Development Level

Tbio 67 | 11,445
Tchem 22 | 1,598
Tclin 10 | 613
Tdark 4 | 6,588

IMPC Phenotype

preweaning lethality, complete... 6 | 979
decreased vertical activity 3 | 208
preweaning lethality, incomple... 3 | 499
abnormal bone structure 2 | 187
decreased circulating bilirubi... 2 | 19
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular hem... 2 | 31
decreased mean corpuscular vol... 2 | 79
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal cornea morphology 1 | 31
abnormal epididymis morphology 1 | 42
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal spleen morphology 1 | 55
decreased blood urea nitrogen ... 1 | 51
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased thermal nociceptive ... 1 | 2
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged spleen 1 | 41
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased circulating magnesiu... 1 | 10
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
increased thermal nociceptive ... 1 | 9
premature death 1 | 5
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

ovarian cancer 66 | 8,520
Carcinoma 51 | 11,493
lung cancer 48 | 4,740
psoriasis 48 | 6,694
glioblastoma 42 | 5,792
osteosarcoma 38 | 7,950
Cancer 34 | 2,499
Multiple myeloma 32 | 1,332
medulloblastoma, large-cell 26 | 6,241
atypical teratoid / rhabdoid tumor 25 | 5,112
malignant mesothelioma 21 | 3,232
ependymoma 20 | 4,679
dermatomyositis 19 | 966
lung carcinoma 19 | 2,843
oligodendroglioma 19 | 2,850
Rheumatoid arthritis 18 | 1,191
adult high grade glioma 18 | 3,801
tuberculosis 18 | 2,010
Breast cancer 17 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
subependymal giant cell astrocytoma 17 | 2,287
Astrocytoma, Pilocytic 16 | 3,081
pancreatic cancer 16 | 2,398
HIV Infections 15 | 102
non-small cell lung cancer 15 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
astrocytic glioma 14 | 2,597
Pick disease 13 | 1,894
astrocytoma 13 | 1,146
group 3 medulloblastoma 13 | 4,104
Waldenstrons macroglobulinemia 12 | 765
diabetes mellitus 12 | 1,728
cystic fibrosis 11 | 1,696
interstitial cystitis 11 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
invasive ductal carcinoma 11 | 2,951
primitive neuroectodermal tumor 11 | 3,035
ulcerative colitis 11 | 1,819
Arthritis 10 | 290
acute myeloid leukemia 10 | 783
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
lung adenocarcinoma 10 | 2,716
primary pancreatic ductal adenocarcinoma 10 | 1,109
Brain Ischemia 9 | 110
Liver Cirrhosis, Experimental 9 | 769
group 4 medulloblastoma 9 | 1,855
Asthma 8 | 385
Inflammatory bowel disease 8 | 151
Kidney cancer 8 | 2,613
Mantle cell lymphoma 8 | 23
Pneumonia 8 | 174
colon cancer 8 | 1,478
juvenile dermatomyositis 8 | 1,187
pituitary cancer 8 | 1,972
Alzheimer's disease 7 | 658
Osteoporosis 7 | 363
cutaneous lupus erythematosus 7 | 1,057
esophageal adenocarcinoma 7 | 737
non primary Sjogren syndrome sicca 7 | 891
posterior fossa group A ependymoma 7 | 468
Alcoholic Intoxication, Chronic 6 | 289
Autosomal recessive predisposition 6 | 1,442
Crohn's disease 6 | 321
Hypersensitivity reaction type II disease 6 | 253
Immunologic Deficiency Syndromes 6 | 113
Myocardial Ischemia 6 | 169
Parkinson's disease 6 | 392
Schizophrenia 6 | 1,160
active ulcerative colitis 6 | 764
hepatocellular carcinoma 6 | 547
Anemia 5 | 365
Ankylosing spondylitis 5 | 140
Atopic dermatitis 5 | 952
Bipolar Disorder 5 | 666
Brain Injuries 5 | 65
Cholestasis, Extrahepatic 5 | 25
Colitis, Ulcerative 5 | 59
Colonic Neoplasms 5 | 142
Cryopyrin associated periodic syndrome 5 | 5
Depressive disorder 5 | 409
Dermatologic disorders 5 | 93
Endometriosis 5 | 540
Heat Stroke 5 | 13
Inflammation 5 | 120
Lung disease 5 | 142
Myocardial Infarction 5 | 151
Reperfusion Injury 5 | 86
Seizures 5 | 596
Skin Diseases 5 | 71
Splenomegaly 5 | 190
Vascular disease 5 | 319
active Crohn's disease 5 | 922
acute quadriplegic myopathy 5 | 1,158
adrenocortical carcinoma 5 | 1,428
medulloblastoma 5 | 720
spina bifida 5 | 1,074
Arthritis, Rheumatoid 4 | 174
Epilepsy 4 | 792
Mental Depression 4 | 333
breast carcinoma 4 | 1,638

Tissue

Endocrine System 102 | 18,159
Blood and immune system 101 | 16,909
Digestive Tract 101 | 17,369
Female tissues 101 | 17,400
Male tissues 101 | 17,142
Nervous System 101 | 16,725
Respiratory system 101 | 16,393
Urinary Tract 101 | 16,678
Liver and Pancreas 100 | 16,750
Skin and soft tissues 100 | 17,230
Cardiovascular System 99 | 15,192

Target Family

Enzyme 49 | 4,145
Non-IDG 35 | 12,091
Kinase 15 | 634
Transcription Factor 4 | 1,400

Reactome Pathway

Interleukin-1 signaling 103 | 103
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
Ubiquitin-conjugating enzyme E2 variant 1 UBE2V1 Tbio Non-IDG -1.33153 18.0 188
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Nucleotide-binding oligomerization domain-containing protein 2 NOD2 Tclin Non-IDG -3.13621 1445.5 370
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
NF-kappa-B inhibitor-interacting Ras-like protein 1 NKIRAS1 Tbio Enzyme -0.82896 5.23 242
Proteasome activator complex subunit 4 PSME4 Tdark Non-IDG -1.60128 39.3 43
ATP-dependent RNA helicase A DHX9 Tbio Enzyme -2.85807 734.3 204