Development Level

Tbio 105 | 10,625
Tchem 40 | 1,890
Tclin 37 | 602
Tdark 22 | 7,003

Collection

Eligible Ion Channel Proteins 28 | 117
Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 12 | 633
embryonic lethality prior to t... 7 | 187
embryonic lethality prior to o... 5 | 148
abnormal behavior 4 | 226
decreased prepulse inhibition 3 | 52
hypoactivity 3 | 89
preweaning lethality, incomple... 3 | 260
abnormal retina morphology 2 | 100
abnormal seminal vesicle morph... 2 | 47
absent vibrissae 2 | 14
decreased bone mineral density 2 | 126
decreased circulating amylase ... 2 | 24
decreased erythrocyte cell num... 2 | 43
decreased lean body mass 2 | 195
decreased mean corpuscular vol... 2 | 50
decreased rib number 2 | 59
decreased total body fat amoun... 2 | 186
hyperactivity 2 | 108
increased bone mineral density 2 | 52
increased mature B cell number 2 | 12
limb grasping 2 | 35
short tibia 2 | 82
abnormal epididymis morphology 1 | 31
abnormal forelimb morphology 1 | 2
abnormal gait 1 | 51
abnormal heart morphology 1 | 51
abnormal kidney morphology 1 | 30
abnormal lens morphology 1 | 73
abnormal locomotor activation 1 | 26
abnormal pelvic girdle bone mo... 1 | 11
abnormal response to new envir... 1 | 8
abnormal retinal pigmentation 1 | 61
abnormal sensory capabilities/... 1 | 3
abnormal testis morphology 1 | 30
abnormal vibrissa morphology 1 | 17
abnormal vocalization 1 | 21
absent startle reflex 1 | 15
cardiovascular system phenotyp... 1 | 35
cataract 1 | 26
corneal vascularization 1 | 5
decreased body weight 1 | 174
decreased caudal vertebrae num... 1 | 49
decreased circulating calcium ... 1 | 33
decreased circulating glycerol... 1 | 19
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased grip strength 1 | 123
decreased hemoglobin content 1 | 53
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular hem... 1 | 19
decreased mean platelet volume 1 | 12
decreased memory-marker CD4-po... 1 | 4
decreased startle reflex 1 | 48
enlarged epididymis 1 | 27
enlarged heart 1 | 111
enlarged lymph nodes 1 | 27
hydrometra 1 | 13
impaired glucose tolerance 1 | 52
increased B cell number 1 | 23
increased NK T cell number 1 | 11
increased T cell number 1 | 15
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased body weight 1 | 42
increased bone mineral content 1 | 92
increased caudal vertebrae num... 1 | 8
increased circulating aspartat... 1 | 17
increased circulating creatine... 1 | 2
increased eosinophil cell numb... 1 | 9
increased gamma-delta T cell n... 1 | 16
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 93
increased mean corpuscular hem... 1 | 25
increased or absent threshold ... 1 | 128
increased rib number 1 | 41
increased startle reflex 1 | 38
small adrenal glands 1 | 15
small lymph nodes 1 | 1
small superior vagus ganglion 1 | 20
small testis 1 | 37
thrombocytosis 1 | 23

