Development Level

Tbio 105 | 10,625
Tchem 40 | 1,890
Tclin 37 | 602
Tdark 22 | 7,003

Collection

Ion Channel: IDG Consortium (Targets) 21 | 102
Kinase: IDG Consortium (Complete/Control) 1 | 37
Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

preweaning lethality, complete... 12 | 633
embryonic lethality prior to t... 7 | 187
embryonic lethality prior to o... 5 | 148
abnormal behavior 4 | 226
decreased prepulse inhibition 3 | 52
hypoactivity 3 | 89
preweaning lethality, incomple... 3 | 260
abnormal retina morphology 2 | 100
abnormal seminal vesicle morph... 2 | 47
absent vibrissae 2 | 14
decreased bone mineral density 2 | 126
decreased circulating amylase ... 2 | 24
decreased erythrocyte cell num... 2 | 43
decreased lean body mass 2 | 195
decreased mean corpuscular vol... 2 | 50
decreased rib number 2 | 59
decreased total body fat amoun... 2 | 186
hyperactivity 2 | 108
increased bone mineral density 2 | 52
increased mature B cell number 2 | 12
limb grasping 2 | 35
short tibia 2 | 82
abnormal epididymis morphology 1 | 31
abnormal forelimb morphology 1 | 2
abnormal gait 1 | 51
abnormal heart morphology 1 | 51
abnormal kidney morphology 1 | 30
abnormal lens morphology 1 | 73
abnormal locomotor activation 1 | 26
abnormal pelvic girdle bone mo... 1 | 11
abnormal response to new envir... 1 | 8
abnormal retinal pigmentation 1 | 61
abnormal sensory capabilities-... 1 | 3
abnormal testis morphology 1 | 30
abnormal vibrissa morphology 1 | 17
abnormal vocalization 1 | 21
absent startle reflex 1 | 15
cardiovascular system phenotyp... 1 | 35
cataract 1 | 26
corneal vascularization 1 | 5
decreased body weight 1 | 174
decreased caudal vertebrae num... 1 | 49
decreased circulating calcium ... 1 | 33
decreased circulating glycerol... 1 | 19
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased grip strength 1 | 123
decreased hemoglobin content 1 | 53
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular hem... 1 | 19
decreased mean platelet volume 1 | 12
decreased memory-marker CD4-po... 1 | 4
decreased startle reflex 1 | 48
enlarged epididymis 1 | 27
enlarged heart 1 | 111
enlarged lymph nodes 1 | 27
hydrometra 1 | 13
impaired glucose tolerance 1 | 52
increased B cell number 1 | 23
increased NK T cell number 1 | 11
increased T cell number 1 | 15
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased body weight 1 | 42
increased bone mineral content 1 | 92
increased caudal vertebrae num... 1 | 8
increased circulating aspartat... 1 | 17
increased circulating creatine... 1 | 2
increased eosinophil cell numb... 1 | 9
increased gamma-delta T cell n... 1 | 16
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 93
increased mean corpuscular hem... 1 | 25
increased or absent threshold ... 1 | 128
increased rib number 1 | 41
increased startle reflex 1 | 38
small adrenal glands 1 | 15
small lymph nodes 1 | 1
small superior vagus ganglion 1 | 20
small testis 1 | 37
thrombocytosis 1 | 23

