Development Level

Tbio 13 | 11,445
Tchem 6 | 1,598
Tclin 3 | 613

IMPC Phenotype

decreased body weight 1 | 161
decreased circulating creatini... 1 | 39
preweaning lethality, complete... 1 | 979

Disease

Cancer 19 | 2,499
Carcinoma 17 | 11,493
osteosarcoma 15 | 7,950
lung cancer 13 | 4,740
psoriasis 12 | 6,694
Breast cancer 11 | 3,578
invasive ductal carcinoma 11 | 2,951
ovarian cancer 11 | 8,520
malignant mesothelioma 10 | 3,232
medulloblastoma, large-cell 9 | 6,241
Rheumatoid arthritis 8 | 1,191
Severe combined immunodeficiency 8 | 51
atypical teratoid / rhabdoid tumor 8 | 5,112
ductal carcinoma in situ 8 | 1,745
Atopic dermatitis 7 | 952
adult high grade glioma 7 | 3,801
lung adenocarcinoma 7 | 2,716
pituitary cancer 7 | 1,972
Anemia 6 | 365
Autosomal recessive predisposition 6 | 1,442
Failure to gain weight 6 | 365
Fever 6 | 138
Kidney cancer 6 | 2,613
Pediatric failure to thrive 6 | 365
Pneumonia 6 | 174
breast carcinoma 6 | 1,638
diabetes mellitus 6 | 1,728
interstitial cystitis 6 | 2,312
tuberculosis 6 | 2,010
Diarrhea 5 | 253
Eosinophilia 5 | 28
Immune system cancer 5 | 140
Liver Cirrhosis, Experimental 5 | 769
Lymphoid leukemia 5 | 160
Lymphopenia 5 | 67
Multiple Sclerosis 5 | 540
Pruritus 5 | 58
Recurrent respiratory infections 5 | 141
astrocytoma 5 | 1,146
glioblastoma 5 | 5,792
group 3 medulloblastoma 5 | 4,104
group 4 medulloblastoma 5 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
non-small cell lung cancer 5 | 2,890
pancreatic cancer 5 | 2,398
ulcerative colitis 5 | 1,819
Absence of eyebrows 4 | 31
Alopecia 4 | 115
Aplasia/Hypoplasia of the eyebrow 4 | 31
Arthritis 4 | 290
Astrocytoma, Pilocytic 4 | 3,081
Atypical lymphocyte observed 4 | 10
Chronic diarrhea 4 | 29
Desquamation of skin soon after birth 4 | 10
Diffusely thickened skin 4 | 20
Dry skin 4 | 75
Edema 4 | 81
Exfoliative dermatitis 4 | 24
Hepatomegaly 4 | 285
Hypersensitivity reaction type II disease 4 | 253
Infantile onset 4 | 238
Lymphadenopathy 4 | 62
Multiple myeloma 4 | 1,332
Omenn syndrome 4 | 13
Otitis Media 4 | 52
Pachyderma 4 | 20
Polycythemia vera 4 | 27
Precancerous Conditions 4 | 80
Recurrent fungal infections 4 | 13
Sparse or absent eyebrows 4 | 31
Sparse/absent eyebrows 4 | 31
Splenomegaly 4 | 190
Xerosis 4 | 75
active Crohn's disease 4 | 922
adrenocortical carcinoma 4 | 1,428
cutaneous lupus erythematosus 4 | 1,057
cystic fibrosis 4 | 1,696
ependymoma 4 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
lung carcinoma 4 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
primitive neuroectodermal tumor 4 | 3,035
Broad flat nasal bridge 3 | 236
Carcinoma, Hepatocellular 3 | 228
Congenital hypoplasia of thymus 3 | 15
Dermatitis, Allergic Contact 3 | 67
Frontal bossing 3 | 157
Inflammatory bowel disease 3 | 151
Liver cancer 3 | 604
Liver carcinoma 3 | 240
Nasal bridge wide 3 | 236
Reperfusion Injury 3 | 86
Thrombocytopenia 3 | 197
active ulcerative colitis 3 | 764
colon cancer 3 | 1,478
dermatomyositis 3 | 966
juvenile dermatomyositis 3 | 1,187
oligodendroglioma 3 | 2,850
subependymal giant cell astrocytoma 3 | 2,287

Tissue

Blood and immune system 22 | 16,909
Endocrine System 22 | 18,159
Liver and Pancreas 22 | 16,750
Male tissues 22 | 17,142
Urinary Tract 22 | 16,678
Digestive Tract 21 | 17,369
Female tissues 21 | 17,400
Respiratory system 21 | 16,393
Skin and soft tissues 21 | 17,230
Cardiovascular System 20 | 15,192
Nervous System 20 | 16,725

Target Family

Non-IDG 11 | 12,091
Enzyme 3 | 4,145
Kinase 3 | 634
Transcription Factor 3 | 1,400
Epigenetic 2 | 242

Reactome Pathway

Interleukin-7 signaling 22 | 22
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cytokine receptor-like factor 2 CRLF2 Tbio Non-IDG -1.91113 78.7 393
V(D)J recombination-activating protein 1 RAG1 Tbio Non-IDG -3.05993 1094.2 84
Thymic stromal lymphopoietin TSLP Tbio Non-IDG -2.78236 713.0 495
Insulin receptor substrate 2 IRS2 Tbio Non-IDG -2.64133 414.7 227
V(D)J recombination-activating protein 2 RAG2 Tbio Epigenetic -2.94111 784.2 194
Tyrosine-protein kinase JAK3 JAK3 Tclin Kinase -2.64385 453.7 292
Hepatocyte growth factor HGF Tchem Enzyme -3.30841 2392.1 724
Interleukin-7 receptor subunit alpha IL7R Tbio Non-IDG -2.77688 547.0 828
Suppressor of cytokine signaling 1 SOCS1 Tbio Non-IDG -3.05851 1163.8 469
Signal transducer and activator of transcription 5B STAT5B Tchem Transcription Factor -3.02570 950.5 620