Development Level

Tbio 20 | 11,445
Tclin 5 | 613
Tchem 3 | 1,598
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal embryo size 2 | 220
embryonic lethality prior to o... 2 | 239
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal ear morphology 1 | 9
abnormal embryonic autopod pla... 1 | 2
abnormal facial morphology 1 | 17
abnormal placenta morphology 1 | 5
decreased caudal vertebrae num... 1 | 53
decreased lean body mass 1 | 135
decreased prepulse inhibition 1 | 82
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
female infertility 1 | 60
increased bone mineral content 1 | 108
increased or absent threshold ... 1 | 101
long tibia 1 | 25
male infertility 1 | 123
prenatal lethality 1 | 28
preweaning lethality, incomple... 1 | 499
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
unresponsive to tactile stimul... 1 | 8

Disease

lung cancer 17 | 4,740
ovarian cancer 17 | 8,520
Carcinoma 15 | 11,493
medulloblastoma, large-cell 14 | 6,241
glioblastoma 13 | 5,792
group 3 medulloblastoma 13 | 4,104
atypical teratoid / rhabdoid tumor 12 | 5,112
ependymoma 12 | 4,679
osteosarcoma 12 | 7,950
Breast cancer 10 | 3,578
Cancer 10 | 2,499
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
primitive neuroectodermal tumor 10 | 3,035
psoriasis 10 | 6,694
tuberculosis 10 | 2,010
oligodendroglioma 9 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
malignant mesothelioma 8 | 3,232
non-small cell lung cancer 8 | 2,890
Pick disease 7 | 1,894
invasive ductal carcinoma 7 | 2,951
Astrocytoma, Pilocytic 6 | 3,081
Multiple myeloma 6 | 1,332
adult high grade glioma 6 | 3,801
lung adenocarcinoma 6 | 2,716
nasopharyngeal carcinoma 6 | 1,058
acute quadriplegic myopathy 5 | 1,158
adrenocortical carcinoma 5 | 1,428
astrocytic glioma 5 | 2,597
astrocytoma 5 | 1,146
interstitial cystitis 5 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
pancreatic cancer 5 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
pediatric high grade glioma 5 | 1,064
primary pancreatic ductal adenocarcinoma 5 | 1,109
subependymal giant cell astrocytoma 5 | 2,287
Anemia 4 | 365
Carcinoma, Hepatocellular 4 | 228
Colorectal Neoplasms 4 | 243
Endometriosis 4 | 540
Liver carcinoma 4 | 240
Waldenstrons macroglobulinemia 4 | 765
breast carcinoma 4 | 1,638
diabetes mellitus 4 | 1,728
ductal carcinoma in situ 4 | 1,745
ulcerative colitis 4 | 1,819
Adenocarcinoma of lung 3 | 142
Adenocarcinoma of pancreas 3 | 14
Amyotrophic lateral sclerosis 3 | 451
Atopic dermatitis 3 | 952
Autosomal recessive predisposition 3 | 1,442
Contact Dermatitis 3 | 81
Dermatitis, Contact 3 | 71
Diarrhea 3 | 253
Disease Models, Animal 3 | 155
Epilepsy 3 | 792
Failure to gain weight 3 | 365
Metastatic Breast Carcinoma 3 | 21
Pediatric failure to thrive 3 | 365
Reticular dysgenesis 3 | 7
Vascular disease 3 | 319
esophageal adenocarcinoma 3 | 737
Acute lymphoid leukemia 2 | 25
Atrial Fibrillation 2 | 124
Barrett's esophagus 2 | 182
Cerebellar Ataxia 2 | 304
Chronic myeloid leukemia 2 | 12
Congenital deafness 2 | 185
Deafness 2 | 198
Degenerative polyarthritis 2 | 115
Fever 2 | 138
Hearing Loss, Partial 2 | 185
Hemoglobin low 2 | 124
Lymphopenia 2 | 67
Malignant tumor of head and/or neck 2 | 15
Malignant tumor of ovary 2 | 25
Nance-Horan syndrome 2 | 25
Neoplasm Invasiveness 2 | 161
Neurodegenerative disease 2 | 414
Osteoarthritis 2 | 184
Polycystic ovary syndrome 2 | 360
Primary ciliary dyskinesia 2 | 76
Rheumatoid arthritis 2 | 1,191
Schistosomiasis 2 | 35
Weight decreased 2 | 103
Xeroderma pigmentosum group D 2 | 33
chronic rhinosinusitis 2 | 512
cutaneous lupus erythematosus 2 | 1,057
cystic fibrosis 2 | 1,696
cystic fibrosis and chronic rhinosinusitis 2 | 214
dermatomyositis 2 | 966
hearing impairment 2 | 199
lung carcinoma 2 | 2,843
non-small cell lung carcinoma 2 | 317
pituitary cancer 2 | 1,972
posterior fossa group B ependymoma 2 | 416
primary Sjogren syndrome 2 | 735
progressive supranuclear palsy 2 | 676
relapsing-remitting multiple sclerosis 2 | 18

Tissue

Blood and immune system 29 | 16,909
Cardiovascular System 29 | 15,192
Digestive Tract 29 | 17,369
Endocrine System 29 | 18,159
Female tissues 29 | 17,400
Liver and Pancreas 29 | 16,750
Male tissues 29 | 17,142
Nervous System 29 | 16,725
Respiratory system 29 | 16,393
Skin and soft tissues 29 | 17,230
Urinary Tract 29 | 16,678

Target Family

Kinase 14 | 634
Enzyme 13 | 4,145
Non-IDG 3 | 12,091

Reactome Pathway

Interconversion of nucleotide ... 30 | 30
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adenylate kinase 2, mitochondrial AK2 Tbio Kinase -2.00007 98.7 330
Adenylate kinase isoenzyme 5 AK5 Tbio Kinase -1.83209 76.0 225
CTP synthase 1 CTPS1 Tbio Enzyme -2.29349 196.5 107
Adenylate kinase isoenzyme 6 AK6 Tbio Kinase -2.18859 223.1 91
Adenylate kinase 4, mitochondrial AK4 Tbio Kinase -1.83029 66.5 272
Thymidylate synthase TYMS Tclin Enzyme -2.93426 732.0 733
Nucleoside diphosphate kinase A NME1 Tbio Kinase -2.99077 863.1 945
Nucleoside diphosphate kinase 7 NME7 Tbio Enzyme -0.83479 6.29 113
Glutathione reductase, mitochondrial GSR Tclin Enzyme -3.00773 863.8 276
Nucleoside diphosphate kinase, mitochondrial NME4 Tbio Kinase -1.75871 56.4 240