Development Level

Tbio 132 | 10,625
Tdark 30 | 7,003
Tchem 19 | 1,890

IMPC Term

preweaning lethality, complete... 22 | 633
embryonic lethality prior to t... 6 | 187
abnormal behavior 4 | 226
abnormal embryo size 4 | 112
decreased circulating alanine ... 4 | 53
embryonic lethality prior to o... 4 | 148
increased mean corpuscular vol... 4 | 91
abnormal lens morphology 3 | 73
decreased body weight 3 | 174
decreased bone mineral content 3 | 157
decreased circulating aspartat... 3 | 27
decreased circulating choleste... 3 | 85
decreased circulating glucose ... 3 | 121
decreased total body fat amoun... 3 | 186
increased bone mineral content 3 | 92
increased grip strength 3 | 83
increased hematocrit 3 | 36
increased lean body mass 3 | 107
increased or absent threshold ... 3 | 128
abnormal bone structure 2 | 131
abnormal sleep behavior 2 | 63
abnormal testis morphology 2 | 30
decreased circulating free fat... 2 | 39
decreased circulating insulin ... 2 | 75
decreased circulating triglyce... 2 | 83
decreased effector memory CD4-... 2 | 6
decreased grip strength 2 | 123
decreased hematocrit 2 | 25
decreased lactate dehydrogenas... 2 | 14
decreased lean body mass 2 | 195
decreased rib number 2 | 59
decreased startle reflex 2 | 48
hyperactivity 2 | 108
increased circulating alkaline... 2 | 119
increased mean corpuscular hem... 2 | 93
increased mean corpuscular hem... 2 | 25
limb grasping 2 | 35
abnormal QRS complex 1 | 25
abnormal behavioral response t... 1 | 52
abnormal cranium morphology 1 | 32
abnormal epididymis morphology 1 | 31
abnormal facial morphology 1 | 9
abnormal gait 1 | 51
abnormal head morphology 1 | 10
abnormal head shape 1 | 4
abnormal hindbrain development 1 | 24
abnormal joint morphology 1 | 14
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal snout morphology 1 | 18
abnormal tooth morphology 1 | 24
absent pinna reflex 1 | 21
absent vibrissae 1 | 14
cataract 1 | 26
cyanosis 1 | 6
decreased CD8-positive, alpha-... 1 | 26
decreased CD8-positive, naive ... 1 | 5
decreased T cell number 1 | 31
decreased body length 1 | 108
decreased caudal vertebrae num... 1 | 49
decreased circulating creatini... 1 | 31
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased effector memory CD8-... 1 | 24
decreased fasted circulating g... 1 | 49
decreased gamma-delta T cell n... 1 | 18
decreased hemoglobin content 1 | 53
decreased lumbar vertebrae num... 1 | 62
decreased mature B cell number 1 | 25
decreased monocyte cell number 1 | 28
decreased red blood cell distr... 1 | 11
embryonic growth retardation 1 | 28
hemorrhage 1 | 12
impaired glucose tolerance 1 | 52
increased B cell number 1 | 23
increased CD4-positive, alpha ... 1 | 15
increased CD5-positive Ly6C-po... 1 | 4
increased Ly6C high monocyte n... 1 | 12
increased T cell number 1 | 15
increased body weight 1 | 42
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 43
increased circulating creatini... 1 | 29
increased circulating glucose ... 1 | 16
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased effector memory T-he... 1 | 5
increased fasted circulating g... 1 | 68
increased heart weight 1 | 37
increased hemoglobin content 1 | 45
increased mature B cell number 1 | 12
increased sacral vertebrae num... 1 | 62
prenatal lethality prior to he... 1 | 64
small testis 1 | 37
straub tail 1 | 26
thrombocytosis 1 | 23

