
Partial seizure 10 | 15
Prevent Minor Bacterial Skin Infection 10 | 10
Skin irritation 10 | 12
Sore throat symptom 10 | 12
Squamous cell carcinoma 10 | 129
Status Epilepticus 10 | 98
Suppression of the Gag Reflex 10 | 12
Tinea Infections 10 | 10
Tinea corporis 10 | 25
Tinea pedis 10 | 29
Tonic-clonic epilepsy 10 | 47
Urinary Tract Irritation 10 | 24
Ventricular arrhythmia 10 | 27
dermatomyositis 10 | 966
ulcerative colitis 10 | 1,819
Down syndrome 9 | 499
Infantile onset 9 | 238
Mental Depression 9 | 333
Multiple Sclerosis 9 | 540
gastric carcinoma 9 | 807
Duchenne muscular dystrophy 8 | 601
Heart disease 8 | 306
Rheumatoid arthritis 8 | 1,191
Vascular disease 8 | 319
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 510

Tissue

Endocrine System 98 | 18,159
Female tissues 95 | 17,400
Nervous System 94 | 16,725
Liver and Pancreas 93 | 16,750
Male tissues 93 | 17,142
Skin and soft tissues 93 | 17,230
Blood and immune system 92 | 16,909
Digestive Tract 92 | 17,369
Respiratory system 90 | 16,393
Urinary Tract 90 | 16,678
Cardiovascular System 86 | 15,192

Target Family

Non-IDG 62 | 12,091
Kinase 18 | 634
Ion Channel 16 | 344
Enzyme 3 | 4,145

Reactome Pathway

L1CAM interactions 99 | 99
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sodium channel protein type 10 subunit alpha SCN10A Tclin Ion Channel -3.17690 1469.3 126
Ribosomal protein S6 kinase alpha-6 RPS6KA6 Tchem Kinase -1.26563 21.6 158
Moesin MSN Tbio Non-IDG -2.61389 361.7 550
Sodium channel protein type 3 subunit alpha SCN3A Tclin Ion Channel -1.98160 87.0 76
Ankyrin-2 ANK2 Tbio Non-IDG -2.08421 120.5 236
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Sodium channel protein type 11 subunit alpha SCN11A Tclin Ion Channel -2.46568 276.3 60
Spectrin beta chain, non-erythrocytic 2 SPTBN2 Tbio Non-IDG -1.73436 53.8 237
Sodium channel subunit beta-4 SCN4B Tbio Ion Channel -1.42029 24.1 85
Ribosomal protein S6 kinase alpha-3 RPS6KA3 Tchem Kinase -2.50143 325.4 425