Development Level

Tbio 4 | 11,445
Tclin 3 | 613
Tchem 1 | 1,598

IMPC Phenotype

abnormal seminal vesicle morph... 1 | 114
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
increased lean body mass 1 | 172
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 6 | 11,493
osteosarcoma 6 | 7,950
psoriasis 6 | 6,694
Crohn's disease 5 | 321
Rheumatoid arthritis 5 | 1,191
lung cancer 5 | 4,740
ovarian cancer 5 | 8,520
tuberculosis 5 | 2,010
Arthritis 4 | 290
Cancer 4 | 2,499
Multiple Sclerosis 4 | 540
ependymoma 4 | 4,679
glioblastoma 4 | 5,792
ulcerative colitis 4 | 1,819
Anti-nuclear factor positive 3 | 18
Arthralgia 3 | 90
Arthritis, Rheumatoid 3 | 174
Astrocytoma, Pilocytic 3 | 3,081
Biliary cirrhosis 3 | 45
Brain Ischemia 3 | 110
Colitis, Ulcerative 3 | 59
Fever 3 | 138
Immune system cancer 3 | 140
Lymphoid leukemia 3 | 160
Prostatic Neoplasms 3 | 495
Pruritus 3 | 58
Systemic lupus erythematosus 3 | 194
atypical teratoid / rhabdoid tumor 3 | 5,112
diabetes mellitus 3 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
malignant mesothelioma 3 | 3,232
medulloblastoma, large-cell 3 | 6,241
oligodendroglioma 3 | 2,850
Abdominal Pain 2 | 98
Acquired scoliosis 2 | 281
Anemia 2 | 365
Angle class 2 malocclusion 2 | 57
Angle class 3 malocclusion 2 | 57
Apraxias 2 | 27
Autosomal recessive predisposition 2 | 1,442
Behcet Syndrome 2 | 21
Behcet's disease 2 | 89
Behcet's syndrome 2 | 50
Breast cancer 2 | 3,578
C-reactive protein increased 2 | 15
Candidiasis 2 | 55
Crohn Disease 2 | 45
Curvature of spine 2 | 282
Decreased joint mobility 2 | 53
Dermatitis 2 | 157
ESR raised 2 | 20
Elevated IgE 2 | 10
Fatigue 2 | 182
Frequent fractures 2 | 53
Frontal bossing 2 | 157
Gastrointestinal Hemorrhage 2 | 52
Generalized osteopenia 2 | 99
Hypersensitivity reaction type II disease 2 | 253
Hypertension, Portal 2 | 22
Immunologic Deficiency Syndromes 2 | 113
Increased fracture rate 2 | 53
Inflammation 2 | 120
Inflammatory bowel disease 2 | 151
Iridocyclitis 2 | 19
Job's syndrome 2 | 3
Joint swelling 2 | 26
Juvenile rheumatoid arthritis 2 | 111
Kidney cancer 2 | 2,613
Late tooth eruption 2 | 61
Leukemia, Myelocytic, Acute 2 | 120
Leukemia, Myeloid, Acute 2 | 105
Liver Cirrhosis 2 | 181
Liver Cirrhosis, Biliary 2 | 33
Liver Neoplasms, Experimental 2 | 59
Liver carcinoma 2 | 240
Malocclusion 2 | 57
Multiple myeloma 2 | 1,332
Myocardial Ischemia 2 | 169
Osteopenia 2 | 99
Papule 2 | 43
Pauciarticular juvenile rheumatoid arthritis 2 | 9
Polyarthritis 2 | 11
Polycythemia vera 2 | 27
Primary biliary cirrhosis 2 | 51
Recurrent mycobacterial infections 2 | 7
Recurrent respiratory infections 2 | 141
Short stature 2 | 531
Uterine Cervical Neoplasms 2 | 26
Varying degree of multiple fractures 2 | 53
Venous Thrombosis 2 | 47
astrocytic glioma 2 | 2,597
astrocytoma 2 | 1,146
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
lung adenocarcinoma 2 | 2,716
non-small cell lung cancer 2 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
pediatric high grade glioma 2 | 1,064
pituitary cancer 2 | 1,972
primary Sjogren syndrome 2 | 735
primitive neuroectodermal tumor 2 | 3,035

Tissue

Blood and immune system 8 | 16,909
Digestive Tract 8 | 17,369
Endocrine System 8 | 18,159
Female tissues 8 | 17,400
Liver and Pancreas 8 | 16,750
Male tissues 8 | 17,142
Respiratory system 8 | 16,393
Skin and soft tissues 8 | 17,230
Urinary Tract 8 | 16,678
Cardiovascular System 7 | 15,192
Nervous System 7 | 16,725

Target Family

Non-IDG 3 | 12,091
Kinase 2 | 634
Transcription Factor 2 | 1,400
Enzyme 1 | 4,145

Reactome Pathway

Interleukin-23 signaling 8 | 8
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interleukin-12 receptor subunit beta-1 IL12RB1 Tbio Non-IDG -2.33532 220.9 273
Signal transducer and activator of transcription 4 STAT4 Tbio Transcription Factor -2.51382 320.4 790
Non-receptor tyrosine-protein kinase TYK2 TYK2 Tclin Kinase -2.47105 252.9 547
Interleukin-23 receptor IL23R Tbio Non-IDG -2.10723 113.9 383
Signal transducer and activator of transcription 3 STAT3 Tchem Transcription Factor -3.81500 6459.7 1749
Protein disulfide-isomerase P4HB Tbio Enzyme -3.03189 1042.5 381
Interleukin-23 subunit alpha IL23A Tclin Non-IDG -2.25055 158.2 497
Tyrosine-protein kinase JAK2 JAK2 Tclin Kinase -3.54037 3339.7 801