Development Level

Tbio 90 | 11,445
Tchem 47 | 1,598
Tclin 21 | 613
Tdark 19 | 6,588

Collection

RFA-RM-18-021 14 | 328
Ion Channel: IDG Consortium (T... 13 | 99
Kinase: IDG Consortium (Comple... 1 | 37
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 16 | 979
embryonic lethality prior to t... 8 | 278
abnormal behavior 7 | 298
embryonic lethality prior to o... 6 | 239
preweaning lethality, incomple... 6 | 499
decreased prepulse inhibition 4 | 82
hyperactivity 4 | 148
abnormal seminal vesicle morph... 3 | 114
decreased vertical activity 3 | 208
hypoactivity 3 | 132
abnormal retina morphology 2 | 71
decreased circulating alkaline... 2 | 46
decreased circulating amylase ... 2 | 28
decreased erythrocyte cell num... 2 | 62
decreased hemoglobin content 2 | 68
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular vol... 2 | 79
decreased mean platelet volume 2 | 25
hydrometra 2 | 53
impaired glucose tolerance 2 | 75
increased mean platelet volume 2 | 45
increased monocyte cell number 2 | 63
increased or absent threshold ... 2 | 101
increased startle reflex 2 | 112
limb grasping 2 | 41
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
small superior vagus ganglion 2 | 74
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal forelimb morphology 1 | 2
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal locomotor activation 1 | 16
abnormal pelvic girdle bone mo... 1 | 12
abnormal response to new envir... 1 | 10
abnormal sensory capabilities-... 1 | 8
abnormal vibrissa morphology 1 | 25
abnormal vocalization 1 | 21
absent startle reflex 1 | 24
absent vibrissae 1 | 12
brachydactyly 1 | 19
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
corneal vascularization 1 | 6
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating glycerol... 1 | 16
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased red blood cell distr... 1 | 41
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
increased blood urea nitrogen ... 1 | 48
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating creatine... 1 | 5
increased circulating triglyce... 1 | 42
increased heart rate variabili... 1 | 7
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 36
increased respiratory quotient 1 | 2
increased spleen weight 1 | 10
increased total body fat amoun... 1 | 134
mammalian phenotype 1 | 17
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small adrenal glands 1 | 16
small lymph nodes 1 | 1
syndactyly 1 | 23
thrombocytosis 1 | 27

