Development Level

Tchem 43 | 1,885
Tbio 42 | 11,178
Tclin 25 | 612

IMPC Phenotype

preweaning lethality, incomple... 4 | 499
abnormal seminal vesicle morph... 3 | 114
decreased total body fat amoun... 3 | 207
enlarged heart 3 | 210
increased mean corpuscular vol... 3 | 92
preweaning lethality, complete... 3 | 979
abnormal femur morphology 2 | 14
abnormal retina morphology 2 | 71
abnormal sleep behavior 2 | 70
decreased circulating creatini... 2 | 39
decreased circulating glucose ... 2 | 126
decreased erythrocyte cell num... 2 | 62
decreased vertical activity 2 | 208
increased heart weight 2 | 62
increased mean corpuscular hem... 2 | 96
increased neutrophil cell numb... 2 | 46
increased or absent threshold ... 2 | 101
short tibia 2 | 97
thrombocytopenia 2 | 56
abnormal behavior 1 | 298
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal humerus morphology 1 | 11
abnormal lung morphology 1 | 26
abnormal snout morphology 1 | 23
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
decreased T cell number 1 | 15
decreased bone mineral density 1 | 126
decreased circulating aspartat... 1 | 34
decreased circulating free fat... 1 | 31
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
dilated heart left ventricle 1 | 11
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
hydrometra 1 | 53
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased blood uric acid leve... 1 | 5
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating chloride... 1 | 41
increased fasted circulating g... 1 | 76
increased granulocyte number 1 | 1
increased grip strength 1 | 41
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 36
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
male infertility 1 | 123
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
small testis 1 | 58
vertebral fusion 1 | 23

Disease

Cancer 76 | 2,388
psoriasis 71 | 6,514
Carcinoma 63 | 11,192
ovarian cancer 63 | 8,297
lung cancer 57 | 4,607
osteosarcoma 57 | 7,766
glioblastoma 50 | 5,635
ulcerative colitis 45 | 1,765
malignant mesothelioma 44 | 3,135
medulloblastoma, large-cell 44 | 6,086
Asthma 38 | 370
Breast cancer 38 | 3,469
lung carcinoma 38 | 2,755
ependymoma 37 | 4,559
invasive ductal carcinoma 37 | 2,867
tuberculosis 37 | 1,963
atypical teratoid / rhabdoid tumor 36 | 4,971
diabetes mellitus 36 | 1,683
pancreatic cancer 36 | 2,322
interstitial cystitis 34 | 2,237
Arthritis 33 | 276
Rheumatoid arthritis 33 | 1,156
Multiple Sclerosis 31 | 527
Astrocytoma, Pilocytic 30 | 3,006
Schizophrenia 30 | 1,136
non-small cell lung cancer 30 | 2,799
pituitary cancer 30 | 1,915
Liver Cirrhosis, Experimental 29 | 733
adult high grade glioma 29 | 3,701
Inflammatory bowel disease 28 | 148
Kidney disease 27 | 411
Obesity 27 | 655
lung adenocarcinoma 27 | 2,627
Hypersensitivity reaction type II disease 26 | 245
cystic fibrosis 26 | 1,629
Dermatitis 25 | 154
Lung disease 25 | 135
breast carcinoma 25 | 1,589
intraductal papillary-mucinous adenoma (IPMA) 25 | 2,872
subependymal giant cell astrocytoma 25 | 2,230
ductal carcinoma in situ 24 | 1,686
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,204
Vascular disease 23 | 294
Inflammation 22 | 116
Prostatic Neoplasms 22 | 472
Reperfusion Injury 22 | 84
group 3 medulloblastoma 22 | 4,002
Atherosclerosis 21 | 276
Hypertension 21 | 372
Liver disease 21 | 227
Pneumonia 21 | 169
Allergic hypersensitivity disease 20 | 124
Bipolar Disorder 20 | 646
Depressive disorder 20 | 401
Hypertensive disease 20 | 278
intraductal papillary-mucinous carcinoma (IPMC) 20 | 2,902
pancreatic ductal adenocarcinoma liver metastasis 20 | 1,911
periodontitis 20 | 280
Heart disease 19 | 288
Myocardial Ischemia 19 | 162
Neoplasm Metastasis 19 | 160
astrocytoma 19 | 1,113
cutaneous lupus erythematosus 19 | 1,016
oligodendroglioma 19 | 2,768
Fever 18 | 136
Mental Depression 18 | 325
Stomach Neoplasms 18 | 287
acute quadriplegic myopathy 18 | 1,133
juvenile dermatomyositis 18 | 1,147
primitive neuroectodermal tumor 18 | 2,957
Alzheimer's disease 17 | 640
Anemia 17 | 353
Breast Neoplasms 17 | 423
Hypereosinophilic syndrome 17 | 70
Mammary Neoplasms 17 | 403
dermatomyositis 17 | 941
nasopharyngeal carcinoma 17 | 1,024
Allergic rhinitis 16 | 93
Arthritis, Rheumatoid 16 | 169
Brain Ischemia 16 | 107
Endometriosis 16 | 521
gastric carcinoma 16 | 781
mucosa-associated lymphoid tissue lymphoma 16 | 473
Atopic dermatitis 15 | 915
Hyperglycemia 15 | 134
Liver carcinoma 15 | 229
Lung Neoplasms 15 | 217
Malaria 15 | 155
Multiple myeloma 15 | 1,296
Myocardial Infarction 15 | 142
Neoplasm Invasiveness 15 | 151
Pulmonary Fibrosis 15 | 101
adrenocortical carcinoma 15 | 1,385
group 4 medulloblastoma 15 | 1,806
Carcinoma, Hepatocellular 14 | 217
Kidney cancer 14 | 2,548
Major Depressive Disorder 14 | 293
Squamous cell carcinoma 14 | 125
colon cancer 14 | 1,428
primary Sjogren syndrome 14 | 710

Tissue

Blood and immune system 107 | 16,909
Digestive Tract 107 | 17,369
Endocrine System 106 | 18,159
Liver and Pancreas 106 | 16,750
Male tissues 106 | 17,142
Skin and soft tissues 106 | 17,230
Urinary Tract 106 | 16,678
Female tissues 104 | 17,400
Respiratory system 104 | 16,393
Nervous System 101 | 16,725
Cardiovascular System 94 | 15,192

Target Family

Non-IDG 64 | 12,091
Transcription Factor 20 | 1,400
Enzyme 15 | 4,145
Kinase 6 | 634
GPCR 3 | 408
Nuclear Receptor 2 | 48

Reactome Pathway

Interleukin-4 and 13 signaling 110 | 110
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interleukin-4 IL4 Tbio Non-IDG -3.98318 9219.0 1325
Neutrophil gelatinase-associated lipocalin LCN2 Tbio Enzyme -3.35178 2368.1 847
Basic leucine zipper transcriptional factor ATF-like BATF Tbio Transcription Factor -1.88914 81.4 286
Tumor necrosis factor receptor superfamily member 1B TNFRSF1B Tchem Non-IDG -3.67481 4484.7 712
Homeobox protein NANOG NANOG Tchem Transcription Factor -2.94914 1130.5 958
Rho-related GTP-binding protein RhoU RHOU Tbio Enzyme -1.30084 24.8 95
Interferon regulatory factor 4 IRF4 Tbio Transcription Factor -2.54787 365.3 532
Lipopolysaccharide-binding protein LBP Tbio Non-IDG -2.61682 357.2 225
Low affinity immunoglobulin epsilon Fc receptor FCER2 Tchem Non-IDG -2.51671 325.7 1205
Necdin NDN Tbio Non-IDG -2.22453 171.0 277