Development Level

Tbio 24 | 10,625
Tchem 11 | 1,890
Tdark 9 | 7,003

IMPC Term

preweaning lethality, complete... 7 | 633
abnormal embryo size 2 | 112
hyperactivity 2 | 108
abnormal behavior 1 | 226
abnormal behavioral response t... 1 | 52
abnormal bone structure 1 | 131
abnormal facial morphology 1 | 9
abnormal head shape 1 | 4
abnormal lens morphology 1 | 73
abnormal limb morphology 1 | 7
abnormal outer ear morphology 1 | 1
abnormal sleep behavior 1 | 63
absent pinna reflex 1 | 21
cyanosis 1 | 6
decreased bone mineral content 1 | 157
decreased circulating alanine ... 1 | 53
decreased circulating aspartat... 1 | 27
decreased circulating free fat... 1 | 39
decreased circulating glucose ... 1 | 121
decreased circulating serum al... 1 | 79
decreased circulating total pr... 1 | 41
decreased lean body mass 1 | 195
decreased red blood cell distr... 1 | 11
decreased startle reflex 1 | 48
hemorrhage 1 | 12
impaired glucose tolerance 1 | 52
increased bone mineral content 1 | 92
increased circulating HDL chol... 1 | 63
increased circulating chloride... 1 | 43
increased circulating glucose ... 1 | 16
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 68
increased grip strength 1 | 83
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 25
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
prenatal lethality prior to he... 1 | 64

Disease

medulloblastoma, large-cell 26 | 6,234
glioblastoma 25 | 5,572
ovarian cancer 25 | 8,484
atypical teratoid / rhabdoid tumor 21 | 4,369
lung cancer 21 | 4,466
osteosarcoma 19 | 7,933
pediatric high grade glioma 19 | 2,712
malignant mesothelioma 16 | 3,162
non-small cell lung cancer 16 | 2,798
psoriasis 16 | 6,685
Breast cancer 15 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,988
primitive neuroectodermal tumor 15 | 3,031
group 3 medulloblastoma 14 | 2,254
invasive ductal carcinoma 14 | 2,950
Carcinoma 13 | 2,147
adrenocortical carcinoma 13 | 1,427
pilocytic astrocytoma 13 | 3,086
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,289
Atopic dermatitis 11 | 944
colon cancer 11 | 1,475
oligodendroglioma 11 | 2,849
breast carcinoma 10 | 1,614
ductal carcinoma in situ 10 | 1,745
Endometriosis 9 | 535
nasopharyngeal carcinoma 9 | 1,056
posterior fossa group A ependymoma 9 | 1,511
IGA Glomerulonephritis 8 | 454
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,956
lung adenocarcinoma 8 | 2,713
lung carcinoma 8 | 2,844
pituitary cancer 8 | 1,972
posterior fossa group B ependymoma 8 | 1,530
astrocytoma 6 | 1,493
group 4 medulloblastoma 6 | 1,875
pancreatic cancer 6 | 2,300
sonic hedgehog group medulloblastoma 6 | 1,482
Cancer 5 | 2,346
Neurodegenerative disease 5 | 383
Neuropathy 5 | 210
Paraplegia 5 | 71
adult high grade glioma 5 | 2,148
interstitial cystitis 5 | 2,299
subependymal giant cell astrocytoma 5 | 2,287
Microcephaly 4 | 149
Pick disease 4 | 1,893
ependymoma 4 | 2,514
medulloblastoma 4 | 1,524
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795
primary Sjogren syndrome 4 | 789
ulcerative colitis 4 | 2,087
Amyotrophic Lateral Sclerosis 3 | 431
astrocytic glioma 3 | 2,241
atypical teratoid/rhabdoid tumor 3 | 1,095
cutaneous lupus erythematosus 3 | 1,056
hereditary spastic paraplegia 3 | 313
inflammatory breast cancer 3 | 404
spina bifida 3 | 1,064
Attention deficit hyperactivity disorder 2 | 156
Benign glioma 2 | 2
Congenital fibrosis of the extraocular muscles 2 | 11
Goldberg-Shprintzen syndrome 2 | 8
Malformations of Cortical Development 2 | 11
Polycystic kidney disease 2 | 54
SPOAN syndrome 2 | 2
Seckel syndrome 2 | 34
active Crohn's disease 2 | 918
acute myeloid leukemia 2 | 780
chronic rhinosinusitis 2 | 512
cystic fibrosis and chronic rhinosinusitis 2 | 213
dermatomyositis 2 | 933
diabetes mellitus 2 | 1,663
facioscapulohumeral dystrophy 2 | 286
fibroadenoma 2 | 557
primary pancreatic ductal adenocarcinoma 2 | 1,271
tuberculosis and treatment for 6 months 2 | 686
AMYOTROPHIC LATERAL SCLEROSIS 1 1 | 49
Ankylosing spondylitis 1 | 138
Barrett's esophagus 1 | 183
Basal cell carcinoma 1 | 29
Bipolar Disorder 1 | 266
Carpenter syndrome 1 | 13
Cerebellar Ataxia 1 | 72
Charcot-Marie-Tooth disease 1 | 74
Craniofacial Abnormalities 1 | 147
Filariasis 1 | 21
Gangliosidosis 1 | 17
Hyperopia 1 | 33
Liver cancer 1 | 31
Lymphedema 1 | 26
Orchitis 1 | 16
Pallister-Hall syndrome 1 | 11
Ptosis 1 | 42
Retinitis pigmentosa 1 | 153
Situs Inversus 1 | 48
Testicular Germ Cell Tumor 1 | 22
Testicular cancer 1 | 24
active ulcerative colitis 1 | 477
fascioscapulohumeral muscular dystrophy 1 | 100
head and neck cancer and chronic obstructive pulmonary disease 1 | 237

Tissue

Blood and immune system 43 | 17,995
Cardiovascular System 43 | 17,958
Digestive Tract 43 | 18,473
Endocrine System 43 | 18,512
Female tissues 43 | 18,647
Liver and Pancreas 43 | 18,136
Male tissues 43 | 17,969
Nervous System 43 | 18,561
Skin and soft tissues 43 | 18,115
Urinary Tract 43 | 18,444
Respiratory system 42 | 17,484

Target Family

Non-IDG 43 | 11,971
Enzyme 1 | 4,146

Reactome Pathway

Kinesins 44 | 44
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Kinesin-like protein KIF1C KIF1C Tbio Non-IDG -1.21884 20.0 95
Kinesin-like protein KIF3B KIF3B Tbio Non-IDG -1.33400 20.0 84
Kinesin-like protein KIF18A KIF18A Tbio Non-IDG -1.37782 29.6 81
Kinesin-like protein KIF21B KIF21B Tbio Non-IDG -0.94345 9.49 31
Rac GTPase-activating protein 1 RACGAP1 Tbio Enzyme -1.64660 53.0 346
Kinesin light chain 2 KLC2 Tbio Non-IDG -0.68225 4.64 136
Kinesin light chain 3 KLC3 Tbio Non-IDG -0.95317 10.1 83
Kinesin-like protein KIF28P KIF28P Tdark Non-IDG 0.00000 0
Kinesin-like protein KIFC1 KIFC1 Tchem Non-IDG -1.88802 78.4 79
Kinesin-like protein KIF20B KIF20B Tchem Non-IDG -0.97256 11.2 39