Development Level

Tclin 6 | 612
Tchem 5 | 1,388

IMPC Phenotype

abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal colon morphology 1 | 3
abnormal duodenum morphology 1 | 4
abnormal eye anterior chamber ... 1 | 9
abnormal spleen morphology 1 | 55
abnormal vertebrae morphology 1 | 18
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
enlarged lymph nodes 1 | 37
female infertility 1 | 60
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased heart rate 1 | 23
increased total body fat amoun... 1 | 134
male infertility 1 | 123
preweaning lethality, complete... 1 | 979

Disease

Cancer 11 | 2,499
Carcinoma 11 | 11,493
medulloblastoma, large-cell 8 | 6,241
osteosarcoma 8 | 7,950
malignant mesothelioma 6 | 3,232
ovarian cancer 6 | 8,520
Rheumatoid arthritis 5 | 1,191
Severe combined immunodeficiency 5 | 51
glioblastoma 5 | 5,792
interstitial cystitis 5 | 2,312
lung cancer 5 | 4,740
psoriasis 5 | 6,694
Polycythemia vera 4 | 27
atypical teratoid / rhabdoid tumor 4 | 5,112
group 4 medulloblastoma 4 | 1,855
invasive ductal carcinoma 4 | 2,951
lung carcinoma 4 | 2,843
subependymal giant cell astrocytoma 4 | 2,287
Acute myeloid leukemia, disease 3 | 30
Anemia 3 | 365
Autosomal recessive predisposition 3 | 1,442
Failure to gain weight 3 | 365
Hypersensitivity reaction type II disease 3 | 253
Metastatic malignant melanoma 3 | 9
Metastatic renal cell carcinoma 3 | 5
Multiple Sclerosis 3 | 540
Multiple myeloma 3 | 1,332
Pediatric failure to thrive 3 | 365
Pneumonia 3 | 174
Primary cutaneous T-cell lymphoma 3 | 29
Relapsing remitting multiple sclerosis 3 | 14
Renal transplant rejection 3 | 13
adult high grade glioma 3 | 3,801
astrocytoma 3 | 1,146
cutaneous lupus erythematosus 3 | 1,057
ductal carcinoma in situ 3 | 1,745
pituitary cancer 3 | 1,972
primary Sjogren syndrome 3 | 735
AMYOTROPHIC LATERAL SCLEROSIS 1 2 | 49
Acquired immunodeficiency syndrome 2 | 197
Alopecia 2 | 115
Angle class 2 malocclusion 2 | 57
Angle class 3 malocclusion 2 | 57
Anti-nuclear factor positive 2 | 18
Apraxias 2 | 27
Arthralgia 2 | 90
Arthritis, Rheumatoid 2 | 174
Asthma 2 | 385
Astrocytoma, Pilocytic 2 | 3,081
Atopic dermatitis 2 | 952
C-reactive protein increased 2 | 15
Chronic diarrhea 2 | 29
Decreased joint mobility 2 | 53
Diarrhea 2 | 253
ESR raised 2 | 20
Elevated C-reactive protein level 2 | 15
Hepatomegaly 2 | 285
Immune system cancer 2 | 140
Immunologic Deficiency Syndromes 2 | 113
Iridocyclitis 2 | 19
Joint swelling 2 | 26
Juvenile rheumatoid arthritis 2 | 111
Juvenile rheumatoid factor-negative polyarthritis 2 | 9
Kidney cancer 2 | 2,613
Liver Cirrhosis, Experimental 2 | 769
Lymphadenopathy 2 | 62
Lymphoid leukemia 2 | 160
Lymphopenia 2 | 67
Malocclusion 2 | 57
Mastocytosis 2 | 27
Melanoma 2 | 711
Oligoarticular juvenile arthritis 2 | 9
Pauciarticular juvenile rheumatoid arthritis 2 | 9
Polyarthritis 2 | 11
Primary immunodeficiency disease 2 | 54
Primary polycythemia 2 | 8
Recurrent fungal infections 2 | 13
Recurrent respiratory infections 2 | 141
Schizophrenia 2 | 1,160
Splenomegaly 2 | 190
T-Lymphocytopenia 2 | 9
Type 1 diabetes mellitus 2 | 109
diabetes mellitus 2 | 1,728
ependymoma 2 | 4,679
group 3 medulloblastoma 2 | 4,104
lung adenocarcinoma 2 | 2,716
oligodendroglioma 2 | 2,850
pancreatic cancer 2 | 2,398
periodontitis 2 | 293
primitive neuroectodermal tumor 2 | 3,035
tuberculosis 2 | 2,010
ulcerative colitis 2 | 1,819
LYMPH NODE ABNORMALITY 1 | 1
Lack of delayed skin hypersensitivity reaction 1 | 5
Lactocele 1 | 3
Lymphoma, B-Cell 1 | 6
Lymphoma, Extranodal NK-T-Cell 1 | 2
Lymphoproliferative syndrome 1 | 58
Panhypogammaglobulinemia 1 | 9
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, NK Cell-Negative 1 | 3

Tissue

Blood and immune system 11 | 16,909
Cardiovascular System 11 | 15,192
Digestive Tract 11 | 17,369
Endocrine System 11 | 18,159
Female tissues 11 | 17,400
Liver and Pancreas 11 | 16,750
Male tissues 11 | 17,142
Nervous System 11 | 16,725
Respiratory system 11 | 16,393
Skin and soft tissues 11 | 17,230
Urinary Tract 11 | 16,678

Target Family

Kinase 5 | 634
Non-IDG 4 | 12,091
Transcription Factor 2 | 1,400

Reactome Pathway

Interleukin-2 signaling 11 | 11
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.14835 1437.4 1136
Tyrosine-protein kinase JAK3 JAK3 Tclin Kinase -2.64385 453.7 292
Interleukin-2 receptor subunit beta IL2RB Tclin Non-IDG -2.17998 125.4 654
Interleukin-2 receptor subunit alpha IL2RA Tclin Non-IDG -3.02107 927.8 1917
Signal transducer and activator of transcription 5B STAT5B Tchem Transcription Factor -3.02570 950.5 620
Tyrosine-protein kinase JAK1 JAK1 Tclin Kinase -2.80024 518.7 425
Tyrosine-protein kinase Lck LCK Tclin Kinase -3.17774 1500.3 1180
Protein-tyrosine kinase 2-beta PTK2B Tchem Kinase -2.68425 538.8 742
SHC-transforming protein 1 SHC1 Tchem Non-IDG -2.79171 598.1 840
Cytokine receptor common subunit gamma IL2RG Tclin Non-IDG -2.81131 605.4 421