Development Level

Tbio 47 | 10,625
Tclin 5 | 602
Tchem 4 | 1,890
Tdark 4 | 7,003

IMPC Phenotype

decreased circulating HDL chol... 4 | 77
decreased circulating choleste... 4 | 85
increased lean body mass 4 | 107
abnormal bone structure 3 | 131
decreased body weight 3 | 174
decreased grip strength 3 | 123
decreased total body fat amoun... 3 | 186
tremors 3 | 34
abnormal heart left ventricle ... 2 | 20
abnormal locomotor activation 2 | 26
decreased circulating alkaline... 2 | 41
decreased exploration in new e... 2 | 9
decreased fasted circulating g... 2 | 49
decreased lean body mass 2 | 195
decreased pulmonary respirator... 2 | 4
enlarged stomach 2 | 2
impaired glucose tolerance 2 | 52
increased circulating alkaline... 2 | 119
lethargy 2 | 5
preweaning lethality, incomple... 2 | 260
short tibia 2 | 82
small thymus 2 | 11
abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
abnormal retina morphology 1 | 100
decreased bone mineral content 1 | 157
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating aspartat... 1 | 27
decreased circulating glycerol... 1 | 19
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased effector memory CD8-... 1 | 24
decreased heart weight 1 | 44
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased neutrophil cell numb... 1 | 37
enlarged heart 1 | 111
hypoactivity 1 | 89
increased bone mineral content 1 | 92
increased circulating calcium ... 1 | 32
increased circulating chloride... 1 | 43
increased circulating phosphat... 1 | 24
increased eosinophil cell numb... 1 | 9
increased erythrocyte cell num... 1 | 26
increased heart weight 1 | 37
increased mean corpuscular hem... 1 | 25
increased mean corpuscular vol... 1 | 91
increased rib number 1 | 41
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
thrombocytopenia 1 | 46

