Development Level

Tbio 89 | 11,445
Tchem 34 | 1,598
Tclin 11 | 613
Tdark 5 | 6,588

IMPC Phenotype

preweaning lethality, complete... 8 | 979
decreased vertical activity 4 | 208
preweaning lethality, incomple... 4 | 499
abnormal bone structure 3 | 187
abnormal seminal vesicle morph... 2 | 114
decreased circulating bilirubi... 2 | 19
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular hem... 2 | 31
decreased mean corpuscular vol... 2 | 79
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
increased lean body mass 2 | 172
male infertility 2 | 123
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal coat- hair morphology 1 | 19
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal eye anterior chamber ... 1 | 9
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal pericardium morpholog... 1 | 26
abnormal skin condition 1 | 6
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased large unstained cell... 1 | 11
decreased thermal nociceptive ... 1 | 2
decreased total body fat amoun... 1 | 207
edema 1 | 59
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged epididymis 1 | 31
enlarged spleen 1 | 41
enlarged uterus 1 | 11
hydrometra 1 | 53
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating magnesiu... 1 | 10
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased prepulse inhibition 1 | 32
increased thermal nociceptive ... 1 | 9
limb grasping 1 | 41
premature death 1 | 5
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small kidney 1 | 16
small superior vagus ganglion 1 | 74

Disease

ovarian cancer 82 | 8,520
Carcinoma 74 | 11,493
psoriasis 69 | 6,694
glioblastoma 59 | 5,792
lung cancer 59 | 4,740
osteosarcoma 57 | 7,950
Cancer 46 | 2,499
medulloblastoma, large-cell 41 | 6,241
Multiple myeloma 35 | 1,332
atypical teratoid / rhabdoid tumor 35 | 5,112
malignant mesothelioma 33 | 3,232
adult high grade glioma 30 | 3,801
ependymoma 30 | 4,679
lung carcinoma 28 | 2,843
Astrocytoma, Pilocytic 27 | 3,081
tuberculosis 26 | 2,010
Breast cancer 25 | 3,578
non-small cell lung cancer 24 | 2,890
oligodendroglioma 23 | 2,850
Rheumatoid arthritis 22 | 1,191
dermatomyositis 22 | 966
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,291
pancreatic ductal adenocarcinoma liver metastasis 21 | 1,962
subependymal giant cell astrocytoma 21 | 2,287
astrocytic glioma 20 | 2,597
diabetes mellitus 20 | 1,728
group 3 medulloblastoma 20 | 4,104
interstitial cystitis 20 | 2,312
lung adenocarcinoma 20 | 2,716
ulcerative colitis 20 | 1,819
Arthritis 19 | 290
Pick disease 19 | 1,894
Asthma 18 | 385
Kidney cancer 18 | 2,613
pancreatic cancer 18 | 2,398
Inflammatory bowel disease 16 | 151
astrocytoma 16 | 1,146
cystic fibrosis 16 | 1,696
HIV Infections 15 | 102
Pneumonia 15 | 174
group 4 medulloblastoma 15 | 1,855
invasive ductal carcinoma 15 | 2,951
primitive neuroectodermal tumor 15 | 3,035
Liver Cirrhosis, Experimental 14 | 769
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
Waldenstrons macroglobulinemia 13 | 765
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
Schizophrenia 12 | 1,160
cutaneous lupus erythematosus 12 | 1,057
pituitary cancer 12 | 1,972
Brain Ischemia 11 | 110
Dermatitis 11 | 157
Hypersensitivity reaction type II disease 11 | 253
Vascular disease 11 | 319
acute myeloid leukemia 11 | 783
primary pancreatic ductal adenocarcinoma 11 | 1,109
spina bifida 11 | 1,074
Alzheimer's disease 10 | 658
Atopic dermatitis 10 | 952
Crohn's disease 10 | 321
Lung disease 10 | 142
non primary Sjogren syndrome sicca 10 | 891
primary Sjogren syndrome 10 | 735
Depressive disorder 9 | 409
Kidney disease 9 | 430
adrenocortical carcinoma 9 | 1,428
colon cancer 9 | 1,478
esophageal adenocarcinoma 9 | 737
juvenile dermatomyositis 9 | 1,187
Autosomal recessive predisposition 8 | 1,442
Colitis 8 | 54
Colitis, Ulcerative 8 | 59
Hypersensitivity 8 | 63
Inflammation 8 | 120
Mantle cell lymphoma 8 | 23
Obesity 8 | 678
Osteoporosis 8 | 363
Reperfusion Injury 8 | 86
active Crohn's disease 8 | 922
active ulcerative colitis 8 | 764
breast carcinoma 8 | 1,638
posterior fossa group A ependymoma 8 | 468
Allergic hypersensitivity disease 7 | 126
Anemia 7 | 365
Arthritis, Experimental 7 | 39
Arthritis, Rheumatoid 7 | 174
Colonic Neoplasms 7 | 142
Endometriosis 7 | 540
Multiple Sclerosis 7 | 540
Parkinson's disease 7 | 392
hepatocellular carcinoma 7 | 547
Acquired scoliosis 6 | 281
Atherosclerosis 6 | 291
Byzanthine arch palate 6 | 194
Curvature of spine 6 | 282
Mental Depression 6 | 333
Myocardial Ischemia 6 | 169
mucosa-associated lymphoid tissue lymphoma 6 | 484
periodontitis 6 | 293
progressive supranuclear palsy 6 | 676

Tissue

Blood and immune system 136 | 16,909
Digestive Tract 136 | 17,369
Female tissues 136 | 17,400
Skin and soft tissues 136 | 17,230
Endocrine System 135 | 18,159
Male tissues 133 | 17,142
Urinary Tract 133 | 16,678
Liver and Pancreas 132 | 16,750
Nervous System 132 | 16,725
Respiratory system 131 | 16,393
Cardiovascular System 128 | 15,192

Target Family

Enzyme 64 | 4,145
Non-IDG 52 | 12,091
Kinase 17 | 634
Transcription Factor 6 | 1,400

Reactome Pathway

Interleukin-1 family signaling 139 | 139
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein phosphatase non-receptor type 5 PTPN5 Tchem Enzyme -1.85420 70.8 225
Interleukin-18-binding protein IL18BP Tbio Non-IDG -2.00596 101.6 307
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
Tyrosine-protein phosphatase non-receptor type 18 PTPN18 Tbio Enzyme -0.77241 5.46 77
Ubiquitin-conjugating enzyme E2 variant 1 UBE2V1 Tbio Non-IDG -1.33153 18.0 188
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Nucleotide-binding oligomerization domain-containing protein 2 NOD2 Tclin Non-IDG -3.13621 1445.5 370
Single Ig IL-1-related receptor SIGIRR Tbio Non-IDG -1.74139 69.6 182
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427