Development Level

Tbio 34 | 11,651
Tdark 6 | 6,593
Tchem 3 | 1,388

IMPC Phenotype

preweaning lethality, complete... 9 | 979
abnormal embryo size 4 | 220
cyanosis 2 | 7
hyperactivity 2 | 148
prenatal lethality prior to he... 2 | 87
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal facial morphology 1 | 17
abnormal head shape 1 | 10
abnormal limb morphology 1 | 13
abnormal outer ear morphology 1 | 3
abnormal skin coloration 1 | 25
abnormal sleep behavior 1 | 70
absent pinna reflex 1 | 23
decreased bone mineral content 1 | 151
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating free fat... 1 | 31
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased lean body mass 1 | 135
decreased red blood cell distr... 1 | 41
decreased startle reflex 1 | 75
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
hemorrhage 1 | 23
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
increased bone mineral content 1 | 108
increased circulating chloride... 1 | 41
increased circulating glucose ... 1 | 24
increased circulating sodium l... 1 | 71
increased grip strength 1 | 41
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

Carcinoma 40 | 11,493
medulloblastoma, large-cell 25 | 6,241
glioblastoma 24 | 5,792
ovarian cancer 24 | 8,519
atypical teratoid / rhabdoid tumor 23 | 5,112
lung cancer 23 | 4,740
group 3 medulloblastoma 22 | 4,104
adult high grade glioma 20 | 3,801
osteosarcoma 19 | 7,950
ependymoma 18 | 4,679
Breast cancer 16 | 3,577
malignant mesothelioma 16 | 3,232
non-small cell lung cancer 15 | 2,890
psoriasis 15 | 6,694
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,988
primitive neuroectodermal tumor 14 | 3,035
Astrocytoma, Pilocytic 13 | 3,081
invasive ductal carcinoma 13 | 2,950
adrenocortical carcinoma 12 | 1,428
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,290
oligodendroglioma 11 | 2,850
Atopic dermatitis 10 | 952
Kidney cancer 10 | 2,613
breast carcinoma 10 | 1,637
colon cancer 10 | 1,478
ductal carcinoma in situ 9 | 1,744
Endometriosis 8 | 540
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,954
lung carcinoma 8 | 2,843
nasopharyngeal carcinoma 8 | 1,058
pituitary cancer 8 | 1,972
lung adenocarcinoma 7 | 2,716
pancreatic cancer 6 | 2,398
Neurodegenerative disease 5 | 414
Neuropathy 5 | 261
Paraplegia 5 | 74
astrocytic glioma 5 | 2,597
group 4 medulloblastoma 5 | 1,855
interstitial cystitis 5 | 2,312
subependymal giant cell astrocytoma 5 | 2,287
Cancer 4 | 2,499
Cognitive delay 4 | 608
Endometrial cancer 4 | 311
Epilepsy 4 | 792
Global developmental delay 4 | 608
Liver cancer 4 | 604
Mental and motor retardation 4 | 608
Microcephaly 4 | 166
Pick disease 4 | 1,894
Small head 4 | 374
astrocytoma 4 | 1,146
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
ulcerative colitis 4 | 1,819
Amyotrophic lateral sclerosis 3 | 451
Anteverted nostril 3 | 191
Babinski Reflex 3 | 100
Congenital fibrosis of the extraocular muscles 3 | 13
Hyperreflexia 3 | 209
Progressive disorder 3 | 142
Seizures 3 | 596
cutaneous lupus erythematosus 3 | 1,057
hereditary spastic paraplegia 3 | 318
pediatric high grade glioma 3 | 1,064
primary Sjogren syndrome 3 | 735
spina bifida 3 | 1,074
Absent reflex 2 | 92
Absent tendon reflex 2 | 92
Acquired scoliosis 2 | 281
Attention deficit hyperactivity disorder 2 | 278
Concave bridge of nose 2 | 195
Congenital Epicanthus 2 | 177
Congenital pes cavus 2 | 88
Curvature of spine 2 | 282
Decreased number of large and small myelinated fibers 2 | 20
Decreased tendon reflex 2 | 122
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Highly variable severity 2 | 157
Hypoplasia of corpus callosum 2 | 90
Large intestine cancer 2 | 126
Monoparesis - leg 2 | 27
Reflex, Deep Tendon, Absent 2 | 92
Schizophrenia 2 | 1,160
Short nose 2 | 132
Slow progression 2 | 89
Small nose 2 | 132
Spastic Paraplegia 2 | 42
Variable expressivity 2 | 157
Weakness of lower limb 2 | 27
active Crohn's disease 2 | 922
acute myeloid leukemia 2 | 783
chronic rhinosinusitis 2 | 512
cystic fibrosis and chronic rhinosinusitis 2 | 214
dermatomyositis 2 | 966
diabetes mellitus 2 | 1,728
fibroadenoma 2 | 559
medulloblastoma 2 | 720
posterior fossa group A ependymoma 2 | 468
primary pancreatic ductal adenocarcinoma 2 | 1,108
tuberculosis and treatment for 6 months 2 | 409

Tissue

Endocrine System 42 | 18,159
Blood and immune system 40 | 16,909
Digestive Tract 40 | 17,369
Female tissues 40 | 17,400
Liver and Pancreas 40 | 16,750
Male tissues 40 | 17,142
Nervous System 40 | 16,725
Respiratory system 40 | 16,393
Skin and soft tissues 40 | 17,230
Urinary Tract 40 | 16,678
Cardiovascular System 39 | 15,192

Target Family

Non-IDG 42 | 12,091
Enzyme 1 | 4,145

Reactome Pathway

Kinesins 43 | 43
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Kinesin-like protein KIF3A KIF3A Tbio Non-IDG -2.06068 113.6 153
Kinesin-like protein KIF22 KIF22 Tbio Non-IDG -1.69996 54.3 147
Kinesin-like protein KIF6 KIF6 Tbio Non-IDG -1.53414 38.4 157
Kinesin-like protein KIF3B KIF3B Tbio Non-IDG -1.37859 20.9 98
Kinesin light chain 2 KLC2 Tbio Non-IDG -0.71842 5.05 153
Rac GTPase-activating protein 1 RACGAP1 Tbio Enzyme -1.69445 57.6 382
Kinesin light chain 1 KLC1 Tbio Non-IDG -2.17598 25.5 180
Kinesin-associated protein 3 KIFAP3 Tbio Non-IDG -1.36007 24.1 87
Kinesin-like protein KIF2A KIF2A Tbio Non-IDG -1.60781 42.7 145
Kinesin-like protein KIF3C KIF3C Tdark Non-IDG -0.64615 4.15 56