Development Level

Tbio 226 | 10,625
Tchem 27 | 1,890
Tdark 15 | 7,003
Tclin 7 | 602

IMPC Term

preweaning lethality, complete... 8 | 633
decreased body length 3 | 108
decreased bone mineral content 3 | 157
decreased lean body mass 3 | 195
increased lean body mass 3 | 107
preweaning lethality, incomple... 3 | 260
abnormal embryo size 2 | 112
abnormal neural tube closure 2 | 37
decreased CD4-positive, CD25-p... 2 | 24
decreased Ly6C low monocyte nu... 2 | 23
decreased circulating HDL chol... 2 | 77
embryonic lethality prior to o... 2 | 148
embryonic lethality prior to t... 2 | 187
increased mean corpuscular hem... 2 | 93
abnormal anxiety-related respo... 1 | 1
abnormal bone structure 1 | 131
abnormal coping response 1 | 12
abnormal forebrain development 1 | 18
abnormal gait 1 | 51
abnormal hindbrain development 1 | 24
abnormal midbrain development 1 | 22
abnormal optic disc morphology 1 | 10
abnormal placenta size 1 | 10
abnormal sleep behavior 1 | 63
abnormal social/conspecific in... 1 | 3
abnormal spinal cord morpholog... 1 | 8
absent seminal vesicle 1 | 2
decreased B cell number 1 | 30
decreased CD5-positive Ly6C-po... 1 | 4
decreased KLRG1+ CD8 alpha bet... 1 | 8
decreased NK T cell number 1 | 28
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating aspartat... 1 | 27
decreased circulating calcium ... 1 | 33
decreased circulating chloride... 1 | 32
decreased circulating choleste... 1 | 85
decreased effector memory CD4-... 1 | 6
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased erythrocyte cell num... 1 | 43
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased lactate dehydrogenas... 1 | 14
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased monocyte cell number 1 | 28
decreased neutrophil cell numb... 1 | 37
decreased total body fat amoun... 1 | 186
enlarged lymph nodes 1 | 27
female infertility 1 | 34
hyperactivity 1 | 108
improved glucose tolerance 1 | 56
increased B cell number 1 | 23
increased NK cell number 1 | 19
increased circulating HDL chol... 1 | 63
increased circulating alkaline... 1 | 119
increased circulating sodium l... 1 | 71
increased exploration in new e... 1 | 56
increased hemoglobin content 1 | 45
increased mature B cell number 1 | 12
increased mean corpuscular vol... 1 | 91
increased prepulse inhibition 1 | 21
male infertility 1 | 62
pale yolk sac 1 | 12
pallor 1 | 13
short tibia 1 | 82
thrombocytopenia 1 | 46

