Development Level

Tclin 6 | 613
Tchem 3 | 1,598
Tbio 1 | 11,445

IMPC Phenotype

abnormal gait 1 | 69
decreased circulating glucose ... 1 | 126
decreased mean corpuscular vol... 1 | 79
decreased total body fat amoun... 1 | 207
enlarged lymph nodes 1 | 37
impaired righting response 1 | 26
increased bone mineral density 1 | 72
increased lymphocyte cell numb... 1 | 32
increased neutrophil cell numb... 1 | 46
preweaning lethality, incomple... 1 | 499

Disease

Cancer 10 | 2,499
Rheumatoid arthritis 9 | 1,191
osteosarcoma 9 | 7,950
Carcinoma 8 | 11,493
lung cancer 8 | 4,740
ovarian cancer 8 | 8,520
ependymoma 7 | 4,679
glioblastoma 7 | 5,792
medulloblastoma, large-cell 7 | 6,241
Multiple myeloma 6 | 1,332
psoriasis 6 | 6,694
Arthritis 5 | 290
Arthritis, Rheumatoid 5 | 174
Asthma 5 | 385
Astrocytoma, Pilocytic 5 | 3,081
Immune system cancer 5 | 140
Kidney cancer 5 | 2,613
Lymphoid leukemia 5 | 160
atypical teratoid / rhabdoid tumor 5 | 5,112
invasive ductal carcinoma 5 | 2,951
lung carcinoma 5 | 2,843
non-small cell lung cancer 5 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
pituitary cancer 5 | 1,972
ulcerative colitis 5 | 1,819
Anemia 4 | 365
Atherosclerosis 4 | 291
Breast cancer 4 | 3,578
Inflammatory bowel disease 4 | 151
Juvenile rheumatoid arthritis 4 | 111
Multiple Sclerosis 4 | 540
Myocardial Ischemia 4 | 169
Obesity 4 | 678
adult high grade glioma 4 | 3,801
cystic fibrosis 4 | 1,696
dermatomyositis 4 | 966
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
lung adenocarcinoma 4 | 2,716
malignant mesothelioma 4 | 3,232
tuberculosis 4 | 2,010
Angiofollicular lymph node hyperplasia 3 | 3
Arthralgia 3 | 90
Arthritis, Experimental 3 | 39
Atopic dermatitis 3 | 952
Brain Ischemia 3 | 110
Candidiasis 3 | 55
Carcinoma, Hepatocellular 3 | 228
Carcinoma, Squamous Cell 3 | 110
Crohn's disease 3 | 321
Depressive disorder 3 | 409
Dermatitis 3 | 157
Fever 3 | 138
Gaucher disease type 1 3 | 180
Hepatitis C 3 | 94
Hypersensitivity reaction type II disease 3 | 253
Infarction, Middle Cerebral Artery 3 | 33
Inflammation 3 | 120
Leukemia, Myeloid, Acute 3 | 105
Liver Cirrhosis 3 | 181
Liver Neoplasms, Experimental 3 | 59
Liver carcinoma 3 | 240
Liver disease 3 | 237
Neoplasm Metastasis 3 | 168
Osteoporosis 3 | 363
Ovarian Neoplasms 3 | 102
Pick disease 3 | 1,894
Pneumonia 3 | 174
Polycythemia vera 3 | 27
Prostatic Neoplasms 3 | 495
Recurrent respiratory infections 3 | 141
Reperfusion Injury 3 | 86
Short stature 3 | 531
Squamous cell carcinoma 3 | 129
Stomach Neoplasms 3 | 300
Systemic lupus erythematosus 3 | 194
Thrombocytopenia 3 | 197
Vascular disease 3 | 319
acute quadriplegic myopathy 3 | 1,158
astrocytic glioma 3 | 2,597
astrocytoma 3 | 1,146
diabetes mellitus 3 | 1,728
group 4 medulloblastoma 3 | 1,855
interstitial cystitis 3 | 2,312
juvenile dermatomyositis 3 | 1,187
oligodendroglioma 3 | 2,850
ovarian neoplasm 3 | 99
pancreatic cancer 3 | 2,398
pancreatic carcinoma 3 | 562
primary Sjogren syndrome 3 | 735
progressive supranuclear palsy 3 | 676
Diarrhea 2 | 253
Joint hyperflexibility 2 | 78
Major Depressive Disorder 2 | 301
Recurrent mycobacterial infections 2 | 7
Unipolar Depression 2 | 250
active ulcerative colitis 2 | 764
head and neck cancer 2 | 271
type II diabetes mellitus and post-ischemic heart failure 2 | 88

Tissue

Blood and immune system 10 | 16,909
Cardiovascular System 10 | 15,192
Digestive Tract 10 | 17,369
Endocrine System 10 | 18,159
Female tissues 10 | 17,400
Liver and Pancreas 10 | 16,750
Male tissues 10 | 17,142
Nervous System 10 | 16,725
Respiratory system 10 | 16,393
Skin and soft tissues 10 | 17,230
Urinary Tract 10 | 16,678

Target Family

Non-IDG 4 | 12,091
Kinase 3 | 634
Transcription Factor 2 | 1,400
Enzyme 1 | 4,145

Reactome Pathway

Interleukin-6 signaling 10 | 10
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Non-receptor tyrosine-protein kinase TYK2 TYK2 Tclin Kinase -2.47105 252.9 547
Interleukin-6 receptor subunit beta IL6ST Tclin Non-IDG -1.72489 55.4 555
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075
Suppressor of cytokine signaling 3 SOCS3 Tbio Non-IDG -3.05657 1157.2 518
Tyrosine-protein phosphatase non-receptor type 11 PTPN11 Tchem Enzyme -3.11032 1400.0 1077
Interleukin-6 receptor subunit alpha IL6R Tclin Non-IDG -2.52639 271.6 613
Signal transducer and activator of transcription 3 STAT3 Tchem Transcription Factor -3.81500 6459.7 1749
Tyrosine-protein kinase JAK1 JAK1 Tclin Kinase -2.80024 518.7 425
Tyrosine-protein kinase JAK2 JAK2 Tclin Kinase -3.54037 3339.7 801
Signal transducer and activator of transcription 1-alpha/beta STAT1 Tchem Transcription Factor -3.33049 2009.0 1596