Development Level

Tbio 122 | 11,445
Tchem 5 | 1,598
Tclin 5 | 613
Tdark 2 | 6,588

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

abnormal embryo size 2 | 220
abnormal neural tube closure 2 | 46
decreased bone mineral content 2 | 151
decreased mean corpuscular vol... 2 | 79
embryonic lethality prior to t... 2 | 278
increased lean body mass 2 | 172
preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal midbrain development 1 | 20
abnormal placenta size 1 | 20
abnormal sleep behavior 1 | 70
absent seminal vesicle 1 | 4
cataract 1 | 92
decreased body length 1 | 101
decreased erythrocyte cell num... 1 | 62
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 50
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged lymph nodes 1 | 37
female infertility 1 | 60
impaired righting response 1 | 26
increased circulating chloride... 1 | 41
increased circulating sodium l... 1 | 71
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
increased prepulse inhibition 1 | 32
male infertility 1 | 123
pale yolk sac 1 | 25
pallor 1 | 34
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
small uterus 1 | 3
thrombocytopenia 1 | 56

Disease

Cancer 103 | 2,499
psoriasis 80 | 6,694
Carcinoma 72 | 11,493
Ankylosing spondylitis 70 | 140
Behcet's disease 70 | 89
diabetes mellitus 64 | 1,728
dermatomyositis 61 | 966
Arthritis 60 | 290
Hypersensitivity reaction type II disease 59 | 253
Herpes zoster 57 | 68
Juvenile rheumatoid arthritis 57 | 111
Acquired immunodeficiency syndrome 56 | 197
Uveitis 56 | 103
Human immunodeficiency virus infectious disease 53 | 138
Stevens-Johnson syndrome 51 | 92
Psoriatic arthritis 49 | 86
Multiple Sclerosis 46 | 540
Rheumatoid arthritis 44 | 1,191
ovarian cancer 40 | 8,520
lung cancer 39 | 4,740
tuberculosis 38 | 2,010
Dermatitis 36 | 157
Synovitis 36 | 78
juvenile dermatomyositis 36 | 1,187
Behcet's syndrome 35 | 50
Congenital adrenal hyperplasia 35 | 73
Nephritis 35 | 51
Retinal vasculitis 35 | 36
Spondyloarthropathy, Susceptibility To, 1 35 | 35
Takayasu's arteritis 35 | 53
drug-induced hepatitis 35 | 44
cutaneous lupus erythematosus 32 | 1,057
pancreatic cancer 30 | 2,398
glioblastoma 28 | 5,792
osteosarcoma 28 | 7,950
Hepatitis B 26 | 108
medulloblastoma, large-cell 26 | 6,241
Anemia 25 | 365
lung carcinoma 25 | 2,843
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,291
Liver disease 23 | 237
malignant mesothelioma 23 | 3,232
Breast cancer 22 | 3,578
Hemochromatosis 22 | 54
Influenza 22 | 142
Kidney disease 22 | 430
Primary immunodeficiency disease 22 | 54
Skin disease 22 | 66
cystic fibrosis 22 | 1,696
subependymal giant cell astrocytoma 22 | 2,287
Astrocytoma, Pilocytic 21 | 3,081
Birdshot chorioretinopathy 21 | 23
Leprosy 21 | 73
Multiple myeloma 21 | 1,332
Systemic lupus erythematosus 21 | 194
interstitial cystitis 21 | 2,312
active Crohn's disease 20 | 922
invasive ductal carcinoma 20 | 2,951
primary Sjogren syndrome 20 | 735
Microphthalmia with limb anomalies 19 | 40
Influenza, Human 18 | 51
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,955
active ulcerative colitis 17 | 764
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,989
pituitary cancer 16 | 1,972
Pre-Eclampsia 15 | 68
astrocytoma 15 | 1,146
breast carcinoma 15 | 1,638
ependymoma 15 | 4,679
Human immunodeficiency virus type 1, susceptibility to 14 | 26
Psoriasis susceptibility 1 14 | 14
group 4 medulloblastoma 14 | 1,855
Atopic dermatitis 13 | 952
Hepatitis C 13 | 94
esophageal adenocarcinoma 13 | 737
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
Duchenne muscular dystrophy 11 | 601
adult high grade glioma 11 | 3,801
non-small cell lung cancer 11 | 2,890
Liver Cirrhosis, Experimental 10 | 769
atypical teratoid / rhabdoid tumor 10 | 5,112
lung adenocarcinoma 10 | 2,716
Autosomal recessive predisposition 9 | 1,442
ulcerative colitis 9 | 1,819
group 3 medulloblastoma 8 | 4,104
nasopharyngeal carcinoma 8 | 1,058
posterior fossa group A ependymoma 8 | 468
primary pancreatic ductal adenocarcinoma 8 | 1,109
Down syndrome 7 | 499
Hepatitis 7 | 67
Schizophrenia 7 | 1,160
acute quadriplegic myopathy 7 | 1,158
pediatric high grade glioma 7 | 1,064
Kidney cancer 6 | 2,613
limb girdle muscular dystrophy 2I 6 | 32
pancreatic carcinoma 6 | 562
Asthma 5 | 385
acute myeloid leukemia 5 | 783
gastric carcinoma 5 | 807
oligodendroglioma 5 | 2,850

Tissue

Blood and immune system 54 | 16,909
Digestive Tract 53 | 17,369
Endocrine System 53 | 18,159
Female tissues 53 | 17,400
Liver and Pancreas 53 | 16,750
Male tissues 53 | 17,142
Respiratory system 53 | 16,393
Cardiovascular System 52 | 15,192
Nervous System 52 | 16,725
Skin and soft tissues 52 | 17,230
Urinary Tract 52 | 16,678

Target Family

Non-IDG 107 | 12,091
Transcription Factor 12 | 1,400
Enzyme 11 | 4,145
Kinase 4 | 634

Reactome Pathway

Interferon alpha/beta signalin... 134 | 134
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
2'-5'-oligoadenylate synthase 3 OAS3 Tbio Enzyme -1.30083 17.8 141
Interferon alpha-inducible protein 27, mitochondrial IFI27 Tbio Non-IDG -1.51419 33.3 0
HLA class I histocompatibility antigen, B-35 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 0
Interferon regulatory factor 5 IRF5 Tbio Transcription Factor -2.33923 241.0 400
Interferon alpha-17 IFNA17 Tbio Non-IDG -2.39299 231.1 56
Bone marrow stromal antigen 2 BST2 Tbio Non-IDG -2.59753 424.5 464
HLA class I histocompatibility antigen, Cw-17 alpha chain HLA-C Tbio Non-IDG -1.90661 830.5 0
HLA class I histocompatibility antigen, Cw-15 alpha chain HLA-C Tbio Non-IDG -1.90661 830.5 0
Interferon-induced transmembrane protein 3 IFITM3 Tbio Non-IDG -1.93256 151.2 200
Interferon-induced transmembrane protein 2 IFITM2 Tbio Non-IDG -2.24139 171.1 155