Development Level

Tbio 151 | 11,651
Tdark 26 | 6,593
Tchem 9 | 1,388

IMPC Phenotype

preweaning lethality, complete... 32 | 979
embryonic lethality prior to t... 7 | 278
abnormal embryo size 6 | 220
abnormal behavior 5 | 298
decreased total body fat amoun... 5 | 207
embryonic lethality prior to o... 5 | 239
preweaning lethality, incomple... 5 | 499
decreased bone mineral content 4 | 151
increased grip strength 4 | 41
increased mean corpuscular vol... 4 | 92
abnormal bone structure 3 | 187
abnormal lens morphology 3 | 81
cataract 3 | 92
decreased body weight 3 | 161
decreased circulating alanine ... 3 | 47
decreased circulating aspartat... 3 | 34
decreased circulating choleste... 3 | 93
decreased grip strength 3 | 116
decreased vertical activity 3 | 208
embryonic growth retardation 3 | 106
hyperactivity 3 | 148
increased bone mineral content 3 | 108
increased lean body mass 3 | 172
abnormal behavioral response t... 2 | 66
abnormal seminal vesicle morph... 2 | 114
abnormal sleep behavior 2 | 70
abnormal testis morphology 2 | 43
cyanosis 2 | 7
decreased blood urea nitrogen ... 2 | 51
decreased body length 2 | 101
decreased caudal vertebrae num... 2 | 53
decreased circulating glucose ... 2 | 126
decreased circulating insulin ... 2 | 76
decreased circulating serum al... 2 | 82
decreased hematocrit 2 | 46
decreased lactate dehydrogenas... 2 | 16
decreased lean body mass 2 | 135
decreased startle reflex 2 | 75
impaired glucose tolerance 2 | 75
impaired pupillary reflex 2 | 26
increased bone mineral density 2 | 72
increased fasted circulating g... 2 | 76
increased heart weight 2 | 62
increased hematocrit 2 | 46
increased mean corpuscular hem... 2 | 96
limb grasping 2 | 41
prenatal lethality prior to he... 2 | 87
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
abnormal cranium morphology 1 | 36
abnormal epididymis morphology 1 | 42
abnormal facial morphology 1 | 17
abnormal gait 1 | 69
abnormal head shape 1 | 10
abnormal joint morphology 1 | 23
abnormal kidney morphology 1 | 65
abnormal lung morphology 1 | 26
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal skin coloration 1 | 25
abnormal snout morphology 1 | 23
abnormal spinal cord morpholog... 1 | 9
abnormal tooth morphology 1 | 24
absent pinna reflex 1 | 23
cardiovascular system phenotyp... 1 | 36
decreased circulating creatini... 1 | 39
decreased circulating free fat... 1 | 31
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased heart left ventricle... 1 | 28
decreased heart rate 1 | 18
decreased hemoglobin content 1 | 68
decreased mature B cell number 1 | 7
decreased red blood cell distr... 1 | 41
enlarged epididymis 1 | 31
enlarged lymph nodes 1 | 37
hemorrhage 1 | 23
hydroencephaly 1 | 14
increased anti-nuclear antigen... 1 | 19
increased circulating alkaline... 1 | 122
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased exploration in new e... 1 | 8
increased heart rate 1 | 23
increased hemoglobin content 1 | 45
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
long tibia 1 | 25
male infertility 1 | 123
microphthalmia 1 | 26
prolonged PR interval 1 | 15
prolonged RR interval 1 | 8
small testis 1 | 58
thrombocytosis 1 | 27