Disease

Cancer 131 | 2,346
psoriasis 131 | 6,685
ovarian cancer 115 | 8,484
osteosarcoma 99 | 7,933
lung cancer 96 | 4,466
diabetes mellitus 88 | 1,663
glioblastoma 87 | 5,572
Hypersensitivity reaction type II disease 75 | 235
medulloblastoma, large-cell 72 | 6,234
Ankylosing spondylitis 71 | 138
Multiple Sclerosis 70 | 498
Rheumatoid Arthritis 69 | 1,160
Arthritis 66 | 248
Juvenile rheumatoid arthritis 62 | 104
Acquired immunodeficiency syndrome 60 | 164
Uveitis 59 | 103
juvenile dermatomyositis 59 | 1,189
lung carcinoma 57 | 2,844
Behcet's disease 56 | 74
dermatomyositis 56 | 933
pilocytic astrocytoma 55 | 3,086
Psoriatic arthritis 52 | 83
intraductal papillary-mucinous neoplasm (IPMN) 50 | 3,289
cutaneous lupus erythematosus 49 | 1,056
malignant mesothelioma 48 | 3,162
pancreatic cancer 48 | 2,300
subependymal giant cell astrocytoma 47 | 2,287
ulcerative colitis 44 | 2,087
atypical teratoid / rhabdoid tumor 42 | 4,369
primary Sjogren syndrome 42 | 789
Stevens-Johnson syndrome 41 | 78
invasive ductal carcinoma 41 | 2,950
interstitial cystitis 40 | 2,299
pediatric high grade glioma 40 | 2,712
Multiple myeloma 37 | 1,327
intraductal papillary-mucinous adenoma (IPMA) 37 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 37 | 2,988
astrocytoma 36 | 1,493
tuberculosis 36 | 1,557
Breast cancer 35 | 3,094
Congenital adrenal hyperplasia 35 | 74
Retinal vasculitis 35 | 36
Takayasu's arteritis 35 | 52
cystic fibrosis 35 | 1,665
non-small cell lung cancer 35 | 2,798
active Crohn's disease 32 | 918
posterior fossa group A ependymoma 32 | 1,511
Hepatitis B 31 | 103
Influenza 31 | 142
Liver disease 30 | 219
breast carcinoma 30 | 1,614
group 3 medulloblastoma 29 | 2,254
pituitary cancer 29 | 1,972
Anemia 28 | 252
Kidney disease 28 | 396
Leprosy 25 | 77
Skin disease 25 | 65
group 4 medulloblastoma 25 | 1,875
oligodendroglioma 25 | 2,849
systemic lupus erythematosus 25 | 156
adult high grade glioma 24 | 2,148
ependymoma 24 | 2,514
Hemochromatosis 23 | 55
Primary immunodeficiency disease 22 | 52
esophageal adenocarcinoma 22 | 737
primitive neuroectodermal tumor 22 | 3,031
Human immunodeficiency virus infectious disease 21 | 92
Pick disease 21 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 21 | 1,795
primary pancreatic ductal adenocarcinoma 21 | 1,271
Atopic dermatitis 20 | 944
Carcinoma 20 | 2,147
lung adenocarcinoma 20 | 2,713
Duchenne muscular dystrophy 19 | 602
Waldenstrons macroglobulinemia 18 | 765
acute quadriplegic myopathy 18 | 1,157
astrocytic glioma 17 | 2,241
Down syndrome 16 | 548
Hepatitis C 16 | 90
active ulcerative colitis 15 | 477
acute myeloid leukemia 15 | 780
nasopharyngeal carcinoma 15 | 1,056
pre-eclampsia 15 | 67
colon cancer 14 | 1,475
gastric carcinoma 14 | 832
Asthma 13 | 349
ductal carcinoma in situ 13 | 1,745
hepatocellular carcinoma 13 | 532
inflammatory breast cancer 13 | 404
pancreatic carcinoma 13 | 567
Myocardial Ischemia 12 | 169
adrenocortical carcinoma 12 | 1,427
sarcoidosis 12 | 358
Amyotrophic Lateral Sclerosis 11 | 431
aldosterone-producing adenoma 11 | 664
atypical teratoid/rhabdoid tumor 11 | 1,095
limb girdle muscular dystrophy 2I 11 | 56
progressive supranuclear palsy 11 | 674
sonic hedgehog group medulloblastoma 11 | 1,482
tuberculosis and treatment for 3 months 11 | 327

Tissue

Nervous System 202 | 18,561
Digestive Tract 199 | 18,473
Female tissues 199 | 18,647
Urinary Tract 199 | 18,444
Blood and immune system 195 | 17,995
Endocrine System 195 | 18,512
Liver and Pancreas 194 | 18,136
Cardiovascular System 193 | 17,958
Respiratory system 191 | 17,484
Male tissues 190 | 17,969
Skin and soft tissues 187 | 18,115

Target Family

Non-IDG 215 | 11,971
Enzyme 33 | 4,146
Transcription Factor 13 | 1,400
Kinase 12 | 634
GPCR 1 | 406
TF/Epigenetic 1 | 38

Reactome Pathway

Interferon Signaling 275 | 275
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

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