Development Level

Tchem 11 | 1,890
Tbio 6 | 10,625
Tclin 1 | 602

IMPC Phenotype

preweaning lethality, complete... 3 | 633
increased erythrocyte cell num... 2 | 26
abnormal lens morphology 1 | 73
decreased KLRG1+ CD8 alpha bet... 1 | 8
decreased circulating creatini... 1 | 31
embryonic lethality prior to t... 1 | 187
increased NK cell number 1 | 19
increased hematocrit 1 | 36
polydactyly 1 | 22

Disease

glioblastoma 11 | 5,572
ovarian cancer 10 | 8,491
medulloblastoma, large-cell 9 | 6,234
osteosarcoma 9 | 7,933
Cancer 8 | 2,346
atypical teratoid / rhabdoid tumor 8 | 4,369
psoriasis 7 | 6,685
adult high grade glioma 5 | 2,148
astrocytic glioma 5 | 2,241
ependymoma 5 | 2,514
oligodendroglioma 5 | 2,849
subependymal giant cell astrocytoma 5 | 2,287
Pick disease 4 | 1,893
acute myeloid leukemia 4 | 785
lung cancer 4 | 4,473
primitive neuroectodermal tumor 4 | 3,031
Arthritis 3 | 248
Blau syndrome 3 | 8
Crohn's disease 3 | 304
Hypohidrotic ectodermal dysplasia 3 | 14
Precancerous Conditions 3 | 69
Toxic encephalopathy 3 | 131
Vascular disease 3 | 281
group 4 medulloblastoma 3 | 1,875
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,988
invasive ductal carcinoma 3 | 2,950
medulloblastoma 3 | 1,524
pilocytic astrocytoma 3 | 3,086
Colitis 2 | 46
Coronary artery disease 2 | 240
Exanthem 2 | 39
Gastrointestinal system disease 2 | 50
IGA Glomerulonephritis 2 | 454
Leprosy 2 | 77
Lung Neoplasms 2 | 171
Osteopetrosis 2 | 40
Osteoporosis 2 | 259
Reperfusion Injury 2 | 84
Rheumatoid Arthritis 2 | 1,170
acute quadriplegic myopathy 2 | 1,157
dermatomyositis 2 | 966
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,289
juvenile dermatomyositis 2 | 1,189
lung adenocarcinoma 2 | 2,714
lung carcinoma 2 | 2,844
malignant mesothelioma 2 | 3,163
non primary Sjogren syndrome sicca 2 | 840
pediatric high grade glioma 2 | 2,712
pituitary cancer 2 | 1,972
posterior fossa group A ependymoma 2 | 1,511
primary pancreatic ductal adenocarcinoma 2 | 1,271
spina bifida 2 | 1,064
tuberculosis 2 | 1,563
ulcerative colitis 2 | 2,087
ATYPICAL MYCOBACTERIOSIS, FAMILIAL, X-LINKED 1 (disorder) 1 | 1
Autosomal dominant hypohidrotic ectodermal dysplasia syndrome (disorder) 1 | 3
Bloch Sulzberger syndrome 1 | 1
Bloch-Sulzberger syndrome 1 | 2
Brain disease 1 | 84
Ectodermal Dysplasia, Anhidrotic, with Immunodeficiency, Osteopetrosis, and Lymphedema 1 | 1
Ectodermal dysplasia, anhidrotic, with immunodeficiency X-linked 1 | 1
Ectodermal dysplasia, anhidrotic, with immunodeficiency, osteopetrosis and lymphedema 1 | 1
Ectodermal dysplasia, hypohidrotic, with immune deficiency 1 | 1
Epilepsy 1 | 346
Eye disease 1 | 55
Fatty liver disease 1 | 86
Fibrosis 1 | 40
Gaucher disease type 3 1 | 76
Heart disease 1 | 279
Heart failure 1 | 80
Hypoxia-Ischemia, Brain 1 | 5
INVASIVE PNEUMOCOCCAL DISEASE, RECURRENT ISOLATED, 2 (disorder) 1 | 1
Immunodeficiency 33 1 | 1
Immunodeficiency without anhidrotic ectodermal dysplasia 1 | 1
Immunodeficiency, NEMO-related, without anhidrotic ectodermal dysplasia 1 | 1
Incontinentia pigmenti 1 | 1
Incontinentia pigmenti, familial male-lethal type 1 | 1
Lennox-Gastaut syndrome 1 | 34
Lung disease 1 | 136
Lupus erythematosus 1 | 80
Lymphedema 1 | 26
Mammary Neoplasms 1 | 410
Mammary Neoplasms, Experimental 1 | 149
Metabolic syndrome X 1 | 155
Neoplasm Metastasis 1 | 138
Neurodegenerative disease 1 | 383
Non-alcoholic Fatty Liver Disease 1 | 40
Parkinson's disease 1 | 364
Paronychia 1 | 7
Progressive relapsing multiple sclerosis 1 | 18
Recurrent isolated invasive pneumococcal disease 2 1 | 1
Renal Cell Carcinoma 1 | 199
Skin disease 1 | 65
Stomach Neoplasms 1 | 282
Tactile agnosia 1 | 3
Tooth agenesis 1 | 38
active ulcerative colitis 1 | 477
atypical teratoid/rhabdoid tumor 1 | 1,095
nervous system disorder 1 | 53
sarcoidosis 1 | 368

Tissue

Blood and immune system 18 | 17,994
Cardiovascular System 18 | 17,957
Digestive Tract 18 | 18,472
Endocrine System 18 | 18,511
Female tissues 18 | 18,646
Liver and Pancreas 18 | 18,135
Male tissues 18 | 17,968
Nervous System 18 | 18,560
Respiratory system 18 | 17,483
Urinary Tract 18 | 18,443
Skin and soft tissues 17 | 18,114

Target Family

Kinase 11 | 634
Non-IDG 5 | 11,969
Enzyme 2 | 4,146

Reactome Pathway

JNK (c-Jun kinases) phosphoryl... 18 | 18
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

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