Development Level

Tbio 233 | 11,651
Tchem 23 | 1,388
Tdark 12 | 6,593
Tclin 7 | 612

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 14 | 979
embryonic lethality prior to o... 5 | 239
embryonic lethality prior to t... 5 | 278
decreased bone mineral content 4 | 151
abnormal embryo size 3 | 220
abnormal heart morphology 3 | 162
enlarged heart 3 | 210
increased lean body mass 3 | 172
preweaning lethality, incomple... 3 | 499
abnormal bone structure 2 | 187
abnormal gait 2 | 69
abnormal neural tube closure 2 | 46
abnormal seminal vesicle morph... 2 | 114
decreased circulating chloride... 2 | 30
decreased lean body mass 2 | 135
decreased mature B cell number 2 | 7
decreased mean corpuscular vol... 2 | 79
decreased red blood cell distr... 2 | 41
embryonic growth retardation 2 | 106
increased circulating alkaline... 2 | 122
increased lymphocyte cell numb... 2 | 32
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
increased neutrophil cell numb... 2 | 46
abnormal anxiety-related respo... 1 | 1
abnormal behavior 1 | 298
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal midbrain development 1 | 20
abnormal placenta size 1 | 20
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal social-conspecific in... 1 | 3
absent seminal vesicle 1 | 4
cataract 1 | 92
decreased body length 1 | 101
decreased body weight 1 | 161
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased erythrocyte cell num... 1 | 62
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lactate dehydrogenas... 1 | 16
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased threshold for audito... 1 | 26
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
enlarged lymph nodes 1 | 37
female infertility 1 | 60
hydrometra 1 | 53
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased circulating chloride... 1 | 41
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased exploration in new e... 1 | 8
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 36
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
male infertility 1 | 123
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality 1 | 28
prolonged PR interval 1 | 15
short tibia 1 | 97
small superior vagus ganglion 1 | 74
small uterus 1 | 3
thrombocytopenia 1 | 56

Disease

Carcinoma 164 | 11,493
Cancer 133 | 2,499
psoriasis 132 | 6,694
ovarian cancer 116 | 8,520
osteosarcoma 98 | 7,950
lung cancer 97 | 4,740
diabetes mellitus 91 | 1,728
glioblastoma 89 | 5,792
dermatomyositis 87 | 966
Rheumatoid arthritis 80 | 1,191
Hypersensitivity reaction type II disease 75 | 253
medulloblastoma, large-cell 72 | 6,241
Ankylosing spondylitis 71 | 140
Behcet's disease 70 | 89
Multiple Sclerosis 70 | 540
Arthritis 68 | 290
tuberculosis 66 | 2,010
Juvenile rheumatoid arthritis 65 | 111
Acquired immunodeficiency syndrome 60 | 197
Uveitis 60 | 103
juvenile dermatomyositis 59 | 1,187
Human immunodeficiency virus infectious disease 58 | 138
Herpes zoster 57 | 68
lung carcinoma 57 | 2,843
Astrocytoma, Pilocytic 55 | 3,081
Stevens-Johnson syndrome 54 | 92
ependymoma 53 | 4,679
Psoriatic arthritis 52 | 86
intraductal papillary-mucinous neoplasm (IPMN) 50 | 3,291
adult high grade glioma 49 | 3,801
cutaneous lupus erythematosus 49 | 1,057
malignant mesothelioma 49 | 3,232
atypical teratoid / rhabdoid tumor 48 | 5,112
pancreatic cancer 48 | 2,398
subependymal giant cell astrocytoma 47 | 2,287
Breast cancer 45 | 3,578
group 3 medulloblastoma 45 | 4,104
invasive ductal carcinoma 41 | 2,951
Dermatitis 40 | 157
interstitial cystitis 40 | 2,312
Systemic lupus erythematosus 39 | 194
Multiple myeloma 38 | 1,332
primary Sjogren syndrome 38 | 735
Synovitis 37 | 78
intraductal papillary-mucinous adenoma (IPMA) 37 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 37 | 2,989
Behcet's syndrome 35 | 50
Congenital adrenal hyperplasia 35 | 73
Nephritis 35 | 51
Retinal vasculitis 35 | 36
Spondyloarthropathy, Susceptibility To, 1 35 | 35
Takayasu's arteritis 35 | 53
cystic fibrosis 35 | 1,696
drug-induced hepatitis 35 | 44
non-small cell lung cancer 35 | 2,890
Hepatitis B 33 | 108
Anemia 32 | 365
active Crohn's disease 32 | 922
Influenza 31 | 142
astrocytoma 31 | 1,146
Liver disease 30 | 237
active ulcerative colitis 30 | 764
breast carcinoma 30 | 1,638
pituitary cancer 29 | 1,972
ulcerative colitis 29 | 1,819
Kidney disease 28 | 430
Kidney cancer 27 | 2,613
pancreatic ductal adenocarcinoma liver metastasis 26 | 1,962
Leprosy 25 | 73
Skin disease 25 | 66
oligodendroglioma 25 | 2,850
Influenza, Human 24 | 51
Hemochromatosis 23 | 54
Primary immunodeficiency disease 23 | 54
Schizophrenia 22 | 1,160
astrocytic glioma 22 | 2,597
esophageal adenocarcinoma 22 | 737
group 4 medulloblastoma 22 | 1,855
primitive neuroectodermal tumor 22 | 3,035
sarcoidosis 22 | 370
Birdshot chorioretinopathy 21 | 23
Microphthalmia with limb anomalies 21 | 40
Pick disease 21 | 1,894
Atopic dermatitis 20 | 952
Liver Cirrhosis, Experimental 20 | 769
lung adenocarcinoma 20 | 2,716
Autosomal recessive predisposition 19 | 1,442
Duchenne muscular dystrophy 19 | 601
acute quadriplegic myopathy 19 | 1,158
Waldenstrons macroglobulinemia 18 | 765
Narcolepsy 17 | 72
Hepatitis C 16 | 94
primary pancreatic ductal adenocarcinoma 16 | 1,109
Berylliosis 15 | 28
Human immunodeficiency virus type 1, susceptibility to 15 | 26
Pre-Eclampsia 15 | 68
acute myeloid leukemia 15 | 783
nasopharyngeal carcinoma 15 | 1,058
pediatric high grade glioma 15 | 1,064
Asthma 14 | 385

Tissue

Digestive Tract 176 | 17,369
Female tissues 175 | 17,400
Liver and Pancreas 175 | 16,750
Respiratory system 175 | 16,393
Blood and immune system 174 | 16,909
Endocrine System 174 | 18,159
Skin and soft tissues 173 | 17,230
Urinary Tract 173 | 16,678
Male tissues 171 | 17,142
Nervous System 171 | 16,725
Cardiovascular System 168 | 15,192

Target Family

Non-IDG 214 | 12,091
Enzyme 33 | 4,145
Transcription Factor 13 | 1,400
Kinase 12 | 634
GPCR 1 | 408
TF/Epigenetic 1 | 38
Transporter 1 | 473

Reactome Pathway

Interferon Signaling 275 | 275
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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