Development Level

Tbio 14 | 11,445
Tchem 2 | 1,598

IMPC Phenotype

preweaning lethality, complete... 4 | 979
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 2 | 278
abnormal coat-hair pigmentatio... 1 | 64
abnormal heart morphology 1 | 162
abnormal retina morphology 1 | 71
abnormal skin morphology 1 | 50
abnormal vitreous body morphol... 1 | 10
decreased circulating insulin ... 1 | 76
decreased total body fat amoun... 1 | 207
edema 1 | 59
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
increased heart weight 1 | 62
increased startle reflex 1 | 112
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97

Disease

osteosarcoma 12 | 7,950
ovarian cancer 11 | 8,520
medulloblastoma, large-cell 7 | 6,241
Carcinoma 6 | 11,493
atypical teratoid / rhabdoid tumor 6 | 5,112
group 3 medulloblastoma 6 | 4,104
glioblastoma 5 | 5,792
psoriasis 5 | 6,694
lung cancer 4 | 4,740
Astrocytoma, Pilocytic 3 | 3,081
Autosomal recessive predisposition 3 | 1,442
Cerebral atrophy 3 | 178
Cognitive delay 3 | 608
Global developmental delay 3 | 608
Mental and motor retardation 3 | 608
Multiple myeloma 3 | 1,332
Waldenstrons macroglobulinemia 3 | 765
adult high grade glioma 3 | 3,801
astrocytic glioma 3 | 2,597
ependymoma 3 | 4,679
malignant mesothelioma 3 | 3,232
oligodendroglioma 3 | 2,850
primitive neuroectodermal tumor 3 | 3,035
Breast cancer 2 | 3,578
Cancer 2 | 2,499
Cardiomyopathies 2 | 110
Dyskeratosis congenita 2 | 24
Failure to gain weight 2 | 365
Feeding difficulties 2 | 127
Liver neoplasms 2 | 130
Neurodegenerative disease 2 | 414
Pediatric failure to thrive 2 | 365
Pontocerebellar Hypoplasia Type 1 2 | 5
Pontocerebellar hypoplasia 2 | 36
X-linked cerebral adrenoleukodystrophy 2 | 116
acute quadriplegic myopathy 2 | 1,158
colon cancer 2 | 1,478
diabetes mellitus 2 | 1,728
group 4 medulloblastoma 2 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
invasive ductal carcinoma 2 | 2,951
medulloblastoma 2 | 720
non-small cell lung cancer 2 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
subependymal giant cell astrocytoma 2 | 2,287
Abnormal blistering of the skin 1 | 54
Abnormal pigmentation 1 | 25
Abnormality of female internal genitalia 1 | 13
Abnormality of the fingernails 1 | 51
Abnormality of the pharynx 1 | 19
Alopecia 1 | 115
Animal Mammary Neoplasms 1 | 136
Anorectal Malformations 1 | 8
Aplasia/Hypoplasia of the skin 1 | 16
Axial hypotonia 1 | 46
Blister of skin 1 | 54
Bone marrow hypocellularity 1 | 20
Brachydactyly 1 | 156
Brain disease 1 | 96
Cerebellar cyst 1 | 5
Decreased platelet count 1 | 111
Dental caries 1 | 164
Dystrophia unguium 1 | 53
Esophageal Stenosis 1 | 15
Gaucher disease type 1 1 | 180
Gingival Diseases 1 | 19
Hyperhidrosis disorder 1 | 81
Hyperpigmented macules 1 | 42
Hypodontia 1 | 81
Hypoplastic-absent toenails 1 | 11
Immunologic Deficiency Syndromes 1 | 113
Increased sweating 1 | 81
Large elongated pulp chamber 1 | 14
Leukokeratosis 1 | 19
Leukoplakia, Oral 1 | 20
Mammary Neoplasms, Animal 1 | 136
Mammary Neoplasms, Experimental 1 | 154
Microvillus inclusion disease 1 | 8
Muscle Weakness 1 | 170
Myositis 1 | 30
Neoplasm Recurrence, Local 1 | 37
Periodontal Diseases 1 | 21
Precancerous Conditions 1 | 80
Progressive microcephaly 1 | 32
Respiratory Failure 1 | 104
Rotting teeth 1 | 73
Rough bone trabeculation 1 | 11
Skin Ulcer 1 | 48
Skin bulla 1 | 54
Spinal muscular atrophy 1 | 34
Sweating 1 | 81
Systemic scleroderma 1 | 60
Taurodontism 1 | 14
Telangiectasia of the skin 1 | 39
Thrombocytopenia 1 | 197
Tracheoesophageal Fistula 1 | 36
Urethral Stricture 1 | 18
axial spondyloarthropathy 1 | 28
hypopigmented skin patch 1 | 59
sarcoidosis 1 | 370

Tissue

Blood and immune system 16 | 16,909
Cardiovascular System 16 | 15,192
Digestive Tract 16 | 17,369
Endocrine System 16 | 18,159
Female tissues 16 | 17,400
Liver and Pancreas 16 | 16,750
Male tissues 16 | 17,142
Nervous System 16 | 16,725
Respiratory system 16 | 16,393
Skin and soft tissues 16 | 17,230
Urinary Tract 16 | 16,678

Target Family

Enzyme 9 | 4,145
Non-IDG 5 | 12,091
Kinase 2 | 634

Reactome Pathway

KSRP (KHSRP) binds and destabi... 16 | 16
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Exosome complex exonuclease RRP44 DIS3 Tbio Enzyme -1.80730 64.2 141
Exosome complex component RRP4 EXOSC2 Tbio Non-IDG -0.28065 2.13 121
Exosome complex component MTR3 EXOSC6 Tbio Enzyme -0.78888 5.11 84
Exosome complex component RRP41 EXOSC4 Tbio Enzyme -1.96200 85.3 113
Exosome complex component RRP45 EXOSC9 Tbio Enzyme -1.17714 13.5 92
Exosome complex component RRP46 EXOSC5 Tbio Enzyme -1.31759 21.1 114
14-3-3 protein zeta/delta YWHAZ Tbio Non-IDG -2.59435 390.4 689
Exosome complex component CSL4 EXOSC1 Tbio Non-IDG -2.07438 110.2 129
m7GpppN-mRNA hydrolase DCP2 Tbio Enzyme -1.94580 87.7 161
Poly(A)-specific ribonuclease PARN PARN Tbio Enzyme -1.87605 76.4 263