Disease

medulloblastoma, large-cell 89 | 6,234
psoriasis 81 | 6,685
ovarian cancer 80 | 8,491
osteosarcoma 77 | 7,933
glioblastoma 74 | 5,572
Carcinoma 58 | 2,147
atypical teratoid / rhabdoid tumor 57 | 4,369
oligodendroglioma 51 | 2,849
primitive neuroectodermal tumor 51 | 3,031
lung carcinoma 50 | 2,844
ependymoma 45 | 2,514
lung cancer 43 | 4,473
pilocytic astrocytoma 43 | 3,086
Pick disease 41 | 1,893
subependymal giant cell astrocytoma 38 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 36 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 34 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 34 | 2,988
pediatric high grade glioma 33 | 2,712
Breast cancer 32 | 3,098
adult high grade glioma 32 | 2,148
astrocytic glioma 31 | 2,241
pituitary cancer 30 | 1,972
cystic fibrosis 29 | 1,670
lung adenocarcinoma 29 | 2,714
malignant mesothelioma 29 | 3,163
astrocytoma 28 | 1,493
ulcerative colitis 26 | 2,087
interstitial cystitis 25 | 2,299
medulloblastoma 25 | 1,524
invasive ductal carcinoma 23 | 2,950
sonic hedgehog group medulloblastoma 23 | 1,482
non-small cell lung cancer 22 | 2,798
atypical teratoid/rhabdoid tumor 21 | 1,095
ductal carcinoma in situ 20 | 1,745
Hypertension 19 | 293
colon cancer 19 | 1,475
group 3 medulloblastoma 19 | 2,254
pancreatic cancer 19 | 2,300
Epilepsy 17 | 346
group 4 medulloblastoma 17 | 1,875
adrenocortical carcinoma 16 | 1,427
Irritable bowel syndrome 15 | 59
active Crohn's disease 15 | 918
Cancer 14 | 2,346
General anesthesia 14 | 53
Hypertensive disease 14 | 193
Multiple myeloma 14 | 1,327
posterior fossa group A ependymoma 14 | 1,511
progressive supranuclear palsy 14 | 674
non primary Sjogren syndrome sicca 13 | 840
posterior fossa group B ependymoma 13 | 1,530
tuberculosis 13 | 1,563
Anxiety 12 | 24
Autistic Disorder 12 | 320
Insomnia 12 | 20
Kidney disease 12 | 397
Osteopetrosis 12 | 40
Tonic-clonic epilepsy 12 | 47
diabetes mellitus 12 | 1,663
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,795
Sedation as Adjunct to Anesthesia 11 | 15
acute quadriplegic myopathy 11 | 1,157
chronic rhinosinusitis 11 | 512
nasopharyngeal carcinoma 11 | 1,056
spina bifida 11 | 1,064
Alcohol dependence 10 | 107
Neurodegenerative disease 10 | 383
Panic disorder 10 | 55
Parkinson's disease 10 | 364
Rheumatoid Arthritis 10 | 1,170
Spasticity 10 | 26
dermatomyositis 10 | 966
primary pancreatic ductal adenocarcinoma 10 | 1,271
Alzheimer's disease 9 | 644
Chronic heart failure 9 | 46
Congestive heart failure 9 | 36
Gastroesophageal reflux disease 9 | 37
Local anesthesia 9 | 40
Peptic ulcer 9 | 22
Status Epilepticus 9 | 85
acute myeloid leukemia 9 | 785
breast carcinoma 9 | 1,614
cutaneous lupus erythematosus 9 | 1,056
Alcohol withdrawal delirium 8 | 9
Atopic dermatitis 8 | 944
Atrial Fibrillation 8 | 110
Bipolar Disorder 8 | 266
Dent disease 8 | 20
Endometriosis 8 | 535
Generalized anxiety disorder 8 | 29
Induce Anterograde Amnesia 8 | 9
Poisoning by digitalis glycoside 8 | 8
Pseudohypoaldosteronism 8 | 22
Schizophrenia 8 | 503
Sedation 8 | 11
Tetanus 8 | 66
aldosterone-producing adenoma 8 | 664
juvenile dermatomyositis 8 | 1,189
primary Sjogren syndrome 8 | 788

Tissue

Digestive Tract 202 | 18,472
Female tissues 202 | 18,646
Nervous System 202 | 18,560
Urinary Tract 202 | 18,443
Endocrine System 201 | 18,511
Skin and soft tissues 201 | 18,114
Liver and Pancreas 200 | 18,135
Blood and immune system 198 | 17,994
Cardiovascular System 198 | 17,957
Male tissues 198 | 17,968
Respiratory system 196 | 17,483

Target Family

Ion Channel 92 | 341
Transporter 42 | 473
Enzyme 31 | 4,146
Non-IDG 25 | 11,969
Kinase 13 | 634
Transcription Factor 1 | 1,400

Reactome Pathway

Ion channel transport 204 | 204
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Short transient receptor potential channel 5 TRPC5 Tchem Ion Channel -2.22055 159.7 209
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 ATP2A2 Tbio Transporter -2.85874 681.4 264
E3 ubiquitin-protein ligase NEDD4-like NEDD4L Tbio Enzyme -2.50001 312.7 133
Sodium/potassium-transporting ATPase subunit beta-3 ATP1B3 Tclin Transporter -1.08214 10.9 189
Anoctamin-3 ANO3 Tbio Non-IDG -1.13472 14.6 69
Two pore calcium channel protein 1 TPCN1 Tbio Ion Channel -1.84159 59.3 38
V-type proton ATPase 16 kDa proteolipid subunit ATP6V0C Tbio Enzyme -1.84880 72.6 59
Probable cation-transporting ATPase 13A4 ATP13A4 Tdark Transporter -0.46548 2.88 3
Probable cation-transporting ATPase 13A5 ATP13A5 Tdark Transporter -0.09108 0.86 4
Sodium/potassium-transporting ATPase subunit beta-2 ATP1B2 Tclin Transporter -1.33849 19.3 155