Development Level

Tdark 118 | 7,003
Tbio 84 | 10,625
Tchem 11 | 1,890

IMPC Phenotype

preweaning lethality, complete... 4 | 633
abnormal bone structure 3 | 131
preweaning lethality, incomple... 3 | 260
abnormal coat appearance 2 | 25
abnormal vibrissa morphology 2 | 17
decreased circulating insulin ... 2 | 75
decreased total body fat amoun... 2 | 186
improved glucose tolerance 2 | 56
abnormal coat- hair morphology 1 | 18
abnormal cornea morphology 1 | 24
abnormal embryo size 1 | 112
abnormal sleep behavior 1 | 63
brachydactyly 1 | 2
convulsive seizures 1 | 11
corneal opacity 1 | 25
corneal vascularization 1 | 5
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 53
decreased circulating aspartat... 1 | 27
decreased circulating calcium ... 1 | 33
decreased circulating free fat... 1 | 39
decreased circulating triglyce... 1 | 83
decreased coping response 1 | 5
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
edema 1 | 11
embryonic lethality prior to t... 1 | 187
impaired righting response 1 | 19
increased bone mineral content 1 | 92
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased or absent threshold ... 1 | 128
increased respiratory quotient 1 | 12
male infertility 1 | 62
narrow eye opening 1 | 15
prenatal lethality 1 | 16

Disease

psoriasis 143 | 6,685
diabetes mellitus 56 | 1,663
Atopic dermatitis 48 | 944
ovarian cancer 40 | 8,491
esophageal adenocarcinoma 32 | 737
osteosarcoma 32 | 7,933
cystic fibrosis 31 | 1,670
non-small cell lung cancer 29 | 2,798
lung cancer 27 | 4,473
spina bifida 25 | 1,064
Cancer 24 | 2,346
Breast cancer 23 | 3,098
medulloblastoma, large-cell 22 | 6,234
malignant mesothelioma 21 | 3,163
interstitial cystitis 19 | 2,299
nasopharyngeal carcinoma 19 | 1,056
pancreatic cancer 18 | 2,300
lung adenocarcinoma 16 | 2,714
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,289
Palmoplantar keratosis 14 | 36
Carcinoma 13 | 2,147
adult high grade glioma 13 | 2,148
breast carcinoma 13 | 1,614
atypical teratoid / rhabdoid tumor 12 | 4,369
cutaneous lupus erythematosus 12 | 1,056
ductal carcinoma in situ 12 | 1,745
Keratosis 11 | 34
Monilethrix 11 | 17
Congenital ichthyosiform erythroderma 10 | 27
Epidermolytic hyperkeratosis 10 | 13
Netherton syndrome 10 | 14
periodontitis 10 | 269
Dermatitis 9 | 141
Hypotrichosis 9 | 29
colon cancer 9 | 1,475
glioblastoma 9 | 5,572
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,988
lung carcinoma 9 | 2,844
ulcerative colitis 9 | 2,087
Pachyonychia Congenita 8 | 9
Peeling skin syndrome 8 | 16
Squamous cell carcinoma 8 | 96
invasive ductal carcinoma 8 | 2,950
Arrhythmogenic right ventricular cardiomyopathy 7 | 27
Epidermolysis bullosa simplex 7 | 9
Hereditary mucosal leukokeratosis 7 | 7
Ichthyosis vulgaris 7 | 15
Prostatic Neoplasms 7 | 471
pituitary cancer 7 | 1,972
posterior fossa group A ependymoma 7 | 1,511
primitive neuroectodermal tumor 7 | 3,031
Alopecia 6 | 55
Cardiomyopathy 6 | 110
Papilloma 6 | 27
Skin disease 6 | 65
group 4 medulloblastoma 6 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,956
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,795
Contact Dermatitis 5 | 80
Pemphigus 5 | 18
Ritter's disease 5 | 10
Skin Neoplasms 5 | 49
oligodendroglioma 5 | 2,849
pilocytic astrocytoma 5 | 3,086
subependymal giant cell astrocytoma 5 | 2,287
Adenoma 4 | 165
Ameloblastoma 4 | 25
Arrhythmogenic Right Ventricular Dysplasia 4 | 10
Asthma 4 | 349
Bullous pemphigoid 4 | 17
Dilated cardiomyopathy 4 | 51
Endometriosis 4 | 535
Epidermolysis bullosa 4 | 21
Liver disease 4 | 219
Neoplastic Cell Transformation 4 | 81
Rheumatoid Arthritis 4 | 1,170
Squamous cell carcinoma of esophagus 4 | 82
Syringoma 4 | 10
active ulcerative colitis 4 | 477
astrocytic glioma 4 | 2,241
posterior fossa group B ependymoma 4 | 1,530
primary pancreatic ductal adenocarcinoma 4 | 1,271
Animal Mammary Neoplasms 3 | 135
Cardiomyopathies 3 | 90
Cholesteatoma 3 | 13
Corneal dystrophy 3 | 15
Eczema herpeticum 3 | 7
Malaria 3 | 140
Mammary Neoplasms 3 | 410
Mammary Neoplasms, Experimental 3 | 149
Pick disease 3 | 1,893
Stomach Neoplasms 3 | 282
acute myeloid leukemia 3 | 785
acute quadriplegic myopathy 3 | 1,157
atypical teratoid/rhabdoid tumor 3 | 1,095
cystic fibrosis and chronic rhinosinusitis 3 | 213
medulloblastoma 3 | 1,524
mucosa-associated lymphoid tissue lymphoma 3 | 480
pediatric high grade glioma 3 | 2,712
urothelial carcinoma 3 | 318

Tissue

Female tissues 190 | 18,646
Skin and soft tissues 190 | 18,114
Digestive Tract 184 | 18,472
Nervous System 180 | 18,560
Urinary Tract 173 | 18,443
Endocrine System 170 | 18,511
Liver and Pancreas 157 | 18,135
Cardiovascular System 152 | 17,957
Blood and immune system 142 | 17,994
Male tissues 132 | 17,968
Respiratory system 115 | 17,483

Target Family

Non-IDG 198 | 11,969
Enzyme 15 | 4,146

Reactome Pathway

Keratinization 213 | 213
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Calpain small subunit 1 CAPNS1 Tbio Non-IDG -2.88291 736.0 131
Late cornified envelope protein 5A LCE5A Tdark Non-IDG 0.50 0.32 0
Protein-glutamine gamma-glutamyltransferase 5 TGM5 Tbio Enzyme -1.90931 75.5 113
Keratin-associated protein 2-2 KRTAP2-2 Tdark Non-IDG 0.00000 0
Keratin-associated protein 2-1 KRTAP2-1 Tdark Non-IDG 0.78 0.17 8
Keratin-associated protein 16-1 KRTAP16-1 Tdark Non-IDG 0.00000 0
Keratin, type II cytoskeletal 80 KRT80 Tbio Non-IDG -0.75979 5.56 91
Serine protease inhibitor Kazal-type 9 SPINK9 Tbio Enzyme -0.32516 3.16 22
Late cornified envelope protein 4A LCE4A Tdark Non-IDG 0.12 0.33 0
Late cornified envelope protein 2A LCE2A Tdark Non-IDG -0.17609 1.29 4