Development Level

Tbio 47 | 11,445
Tchem 9 | 1,598
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, complete... 11 | 979
embryonic lethality prior to t... 8 | 278
embryonic lethality prior to o... 6 | 239
abnormal behavior 3 | 298
decreased total body fat amoun... 3 | 207
decreased circulating bilirubi... 2 | 19
decreased hemoglobin content 2 | 68
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular vol... 2 | 79
hyperactivity 2 | 148
preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
abnormal gait 1 | 69
abnormal kidney morphology 1 | 65
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
brachydactyly 1 | 19
cardiovascular system phenotyp... 1 | 36
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating aspartat... 1 | 34
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 31
decreased mean platelet volume 1 | 25
decreased monocyte cell number 1 | 8
decreased prepulse inhibition 1 | 82
decreased vertical activity 1 | 208
enlarged heart 1 | 210
enlarged spleen 1 | 41
hypoactivity 1 | 132
increased body length 1 | 32
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased heart rate variabili... 1 | 7
increased heart weight 1 | 62
increased mean corpuscular hem... 1 | 96
increased or absent threshold ... 1 | 101
long tibia 1 | 25
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
short tibia 1 | 97
small adrenal glands 1 | 16
small lymph nodes 1 | 1
syndactyly 1 | 23
thrombocytosis 1 | 27

Disease

ovarian cancer 35 | 8,520
Carcinoma 34 | 11,493
medulloblastoma, large-cell 26 | 6,241
psoriasis 26 | 6,694
osteosarcoma 24 | 7,950
glioblastoma 22 | 5,792
atypical teratoid / rhabdoid tumor 21 | 5,112
Anemia 20 | 365
ependymoma 20 | 4,679
lung carcinoma 17 | 2,843
adult high grade glioma 16 | 3,801
lung cancer 16 | 4,740
Breast cancer 15 | 3,578
group 3 medulloblastoma 15 | 4,104
malignant mesothelioma 15 | 3,232
primitive neuroectodermal tumor 14 | 3,035
subependymal giant cell astrocytoma 14 | 2,287
Autosomal recessive predisposition 13 | 1,442
Pick disease 13 | 1,894
astrocytic glioma 13 | 2,597
oligodendroglioma 13 | 2,850
Astrocytoma, Pilocytic 12 | 3,081
invasive ductal carcinoma 12 | 2,951
Cancer 11 | 2,499
Hemochromatosis 11 | 54
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
tuberculosis 11 | 2,010
Multiple myeloma 10 | 1,332
lung adenocarcinoma 10 | 2,716
non-small cell lung cancer 10 | 2,890
pancreatic cancer 10 | 2,398
pituitary cancer 10 | 1,972
cystic fibrosis 9 | 1,696
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
Alzheimer's disease 8 | 658
adrenocortical carcinoma 8 | 1,428
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
Aceruloplasminemia 7 | 16
Hyperferritinaemia 7 | 14
Increased ferritin 7 | 14
Parkinson's disease 7 | 392
Serum ferritin increased 7 | 14
diabetes mellitus 7 | 1,728
Liver disease 6 | 237
Neoplasm Invasiveness 6 | 161
Neurodegenerative disease 6 | 414
Vascular disease 6 | 319
astrocytoma 6 | 1,146
breast carcinoma 6 | 1,638
nasopharyngeal carcinoma 6 | 1,058
primary pancreatic ductal adenocarcinoma 6 | 1,109
ulcerative colitis 6 | 1,819
Atransferrinemia 5 | 8
Chemical and Drug Induced Liver Injury 5 | 195
Hemoglobin low 5 | 124
Kidney disease 5 | 430
Obesity 5 | 678
Osteopetrosis 5 | 43
Schizophrenia 5 | 1,160
Waldenstrons macroglobulinemia 5 | 765
acute myeloid leukemia 5 | 783
acute quadriplegic myopathy 5 | 1,158
aldosterone-producing adenoma 5 | 665
ductal carcinoma in situ 5 | 1,745
hepatocellular carcinoma 5 | 547
Cutis Laxa 4 | 39
Failure to gain weight 4 | 365
Hepatomegaly 4 | 285
Hypertension 4 | 396
Inflammation 4 | 120
Iron Metabolism Disorders 4 | 5
Iron Overload 4 | 5
Iron deficiency anemia 4 | 12
Kidney cancer 4 | 2,613
Liver Cirrhosis 4 | 181
Liver Cirrhosis, Experimental 4 | 769
Liver diseases 4 | 87
Pediatric failure to thrive 4 | 365
Rheumatoid arthritis 4 | 1,191
Seizures 4 | 596
Thalassemia 4 | 53
chronic rhinosinusitis 4 | 512
colon cancer 4 | 1,478
cutaneous lupus erythematosus 4 | 1,057
esophageal adenocarcinoma 4 | 737
gastric carcinoma 4 | 807
interstitial cystitis 4 | 2,312
medulloblastoma 4 | 720
pediatric high grade glioma 4 | 1,064
progressive supranuclear palsy 4 | 676
Atopic dermatitis 3 | 952
Contact Dermatitis 3 | 81
Depressive disorder 3 | 409
Dermatitis, Contact 3 | 71
Epilepsy 3 | 792
active Crohn's disease 3 | 922
dermatomyositis 3 | 966
mucosa-associated lymphoid tissue lymphoma 3 | 484
pancreatic carcinoma 3 | 562

Tissue

Blood and immune system 57 | 16,909
Endocrine System 57 | 18,159
Digestive Tract 56 | 17,369
Female tissues 56 | 17,400
Male tissues 56 | 17,142
Nervous System 56 | 16,725
Urinary Tract 56 | 16,678
Liver and Pancreas 55 | 16,750
Respiratory system 55 | 16,393
Skin and soft tissues 55 | 17,230
Cardiovascular System 54 | 15,192

Target Family

Enzyme 34 | 4,145
Non-IDG 19 | 12,091
Transporter 4 | 473
Ion Channel 1 | 344

Reactome Pathway

Iron uptake and transport 58 | 58
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Feline leukemia virus subgroup C receptor-related protein 1 FLVCR1 Tbio Non-IDG -1.54460 33.8 139
Hephaestin HEPH Tbio Non-IDG -2.02535 102.7 111
Proton-coupled folate transporter SLC46A1 Tchem Transporter -2.23182 177.1 76
V-type proton ATPase 116 kDa subunit a isoform 4 ATP6V0A4 Tbio Enzyme -2.84949 692.2 90
Serotransferrin TF Tbio Non-IDG -4.15070 13447.9 1168
Iron-responsive element-binding protein 2 IREB2 Tbio Non-IDG -2.33609 211.7 253
Transferrin receptor protein 1 TFRC Tbio Non-IDG -3.43851 2558.3 1677
Ferritin light chain FTL Tbio Non-IDG -2.36162 227.3 549
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143