Development Level

Tbio 46 | 10,625
Tchem 12 | 1,890
Tclin 8 | 602
Tdark 1 | 7,003

IMPC Term

decreased circulating insulin ... 2 | 75
enlarged heart 2 | 111
preweaning lethality, incomple... 2 | 260
abnormal ear morphology 1 | 5
abnormal eye morphology 1 | 38
abnormal femur morphology 1 | 14
abnormal heart morphology 1 | 51
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 14
abnormal liver morphology 1 | 5
abnormal lung morphology 1 | 15
abnormal pelvic girdle bone mo... 1 | 11
abnormal radius morphology 1 | 8
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal seminal vesicle morph... 1 | 47
abnormal tail morphology 1 | 17
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
decreased body length 1 | 108
decreased bone mineral density 1 | 126
decreased circulating glucose ... 1 | 121
decreased hemoglobin content 1 | 53
decreased leukocyte cell numbe... 1 | 54
herniated abdominal wall 1 | 4
immune system phenotype 1 | 17
increased bone mineral content 1 | 92
increased circulating alkaline... 1 | 119
increased circulating free fat... 1 | 17
increased circulating potassiu... 1 | 31
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased fasted circulating g... 1 | 68
increased hematocrit 1 | 36
increased leukocyte cell numbe... 1 | 37
increased or absent threshold ... 1 | 128
increased vertical activity 1 | 18
irregularly shaped pupil 1 | 7
polydactyly 1 | 22
preweaning lethality, complete... 1 | 633
short tibia 1 | 82
tremors 1 | 34

Disease

ovarian cancer 44 | 8,484
glioblastoma 39 | 5,572
osteosarcoma 36 | 7,933
lung cancer 34 | 4,466
Cancer 30 | 2,346
interstitial cystitis 30 | 2,299
malignant mesothelioma 30 | 3,162
pilocytic astrocytoma 30 | 3,086
psoriasis 28 | 6,685
invasive ductal carcinoma 27 | 2,950
lung carcinoma 27 | 2,844
ulcerative colitis 27 | 2,087
non-small cell lung cancer 26 | 2,798
Breast cancer 25 | 3,094
atypical teratoid / rhabdoid tumor 25 | 4,369
lung adenocarcinoma 23 | 2,713
medulloblastoma, large-cell 23 | 6,234
pediatric high grade glioma 23 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,956
cystic fibrosis 21 | 1,665
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,988
pancreatic cancer 21 | 2,300
Carcinoma 20 | 2,147
Duchenne muscular dystrophy 19 | 602
ductal carcinoma in situ 19 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,289
tuberculosis 17 | 1,557
primary pancreatic ductal adenocarcinoma 16 | 1,271
diabetes mellitus 15 | 1,663
gastric carcinoma 15 | 832
posterior fossa group A ependymoma 15 | 1,511
ependymoma 14 | 2,514
oligodendroglioma 14 | 2,849
primitive neuroectodermal tumor 14 | 3,031
dermatomyositis 13 | 933
juvenile dermatomyositis 13 | 1,189
pituitary cancer 13 | 1,972
Kidney disease 12 | 396
astrocytoma 12 | 1,493
Atherosclerosis 11 | 275
adrenocortical carcinoma 11 | 1,427
autosomal dominant Emery-Dreifuss muscular dystrophy 11 | 499
breast carcinoma 11 | 1,614
colon cancer 11 | 1,475
cutaneous lupus erythematosus 11 | 1,056
nasopharyngeal carcinoma 11 | 1,056
subependymal giant cell astrocytoma 11 | 2,287
primary Sjogren syndrome 10 | 789
Arthritis 9 | 248
Multiple Sclerosis 9 | 498
Pick disease 9 | 1,893
acute quadriplegic myopathy 9 | 1,157
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,795
sonic hedgehog group medulloblastoma 9 | 1,482
Becker muscular dystrophy 8 | 187
Cerebrovascular disease 8 | 231
Coronary artery disease 8 | 240
Endometriosis 8 | 535
Inflammatory bowel disease 8 | 142
Vascular disease 8 | 281
esophageal adenocarcinoma 8 | 737
group 4 medulloblastoma 8 | 1,875
head and neck cancer and chronic obstructive pulmonary disease 8 | 237
urothelial carcinoma 8 | 318
Atopic dermatitis 7 | 944
Heart disease 7 | 279
Hypersensitivity reaction type II disease 7 | 235
adult high grade glioma 7 | 2,148
group 3 medulloblastoma 7 | 2,254
nephrosclerosis 7 | 329
periodontitis 7 | 269
Asthma 6 | 349
Down syndrome 6 | 548
Gliosis 6 | 16
IGA Glomerulonephritis 6 | 454
Leukocyte adhesion deficiency 6 | 15
Mammary Neoplasms 6 | 410
Neoplasm Metastasis 6 | 138
Rheumatoid Arthritis 6 | 1,160
Stomach Neoplasms 6 | 282
aldosterone-producing adenoma 6 | 664
head and neck cancer 6 | 270
Acute Promyelocytic Leukemia 5 | 31
Cerebral Hemorrhage 5 | 27
Colon carcinoma in situ 5 | 8
Crohn's disease 5 | 304
Eosinophilia 5 | 65
Hypertension 5 | 287
Lung disease 5 | 132
Multiple myeloma 5 | 1,327
Neoplasm Invasiveness 5 | 127
Osteoporosis 5 | 257
active Crohn's disease 5 | 918
mucosa-associated lymphoid tissue lymphoma 5 | 480
non diabetic and post-ischemic heart failure 5 | 200
non-small cell lung carcinoma 5 | 413
Prostatic Neoplasms 4 | 471
Schizophrenia 4 | 501
acute myeloid leukemia 4 | 780
pancreatic carcinoma 4 | 567

Tissue

Cardiovascular System 67 | 17,958
Digestive Tract 67 | 18,473
Endocrine System 67 | 18,512
Female tissues 67 | 18,647
Nervous System 67 | 18,561
Respiratory system 67 | 17,484
Urinary Tract 67 | 18,444
Blood and immune system 66 | 17,995
Liver and Pancreas 66 | 18,136
Male tissues 66 | 17,969
Skin and soft tissues 66 | 18,115

Target Family

Non-IDG 63 | 11,971
Enzyme 2 | 4,146
Kinase 1 | 634
Transcription Factor 1 | 1,400

Reactome Pathway

Integrin cell surface interact... 67 | 67
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
Fibrinogen alpha chain FGA Tbio Non-IDG -2.84597 716.2 457
Fibronectin FN1 Tchem Non-IDG -3.04098 1121.3 1253
Collagen alpha-1(XVI) chain COL16A1 Tbio Non-IDG -0.84735 6.90 35
Leukocyte surface antigen CD47 CD47 Tbio Non-IDG -2.64623 506.0 450
Integrin alpha-4 ITGA4 Tclin Non-IDG -2.47245 289.0 895
Integrin alpha-6 ITGA6 Tchem Non-IDG -2.25486 168.8 756
Integrin alpha-M ITGAM Tchem Non-IDG -3.58843 3795.9 1805
Intercellular adhesion molecule 2 ICAM2 Tbio Non-IDG -2.18550 142.0 532
Intercellular adhesion molecule 5 ICAM5 Tbio Non-IDG -1.73310 64.9 170