Development Level

Tclin 12 | 612
Tbio 7 | 11,651
Tchem 7 | 1,388

IMPC Phenotype

decreased circulating creatini... 2 | 39
female infertility 2 | 60
male infertility 2 | 123
abnormal behavior 1 | 298
abnormal colon morphology 1 | 3
abnormal duodenum morphology 1 | 4
abnormal eye anterior chamber ... 1 | 9
abnormal spleen morphology 1 | 55
abnormal vertebrae morphology 1 | 18
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased heart weight 1 | 27
enlarged lymph nodes 1 | 37
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased heart rate 1 | 23
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 22 | 11,493
Cancer 21 | 2,499
ovarian cancer 16 | 8,520
osteosarcoma 15 | 7,950
lung cancer 13 | 4,740
medulloblastoma, large-cell 13 | 6,241
Schizophrenia 12 | 1,160
malignant mesothelioma 12 | 3,232
psoriasis 11 | 6,694
interstitial cystitis 10 | 2,312
Rheumatoid arthritis 9 | 1,191
glioblastoma 9 | 5,792
Kidney cancer 8 | 2,613
invasive ductal carcinoma 8 | 2,951
lung carcinoma 8 | 2,843
tuberculosis 8 | 2,010
lung adenocarcinoma 7 | 2,716
Autosomal recessive predisposition 6 | 1,442
atypical teratoid / rhabdoid tumor 6 | 5,112
cutaneous lupus erythematosus 6 | 1,057
juvenile dermatomyositis 6 | 1,187
subependymal giant cell astrocytoma 6 | 2,287
Asthma 5 | 385
Hypereosinophilic syndrome 5 | 71
Liver Cirrhosis, Experimental 5 | 769
Severe combined immunodeficiency 5 | 51
Splenomegaly 5 | 190
non-small cell lung cancer 5 | 2,890
pancreatic cancer 5 | 2,398
primary Sjogren syndrome 5 | 735
Anemia 4 | 365
Angle class 2 malocclusion 4 | 57
Angle class 3 malocclusion 4 | 57
Big calvaria 4 | 147
Breast cancer 4 | 3,578
Concave bridge of nose 4 | 195
Depressed nasal bridge 4 | 195
Depressed nasal root/bridge 4 | 195
Failure to gain weight 4 | 365
Fever 4 | 138
Frontal bossing 4 | 157
Hepatomegaly 4 | 285
Hypersensitivity reaction type II disease 4 | 253
Increased head circumference 4 | 147
Increased size of cranium 4 | 147
Increased size of skull 4 | 147
Malocclusion 4 | 57
Orbital separation excessive 4 | 244
Pediatric failure to thrive 4 | 365
Pneumonia 4 | 174
Prostatic Neoplasms 4 | 495
Thrombocytopenia 4 | 197
Waldenstrons macroglobulinemia 4 | 765
adult high grade glioma 4 | 3,801
astrocytoma 4 | 1,146
dermatomyositis 4 | 966
diabetes mellitus 4 | 1,728
ductal carcinoma in situ 4 | 1,745
group 3 medulloblastoma 4 | 4,104
group 4 medulloblastoma 4 | 1,855
ulcerative colitis 4 | 1,819
Acute myeloid leukemia, disease 3 | 30
Allergic hypersensitivity disease 3 | 126
Allergic rhinitis 3 | 95
Arthralgia 3 | 90
Arthritis 3 | 290
Astrocytoma, Pilocytic 3 | 3,081
Crohn's disease 3 | 321
Delayed bone age 3 | 136
Dermatitis, Allergic Contact 3 | 67
Diarrhea 3 | 253
Fatigue 3 | 182
High forehead 3 | 102
Immune system cancer 3 | 140
Immunologic Deficiency Syndromes 3 | 113
Influenza 3 | 142
Leukemia 3 | 104
Liver Cirrhosis 3 | 181
Lymphadenopathy 3 | 62
Lymphoid leukemia 3 | 160
Major Depressive Disorder 3 | 301
Multiple Sclerosis 3 | 540
Multiple myeloma 3 | 1,332
Neoplasm Metastasis 3 | 168
Polycythemia vera 3 | 27
Primary cutaneous T-cell lymphoma 3 | 29
Recurrent respiratory infections 3 | 141
Relapsing remitting multiple sclerosis 3 | 14
Respiratory Insufficiency 3 | 132
Respiratory function loss 3 | 121
Tall forehead 3 | 102
Ventricular Septal Defects 3 | 119
active Crohn's disease 3 | 922
acute myeloid leukemia 3 | 783
breast carcinoma 3 | 1,638
cystic fibrosis 3 | 1,696
pancreatic carcinoma 3 | 562
periodontitis 3 | 293
pituitary cancer 3 | 1,972
primitive neuroectodermal tumor 3 | 3,035

Tissue

Blood and immune system 26 | 16,909
Male tissues 26 | 17,142
Digestive Tract 25 | 17,369
Endocrine System 25 | 18,159
Female tissues 25 | 17,400
Liver and Pancreas 25 | 16,750
Skin and soft tissues 25 | 17,230
Cardiovascular System 24 | 15,192
Nervous System 24 | 16,725
Respiratory system 24 | 16,393
Urinary Tract 24 | 16,678

Target Family

Non-IDG 14 | 12,091
Kinase 7 | 634
Enzyme 5 | 4,145

Reactome Pathway

Interleukin receptor SHC signa... 26 | 26
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein kinase JAK3 JAK3 Tclin Kinase -2.64385 453.7 292
Interleukin-2 receptor subunit beta IL2RB Tclin Non-IDG -2.17998 125.4 654
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha CSF2RA Tclin Non-IDG -2.16603 137.4 453
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -3.02404 981.4 501
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.51919 316.4 758
Interleukin-2 receptor subunit alpha IL2RA Tclin Non-IDG -3.02107 927.8 1917
Interleukin-3 receptor subunit alpha IL3RA Tbio Non-IDG -2.44398 253.0 693
Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 Tbio Enzyme -1.57214 38.2 155
Son of sevenless homolog 1 SOS1 Tbio Non-IDG -2.69482 466.2 147
Tyrosine-protein kinase JAK1 JAK1 Tclin Kinase -2.80024 518.7 425