Development Level

Tbio 37 | 11,445
Tchem 9 | 1,598
Tclin 9 | 613

IMPC Phenotype

decreased total body fat amoun... 3 | 207
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
increased neutrophil cell numb... 3 | 46
preweaning lethality, incomple... 3 | 499
abnormal retina morphology 2 | 71
abnormal seminal vesicle morph... 2 | 114
abnormal sleep behavior 2 | 70
increased mean corpuscular hem... 2 | 96
short tibia 2 | 97
abnormal cranium morphology 1 | 36
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal lung morphology 1 | 26
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating calcium ... 1 | 36
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
hypoactivity 1 | 132
impaired righting response 1 | 26
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased lean body mass 1 | 172
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased spleen weight 1 | 10
preweaning lethality, complete... 1 | 979
thrombocytopenia 1 | 56
vertebral fusion 1 | 23

Disease

ovarian cancer 32 | 8,520
Cancer 30 | 2,499
Carcinoma 29 | 11,493
psoriasis 29 | 6,694
osteosarcoma 24 | 7,950
glioblastoma 23 | 5,792
ependymoma 21 | 4,679
medulloblastoma, large-cell 20 | 6,241
atypical teratoid / rhabdoid tumor 19 | 5,112
Multiple myeloma 17 | 1,332
lung cancer 17 | 4,740
malignant mesothelioma 16 | 3,232
Astrocytoma, Pilocytic 15 | 3,081
Rheumatoid arthritis 15 | 1,191
diabetes mellitus 15 | 1,728
adult high grade glioma 14 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
tuberculosis 14 | 2,010
ulcerative colitis 14 | 1,819
Breast cancer 13 | 3,578
Schizophrenia 13 | 1,160
acute quadriplegic myopathy 12 | 1,158
pancreatic cancer 12 | 2,398
interstitial cystitis 11 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
lung carcinoma 11 | 2,843
Multiple Sclerosis 10 | 540
Prostatic Neoplasms 10 | 495
Waldenstrons macroglobulinemia 10 | 765
group 3 medulloblastoma 10 | 4,104
juvenile dermatomyositis 10 | 1,187
lung adenocarcinoma 10 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
primitive neuroectodermal tumor 10 | 3,035
Arthritis 9 | 290
Arthritis, Rheumatoid 9 | 174
Crohn's disease 9 | 321
Fever 9 | 138
dermatomyositis 9 | 966
non-small cell lung cancer 9 | 2,890
Anemia 8 | 365
Liver Cirrhosis, Experimental 8 | 769
Vascular disease 8 | 319
astrocytic glioma 8 | 2,597
cystic fibrosis 8 | 1,696
group 4 medulloblastoma 8 | 1,855
oligodendroglioma 8 | 2,850
subependymal giant cell astrocytoma 8 | 2,287
Asthma 7 | 385
Breast Neoplasms 7 | 445
Inflammatory bowel disease 7 | 151
Liver carcinoma 7 | 240
Myocardial Ischemia 7 | 169
invasive ductal carcinoma 7 | 2,951
Alzheimer's disease 6 | 658
Arthralgia 6 | 90
Atopic dermatitis 6 | 952
Autosomal recessive predisposition 6 | 1,442
Candidiasis 6 | 55
Esophageal Squamous Cell Carcinoma 6 | 77
Fatigue 6 | 182
Hypersensitivity reaction type II disease 6 | 253
Inflammation 6 | 120
Kidney cancer 6 | 2,613
Mammary Neoplasms 6 | 425
Mammary Neoplasms, Experimental 6 | 154
Obesity 6 | 678
Osteoporosis 6 | 363
Reperfusion Injury 6 | 86
Squamous cell carcinoma of esophagus 6 | 77
Stomach Neoplasms 6 | 300
Systemic lupus erythematosus 6 | 194
astrocytoma 6 | 1,146
breast carcinoma 6 | 1,638
cutaneous lupus erythematosus 6 | 1,057
non-small cell lung carcinoma 6 | 317
pancreatic carcinoma 6 | 562
pediatric high grade glioma 6 | 1,064
primary Sjogren syndrome 6 | 735
Atherosclerosis 5 | 291
Autoimmune Diseases 5 | 67
Brain Ischemia 5 | 110
Carcinoma, Hepatocellular 5 | 228
Chemical and Drug Induced Liver Injury 5 | 195
Crohn Disease 5 | 45
Depressive disorder 5 | 409
Dermatitis 5 | 157
Disease Models, Animal 5 | 155
Duchenne muscular dystrophy 5 | 601
Liver Cirrhosis 5 | 181
Mesothelioma, Malignant 5 | 105
Neoplasm Invasiveness 5 | 161
Neoplasm Metastasis 5 | 168
Pick disease 5 | 1,894
Vasculitis 5 | 80
active ulcerative colitis 5 | 764
acute myeloid leukemia 5 | 783
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
pituitary cancer 5 | 1,972
spina bifida 5 | 1,074

Tissue

Blood and immune system 55 | 16,909
Digestive Tract 55 | 17,369
Endocrine System 55 | 18,159
Female tissues 55 | 17,400
Liver and Pancreas 55 | 16,750
Male tissues 55 | 17,142
Respiratory system 55 | 16,393
Skin and soft tissues 55 | 17,230
Urinary Tract 55 | 16,678
Nervous System 54 | 16,725
Cardiovascular System 51 | 15,192

Target Family

Non-IDG 34 | 12,091
Enzyme 13 | 4,145
Kinase 4 | 634
Transcription Factor 4 | 1,400

Reactome Pathway

Interleukin-12 family signalin... 55 | 55
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Moesin MSN Tbio Non-IDG -2.61389 361.7 550
T-complex protein 1 subunit alpha TCP1 Tbio Non-IDG -2.26984 173.7 468
Ras-related protein Rap-1b RAP1B Tbio Enzyme -2.38904 417.6 114
Forkhead box protein O3 FOXO3 Tbio Transcription Factor -2.94477 863.9 864
Phosphatidylinositol transfer protein alpha isoform PITPNA Tbio Non-IDG -1.53999 36.3 126
Programmed cell death protein 4 PDCD4 Tchem Non-IDG -2.50341 321.0 599
Peptidyl-prolyl cis-trans isomerase A PPIA Tclin Enzyme -2.97822 870.7 436
Cell division control protein 42 homolog CDC42 Tchem Enzyme -3.37283 2188.5 380
Heterogeneous nuclear ribonucleoproteins A2/B1 HNRNPA2B1 Tbio Non-IDG -2.32003 210.3 321