Disease

ovarian cancer 116 | 8,484
osteosarcoma 98 | 7,933
glioblastoma 78 | 5,572
medulloblastoma, large-cell 76 | 6,234
atypical teratoid / rhabdoid tumor 61 | 4,369
psoriasis 60 | 6,685
lung cancer 54 | 4,466
pediatric high grade glioma 43 | 2,712
Breast cancer 42 | 3,094
malignant mesothelioma 40 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 37 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 35 | 2,956
invasive ductal carcinoma 33 | 2,950
pilocytic astrocytoma 33 | 3,086
primitive neuroectodermal tumor 33 | 3,031
non-small cell lung cancer 32 | 2,798
intraductal papillary-mucinous neoplasm (IPMN) 31 | 3,289
pancreatic ductal adenocarcinoma liver metastasis 31 | 1,795
lung adenocarcinoma 29 | 2,713
Pick disease 28 | 1,893
ependymoma 27 | 2,514
oligodendroglioma 27 | 2,849
Carcinoma 26 | 2,147
Multiple myeloma 26 | 1,327
astrocytoma 25 | 1,493
group 4 medulloblastoma 25 | 1,875
group 3 medulloblastoma 24 | 2,254
adrenocortical carcinoma 23 | 1,427
diabetes mellitus 23 | 1,663
posterior fossa group B ependymoma 21 | 1,530
acute quadriplegic myopathy 20 | 1,157
breast carcinoma 20 | 1,614
ductal carcinoma in situ 20 | 1,745
lung carcinoma 20 | 2,844
colon cancer 19 | 1,475
pancreatic cancer 18 | 2,300
pituitary cancer 17 | 1,972
posterior fossa group A ependymoma 17 | 1,511
subependymal giant cell astrocytoma 17 | 2,287
tuberculosis and treatment for 6 months 17 | 686
adult high grade glioma 16 | 2,148
juvenile dermatomyositis 16 | 1,189
Atopic dermatitis 15 | 944
astrocytic glioma 15 | 2,241
dermatomyositis 15 | 933
medulloblastoma 15 | 1,524
sonic hedgehog group medulloblastoma 13 | 1,482
tuberculosis 13 | 1,557
IGA Glomerulonephritis 12 | 454
Rheumatoid Arthritis 12 | 1,160
cystic fibrosis 12 | 1,665
interstitial cystitis 12 | 2,299
active Crohn's disease 11 | 918
nasopharyngeal carcinoma 11 | 1,056
non primary Sjogren syndrome sicca 11 | 840
spina bifida 11 | 1,064
Neurodegenerative disease 10 | 383
cutaneous lupus erythematosus 10 | 1,056
primary pancreatic ductal adenocarcinoma 10 | 1,271
Cancer 9 | 2,346
Endometriosis 9 | 535
esophageal adenocarcinoma 9 | 737
hereditary spastic paraplegia 9 | 313
Microcephaly 8 | 149
Paraplegia 8 | 71
acute myeloid leukemia 8 | 780
progressive supranuclear palsy 8 | 674
Alzheimer's disease 7 | 644
Amyotrophic Lateral Sclerosis 7 | 431
Intellectual disability 7 | 573
Neuropathy 7 | 210
atypical teratoid/rhabdoid tumor 7 | 1,095
inflammatory breast cancer 7 | 404
pancreatic carcinoma 7 | 567
primary Sjogren syndrome 7 | 789
ulcerative colitis 7 | 2,087
Congenital disorder of glycosylation 6 | 53
Prostatic Neoplasms 6 | 471
Waldenstrons macroglobulinemia 6 | 765
hepatocellular carcinoma 6 | 532
Down syndrome 5 | 548
Duchenne muscular dystrophy 5 | 602
Polycystic Ovary Syndrome 5 | 332
aldosterone-producing adenoma 5 | 664
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 499
gastric cancer 5 | 430
Gaucher disease type 1 4 | 171
Heart disease 4 | 279
Legionnaires' disease 4 | 20
Menkes disease 4 | 20
Oculocerebrorenal syndrome 4 | 23
Parkinson's disease 4 | 364
Schizophrenia 4 | 501
Warburg micro syndrome 4 | 19
active ulcerative colitis 4 | 477
fibroadenoma 4 | 557
gastric carcinoma 4 | 832
Attention deficit hyperactivity disorder 3 | 156
Multiple Sclerosis 3 | 498
mucosa-associated lymphoid tissue lymphoma 3 | 480

Tissue

Blood and immune system 180 | 17,995
Digestive Tract 180 | 18,473
Endocrine System 180 | 18,512
Female tissues 180 | 18,647
Liver and Pancreas 180 | 18,136
Male tissues 180 | 17,969
Nervous System 180 | 18,561
Urinary Tract 180 | 18,444
Cardiovascular System 179 | 17,958
Respiratory system 179 | 17,484
Skin and soft tissues 178 | 18,115

Target Family

Non-IDG 137 | 11,971
Enzyme 43 | 4,146
Transcription Factor 1 | 1,400

Reactome Pathway

Intra-Golgi and retrograde Gol... 181 | 181
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Kinesin-like protein KIF1C KIF1C Tbio Non-IDG -1.21884 20.0 95
Dynein light chain 1, cytoplasmic DYNLL1 Tbio Non-IDG -2.65303 525.6 142
BET1-like protein BET1L Tbio Non-IDG 0.12 0.65 16
Ras-related protein Rab-43 RAB43 Tbio Enzyme -1.56506 35.9 63
GRIP and coiled-coil domain-containing protein 2 GCC2 Tbio Non-IDG -1.00799 11.7 134
Ras-related protein Rab-9A RAB9A Tchem Enzyme -0.85649 7.48 172
Transmembrane emp24 domain-containing protein 9 TMED9 Tdark Non-IDG -0.05436 0.58 101
Kinesin-like protein KIF3B KIF3B Tbio Non-IDG -1.33400 20.0 84
Ras-related protein Rab-33B RAB33B Tbio Enzyme -0.75609 7.38 45
ER lumen protein-retaining receptor 1 KDELR1 Tbio Non-IDG -2.24993 170.8 122