Development Level

Tchem 12 | 1,598
Tbio 11 | 11,445
Tclin 3 | 613

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal femur morphology 1 | 14
abnormal seminal vesicle morph... 1 | 114
decreased circulating phosphat... 1 | 27
decreased lean body mass 1 | 135
enlarged heart 1 | 210
increased total body fat amoun... 1 | 134
preweaning lethality, incomple... 1 | 499

Disease

osteosarcoma 19 | 7,950
Cancer 18 | 2,499
Carcinoma 18 | 11,493
ovarian cancer 17 | 8,520
glioblastoma 11 | 5,792
Breast cancer 10 | 3,578
medulloblastoma, large-cell 10 | 6,241
psoriasis 10 | 6,694
Astrocytoma, Pilocytic 9 | 3,081
Kidney cancer 9 | 2,613
adult high grade glioma 9 | 3,801
atypical teratoid / rhabdoid tumor 9 | 5,112
diabetes mellitus 9 | 1,728
invasive ductal carcinoma 9 | 2,951
lung cancer 9 | 4,740
lung adenocarcinoma 8 | 2,716
non-small cell lung cancer 8 | 2,890
Autosomal recessive predisposition 7 | 1,442
Epistaxis 7 | 43
lung carcinoma 7 | 2,843
Gastrointestinal Hemorrhage 6 | 52
ependymoma 6 | 4,679
group 4 medulloblastoma 6 | 1,855
tuberculosis 6 | 2,010
Atherosclerosis 5 | 291
Gingival Hemorrhage 5 | 18
Liver Cirrhosis, Experimental 5 | 769
Neoplasm Invasiveness 5 | 161
Osteoporosis 5 | 363
Schizophrenia 5 | 1,160
cystic fibrosis 5 | 1,696
group 3 medulloblastoma 5 | 4,104
interstitial cystitis 5 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
malignant mesothelioma 5 | 3,232
oligodendroglioma 5 | 2,850
pancreatic cancer 5 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
primitive neuroectodermal tumor 5 | 3,035
Bleeding tendency 4 | 37
Bleeding time prolonged 4 | 31
Cerebrovascular disease 4 | 238
Congenital afibrinogenemia 4 | 11
Coronary artery disease 4 | 268
Glanzmann's thrombasthenia 4 | 23
Spontaneous abortion 4 | 113
Thrombophilia 4 | 38
adrenocortical carcinoma 4 | 1,428
ductal carcinoma in situ 4 | 1,745
subependymal giant cell astrocytoma 4 | 2,287
ulcerative colitis 4 | 1,819
urothelial carcinoma 4 | 318
Abnormal dermatoglyphic pattern 3 | 24
Acquired scoliosis 3 | 281
Afibrinogenemia 3 | 4
Afibrinogenemia, congenital 3 | 3
Anemia 3 | 365
Asthma 3 | 385
Bernard-Soulier syndrome 3 | 14
Blepharoptosis 3 | 231
Breast Neoplasms 3 | 445
Byzanthine arch palate 3 | 194
Congenital hypofibrinogenemia 3 | 3
Curvature of spine 3 | 282
Dysfibrinogenemia, Congenital 3 | 3
Ecchymosis 3 | 66
Familial dysfibrinogenemia 3 | 3
Familial hypofibrinogenemia 3 | 3
Heart disease 3 | 306
Hypertension 3 | 396
Hypertensive disease 3 | 292
Hypofibrinogenemia 3 | 4
Impaired platelet aggregation 3 | 8
Increased tendency to bruise 3 | 66
Intermenstrual heavy bleeding 3 | 4
Joint hyperflexibility 3 | 78
Joint swelling 3 | 26
Kidney disease 3 | 430
Mammary Neoplasms 3 | 425
Menorrhagia 3 | 25
Muscle hypotonia 3 | 571
Obesity 3 | 678
Purpura 3 | 43
Rheumatoid arthritis 3 | 1,191
Short stature 3 | 531
Strabismus 3 | 270
Thrombocytopenia 3 | 197
Venous Thrombosis 3 | 47
astrocytic glioma 3 | 2,597
astrocytoma 3 | 1,146
juvenile dermatomyositis 3 | 1,187
primary Sjogren syndrome 3 | 735
primary pancreatic ductal adenocarcinoma 3 | 1,109
Large dysplastic ears 2 | 87
Large pinnae 2 | 87
Large prominent ears 2 | 87
Large, floppy ears 2 | 87
Protruding ears 2 | 56

Tissue

Blood and immune system 26 | 16,909
Digestive Tract 26 | 17,369
Endocrine System 26 | 18,159
Female tissues 26 | 17,400
Liver and Pancreas 26 | 16,750
Male tissues 26 | 17,142
Respiratory system 26 | 16,393
Skin and soft tissues 26 | 17,230
Urinary Tract 26 | 16,678
Cardiovascular System 25 | 15,192
Nervous System 24 | 16,725

Target Family

Non-IDG 18 | 12,091
Kinase 5 | 634
Enzyme 3 | 4,145

Reactome Pathway

Integrin signaling 26 | 26
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Fibronectin FN1 Tchem Non-IDG -3.09873 1208.8 1583
Ras-related protein Rap-1b RAP1B Tbio Enzyme -2.38904 417.6 114
Rap guanine nucleotide exchange factor 4 RAPGEF4 Tchem Non-IDG -2.46995 289.7 118
RAS guanyl-releasing protein 2 RASGRP2 Tbio Non-IDG -1.23693 18.9 108
Fibrinogen alpha chain FGA Tbio Non-IDG -2.88066 753.1 595
Fibrinogen gamma chain FGG Tbio Non-IDG -2.21041 158.7 384
Focal adhesion kinase 1 PTK2 Tchem Kinase -3.06733 1038.3 2013
RAS guanyl-releasing protein 1 RASGRP1 Tchem Non-IDG -1.99263 105.6 99
Integrin alpha-IIb ITGA2B Tclin Non-IDG -3.52120 3309.8 1170
von Willebrand factor VWF Tbio Non-IDG -3.93535 9001.4 1081