Development Level

Tbio 14 | 11,445
Tchem 8 | 1,598
Tclin 4 | 613
Tdark 4 | 6,588

Collection

Ion Channel: IDG Consortium (T... 2 | 99

IMPC Phenotype

abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal epididymis morphology 1 | 42
abnormal response to tactile s... 1 | 17
abnormal startle reflex 1 | 15
decreased basophil cell number 1 | 16
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased fasted circulating g... 1 | 65
decreased mean platelet volume 1 | 25
enlarged epididymis 1 | 31
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased bone mineral content 1 | 108
increased mean platelet volume 1 | 45
increased startle reflex 1 | 112
limb grasping 1 | 41
preweaning lethality, complete... 1 | 979
tremors 1 | 39

Disease

medulloblastoma, large-cell 17 | 6,241
Carcinoma 16 | 11,493
ependymoma 15 | 4,679
glioblastoma 14 | 5,792
group 3 medulloblastoma 14 | 4,104
primitive neuroectodermal tumor 14 | 3,035
atypical teratoid / rhabdoid tumor 13 | 5,112
psoriasis 13 | 6,694
Astrocytoma, Pilocytic 12 | 3,081
adult high grade glioma 12 | 3,801
subependymal giant cell astrocytoma 12 | 2,287
ovarian cancer 11 | 8,520
oligodendroglioma 10 | 2,850
osteosarcoma 10 | 7,950
Breast cancer 8 | 3,578
lung cancer 8 | 4,740
pituitary cancer 8 | 1,972
Pick disease 7 | 1,894
astrocytic glioma 7 | 2,597
interstitial cystitis 7 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
lung carcinoma 7 | 2,843
pancreatic cancer 7 | 2,398
Schnyder Corneal Dystrophy 6 | 23
ductal carcinoma in situ 6 | 1,745
invasive ductal carcinoma 6 | 2,951
lung adenocarcinoma 6 | 2,716
non-small cell lung cancer 6 | 2,890
Intellectual disability 5 | 1,016
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
malignant mesothelioma 5 | 3,232
Depressive disorder 4 | 409
Epilepsy 4 | 792
Failure to gain weight 4 | 365
Hypokalemia 4 | 52
Pediatric failure to thrive 4 | 365
Schizophrenia 4 | 1,160
Seizures 4 | 596
adrenocortical carcinoma 4 | 1,428
cystic fibrosis 4 | 1,696
tuberculosis 4 | 2,010
Alcoholic Intoxication, Chronic 3 | 289
Anteverted nostril 3 | 191
Atrial Fibrillation 3 | 124
Autosomal recessive predisposition 3 | 1,442
Big calvaria 3 | 147
Cognitive delay 3 | 608
Delayed bone age 3 | 136
Down syndrome 3 | 499
Duchenne muscular dystrophy 3 | 601
Dull intelligence 3 | 645
Global developmental delay 3 | 608
Hyperaldosteronism 3 | 35
Hypertension 3 | 396
Hypertensive disease 3 | 292
Increased head circumference 3 | 147
Increased size of cranium 3 | 147
Increased size of skull 3 | 147
Kidney cancer 3 | 2,613
Leber congenital amaurosis 16 3 | 5
Long QT syndrome 3 | 39
Long philtrum 3 | 137
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental and motor retardation 3 | 608
Mental deficiency 3 | 645
Pain agnosia 3 | 104
Paroxysmal atrial fibrillation 3 | 14
Poor school performance 3 | 645
Rheumatoid arthritis 3 | 1,191
Small head 3 | 374
breast carcinoma 3 | 1,638
diabetes mellitus 3 | 1,728
gastric carcinoma 3 | 807
group 4 medulloblastoma 3 | 1,855
mucosa-associated lymphoid tissue lymphoma 3 | 484
nephrosclerosis 3 | 333
non primary Sjogren syndrome sicca 3 | 891
Autistic Disorder 2 | 364
Blepharophimosis 2 | 70
Bulbous nose 2 | 48
Bulging forehead 2 | 66
Diarrhea 2 | 253
Familial atrial fibrillation 2 | 23
Globe of eye large 2 | 20
Heart disease 2 | 306
Liver Cirrhosis, Experimental 2 | 769
Low Birth Weights 2 | 69
Major Depressive Disorder 2 | 301
Polyhydramnios 2 | 108
Prominent forehead 2 | 66
Small for gestational age (disorder) 2 | 69
Tachycardia 2 | 43
Triangular face 2 | 58
Unipolar Depression 2 | 250
Vomiting 2 | 116
active ulcerative colitis 2 | 764
cystic fibrosis and chronic rhinosinusitis 2 | 214
head and neck cancer 2 | 271

Tissue

Endocrine System 30 | 18,159
Digestive Tract 29 | 17,369
Nervous System 29 | 16,725
Blood and immune system 28 | 16,909
Female tissues 28 | 17,400
Skin and soft tissues 28 | 17,230
Liver and Pancreas 27 | 16,750
Male tissues 27 | 17,142
Respiratory system 27 | 16,393
Urinary Tract 27 | 16,678
Cardiovascular System 24 | 15,192

Target Family

Ion Channel 14 | 344
Non-IDG 13 | 12,091
GPCR 2 | 408
Transporter 1 | 473

Reactome Pathway

Inwardly rectifying K+ channel... 30 | 30
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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