Development Level

Tbio 50 | 11,178
Tchem 6 | 1,885
Tdark 2 | 6,569

IMPC Phenotype

preweaning lethality, complete... 11 | 979
embryonic lethality prior to t... 8 | 278
embryonic lethality prior to o... 6 | 239
abnormal behavior 3 | 298
decreased total body fat amoun... 3 | 207
decreased circulating bilirubi... 2 | 19
decreased hemoglobin content 2 | 68
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular vol... 2 | 79
hyperactivity 2 | 148
preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
abnormal gait 1 | 69
abnormal kidney morphology 1 | 65
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
brachydactyly 1 | 19
cardiovascular system phenotyp... 1 | 36
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating aspartat... 1 | 34
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 31
decreased mean platelet volume 1 | 25
decreased monocyte cell number 1 | 8
decreased prepulse inhibition 1 | 82
decreased vertical activity 1 | 208
enlarged heart 1 | 210
enlarged spleen 1 | 41
hypoactivity 1 | 132
increased body length 1 | 32
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased heart rate variabili... 1 | 7
increased heart weight 1 | 62
increased mean corpuscular hem... 1 | 96
increased or absent threshold ... 1 | 101
long tibia 1 | 25
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
short tibia 1 | 97
small adrenal glands 1 | 16
small lymph nodes 1 | 1
syndactyly 1 | 23
thrombocytosis 1 | 27

Disease

ovarian cancer 33 | 8,297
Carcinoma 32 | 11,192
psoriasis 25 | 6,514
medulloblastoma, large-cell 24 | 6,086
osteosarcoma 23 | 7,766
glioblastoma 21 | 5,635
atypical teratoid / rhabdoid tumor 19 | 4,971
ependymoma 19 | 4,559
Anemia 18 | 353
adult high grade glioma 16 | 3,701
lung cancer 16 | 4,607
lung carcinoma 16 | 2,755
group 3 medulloblastoma 15 | 4,002
malignant mesothelioma 15 | 3,135
primitive neuroectodermal tumor 14 | 2,957
subependymal giant cell astrocytoma 14 | 2,230
Breast cancer 13 | 3,469
oligodendroglioma 13 | 2,768
Autosomal recessive predisposition 12 | 1,407
Pick disease 12 | 1,856
astrocytic glioma 12 | 2,530
Astrocytoma, Pilocytic 11 | 3,006
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,872
invasive ductal carcinoma 11 | 2,867
tuberculosis 11 | 1,963
Cancer 10 | 2,388
lung adenocarcinoma 10 | 2,627
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,911
Hemochromatosis 9 | 52
Multiple myeloma 9 | 1,296
cystic fibrosis 9 | 1,629
non-small cell lung cancer 9 | 2,799
pancreatic cancer 9 | 2,322
pituitary cancer 9 | 1,915
adrenocortical carcinoma 8 | 1,385
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,902
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,204
Alzheimer's disease 7 | 640
Parkinson's disease 7 | 378
diabetes mellitus 7 | 1,683
Aceruloplasminemia 6 | 15
Hyperferritinaemia 6 | 13
Increased ferritin 6 | 13
Neoplasm Invasiveness 6 | 151
Serum ferritin increased 6 | 13
astrocytoma 6 | 1,113
breast carcinoma 6 | 1,589
primary pancreatic ductal adenocarcinoma 6 | 1,071
Chemical and Drug Induced Liver Injury 5 | 188
Hemoglobin low 5 | 123
Liver disease 5 | 227
Neurodegenerative disease 5 | 402
Osteopetrosis 5 | 42
Schizophrenia 5 | 1,136
Vascular disease 5 | 294
acute myeloid leukemia 5 | 760
aldosterone-producing adenoma 5 | 646
hepatocellular carcinoma 5 | 536
nasopharyngeal carcinoma 5 | 1,024
ulcerative colitis 5 | 1,765
Atransferrinemia 4 | 7
Cutis Laxa 4 | 39
Failure to gain weight 4 | 359
Hepatomegaly 4 | 280
Hypertension 4 | 372
Iron Overload 4 | 5
Kidney cancer 4 | 2,548
Kidney disease 4 | 411
Liver Cirrhosis, Experimental 4 | 733
Liver diseases 4 | 85
Obesity 4 | 655
Pediatric failure to thrive 4 | 359
Rheumatoid arthritis 4 | 1,156
Seizures 4 | 584
Waldenstrons macroglobulinemia 4 | 742
acute quadriplegic myopathy 4 | 1,133
chronic rhinosinusitis 4 | 505
cutaneous lupus erythematosus 4 | 1,016
ductal carcinoma in situ 4 | 1,686
interstitial cystitis 4 | 2,237
medulloblastoma 4 | 702
pediatric high grade glioma 4 | 1,035
Atopic dermatitis 3 | 915
Contact Dermatitis 3 | 77
Depressive disorder 3 | 401
Dermatitis, Contact 3 | 67
Diarrhea 3 | 245
Epilepsy 3 | 775
Heart disease 3 | 288
Toxic encephalopathy 3 | 139
active Crohn's disease 3 | 882
active ulcerative colitis 3 | 736
colon cancer 3 | 1,428
dermatomyositis 3 | 941
esophageal adenocarcinoma 3 | 696
gastric carcinoma 3 | 781
mucosa-associated lymphoid tissue lymphoma 3 | 473
pancreatic carcinoma 3 | 555
progressive supranuclear palsy 3 | 656
substance-related disorder 3 | 156

Tissue

Blood and immune system 57 | 16,909
Endocrine System 57 | 18,159
Digestive Tract 56 | 17,369
Female tissues 56 | 17,400
Male tissues 56 | 17,142
Nervous System 56 | 16,725
Urinary Tract 56 | 16,678
Liver and Pancreas 55 | 16,750
Respiratory system 55 | 16,393
Skin and soft tissues 55 | 17,230
Cardiovascular System 54 | 15,192

Target Family

Enzyme 34 | 4,145
Non-IDG 19 | 12,091
Transporter 4 | 473
Ion Channel 1 | 344

Reactome Pathway

Iron uptake and transport 58 | 58
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Neutrophil gelatinase-associated lipocalin LCN2 Tbio Enzyme -3.35178 2368.1 847
Mucolipin-1 MCOLN1 Tbio Ion Channel -2.43459 272.2 132
V-type proton ATPase subunit F ATP6V1F Tbio Enzyme -0.91914 8.76 118
Ferritin, mitochondrial FTMT Tbio Non-IDG -1.11598 13.8 34
V-type proton ATPase subunit S1 ATP6AP1 Tchem Enzyme -1.94689 91.3 166
V-type proton ATPase 21 kDa proteolipid subunit ATP6V0B Tbio Enzyme -0.96261 10.7 81
V-type proton ATPase subunit G 2 ATP6V1G2 Tbio Enzyme -0.88393 7.05 52
Hephaestin HEPH Tbio Non-IDG -2.02535 102.7 111
V-type proton ATPase 116 kDa subunit a isoform 4 ATP6V0A4 Tbio Enzyme -2.84949 692.2 90
Proton-coupled folate transporter SLC46A1 Tchem Transporter -2.23182 177.1 76