Development Level

Tclin 16 | 613
Tchem 14 | 1,598
Tbio 13 | 11,445

IMPC Phenotype

preweaning lethality, complete... 4 | 979
preweaning lethality, incomple... 3 | 499
decreased circulating creatini... 2 | 39
enlarged lymph nodes 2 | 37
female infertility 2 | 60
male infertility 2 | 123
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal colon morphology 1 | 3
abnormal duodenum morphology 1 | 4
abnormal eye anterior chamber ... 1 | 9
abnormal gait 1 | 69
abnormal maxilla morphology 1 | 17
abnormal retina morphology 1 | 71
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
abnormal vertebrae morphology 1 | 18
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
edema 1 | 59
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased heart left ventricle... 1 | 4
increased heart rate 1 | 23
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased total body fat amoun... 1 | 134
short tibia 1 | 97
thrombocytopenia 1 | 56

Disease

Carcinoma 38 | 11,493
Cancer 35 | 2,499
osteosarcoma 26 | 7,950
ovarian cancer 26 | 8,520
medulloblastoma, large-cell 22 | 6,241
lung cancer 18 | 4,740
glioblastoma 17 | 5,792
psoriasis 17 | 6,694
invasive ductal carcinoma 15 | 2,951
malignant mesothelioma 15 | 3,232
Schizophrenia 14 | 1,160
interstitial cystitis 14 | 2,312
Kidney cancer 12 | 2,613
group 4 medulloblastoma 12 | 1,855
lung carcinoma 12 | 2,843
tuberculosis 12 | 2,010
Rheumatoid arthritis 11 | 1,191
subependymal giant cell astrocytoma 11 | 2,287
Breast cancer 10 | 3,578
juvenile dermatomyositis 10 | 1,187
Liver Cirrhosis, Experimental 9 | 769
atypical teratoid / rhabdoid tumor 9 | 5,112
cutaneous lupus erythematosus 9 | 1,057
lung adenocarcinoma 9 | 2,716
primary Sjogren syndrome 9 | 735
Anemia 8 | 365
Multiple myeloma 8 | 1,332
astrocytoma 8 | 1,146
diabetes mellitus 8 | 1,728
ependymoma 8 | 4,679
pancreatic cancer 8 | 2,398
Asthma 7 | 385
Astrocytoma, Pilocytic 7 | 3,081
Waldenstrons macroglobulinemia 7 | 765
adult high grade glioma 7 | 3,801
dermatomyositis 7 | 966
ductal carcinoma in situ 7 | 1,745
non-small cell lung cancer 7 | 2,890
oligodendroglioma 7 | 2,850
ulcerative colitis 7 | 1,819
Allergic hypersensitivity disease 6 | 126
Autosomal recessive predisposition 6 | 1,442
Hypereosinophilic syndrome 6 | 71
Melanoma 6 | 711
Orbital separation excessive 6 | 244
Severe combined immunodeficiency 6 | 51
cystic fibrosis 6 | 1,696
group 3 medulloblastoma 6 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
primitive neuroectodermal tumor 6 | 3,035
Allergic rhinitis 5 | 94
Angle class 2 malocclusion 5 | 57
Angle class 3 malocclusion 5 | 57
Blastic phase chronic myeloid leukemia 5 | 58
Chronic Myelocytic Leukemia Accelerated Phase 5 | 59
Concave bridge of nose 5 | 195
Crohn's disease 5 | 321
Depressed nasal bridge 5 | 195
Depressed nasal root/bridge 5 | 195
Frontal bossing 5 | 157
Hepatomegaly 5 | 285
Hypersensitivity reaction type II disease 5 | 253
Immune system cancer 5 | 140
Malocclusion 5 | 57
Multiple Sclerosis 5 | 540
Muscle hypotonia 5 | 571
Pneumonia 5 | 174
Polycythemia vera 5 | 27
Splenomegaly 5 | 190
Thrombocytopenia 5 | 197
Ventricular Septal Defects 5 | 119
breast carcinoma 5 | 1,638
Arthritis 4 | 290
Blepharoptosis 4 | 231
Congenital Epicanthus 4 | 177
Delayed bone age 4 | 136
Failure to gain weight 4 | 365
High forehead 4 | 102
Increased head circumference 4 | 147
Increased size of skull 4 | 147
Influenza 4 | 142
Leukemia 4 | 104
Lung disease 4 | 142
Mastocytosis 4 | 27
Pectus excavatum 4 | 100
Pediatric failure to thrive 4 | 365
Pick disease 4 | 1,894
Prostatic Neoplasms 4 | 495
Tall forehead 4 | 102
Triangular face 4 | 58
active Crohn's disease 4 | 922
astrocytic glioma 4 | 2,597
colon cancer 4 | 1,478
gastric carcinoma 4 | 807
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
pancreatic carcinoma 4 | 562
pediatric high grade glioma 4 | 1,064
periodontitis 4 | 293
pituitary cancer 4 | 1,972

Tissue

Blood and immune system 43 | 16,909
Male tissues 43 | 17,142
Digestive Tract 42 | 17,369
Endocrine System 42 | 18,159
Female tissues 42 | 17,400
Liver and Pancreas 42 | 16,750
Skin and soft tissues 42 | 17,230
Respiratory system 41 | 16,393
Urinary Tract 41 | 16,678
Cardiovascular System 40 | 15,192
Nervous System 40 | 16,725

Target Family

Non-IDG 20 | 12,091
Kinase 14 | 634
Enzyme 7 | 4,145
Transcription Factor 2 | 1,400

Reactome Pathway

Interleukin-3, 5 and GM-CSF si... 43 | 43
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Rap guanine nucleotide exchange factor 1 RAPGEF1 Tbio Non-IDG -2.41980 281.2 167
GRB2-associated-binding protein 2 GAB2 Tbio Non-IDG -2.08460 139.8 494
Interleukin-3 IL3 Tbio Non-IDG -3.35359 2101.5 583
Interleukin-5 IL5 Tclin Non-IDG -3.45852 2701.9 571
Interleukin-2 IL2 Tchem Non-IDG -4.37903 24027.6 1518
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 INPPL1 Tchem Enzyme -2.05056 144.2 215
Tyrosine-protein kinase HCK HCK Tclin Kinase -3.53517 3192.7 428
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 INPP5D Tbio Enzyme -2.06945 104.7 374
Granulocyte-macrophage colony-stimulating factor CSF2 Tbio Non-IDG -3.91682 8450.3 1272
14-3-3 protein zeta/delta YWHAZ Tbio Non-IDG -2.59435 390.4 689