Disease

Carcinoma 123 | 11,493
ovarian cancer 120 | 8,520
osteosarcoma 99 | 7,950
glioblastoma 79 | 5,792
medulloblastoma, large-cell 77 | 6,241
atypical teratoid / rhabdoid tumor 66 | 5,112
psoriasis 63 | 6,694
lung cancer 59 | 4,740
ependymoma 54 | 4,679
Breast cancer 48 | 3,578
group 3 medulloblastoma 46 | 4,104
malignant mesothelioma 41 | 3,232
adult high grade glioma 40 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 37 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 35 | 2,955
invasive ductal carcinoma 33 | 2,951
primitive neuroectodermal tumor 33 | 3,035
Astrocytoma, Pilocytic 32 | 3,081
non-small cell lung cancer 32 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 31 | 3,291
pancreatic ductal adenocarcinoma liver metastasis 31 | 1,962
Kidney cancer 29 | 2,613
lung adenocarcinoma 29 | 2,716
Pick disease 28 | 1,894
Multiple myeloma 27 | 1,332
oligodendroglioma 27 | 2,850
diabetes mellitus 24 | 1,728
group 4 medulloblastoma 24 | 1,855
adrenocortical carcinoma 23 | 1,428
acute quadriplegic myopathy 21 | 1,158
astrocytoma 21 | 1,146
astrocytic glioma 20 | 2,597
breast carcinoma 20 | 1,638
ductal carcinoma in situ 20 | 1,745
lung carcinoma 20 | 2,843
colon cancer 19 | 1,478
pancreatic cancer 19 | 2,398
pediatric high grade glioma 19 | 1,064
subependymal giant cell astrocytoma 18 | 2,287
dermatomyositis 17 | 966
juvenile dermatomyositis 17 | 1,187
pituitary cancer 17 | 1,972
Autosomal recessive predisposition 16 | 1,442
Atopic dermatitis 15 | 952
tuberculosis 15 | 2,010
Cognitive delay 13 | 608
Global developmental delay 13 | 608
Mental and motor retardation 13 | 608
Rheumatoid arthritis 13 | 1,191
non primary Sjogren syndrome sicca 13 | 891
tuberculosis and treatment for 6 months 13 | 409
Epilepsy 12 | 792
Intellectual disability 12 | 1,016
Muscle hypotonia 12 | 571
cystic fibrosis 12 | 1,696
interstitial cystitis 12 | 2,312
spina bifida 12 | 1,074
Small head 11 | 374
active Crohn's disease 11 | 922
nasopharyngeal carcinoma 11 | 1,058
primary pancreatic ductal adenocarcinoma 11 | 1,109
Dull intelligence 10 | 645
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Microcephaly 10 | 166
Neurodegenerative disease 10 | 414
Poor school performance 10 | 645
cutaneous lupus erythematosus 10 | 1,057
hereditary spastic paraplegia 10 | 318
Cancer 9 | 2,499
Endometriosis 9 | 540
Hypomyelinating leukodystrophy 6 9 | 26
Liver cancer 9 | 604
Seizures 9 | 596
esophageal adenocarcinoma 9 | 737
Alzheimer's disease 8 | 658
Anteverted nostril 8 | 191
Cerebral atrophy 8 | 178
Endometrial cancer 8 | 311
Neuropathy 8 | 261
Short nose 8 | 132
Short stature 8 | 531
Small nose 8 | 132
acute myeloid leukemia 8 | 783
progressive supranuclear palsy 8 | 676
Acquired scoliosis 7 | 281
Amyotrophic lateral sclerosis 7 | 451
Concave bridge of nose 7 | 195
Curvature of spine 7 | 282
Depressed nasal bridge 7 | 195
Depressed nasal root/bridge 7 | 195
Hypoplasia of corpus callosum 7 | 90
Optic Atrophy 7 | 242
Pachygyria 7 | 41
Paraplegia 7 | 74
Schizophrenia 7 | 1,160
Waldenstrons macroglobulinemia 7 | 765
hepatocellular carcinoma 7 | 547
pancreatic carcinoma 7 | 562

Tissue

Endocrine System 184 | 18,159
Digestive Tract 182 | 17,369
Female tissues 182 | 17,400
Skin and soft tissues 182 | 17,230
Blood and immune system 181 | 16,909
Liver and Pancreas 181 | 16,750
Male tissues 181 | 17,142
Nervous System 181 | 16,725
Respiratory system 181 | 16,393
Urinary Tract 181 | 16,678
Cardiovascular System 179 | 15,192

Target Family

Non-IDG 142 | 12,091
Enzyme 43 | 4,145
Transcription Factor 1 | 1,400

Reactome Pathway

Intra-Golgi and retrograde Gol... 186 | 186
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
F-actin-capping protein subunit alpha-3 CAPZA3 Tdark Non-IDG -0.56455 3.20 78
Alkaline phosphatase, placental type ALPP Tbio Enzyme -2.71952 511.2 929
ADP-ribosylation factor GTPase-activating protein 2 ARFGAP2 Tbio Enzyme -0.97596 10.1 144
Coatomer subunit beta COPB1 Tbio Non-IDG -1.94049 82.6 148
Coatomer subunit alpha COPA Tbio Non-IDG -2.45140 283.3 88
Cytoplasmic dynein 1 light intermediate chain 1 DYNC1LI1 Tbio Non-IDG -1.67860 45.9 100
Coatomer subunit gamma-1 COPG1 Tbio Non-IDG -1.70829 49.0 89
Dynactin subunit 4 DCTN4 Tbio Non-IDG -0.85019 7.19 160
Dynactin subunit 5 DCTN5 Tdark Non-IDG -0.32495 0.71 53
Kinesin-like protein KIF3A KIF3A Tbio Non-IDG -2.06068 113.6 153