Development Level

Tbio 31 | 11,651
Tdark 4 | 6,593

IMPC Phenotype

preweaning lethality, complete... 8 | 979
abnormal craniofacial morpholo... 1 | 33
abnormal embryo size 1 | 220
abnormal forebrain morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal hindbrain morphology 1 | 10
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal placenta size 1 | 20
decreased circulating alkaline... 1 | 46
decreased lymphocyte cell numb... 1 | 83
decreased vertical activity 1 | 208
edema 1 | 59
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
increased monocyte cell number 1 | 63

Disease

Carcinoma 31 | 11,493
lung cancer 24 | 4,740
group 3 medulloblastoma 22 | 4,104
ovarian cancer 21 | 8,520
osteosarcoma 18 | 7,950
medulloblastoma, large-cell 17 | 6,241
atypical teratoid / rhabdoid tumor 16 | 5,112
glioblastoma 14 | 5,792
primitive neuroectodermal tumor 12 | 3,035
dermatomyositis 11 | 966
psoriasis 11 | 6,694
non-small cell lung cancer 10 | 2,890
Kidney cancer 9 | 2,613
Waldenstrons macroglobulinemia 9 | 765
ependymoma 9 | 4,679
oligodendroglioma 9 | 2,850
Multiple myeloma 8 | 1,332
acute quadriplegic myopathy 8 | 1,158
adult high grade glioma 8 | 3,801
astrocytic glioma 8 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
Breast cancer 7 | 3,578
Pick disease 7 | 1,894
colon cancer 6 | 1,478
malignant mesothelioma 6 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
invasive ductal carcinoma 5 | 2,951
lung adenocarcinoma 5 | 2,716
pediatric high grade glioma 5 | 1,064
tuberculosis 5 | 2,010
Astrocytoma, Pilocytic 4 | 3,081
Atopic dermatitis 4 | 952
Cancer 4 | 2,499
HIV Infections 4 | 102
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
subependymal giant cell astrocytoma 4 | 2,287
Amyotrophic lateral sclerosis 3 | 451
Leukemia, Myelocytic, Acute 3 | 120
acute myeloid leukemia 3 | 783
adrenocortical carcinoma 3 | 1,428
astrocytoma 3 | 1,146
breast carcinoma 3 | 1,638
nasopharyngeal carcinoma 3 | 1,058
pancreatic cancer 3 | 2,398
Autosomal recessive predisposition 2 | 1,442
Galloway-Mowat syndrome 2 | 15
Influenza 2 | 142
Legionnaires' disease 2 | 20
Leukemia 2 | 104
Leukemia, Acute Myeloid 2 | 17
Leukemia, Myeloid, Acute 2 | 105
NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE 2 | 4
Nephrotic syndrome, idiopathic, steroid-resistant 2 | 4
Rheumatoid arthritis 2 | 1,191
diabetes mellitus 2 | 1,728
ductal carcinoma in situ 2 | 1,745
inflammatory breast cancer 2 | 286
interstitial lung disease 2 | 298
juvenile dermatomyositis 2 | 1,187
sonic hedgehog group medulloblastoma 2 | 467
spina bifida 2 | 1,074
ulcerative colitis 2 | 1,819
ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) 1 | 21
Acute Promyelocytic Leukemia 1 | 40
Adenocarcinoma of lung 1 | 142
Animal Mammary Neoplasms 1 | 136
Autosomal recessive hypohidrotic ectodermal dysplasia syndrome 1 | 3
Bejel 1 | 5
Brain disease 1 | 96
Degenerative polyarthritis 1 | 115
Deglutition Disorders 1 | 132
DiGeorge syndrome 1 | 47
Disease Models, Animal 1 | 155
Ectodermal Dysplasia 10A, Hypohidrotic/Hair/Nail Type, Autosomal Dominant 1 | 3
Familial atrial fibrillation 1 | 23
Gaucher disease type 1 1 | 180
Hypohidrotic ectodermal dysplasia 1 | 15
Infectious mononucleosis 1 | 14
Irritable bowel syndrome 1 | 60
Kidney Neoplasms 1 | 37
Large intestine cancer 1 | 126
Lymphoid leukemia 1 | 160
Lymphopenia 1 | 67
MYELODYSPLASTIC SYNDROME 1 | 53
Mammary Neoplasms, Animal 1 | 136
Mammary Neoplasms, Experimental 1 | 154
Neutropenia 1 | 72
Osteitis Deformans 1 | 11
Osteoarthritis 1 | 184
Paget's disease of bone 1 | 36
Panic disorder 1 | 61
Right atrial isomerism 1 | 29
Spinocerebellar ataxia type 1 1 | 16
Velocardiofacial syndrome 1 | 46
Weight Gain 1 | 100
Yaws 1 | 7
cystic fibrosis and chronic rhinosinusitis 1 | 214
permanent atrial fibrillation 1 | 45
triple-A syndrome 1 | 17

Tissue

Blood and immune system 34 | 16,909
Cardiovascular System 34 | 15,192
Digestive Tract 34 | 17,369
Endocrine System 34 | 18,159
Female tissues 34 | 17,400
Liver and Pancreas 34 | 16,750
Male tissues 34 | 17,142
Nervous System 34 | 16,725
Respiratory system 34 | 16,393
Skin and soft tissues 34 | 17,230
Urinary Tract 34 | 16,678

Target Family

Non-IDG 30 | 12,091
Enzyme 5 | 4,145

Reactome Pathway

Interactions of Rev with host ... 35 | 35
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ran-specific GTPase-activating protein RANBP1 Tbio Enzyme -1.80548 64.8 193
Nuclear pore complex protein Nup50 NUP50 Tbio Non-IDG -1.18445 15.9 270
Importin subunit beta-1 KPNB1 Tbio Non-IDG -1.63038 38.8 174
Nucleoporin p58/p45 NUP58 Tdark Non-IDG -0.69756 4.39 42
Nuclear pore glycoprotein p62 NUP62 Tbio Non-IDG -1.80390 62.5 241
Nuclear pore complex protein Nup133 NUP133 Tbio Non-IDG -1.36479 22.8 72
Nucleoporin NDC1 NDC1 Tbio Non-IDG -0.66901 4.57 46
Nucleoporin Nup43 NUP43 Tdark Non-IDG -0.19957 1.46 144
Nucleoporin NUP53 NUP35 Tbio Non-IDG -1.18190 16.6 152
E3 SUMO-protein ligase RanBP2 RANBP2 Tbio Enzyme -2.24609 178.6 172