Development Level

Tbio 32 | 11,445
Tdark 8 | 6,588

IMPC Phenotype

preweaning lethality, complete... 11 | 979
abnormal behavior 4 | 298
hyperactivity 2 | 148
hypoactivity 2 | 132
increased lean body mass 2 | 172
male infertility 2 | 123
prenatal lethality prior to he... 2 | 87
preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal pelvic girdle bone mo... 1 | 12
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal sleep behavior 1 | 70
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating free fat... 1 | 31
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased red blood cell distr... 1 | 41
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
impaired glucose tolerance 1 | 75
increased bone mineral content 1 | 108
increased circulating chloride... 1 | 41
increased circulating free fat... 1 | 20
increased circulating glycerol... 1 | 9
increased circulating magnesiu... 1 | 10
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased heart weight 1 | 62
increased startle reflex 1 | 112
long tibia 1 | 25
persistence of hyaloid vascula... 1 | 33

Disease

Carcinoma 27 | 11,493
ependymoma 26 | 4,679
ovarian cancer 23 | 8,520
osteosarcoma 20 | 7,950
Polydactyly 19 | 107
Ciliopathy 17 | 71
Asphyxiating thoracic dystrophy 15 | 44
atypical teratoid / rhabdoid tumor 15 | 5,112
glioblastoma 13 | 5,792
medulloblastoma, large-cell 13 | 6,241
group 3 medulloblastoma 12 | 4,104
lung cancer 12 | 4,740
Nephronophthisis 11 | 80
Sensenbrenner syndrome 11 | 17
chronic rhinosinusitis 11 | 512
Bardet-Biedl syndrome 10 | 51
Short Rib-Polydactyly Syndrome 10 | 13
Jeune thoracic dystrophy 9 | 10
psoriasis 9 | 6,694
Ellis-Van Creveld syndrome 8 | 19
adult high grade glioma 8 | 3,801
Breast cancer 7 | 3,578
malignant mesothelioma 7 | 3,232
primitive neuroectodermal tumor 7 | 3,035
Brachydactyly 6 | 156
Kidney cancer 6 | 2,613
Narrow thorax 6 | 53
Pick disease 6 | 1,894
Short-rib thoracic dysplasia 3 with or without polydactyly 6 | 9
Abnormality of the metaphyses 5 | 48
Autosomal recessive predisposition 5 | 1,442
Cranioectodermal Dysplasia 5 | 5
Hypoplastic feet 5 | 66
Micromelia 5 | 58
Obesity 5 | 678
Respiratory Insufficiency 5 | 132
Retinitis Pigmentosa 5 | 226
Short rib-polydactyly syndrome, Verma-Naumoff type 5 | 5
Short stature 5 | 531
Short thorax 5 | 21
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
invasive ductal carcinoma 5 | 2,951
lung carcinoma 5 | 2,843
pediatric high grade glioma 5 | 1,064
Abnormal skeletal development 4 | 60
Abnormality of pelvic girdle bone morphology 4 | 37
Abnormality of the clavicle 4 | 14
Abnormality of the ribs 4 | 32
Acrofacial dysostosis 4 | 8
Anteverted nostril 4 | 191
Astrocytoma, Pilocytic 4 | 3,081
Cone-shaped epiphyses 4 | 24
Congenital hypoplasia of penis 4 | 176
Gastrointestinal Stromal Tumors 4 | 48
Hydrocephalus 4 | 152
Intellectual disability 4 | 1,016
Joubert syndrome 4 | 66
Multiple myeloma 4 | 1,332
Nystagmus 4 | 317
Osteochondrodysplasias 4 | 72
Respiratory function loss 4 | 121
Senior-Loken syndrome 4 | 22
Sternal anomalies 4 | 19
astrocytic glioma 4 | 2,597
cystic fibrosis and chronic rhinosinusitis 4 | 214
hepatocellular carcinoma 4 | 547
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
non-small cell lung cancer 4 | 2,890
oligodendroglioma 4 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
Abnormality of retinal pigmentation 3 | 111
Atopic dermatitis 3 | 952
Craniosynostosis 3 | 74
Dull intelligence 3 | 645
Electroretinogram abnormal 3 | 95
Frontal bossing 3 | 157
Hypertensive disease 3 | 292
Hypogonadism 3 | 173
Increase in blood pressure 3 | 119
Kidney Diseases 3 | 114
Leber congenital amaurosis 3 | 69
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Poor school performance 3 | 645
Retinal pigment epithelial abnormality 3 | 111
Short ribs 3 | 30
Situs Inversus 3 | 65
Ulnar polydactyly of fingers 3 | 47
acute myeloid leukemia 3 | 783
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
lung adenocarcinoma 3 | 2,716
medulloblastoma 3 | 720
nasopharyngeal carcinoma 3 | 1,058
pancreatic cancer 3 | 2,398
posterior fossa group B ependymoma 3 | 416
progressive supranuclear palsy 3 | 676
subependymal giant cell astrocytoma 3 | 2,287
tuberculosis 3 | 2,010
tuberculosis and treatment for 6 months 3 | 409

Tissue

Endocrine System 40 | 18,159
Digestive Tract 39 | 17,369
Female tissues 39 | 17,400
Liver and Pancreas 39 | 16,750
Male tissues 39 | 17,142
Nervous System 39 | 16,725
Respiratory system 39 | 16,393
Skin and soft tissues 39 | 17,230
Urinary Tract 39 | 16,678
Blood and immune system 38 | 16,909
Cardiovascular System 38 | 15,192

Target Family

Non-IDG 38 | 12,091
Enzyme 2 | 4,145

Reactome Pathway

Intraflagellar transport 40 | 40
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Intraflagellar transport protein 25 homolog HSPB11 Tbio Non-IDG -1.40552 26.1 61
WD repeat-containing protein 60 WDR60 Tbio Non-IDG -0.64761 3.98 23
Intraflagellar transport protein 52 homolog IFT52 Tbio Non-IDG -1.09507 12.7 13
Cytoplasmic dynein 2 heavy chain 1 DYNC2H1 Tbio Non-IDG -1.60757 39.5 23
Intraflagellar transport protein 140 homolog IFT140 Tbio Non-IDG -1.42568 23.3 45
Tctex1 domain-containing protein 3 TCTE3 Tdark Non-IDG -0.69992 5.53 22
Dynein light chain roadblock-type 1 DYNLRB1 Tbio Non-IDG -2.23639 168.6 41
Dynein light chain roadblock-type 2 DYNLRB2 Tbio Non-IDG -0.65444 2.59 77
WD repeat-containing protein 35 WDR35 Tbio Non-IDG -1.31497 20.6 39
Intraflagellar transport protein 80 homolog IFT80 Tbio Non-IDG -0.92606 9.26 52