Development Level

Tbio 31 | 11,445
Tdark 4 | 6,588

IMPC Phenotype

preweaning lethality, complete... 7 | 979
abnormal heart morphology 1 | 162
decreased circulating chloride... 1 | 30
decreased circulating iron lev... 1 | 32
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
hemorrhage 1 | 23
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased heart weight 1 | 62
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 29 | 11,493
lung cancer 25 | 4,740
ovarian cancer 23 | 8,520
group 3 medulloblastoma 21 | 4,104
medulloblastoma, large-cell 19 | 6,241
osteosarcoma 19 | 7,950
atypical teratoid / rhabdoid tumor 16 | 5,112
glioblastoma 15 | 5,792
dermatomyositis 12 | 966
psoriasis 11 | 6,694
adult high grade glioma 10 | 3,801
primitive neuroectodermal tumor 10 | 3,035
Breast cancer 9 | 3,578
Kidney cancer 9 | 2,613
astrocytic glioma 9 | 2,597
ependymoma 9 | 4,679
malignant mesothelioma 9 | 3,232
non-small cell lung cancer 9 | 2,890
Waldenstrons macroglobulinemia 8 | 765
acute quadriplegic myopathy 8 | 1,158
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
oligodendroglioma 8 | 2,850
Multiple myeloma 7 | 1,332
Cancer 6 | 2,499
Pick disease 6 | 1,894
colon cancer 6 | 1,478
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
invasive ductal carcinoma 6 | 2,951
Astrocytoma, Pilocytic 5 | 3,081
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
Autosomal recessive predisposition 4 | 1,442
breast carcinoma 4 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
lung adenocarcinoma 4 | 2,716
pediatric high grade glioma 4 | 1,064
Amyotrophic lateral sclerosis 3 | 451
Atopic dermatitis 3 | 952
Leukemia, Myelocytic, Acute 3 | 120
ductal carcinoma in situ 3 | 1,745
sonic hedgehog group medulloblastoma 3 | 467
tuberculosis 3 | 2,010
Duchenne muscular dystrophy 2 | 601
Failure to gain weight 2 | 365
Galloway-Mowat syndrome 2 | 15
Hypersensitivity reaction type II disease 2 | 253
Intellectual disability 2 | 1,016
Leukemia 2 | 104
Leukemia, Myeloid, Acute 2 | 105
NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE 2 | 4
Nephrotic syndrome, idiopathic, steroid-resistant 2 | 4
Pediatric failure to thrive 2 | 365
Rheumatoid arthritis 2 | 1,191
Schizophrenia 2 | 1,160
acute myeloid leukemia 2 | 783
adrenocortical carcinoma 2 | 1,428
astrocytoma 2 | 1,146
gastric carcinoma 2 | 807
hepatocellular carcinoma 2 | 547
hereditary spastic paraplegia 2 | 318
interstitial cystitis 2 | 2,312
interstitial lung disease 2 | 298
lung carcinoma 2 | 2,843
nasopharyngeal carcinoma 2 | 1,058
pancreatic cancer 2 | 2,398
posterior fossa group B ependymoma 2 | 416
progressive supranuclear palsy 2 | 676
spina bifida 2 | 1,074
subependymal giant cell astrocytoma 2 | 2,287
ulcerative colitis 2 | 1,819
46 XX gonadal dysgenesis 1 | 5
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 1 | 21
Autosomal recessive hypohidrotic ectodermal dysplasia syndrome 1 | 3
Chromosome 2p16.1-p15 deletion syndrome 1 | 8
Decreased projection of midface 1 | 105
Deglutition Disorders 1 | 132
Diabetes Mellitus, Noninsulin-Dependent 1 | 31
Gonadal Dysgenesis, 46,XX 1 | 5
Hyperglycemia 1 | 137
Hypotrophic midface 1 | 105
Idiopathic pulmonary arterial hypertension 1 | 40
Infantile onset spinocerebellar ataxia 1 | 7
Leiomyosarcoma 1 | 24
Midface retrusion 1 | 105
Nail disease 1 | 9
Nystagmus, continuous pendular 1 | 14
Osteitis Deformans 1 | 11
Paget's disease of bone 1 | 36
Papillary thyroid carcinoma 1 | 43
Pendular Nystagmus 1 | 14
Plague 1 | 19
Pulmonary hypertension 1 | 85
Pure Gonadal Dysgenesis, 46, XX 1 | 5
Right bundle branch block 1 | 17
Small midface 1 | 105
Sparse eyebrow 1 | 42
Sparse eyelashes 1 | 31
Spinocerebellar ataxia type 1 1 | 16
Striatonigral Degeneration, Infantile 1 | 4
Thyroid Neoplasm 1 | 37
Thyroid Neoplasms 1 | 34

Tissue

Blood and immune system 34 | 16,909
Cardiovascular System 34 | 15,192
Digestive Tract 34 | 17,369
Endocrine System 34 | 18,159
Female tissues 34 | 17,400
Liver and Pancreas 34 | 16,750
Male tissues 34 | 17,142
Nervous System 34 | 16,725
Respiratory system 34 | 16,393
Skin and soft tissues 34 | 17,230
Urinary Tract 34 | 16,678

Target Family

Non-IDG 28 | 12,091
Transporter 3 | 473
Enzyme 2 | 4,145
Epigenetic 1 | 242
Transcription Factor 1 | 1,400

Reactome Pathway

Interactions of Vpr with host ... 35 | 35
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nucleoporin NDC1 NDC1 Tbio Non-IDG -0.66901 4.57 46
Nucleoprotein TPR TPR Tbio Non-IDG -2.11491 135.6 161
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.07841 114.8 103
Nuclear pore complex protein Nup160 NUP160 Tbio Non-IDG -1.13177 13.6 169
Nuclear pore complex protein Nup85 NUP85 Tbio Non-IDG -1.23703 17.9 139
Nucleoporin-like protein 2 NUPL2 Tbio Non-IDG -1.04073 10.5 78
Nuclear pore complex protein Nup98-Nup96 NUP98 Tbio Enzyme -2.26305 200.9 189
Nuclear pore complex protein Nup214 NUP214 Tbio Non-IDG -2.25062 166.6 35
ADP/ATP translocase 2 SLC25A5 Tbio Transporter -1.98936 91.6 65
Nuclear pore complex protein Nup93 NUP93 Tbio Non-IDG -1.35565 22.2 62