Development Level

Tbio 53 | 11,651
Tclin 8 | 612
Tchem 4 | 1,388

IMPC Phenotype

preweaning lethality, incomple... 4 | 499
preweaning lethality, complete... 3 | 979
enlarged heart 2 | 210
increased circulating triglyce... 2 | 42
abnormal ear morphology 1 | 9
abnormal embryo size 1 | 220
abnormal femur morphology 1 | 14
abnormal heart morphology 1 | 162
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 23
abnormal liver morphology 1 | 17
abnormal lung morphology 1 | 26
abnormal pelvic girdle bone mo... 1 | 12
abnormal radius morphology 1 | 8
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal tail morphology 1 | 25
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating phosphat... 1 | 27
decreased fasted circulating g... 1 | 65
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased neutrophil cell numb... 1 | 42
decreased vertical activity 1 | 208
hemorrhage 1 | 23
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased leukocyte cell numbe... 1 | 47
increased or absent threshold ... 1 | 101
increased vertical activity 1 | 24
male infertility 1 | 123
short tibia 1 | 97
tremors 1 | 39
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 60 | 11,493
ovarian cancer 43 | 8,520
glioblastoma 40 | 5,792
osteosarcoma 36 | 7,950
lung cancer 33 | 4,740
malignant mesothelioma 31 | 3,232
Astrocytoma, Pilocytic 30 | 3,081
Breast cancer 30 | 3,578
Cancer 30 | 2,499
interstitial cystitis 30 | 2,312
non-small cell lung cancer 28 | 2,890
invasive ductal carcinoma 27 | 2,951
lung carcinoma 27 | 2,843
psoriasis 26 | 6,694
atypical teratoid / rhabdoid tumor 25 | 5,112
ulcerative colitis 25 | 1,819
ependymoma 23 | 4,679
lung adenocarcinoma 23 | 2,716
medulloblastoma, large-cell 23 | 6,241
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,955
Kidney cancer 21 | 2,613
adult high grade glioma 21 | 3,801
cystic fibrosis 21 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,989
pancreatic cancer 21 | 2,398
Duchenne muscular dystrophy 19 | 601
ductal carcinoma in situ 19 | 1,745
tuberculosis 18 | 2,010
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
Autosomal recessive predisposition 16 | 1,442
diabetes mellitus 15 | 1,728
gastric carcinoma 15 | 807
primitive neuroectodermal tumor 14 | 3,035
dermatomyositis 13 | 966
group 3 medulloblastoma 13 | 4,104
oligodendroglioma 13 | 2,850
pituitary cancer 13 | 1,972
primary pancreatic ductal adenocarcinoma 13 | 1,109
Kidney disease 12 | 430
breast carcinoma 12 | 1,638
juvenile dermatomyositis 12 | 1,187
Atherosclerosis 11 | 291
Liver Cirrhosis, Experimental 11 | 769
adrenocortical carcinoma 11 | 1,428
autosomal dominant Emery-Dreifuss muscular dystrophy 11 | 510
colon cancer 11 | 1,478
cutaneous lupus erythematosus 11 | 1,057
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
subependymal giant cell astrocytoma 11 | 2,287
Coronary artery disease 10 | 268
Schizophrenia 10 | 1,160
nasopharyngeal carcinoma 10 | 1,058
Cerebrovascular disease 9 | 238
Pick disease 9 | 1,894
Vascular disease 9 | 319
acute quadriplegic myopathy 9 | 1,158
primary Sjogren syndrome 9 | 735
Arthritis 8 | 290
Becker muscular dystrophy 8 | 191
Endometriosis 8 | 540
Hypersensitivity reaction type II disease 8 | 253
Hypertensive disease 8 | 292
Inflammatory bowel disease 8 | 151
Multiple Sclerosis 8 | 540
Myopia 8 | 176
astrocytic glioma 8 | 2,597
esophageal adenocarcinoma 8 | 737
head and neck cancer and chronic obstructive pulmonary disease 8 | 239
pediatric high grade glioma 8 | 1,064
periodontitis 8 | 293
urothelial carcinoma 8 | 318
Atopic dermatitis 7 | 952
Breast Neoplasms 7 | 445
Cataract 7 | 297
Cerebral Hemorrhage 7 | 42
Lens Opacities 7 | 231
Mammary Neoplasms 7 | 425
Proteinuria 7 | 144
Spontaneous abortion 7 | 113
group 4 medulloblastoma 7 | 1,855
limb girdle muscular dystrophy 2A 7 | 213
nephrosclerosis 7 | 333
Asthma 6 | 385
Gliosis 6 | 56
Heart disease 6 | 306
Hypoplastic mandible condyle 6 | 275
Increase in blood pressure 6 | 119
Leukocyte adhesion deficiency 6 | 16
Mandibular hypoplasia 6 | 275
Micrognathism 6 | 275
Neoplasm Metastasis 6 | 168
Nephrotic Syndrome 6 | 78
Osteoporosis 6 | 363
Rheumatoid arthritis 6 | 1,191
Short stature 6 | 531
Stomach Neoplasms 6 | 300
aldosterone-producing adenoma 6 | 665
astrocytoma 6 | 1,146
head and neck cancer 6 | 271
posterior fossa group A ependymoma 6 | 468

Tissue

Blood and immune system 64 | 16,909
Endocrine System 64 | 18,159
Female tissues 64 | 17,400
Digestive Tract 63 | 17,369
Liver and Pancreas 63 | 16,750
Respiratory system 63 | 16,393
Skin and soft tissues 63 | 17,230
Urinary Tract 63 | 16,678
Male tissues 62 | 17,142
Cardiovascular System 61 | 15,192
Nervous System 60 | 16,725

Target Family

Non-IDG 62 | 12,091
Enzyme 1 | 4,145
Kinase 1 | 634
Transcription Factor 1 | 1,400

Reactome Pathway

Integrin cell surface interact... 65 | 65
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Integrin alpha-11 ITGA11 Tbio Non-IDG -1.13736 14.3 76
Integrin alpha-2 ITGA2 Tbio Non-IDG -2.58423 335.9 895
Thrombospondin-1 THBS1 Tbio Non-IDG -3.06622 1281.6 504
Integrin alpha-9 ITGA9 Tbio Non-IDG -1.46619 29.0 124
Integrin beta-8 ITGB8 Tbio Non-IDG -1.47947 27.7 99
Integrin beta-7 ITGB7 Tclin Non-IDG -1.63572 38.4 374
Integrin alpha-3 ITGA3 Tbio Non-IDG -2.08360 104.1 587
Collagen alpha-3(IV) chain COL4A3 Tbio Non-IDG -2.32017 204.4 209
Junctional adhesion molecule C JAM3 Tbio Non-IDG -1.93757 97.1 251
Mucosal addressin cell adhesion molecule 1 MADCAM1 Tbio Non-IDG -2.38746 252.3 538