Development Level

Tchem 44 | 1,890
Tbio 42 | 10,625
Tclin 25 | 602

IMPC Term

enlarged heart 3 | 111
increased mean corpuscular vol... 3 | 91
preweaning lethality, incomple... 3 | 260
abnormal femur morphology 2 | 14
abnormal retina morphology 2 | 100
abnormal sleep behavior 2 | 63
decreased circulating glucose ... 2 | 121
decreased erythrocyte cell num... 2 | 43
decreased total body fat amoun... 2 | 186
hypoactivity 2 | 89
increased mean corpuscular hem... 2 | 93
preweaning lethality, complete... 2 | 633
thrombocytopenia 2 | 46
abnormal behavioral response t... 1 | 52
abnormal coping response 1 | 12
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal heart morphology 1 | 51
abnormal humerus morphology 1 | 11
abnormal retinal pigmentation 1 | 61
abnormal seminal vesicle morph... 1 | 47
abnormal snout morphology 1 | 18
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
decreased T cell number 1 | 31
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating creatini... 1 | 31
decreased circulating free fat... 1 | 39
decreased circulating insulin ... 1 | 75
decreased circulating triglyce... 1 | 83
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased lean body mass 1 | 195
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased neutrophil cell numb... 1 | 37
decreased prepulse inhibition 1 | 52
decreased startle reflex 1 | 48
dilated heart left ventricle 1 | 10
enlarged epididymis 1 | 27
enlarged lymph nodes 1 | 27
enlarged spleen 1 | 26
impaired glucose tolerance 1 | 52
improved glucose tolerance 1 | 56
increased blood urea nitrogen ... 1 | 44
increased blood uric acid leve... 1 | 5
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating chloride... 1 | 43
increased circulating choleste... 1 | 53
increased fasted circulating g... 1 | 68
increased granulocyte number 1 | 8
increased grip strength 1 | 83
increased lean body mass 1 | 107
limb grasping 1 | 35
male infertility 1 | 62
prolonged QRS complex duration 1 | 2
short tibia 1 | 82
small testis 1 | 37
vertebral fusion 1 | 23

Disease

Cancer 84 | 2,346
psoriasis 79 | 6,685
ovarian cancer 69 | 8,484
lung cancer 62 | 4,466
osteosarcoma 59 | 7,933
ulcerative colitis 57 | 2,087
glioblastoma 53 | 5,572
medulloblastoma, large-cell 46 | 6,234
malignant mesothelioma 44 | 3,162
diabetes mellitus 41 | 1,663
invasive ductal carcinoma 41 | 2,950
lung carcinoma 41 | 2,844
pancreatic cancer 41 | 2,300
Asthma 40 | 349
interstitial cystitis 38 | 2,299
Arthritis 37 | 248
tuberculosis 37 | 1,557
Rheumatoid Arthritis 36 | 1,160
Breast cancer 35 | 3,094
non-small cell lung cancer 35 | 2,798
Multiple Sclerosis 34 | 498
atypical teratoid / rhabdoid tumor 33 | 4,369
lung adenocarcinoma 32 | 2,713
pilocytic astrocytoma 32 | 3,086
pituitary cancer 32 | 1,972
Kidney disease 31 | 396
Obesity 31 | 616
cystic fibrosis 31 | 1,665
pediatric high grade glioma 31 | 2,712
Inflammatory bowel disease 29 | 142
Lung disease 29 | 132
ductal carcinoma in situ 29 | 1,745
breast carcinoma 28 | 1,614
subependymal giant cell astrocytoma 28 | 2,287
Hypersensitivity reaction type II disease 27 | 235
astrocytoma 27 | 1,493
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 26 | 2,956
Atherosclerosis 25 | 275
Inflammation 25 | 109
Liver disease 24 | 219
Mammary Neoplasms 24 | 410
Reperfusion Injury 24 | 84
Vascular disease 24 | 281
Dermatitis 23 | 107
Heart disease 23 | 279
Prostatic Neoplasms 23 | 471
intraductal papillary-mucinous carcinoma (IPMC) 23 | 2,988
periodontitis 23 | 269
Endometriosis 22 | 535
posterior fossa group A ependymoma 22 | 1,511
cutaneous lupus erythematosus 21 | 1,056
nasopharyngeal carcinoma 21 | 1,056
oligodendroglioma 21 | 2,849
primary pancreatic ductal adenocarcinoma 21 | 1,271
primitive neuroectodermal tumor 21 | 3,031
Allergic hypersensitivity disease 20 | 123
Liver Cirrhosis, Experimental 20 | 108
Lung Neoplasms 20 | 171
Neoplasm Metastasis 20 | 138
Alzheimer's disease 19 | 644
Myocardial Ischemia 19 | 169
Pneumonia 19 | 133
Stomach Neoplasms 19 | 282
acute quadriplegic myopathy 19 | 1,157
colon cancer 19 | 1,475
gastric carcinoma 19 | 832
juvenile dermatomyositis 19 | 1,189
Atopic dermatitis 18 | 944
Hypertensive disease 18 | 193
adrenocortical carcinoma 18 | 1,427
ependymoma 18 | 2,514
group 4 medulloblastoma 18 | 1,875
Allergic rhinitis 17 | 91
Carcinoma 17 | 2,147
Eosinophilia 17 | 65
Liver carcinoma 17 | 217
Neoplasm Invasiveness 17 | 127
dermatomyositis 17 | 933
mucosa-associated lymphoid tissue lymphoma 17 | 480
Brain Ischemia 16 | 87
Coronary artery disease 16 | 240
Diabetes Mellitus, Experimental 16 | 106
Pulmonary Fibrosis 16 | 66
esophageal adenocarcinoma 16 | 737
primary Sjogren syndrome 16 | 789
Cerebrovascular disease 15 | 231
Colonic Neoplasms 15 | 126
Duchenne muscular dystrophy 15 | 602
Schizophrenia 15 | 501
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,795
Adenoma 14 | 165
Common cold 14 | 63
Hyperglycemia 14 | 120
Hypertension 14 | 287
Multiple myeloma 14 | 1,327
Myocardial Infarction 14 | 126
Neoplastic Cell Transformation 14 | 81
Squamous cell carcinoma 14 | 94
non-small cell lung carcinoma 14 | 413

Tissue

Digestive Tract 111 | 18,473
Nervous System 111 | 18,561
Urinary Tract 111 | 18,444
Endocrine System 110 | 18,512
Female tissues 110 | 18,647
Liver and Pancreas 110 | 18,136
Skin and soft tissues 110 | 18,115
Blood and immune system 109 | 17,995
Male tissues 108 | 17,969
Respiratory system 108 | 17,484
Cardiovascular System 107 | 17,958

Target Family

Non-IDG 64 | 11,971
Transcription Factor 20 | 1,400
Enzyme 15 | 4,146
Kinase 7 | 634
GPCR 3 | 406
Nuclear Receptor 2 | 48

Reactome Pathway

Interleukin-4 and 13 signaling 111 | 111
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Matrix metalloproteinase-9 MMP9 Tchem Enzyme -3.90528 8199.7 1129
Fibronectin FN1 Tchem Non-IDG -3.04098 1121.3 1253
Nuclear receptor ROR-alpha RORA Tchem Nuclear Receptor -2.17386 139.2 340
Interleukin-13 IL13 Tbio Non-IDG -3.26171 1774.2 682