Disease

medulloblastoma, large-cell 89 | 6,234
psoriasis 81 | 6,685
ovarian cancer 80 | 8,484
osteosarcoma 77 | 7,933
glioblastoma 74 | 5,572
Carcinoma 58 | 2,147
atypical teratoid / rhabdoid tumor 57 | 4,369
oligodendroglioma 51 | 2,849
primitive neuroectodermal tumor 51 | 3,031
lung carcinoma 50 | 2,844
ependymoma 45 | 2,514
lung cancer 43 | 4,466
pilocytic astrocytoma 43 | 3,086
Pick disease 41 | 1,893
subependymal giant cell astrocytoma 38 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 36 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 34 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 34 | 2,988
pediatric high grade glioma 33 | 2,712
adult high grade glioma 32 | 2,148
Breast cancer 31 | 3,094
astrocytic glioma 31 | 2,241
pituitary cancer 30 | 1,972
cystic fibrosis 29 | 1,665
lung adenocarcinoma 29 | 2,713
malignant mesothelioma 29 | 3,162
astrocytoma 28 | 1,493
ulcerative colitis 26 | 2,087
interstitial cystitis 25 | 2,299
medulloblastoma 25 | 1,524
invasive ductal carcinoma 23 | 2,950
sonic hedgehog group medulloblastoma 23 | 1,482
non-small cell lung cancer 22 | 2,798
atypical teratoid/rhabdoid tumor 21 | 1,095
ductal carcinoma in situ 20 | 1,745
colon cancer 19 | 1,475
group 3 medulloblastoma 19 | 2,254
pancreatic cancer 19 | 2,300
Epilepsy 17 | 346
Hypertension 17 | 287
group 4 medulloblastoma 17 | 1,875
adrenocortical carcinoma 16 | 1,427
Irritable bowel syndrome 15 | 59
active Crohn's disease 15 | 918
Cancer 14 | 2,346
General anesthesia 14 | 53
Hypertensive disease 14 | 193
Multiple myeloma 14 | 1,327
posterior fossa group A ependymoma 14 | 1,511
progressive supranuclear palsy 14 | 674
non primary Sjogren syndrome sicca 13 | 840
posterior fossa group B ependymoma 13 | 1,530
tuberculosis 13 | 1,557
Anxiety 12 | 24
Autistic Disorder 12 | 320
Insomnia 12 | 20
Kidney disease 12 | 396
Osteopetrosis 12 | 40
Tonic-clonic epilepsy 12 | 47
diabetes mellitus 12 | 1,663
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,795
Sedation as Adjunct to Anesthesia 11 | 15
acute quadriplegic myopathy 11 | 1,157
chronic rhinosinusitis 11 | 512
nasopharyngeal carcinoma 11 | 1,056
spina bifida 11 | 1,064
Alcohol dependence 10 | 107
Neurodegenerative disease 10 | 383
Panic disorder 10 | 55
Parkinson's disease 10 | 364
Rheumatoid Arthritis 10 | 1,160
Spasticity 10 | 26
dermatomyositis 10 | 933
primary pancreatic ductal adenocarcinoma 10 | 1,271
Alzheimer's disease 9 | 644
Chronic heart failure 9 | 46
Congestive heart failure 9 | 30
Gastroesophageal reflux disease 9 | 37
Local anesthesia 9 | 40
Peptic ulcer 9 | 22
Status Epilepticus 9 | 85
acute myeloid leukemia 9 | 780
breast carcinoma 9 | 1,614
cutaneous lupus erythematosus 9 | 1,056
Alcohol withdrawal delirium 8 | 9
Atopic dermatitis 8 | 944
Atrial Fibrillation 8 | 110
Bipolar Disorder 8 | 266
Dent disease 8 | 20
Endometriosis 8 | 535
Generalized anxiety disorder 8 | 29
Induce Anterograde Amnesia 8 | 9
Poisoning by digitalis glycoside 8 | 8
Pseudohypoaldosteronism 8 | 22
Schizophrenia 8 | 501
Sedation 8 | 11
Tetanus 8 | 66
aldosterone-producing adenoma 8 | 664
juvenile dermatomyositis 8 | 1,189
primary Sjogren syndrome 8 | 789

Tissue

Digestive Tract 202 | 18,473
Female tissues 202 | 18,647
Nervous System 202 | 18,561
Urinary Tract 202 | 18,444
Endocrine System 201 | 18,512
Skin and soft tissues 201 | 18,115
Liver and Pancreas 200 | 18,136
Blood and immune system 198 | 17,995
Cardiovascular System 198 | 17,958
Male tissues 198 | 17,969
Respiratory system 196 | 17,484

Target Family

Ion Channel 92 | 341
Transporter 42 | 473
Enzyme 31 | 4,146
Non-IDG 25 | 11,971
Kinase 13 | 634
Transcription Factor 1 | 1,400

Reactome Pathway

Ion channel transport 204 | 204
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable phospholipid-transporting ATPase IIB ATP9B Tdark Transporter -0.57248 3.74 5
Cardiac phospholamban PLN Tbio Non-IDG -1.89899 84.7 326
Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 Tchem Ion Channel -1.68717 47.7 33
V-type proton ATPase catalytic subunit A ATP6V1A Tbio Enzyme -1.80191 64.7 120
Gamma-aminobutyric acid receptor subunit rho-1 GABRR1 Tchem Ion Channel -1.70715 50.4 134
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
H(+)/Cl(-) exchange transporter 7 CLCN7 Tbio Ion Channel -1.91579 94.4 137
H(+)/Cl(-) exchange transporter 4 CLCN4 Tbio Ion Channel -1.48227 31.6 116
H(+)/Cl(-) exchange transporter 5 CLCN5 Tbio Ion Channel -2.29453 217.9 141
Amiloride-sensitive sodium channel subunit beta SCNN1B Tclin Ion Channel -1.69464 46.7 245