Development Level

Tdark 118 | 7,003
Tbio 84 | 10,625
Tchem 11 | 1,890

IMPC Term

preweaning lethality, complete... 4 | 633
abnormal bone structure 3 | 131
preweaning lethality, incomple... 3 | 260
abnormal coat appearance 2 | 25
abnormal vibrissa morphology 2 | 17
decreased circulating insulin ... 2 | 75
decreased total body fat amoun... 2 | 186
improved glucose tolerance 2 | 56
abnormal coat/ hair morphology 1 | 18
abnormal cornea morphology 1 | 24
abnormal embryo size 1 | 112
abnormal sleep behavior 1 | 63
brachydactyly 1 | 2
convulsive seizures 1 | 11
corneal opacity 1 | 25
corneal vascularization 1 | 5
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 53
decreased circulating aspartat... 1 | 27
decreased circulating calcium ... 1 | 33
decreased circulating free fat... 1 | 39
decreased circulating triglyce... 1 | 83
decreased coping response 1 | 5
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
edema 1 | 11
embryonic lethality prior to t... 1 | 187
impaired righting response 1 | 19
increased bone mineral content 1 | 92
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased or absent threshold ... 1 | 128
increased respiratory quotient 1 | 12
male infertility 1 | 62
narrow eye opening 1 | 15
prenatal lethality 1 | 16

Disease

psoriasis 143 | 6,685
diabetes mellitus 56 | 1,663
Atopic dermatitis 48 | 944
ovarian cancer 40 | 8,484
esophageal adenocarcinoma 32 | 737
osteosarcoma 32 | 7,933
cystic fibrosis 31 | 1,665
non-small cell lung cancer 29 | 2,798
lung cancer 27 | 4,466
spina bifida 25 | 1,064
Cancer 24 | 2,346
Breast cancer 23 | 3,094
medulloblastoma, large-cell 22 | 6,234
malignant mesothelioma 21 | 3,162
interstitial cystitis 19 | 2,299
nasopharyngeal carcinoma 19 | 1,056
pancreatic cancer 18 | 2,300
lung adenocarcinoma 16 | 2,713
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,289
Palmoplantar keratosis 14 | 36
Carcinoma 13 | 2,147
adult high grade glioma 13 | 2,148
breast carcinoma 13 | 1,614
atypical teratoid / rhabdoid tumor 12 | 4,369
cutaneous lupus erythematosus 12 | 1,056
ductal carcinoma in situ 12 | 1,745
Keratosis 11 | 34
Congenital ichthyosiform erythroderma 10 | 27
Epidermolytic hyperkeratosis 10 | 13
Monilethrix 10 | 16
Netherton syndrome 10 | 14
periodontitis 10 | 269
Dermatitis 9 | 107
Hypotrichosis 9 | 29
colon cancer 9 | 1,475
glioblastoma 9 | 5,572
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,988
lung carcinoma 9 | 2,844
ulcerative colitis 9 | 2,087
Pachyonychia Congenita 8 | 9
Peeling skin syndrome 8 | 16
Squamous cell carcinoma 8 | 94
invasive ductal carcinoma 8 | 2,950
Arrhythmogenic right ventricular cardiomyopathy 7 | 27
Epidermolysis bullosa simplex 7 | 9
Hereditary mucosal leukokeratosis 7 | 7
Ichthyosis vulgaris 7 | 15
Prostatic Neoplasms 7 | 471
pituitary cancer 7 | 1,972
posterior fossa group A ependymoma 7 | 1,511
primitive neuroectodermal tumor 7 | 3,031
Alopecia 6 | 55
Cardiomyopathy 6 | 110
Papilloma 6 | 27
Skin disease 6 | 65
group 4 medulloblastoma 6 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,956
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,795
Contact Dermatitis 5 | 80
Pemphigus 5 | 18
Ritter's disease 5 | 10
Skin Neoplasms 5 | 49
oligodendroglioma 5 | 2,849
pilocytic astrocytoma 5 | 3,086
subependymal giant cell astrocytoma 5 | 2,287
Adenoma 4 | 165
Ameloblastoma 4 | 25
Arrhythmogenic Right Ventricular Dysplasia 4 | 10
Asthma 4 | 349
Bullous pemphigoid 4 | 17
Dilated cardiomyopathy 4 | 50
Endometriosis 4 | 535
Epidermolysis bullosa 4 | 21
Liver disease 4 | 219
Neoplastic Cell Transformation 4 | 81
Rheumatoid Arthritis 4 | 1,160
Squamous cell carcinoma of esophagus 4 | 82
Syringoma 4 | 10
active ulcerative colitis 4 | 477
astrocytic glioma 4 | 2,241
posterior fossa group B ependymoma 4 | 1,530
primary pancreatic ductal adenocarcinoma 4 | 1,271
Animal Mammary Neoplasms 3 | 136
Cardiomyopathies 3 | 90
Cholesteatoma 3 | 13
Corneal dystrophy 3 | 15
Eczema herpeticum 3 | 7
Malaria 3 | 140
Mammary Neoplasms 3 | 410
Mammary Neoplasms, Experimental 3 | 150
Pick disease 3 | 1,893
Stomach Neoplasms 3 | 282
acute myeloid leukemia 3 | 780
acute quadriplegic myopathy 3 | 1,157
atypical teratoid/rhabdoid tumor 3 | 1,095
cystic fibrosis and chronic rhinosinusitis 3 | 213
medulloblastoma 3 | 1,524
mucosa-associated lymphoid tissue lymphoma 3 | 480
pediatric high grade glioma 3 | 2,712
urothelial carcinoma 3 | 318

Tissue

Female tissues 190 | 18,647
Skin and soft tissues 190 | 18,115
Digestive Tract 184 | 18,473
Nervous System 180 | 18,561
Urinary Tract 173 | 18,444
Endocrine System 170 | 18,512
Liver and Pancreas 157 | 18,136
Cardiovascular System 152 | 17,958
Blood and immune system 142 | 17,995
Male tissues 132 | 17,969
Respiratory system 115 | 17,484

Target Family

Non-IDG 198 | 11,971
Enzyme 15 | 4,146

Reactome Pathway

Keratinization 213 | 213
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Keratin, type II cytoskeletal 3 KRT3 Tbio Non-IDG -2.12849 126.8 100
Desmoplakin DSP Tbio Non-IDG -2.90088 786.5 167
Keratin, type II cytoskeletal 74 KRT74 Tbio Non-IDG -2.22050 159.7 35
Late cornified envelope protein 2C LCE2C Tdark Non-IDG 0.00000 0
Late cornified envelope protein 2D LCE2D Tdark Non-IDG 1.00 0.08 1
Late cornified envelope protein 4A LCE4A Tdark Non-IDG 0.12 0.33 0
Late cornified envelope protein 2A LCE2A Tdark Non-IDG -0.12494 1.29 4
Late cornified envelope protein 3A LCE3A Tdark Non-IDG -0.07588 1.31 0
Late cornified envelope protein 3B LCE3B Tbio Non-IDG -1.17845 16.5 0
Serine protease inhibitor Kazal-type 9 SPINK9 Tbio Enzyme -0.31352 3.16 22