Development Level

Tbio 52 | 11,651
Tchem 33 | 1,388
Tclin 25 | 612

IMPC Phenotype

preweaning lethality, incomple... 4 | 499
abnormal seminal vesicle morph... 3 | 114
decreased total body fat amoun... 3 | 207
enlarged heart 3 | 210
increased mean corpuscular vol... 3 | 92
preweaning lethality, complete... 3 | 979
abnormal femur morphology 2 | 14
abnormal retina morphology 2 | 71
abnormal sleep behavior 2 | 70
decreased circulating creatini... 2 | 39
decreased circulating glucose ... 2 | 126
decreased erythrocyte cell num... 2 | 62
decreased vertical activity 2 | 208
increased heart weight 2 | 62
increased mean corpuscular hem... 2 | 96
increased neutrophil cell numb... 2 | 46
increased or absent threshold ... 2 | 101
short tibia 2 | 97
thrombocytopenia 2 | 56
abnormal behavior 1 | 298
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal humerus morphology 1 | 11
abnormal lung morphology 1 | 26
abnormal snout morphology 1 | 23
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
decreased T cell number 1 | 15
decreased bone mineral density 1 | 126
decreased circulating aspartat... 1 | 34
decreased circulating free fat... 1 | 31
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
dilated heart left ventricle 1 | 11
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
hydrometra 1 | 53
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased blood uric acid leve... 1 | 5
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating chloride... 1 | 41
increased fasted circulating g... 1 | 76
increased granulocyte number 1 | 1
increased grip strength 1 | 41
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 36
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
male infertility 1 | 123
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
small testis 1 | 58
vertebral fusion 1 | 23

Disease

Cancer 84 | 2,499
psoriasis 78 | 6,694
Carcinoma 68 | 11,493
ovarian cancer 68 | 8,520
lung cancer 64 | 4,740
osteosarcoma 60 | 7,950
glioblastoma 56 | 5,792
ulcerative colitis 50 | 1,819
malignant mesothelioma 49 | 3,232
medulloblastoma, large-cell 46 | 6,241
Breast cancer 42 | 3,578
ependymoma 41 | 4,679
invasive ductal carcinoma 41 | 2,951
lung carcinoma 41 | 2,843
pancreatic cancer 41 | 2,398
tuberculosis 41 | 2,010
Asthma 40 | 385
atypical teratoid / rhabdoid tumor 40 | 5,112
diabetes mellitus 40 | 1,728
Arthritis 39 | 290
interstitial cystitis 38 | 2,312
Rheumatoid arthritis 36 | 1,191
non-small cell lung cancer 36 | 2,890
Multiple Sclerosis 35 | 540
Liver Cirrhosis, Experimental 34 | 769
Schizophrenia 33 | 1,160
Astrocytoma, Pilocytic 32 | 3,081
adult high grade glioma 32 | 3,801
lung adenocarcinoma 32 | 2,716
pituitary cancer 32 | 1,972
Kidney disease 31 | 430
cystic fibrosis 31 | 1,696
Inflammatory bowel disease 30 | 151
Obesity 30 | 678
breast carcinoma 29 | 1,638
ductal carcinoma in situ 29 | 1,745
Hypersensitivity reaction type II disease 28 | 253
Lung disease 28 | 142
subependymal giant cell astrocytoma 28 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,291
Hypertension 26 | 396
intraductal papillary-mucinous adenoma (IPMA) 26 | 2,955
Atherosclerosis 25 | 291
Dermatitis 25 | 157
Inflammation 25 | 120
Vascular disease 25 | 319
Hypertensive disease 24 | 292
Liver disease 24 | 237
Prostatic Neoplasms 24 | 495
Reperfusion Injury 24 | 86
group 3 medulloblastoma 24 | 4,104
periodontitis 24 | 293
Breast Neoplasms 23 | 445
Heart disease 23 | 306
Mammary Neoplasms 23 | 425
intraductal papillary-mucinous carcinoma (IPMC) 23 | 2,989
Bipolar Disorder 22 | 666
Endometriosis 22 | 540
Neoplasm Metastasis 22 | 168
Pneumonia 22 | 174
astrocytoma 22 | 1,146
Depressive disorder 21 | 409
cutaneous lupus erythematosus 21 | 1,057
nasopharyngeal carcinoma 21 | 1,058
oligodendroglioma 21 | 2,850
primitive neuroectodermal tumor 21 | 3,035
Allergic hypersensitivity disease 20 | 126
Neoplasm Invasiveness 20 | 161
pancreatic ductal adenocarcinoma liver metastasis 20 | 1,962
Alzheimer's disease 19 | 658
Liver carcinoma 19 | 240
Lung Neoplasms 19 | 232
Mental Depression 19 | 333
Myocardial Ischemia 19 | 169
Stomach Neoplasms 19 | 300
acute quadriplegic myopathy 19 | 1,158
colon cancer 19 | 1,478
juvenile dermatomyositis 19 | 1,187
Atopic dermatitis 18 | 952
Carcinoma, Hepatocellular 18 | 228
Fever 18 | 138
Pulmonary Fibrosis 18 | 106
adrenocortical carcinoma 18 | 1,428
Anemia 17 | 365
Arthritis, Rheumatoid 17 | 174
Brain Ischemia 17 | 110
Carcinoma, Squamous Cell 17 | 110
Hypereosinophilic syndrome 17 | 71
Myocardial Infarction 17 | 151
Squamous cell carcinoma 17 | 129
dermatomyositis 17 | 966
gastric carcinoma 17 | 807
mucosa-associated lymphoid tissue lymphoma 17 | 484
Allergic rhinitis 16 | 95
Coronary artery disease 16 | 268
Diabetes Mellitus, Experimental 16 | 108
Kidney cancer 16 | 2,613
esophageal adenocarcinoma 16 | 737
group 4 medulloblastoma 16 | 1,855
primary pancreatic ductal adenocarcinoma 16 | 1,109

Tissue

Blood and immune system 107 | 16,909
Digestive Tract 107 | 17,369
Endocrine System 106 | 18,159
Liver and Pancreas 106 | 16,750
Male tissues 106 | 17,142
Skin and soft tissues 106 | 17,230
Urinary Tract 106 | 16,678
Female tissues 104 | 17,400
Respiratory system 104 | 16,393
Nervous System 101 | 16,725
Cardiovascular System 94 | 15,192

Target Family

Non-IDG 64 | 12,091
Transcription Factor 20 | 1,400
Enzyme 15 | 4,145
Kinase 6 | 634
GPCR 3 | 408
Nuclear Receptor 2 | 48

Reactome Pathway

Interleukin-4 and 13 signaling 110 | 110
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075
Tyrosine-protein kinase JAK3 JAK3 Tclin Kinase -2.64385 453.7 292
Platelet glycoprotein 4 CD36 Tbio Non-IDG -2.63884 376.0 1155
Transforming growth factor beta-1 TGFB1 Tchem Non-IDG -3.84680 5672.0 1222
Signal transducer and activator of transcription 3 STAT3 Tchem Transcription Factor -3.81500 6459.7 1749
Matrix metalloproteinase-9 MMP9 Tchem Enzyme -3.96102 8811.6 1442
Hepatocyte growth factor HGF Tchem Enzyme -3.30841 2392.1 724
Nuclear receptor ROR-gamma RORC Tchem Nuclear Receptor -2.17159 123.2 478
Proto-oncogene c-Fos FOS Tbio Transcription Factor -4.14231 13598.8 1058
Pro-opiomelanocortin POMC Tbio Non-IDG -4.56004 36591.2 1334