Disease

medulloblastoma, large-cell 40 | 6,234
glioblastoma 38 | 5,572
atypical teratoid / rhabdoid tumor 33 | 4,369
pilocytic astrocytoma 31 | 3,086
ovarian cancer 30 | 8,491
psoriasis 29 | 6,685
primitive neuroectodermal tumor 28 | 3,031
oligodendroglioma 26 | 2,849
pediatric high grade glioma 24 | 2,712
Autistic Disorder 22 | 320
ependymoma 22 | 2,514
osteosarcoma 22 | 7,933
Carcinoma 20 | 2,147
medulloblastoma 20 | 1,524
subependymal giant cell astrocytoma 20 | 2,287
Schizophrenia 19 | 503
astrocytic glioma 18 | 2,241
pituitary cancer 17 | 1,972
adult high grade glioma 16 | 2,148
lung carcinoma 16 | 2,844
Intellectual disability 15 | 573
Pick disease 15 | 1,893
lung cancer 15 | 4,473
malignant mesothelioma 14 | 3,163
Breast cancer 13 | 3,098
astrocytoma 13 | 1,493
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,956
posterior fossa group A ependymoma 12 | 1,511
invasive ductal carcinoma 11 | 2,950
Epilepsy 10 | 346
colon cancer 10 | 1,475
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,289
non-small cell lung cancer 10 | 2,798
sonic hedgehog group medulloblastoma 10 | 1,482
group 3 medulloblastoma 9 | 2,254
interstitial cystitis 9 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,988
lung adenocarcinoma 9 | 2,714
Parkinson's disease 8 | 364
Toxic encephalopathy 8 | 131
atypical teratoid/rhabdoid tumor 8 | 1,095
breast carcinoma 8 | 1,614
cystic fibrosis 8 | 1,670
ductal carcinoma in situ 8 | 1,745
group 4 medulloblastoma 8 | 1,875
posterior fossa group B ependymoma 8 | 1,530
Alzheimer's disease 7 | 644
Bipolar Disorder 7 | 266
Child Development Disorders, Pervasive 7 | 55
Asperger syndrome 6 | 35
pancreatic cancer 6 | 2,300
Alcoholism 5 | 14
Amyotrophic Lateral Sclerosis 5 | 432
Arteriosclerotic Parkinsonism 5 | 8
Extrapyramidal disease 5 | 8
Fragile X syndrome 5 | 31
General anesthesia 5 | 53
Influenza A Prevention 5 | 7
Influenza due to Influenza A virus 5 | 7
Local anesthesia 5 | 40
Obesity 5 | 616
Parkinsonism 5 | 19
Postencephalitic parkinsonism 5 | 12
active Crohn's disease 5 | 918
aldosterone-producing adenoma 5 | 664
non primary Sjogren syndrome sicca 5 | 840
Acquired metabolic disease 4 | 267
Alcohol dependence 4 | 107
Cocaine-Related Disorders 4 | 88
Huntington's disease 4 | 72
Melanoma 4 | 261
Nicotine dependence 4 | 53
Rheumatoid Arthritis 4 | 1,170
active ulcerative colitis 4 | 477
adrenocortical carcinoma 4 | 1,427
gastric carcinoma 4 | 832
nasopharyngeal carcinoma 4 | 1,056
primary pancreatic ductal adenocarcinoma 4 | 1,271
Attention deficit hyperactivity disorder 3 | 156
Cerebrovascular disease 3 | 231
Down syndrome 3 | 548
Endometriosis 3 | 535
Gaucher disease type 1 3 | 171
Gilles de la Tourette syndrome 3 | 47
Kidney cancer 3 | 121
Language Development Disorders 3 | 9
Moderate to Severe Alzheimer's Type Dementia 3 | 5
diabetes mellitus 3 | 1,663
esophageal adenocarcinoma 3 | 737
interstitial lung disease 3 | 292
obsessive-compulsive disorder 3 | 34
Cancer 2 | 2,346
acute quadriplegic myopathy 2 | 1,157
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
fibroadenoma 2 | 557
nephrosclerosis 2 | 329
pancreatic carcinoma 2 | 567
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
spina bifida 2 | 1,064
urothelial carcinoma 2 | 318

Tissue

Nervous System 59 | 18,560
Female tissues 58 | 18,646
Liver and Pancreas 58 | 18,135
Male tissues 58 | 17,968
Blood and immune system 57 | 17,994
Cardiovascular System 57 | 17,957
Digestive Tract 57 | 18,472
Endocrine System 57 | 18,511
Urinary Tract 57 | 18,443
Respiratory system 55 | 17,483
Skin and soft tissues 55 | 18,114

Target Family

Non-IDG 46 | 11,969
Enzyme 6 | 4,146
Ion Channel 5 | 341
GPCR 2 | 408
Kinase 1 | 634

Reactome Pathway

Interactions of neurexins and ... 60 | 60
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
SH3 and multiple ankyrin repeat domains protein 1 SHANK1 Tbio Non-IDG -1.52802 34.3 167
Neurexin-3-beta NRXN3 Tbio Non-IDG -1.29937 33.0 142
Signal-induced proliferation-associated 1-like protein 1 SIPA1L1 Tdark Non-IDG -0.54525 4.54 37
SH3 and multiple ankyrin repeat domains protein 3 SHANK3 Tbio Non-IDG -2.21170 158.8 0
Band 4.1-like protein 2 EPB41L2 Tbio Non-IDG -1.34243 25.3 156
Synaptotagmin-7 SYT7 Tbio Non-IDG -1.72363 48.4 144
Homer protein homolog 1 HOMER1 Tbio Non-IDG -2.41247 267.3 178
Leucine-rich repeat transmembrane neuronal protein 2 LRRTM2 Tbio Non-IDG -0.84941 8.39 101
Neuroligin-3 NLGN3 Tbio Enzyme -1.79390 63.4 157
Disks large homolog 2 DLG2 Tbio Non-IDG -1.72916 49.9 203