Disease

Carcinoma 135 | 11,493
medulloblastoma, large-cell 75 | 6,241
ovarian cancer 75 | 8,520
osteosarcoma 74 | 7,950
psoriasis 70 | 6,694
glioblastoma 66 | 5,792
atypical teratoid / rhabdoid tumor 63 | 5,112
Kidney cancer 57 | 2,613
ependymoma 54 | 4,679
adult high grade glioma 49 | 3,801
group 3 medulloblastoma 44 | 4,104
lung carcinoma 43 | 2,843
lung cancer 42 | 4,740
oligodendroglioma 42 | 2,850
primitive neuroectodermal tumor 41 | 3,035
Breast cancer 37 | 3,578
Astrocytoma, Pilocytic 35 | 3,081
Pick disease 35 | 1,894
astrocytic glioma 35 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 33 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 33 | 3,291
subependymal giant cell astrocytoma 32 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 31 | 2,955
malignant mesothelioma 30 | 3,232
cystic fibrosis 29 | 1,696
lung adenocarcinoma 29 | 2,716
interstitial cystitis 25 | 2,312
pituitary cancer 25 | 1,972
non-small cell lung cancer 24 | 2,890
Autosomal recessive predisposition 23 | 1,442
invasive ductal carcinoma 23 | 2,951
Hypertension 22 | 396
pancreatic cancer 22 | 2,398
colon cancer 19 | 1,478
ductal carcinoma in situ 19 | 1,745
ulcerative colitis 19 | 1,819
tuberculosis 18 | 2,010
group 4 medulloblastoma 17 | 1,855
Melanoma 16 | 711
Liver cancer 15 | 604
adrenocortical carcinoma 15 | 1,428
Hypertensive disease 14 | 292
Multiple myeloma 14 | 1,332
active Crohn's disease 14 | 922
astrocytoma 14 | 1,146
Cancer 13 | 2,499
Epilepsy 13 | 792
Intellectual disability 13 | 1,016
Skin cancer 13 | 469
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
progressive supranuclear palsy 13 | 676
Failure to gain weight 12 | 365
Kidney disease 12 | 430
Osteopetrosis 12 | 43
Pediatric failure to thrive 12 | 365
diabetes mellitus 12 | 1,728
nasopharyngeal carcinoma 12 | 1,058
Atrial Fibrillation 11 | 124
Seizures 11 | 596
acute quadriplegic myopathy 11 | 1,158
chronic rhinosinusitis 11 | 512
non primary Sjogren syndrome sicca 11 | 891
spina bifida 11 | 1,074
Anemia 10 | 365
Bipolar Disorder 10 | 666
Congestive heart failure 10 | 113
Dull intelligence 10 | 645
Endometrial cancer 10 | 311
Liver Cirrhosis, Experimental 10 | 769
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Neurodegenerative disease 10 | 414
Poor school performance 10 | 645
dermatomyositis 10 | 966
Chronic heart failure 9 | 46
Hyperaldosteronism 9 | 35
Pseudohypoaldosteronism 9 | 23
Rheumatoid arthritis 9 | 1,191
active ulcerative colitis 9 | 764
acute myeloid leukemia 9 | 783
Atopic dermatitis 8 | 952
Dent disease 8 | 18
Edema 8 | 81
Hypokalemia 8 | 52
Muscle hypotonia 8 | 571
Parkinson's disease 8 | 392
Poisoning by digitalis glycoside 8 | 8
Schizophrenia 8 | 1,160
breast carcinoma 8 | 1,638
cutaneous lupus erythematosus 8 | 1,057
juvenile dermatomyositis 8 | 1,187
primary Sjogren syndrome 8 | 735
primary pancreatic ductal adenocarcinoma 8 | 1,109
Asthma 7 | 385
Endometriosis 7 | 540
Feeding difficulties in infancy 7 | 175
Nystagmus 7 | 317
Short stature 7 | 531
aldosterone-producing adenoma 7 | 665

Tissue

Endocrine System 173 | 18,159
Digestive Tract 171 | 17,369
Male tissues 170 | 17,142
Urinary Tract 170 | 16,678
Skin and soft tissues 168 | 17,230
Female tissues 167 | 17,400
Nervous System 165 | 16,725
Blood and immune system 164 | 16,909
Liver and Pancreas 163 | 16,750
Respiratory system 159 | 16,393
Cardiovascular System 139 | 15,192

Target Family

Ion Channel 66 | 344
Transporter 42 | 473
Enzyme 31 | 4,145
Non-IDG 24 | 12,091
Kinase 13 | 634
Transcription Factor 1 | 1,400

Reactome Pathway

Ion channel transport 177 | 177
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sorcin SRI Tbio Non-IDG -2.69915 481.5 119
Transient receptor potential cation channel subfamily M member 2 TRPM2 Tchem Ion Channel -1.34318 25.1 209
Transient receptor potential cation channel subfamily V member 2 TRPV2 Tchem Ion Channel -2.28525 197.9 203
Sodium/potassium-transporting ATPase subunit alpha-4 ATP1A4 Tclin Transporter -1.73566 51.3 5
Acid-sensing ion channel 5 ASIC5 Tbio Ion Channel -0.41218 3.22 86
Calcium-activated chloride channel regulator family member 3 CLCA3P Tdark Ion Channel 0.00000 0
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 ATP2A2 Tbio Transporter -2.87498 737.3 295
Transient receptor potential cation channel subfamily M member 7 TRPM7 Tchem Ion Channel -2.53154 365.5 317
V-type proton ATPase 116 kDa subunit a isoform 4 ATP6V0A4 Tbio Enzyme -2.84949 692.2 90
Calcium/calmodulin-dependent protein kinase type II subunit gamma CAMK2G Tchem Kinase -0.94556 7.03 308