Development Level

Tbio 13 | 11,445
Tclin 7 | 613
Tchem 3 | 1,598

IMPC Phenotype

preweaning lethality, complete... 3 | 979
decreased circulating glucose ... 2 | 126
decreased mean corpuscular vol... 2 | 79
increased bone mineral density 2 | 72
abnormal brain morphology 1 | 13
abnormal embryo size 1 | 220
abnormal gait 1 | 69
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
decreased bone mineral content 1 | 151
decreased circulating free fat... 1 | 31
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased total body fat amoun... 1 | 207
enlarged lymph nodes 1 | 37
impaired righting response 1 | 26
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
increased total body fat amoun... 1 | 134
preweaning lethality, incomple... 1 | 499
thrombocytopenia 1 | 56

Disease

Cancer 14 | 2,499
osteosarcoma 14 | 7,950
psoriasis 14 | 6,694
Carcinoma 12 | 11,493
lung cancer 12 | 4,740
ovarian cancer 12 | 8,520
Rheumatoid arthritis 11 | 1,191
ependymoma 11 | 4,679
glioblastoma 11 | 5,792
malignant mesothelioma 9 | 3,232
medulloblastoma, large-cell 9 | 6,241
non-small cell lung cancer 9 | 2,890
Arthritis 8 | 290
lung adenocarcinoma 8 | 2,716
pituitary cancer 8 | 1,972
ulcerative colitis 8 | 1,819
Asthma 7 | 385
Astrocytoma, Pilocytic 7 | 3,081
Kidney cancer 7 | 2,613
adult high grade glioma 7 | 3,801
atypical teratoid / rhabdoid tumor 7 | 5,112
interstitial cystitis 7 | 2,312
invasive ductal carcinoma 7 | 2,951
lung carcinoma 7 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
tuberculosis 7 | 2,010
Atopic dermatitis 6 | 952
Autosomal recessive predisposition 6 | 1,442
Breast cancer 6 | 3,578
Multiple myeloma 6 | 1,332
Obesity 6 | 678
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
pancreatic cancer 6 | 2,398
Acquired scoliosis 5 | 281
Arthritis, Rheumatoid 5 | 174
Curvature of spine 5 | 282
Depressive disorder 5 | 409
Immune system cancer 5 | 140
Inflammatory bowel disease 5 | 151
Lymphoid leukemia 5 | 160
Mental Depression 5 | 333
Thrombocytopenia 5 | 197
cold-induced sweating syndrome 5 | 7
cystic fibrosis 5 | 1,696
group 4 medulloblastoma 5 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
oligodendroglioma 5 | 2,850
Abortion, Spontaneous 4 | 109
Anemia 4 | 365
Atherosclerosis 4 | 291
Byzanthine arch palate 4 | 194
Feeding difficulties in infancy 4 | 175
Gaucher disease type 1 4 | 180
Hyperhidrosis disorder 4 | 81
Increased sweating 4 | 81
Infarction, Middle Cerebral Artery 4 | 33
Juvenile rheumatoid arthritis 4 | 111
Multiple Sclerosis 4 | 540
Myocardial Ischemia 4 | 169
Neoplasm Metastasis 4 | 168
Osteoporosis 4 | 363
Ovarian Neoplasms 4 | 102
Pick disease 4 | 1,894
Polycystic ovary syndrome 4 | 360
Prostatic Neoplasms 4 | 495
Respiratory Insufficiency 4 | 132
Respiratory function loss 4 | 121
Schizophrenia 4 | 1,160
Short stature 4 | 531
Spontaneous abortion 4 | 113
Sweating 4 | 81
acute quadriplegic myopathy 4 | 1,158
astrocytoma 4 | 1,146
breast carcinoma 4 | 1,638
dermatomyositis 4 | 966
diabetes mellitus 4 | 1,728
ductal carcinoma in situ 4 | 1,745
group 3 medulloblastoma 4 | 4,104
juvenile dermatomyositis 4 | 1,187
non diabetic and post-ischemic heart failure 4 | 200
ovarian neoplasm 4 | 99
progressive supranuclear palsy 4 | 676
Brain Ischemia 3 | 110
Decreased joint mobility 3 | 53
Dermatitis 3 | 157
Heart disease 3 | 306
Hypersensitivity reaction type II disease 3 | 253
Major Depressive Disorder 3 | 301
Reperfusion Injury 3 | 86
Stomach Neoplasms 3 | 300
Unipolar Depression 3 | 250
Vascular disease 3 | 319
active Crohn's disease 3 | 922
aldosterone-producing adenoma 3 | 665
colon cancer 3 | 1,478
head and neck cancer 3 | 271
mucosa-associated lymphoid tissue lymphoma 3 | 484
pancreatic carcinoma 3 | 562
subependymal giant cell astrocytoma 3 | 2,287

Tissue

Blood and immune system 23 | 16,909
Digestive Tract 23 | 17,369
Endocrine System 23 | 18,159
Female tissues 23 | 17,400
Liver and Pancreas 23 | 16,750
Male tissues 23 | 17,142
Skin and soft tissues 23 | 17,230
Urinary Tract 23 | 16,678
Cardiovascular System 22 | 15,192
Nervous System 22 | 16,725
Respiratory system 22 | 16,393

Target Family

Non-IDG 17 | 12,091
Kinase 3 | 634
Transcription Factor 2 | 1,400
Enzyme 1 | 4,145

Reactome Pathway

Interleukin-6 family signaling 23 | 23
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Leukemia inhibitory factor receptor LIFR Tbio Non-IDG -2.35146 221.3 249
Leukemia inhibitory factor LIF Tbio Non-IDG -2.86943 538.7 413
Ciliary neurotrophic factor receptor subunit alpha CNTFR Tbio Non-IDG -1.63139 35.8 217
Interleukin-31 IL31 Tbio Non-IDG -2.18563 154.1 294
Interleukin-11 IL11 Tbio Non-IDG -2.80588 680.7 340
Cardiotrophin-1 CTF1 Tbio Non-IDG -2.30700 246.7 333
Cardiotrophin-like cytokine factor 1 CLCF1 Tbio Non-IDG -1.35883 23.2 162
Oncostatin-M-specific receptor subunit beta OSMR Tbio Non-IDG -2.26877 178.8 258
Non-receptor tyrosine-protein kinase TYK2 TYK2 Tclin Kinase -2.47105 252.9 547
Interleukin-6 receptor subunit beta IL6ST Tclin Non-IDG -1.72489 55.4 555