Development Level

Tbio 45 | 11,178
Tchem 12 | 1,885
Tclin 8 | 612

IMPC Phenotype

preweaning lethality, incomple... 4 | 499
preweaning lethality, complete... 3 | 979
enlarged heart 2 | 210
increased circulating triglyce... 2 | 42
abnormal ear morphology 1 | 9
abnormal embryo size 1 | 220
abnormal femur morphology 1 | 14
abnormal heart morphology 1 | 162
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 23
abnormal liver morphology 1 | 17
abnormal lung morphology 1 | 26
abnormal pelvic girdle bone mo... 1 | 12
abnormal radius morphology 1 | 8
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal tail morphology 1 | 25
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating phosphat... 1 | 27
decreased fasted circulating g... 1 | 65
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased neutrophil cell numb... 1 | 42
decreased vertical activity 1 | 208
hemorrhage 1 | 23
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased leukocyte cell numbe... 1 | 47
increased or absent threshold ... 1 | 101
increased vertical activity 1 | 24
male infertility 1 | 123
short tibia 1 | 97
tremors 1 | 39
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 60 | 11,192
ovarian cancer 43 | 8,297
glioblastoma 40 | 5,635
osteosarcoma 36 | 7,766
lung cancer 33 | 4,607
malignant mesothelioma 31 | 3,135
Astrocytoma, Pilocytic 30 | 3,006
Breast cancer 30 | 3,469
Cancer 30 | 2,388
interstitial cystitis 30 | 2,237
non-small cell lung cancer 28 | 2,799
invasive ductal carcinoma 27 | 2,867
lung carcinoma 27 | 2,755
psoriasis 26 | 6,514
atypical teratoid / rhabdoid tumor 25 | 4,971
ulcerative colitis 25 | 1,765
ependymoma 23 | 4,559
lung adenocarcinoma 23 | 2,627
medulloblastoma, large-cell 23 | 6,086
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,872
Kidney cancer 21 | 2,548
adult high grade glioma 21 | 3,701
cystic fibrosis 21 | 1,629
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,902
pancreatic cancer 21 | 2,322
Duchenne muscular dystrophy 19 | 587
ductal carcinoma in situ 19 | 1,686
tuberculosis 18 | 1,963
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,204
Autosomal recessive predisposition 16 | 1,407
diabetes mellitus 15 | 1,683
gastric carcinoma 15 | 781
primitive neuroectodermal tumor 14 | 2,957
dermatomyositis 13 | 941
group 3 medulloblastoma 13 | 4,002
oligodendroglioma 13 | 2,768
pituitary cancer 13 | 1,915
primary pancreatic ductal adenocarcinoma 13 | 1,071
Kidney disease 12 | 411
breast carcinoma 12 | 1,589
juvenile dermatomyositis 12 | 1,147
Atherosclerosis 11 | 276
Liver Cirrhosis, Experimental 11 | 733
adrenocortical carcinoma 11 | 1,385
autosomal dominant Emery-Dreifuss muscular dystrophy 11 | 492
colon cancer 11 | 1,428
cutaneous lupus erythematosus 11 | 1,016
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,911
subependymal giant cell astrocytoma 11 | 2,230
Coronary artery disease 10 | 253
Schizophrenia 10 | 1,136
nasopharyngeal carcinoma 10 | 1,024
Cerebrovascular disease 9 | 223
Pick disease 9 | 1,856
Vascular disease 9 | 294
acute quadriplegic myopathy 9 | 1,133
primary Sjogren syndrome 9 | 710
Arthritis 8 | 276
Becker muscular dystrophy 8 | 184
Endometriosis 8 | 521
Hypersensitivity reaction type II disease 8 | 245
Hypertensive disease 8 | 278
Inflammatory bowel disease 8 | 148
Multiple Sclerosis 8 | 527
Myopia 8 | 175
astrocytic glioma 8 | 2,530
esophageal adenocarcinoma 8 | 696
head and neck cancer and chronic obstructive pulmonary disease 8 | 226
pediatric high grade glioma 8 | 1,035
periodontitis 8 | 280
urothelial carcinoma 8 | 303
Atopic dermatitis 7 | 915
Breast Neoplasms 7 | 423
Cataract 7 | 290
Cerebral Hemorrhage 7 | 36
Lens Opacities 7 | 227
Mammary Neoplasms 7 | 403
Proteinuria 7 | 143
Spontaneous abortion 7 | 97
group 4 medulloblastoma 7 | 1,806
limb girdle muscular dystrophy 2A 7 | 208
nephrosclerosis 7 | 314
Asthma 6 | 370
Gliosis 6 | 56
Heart disease 6 | 288
Hypoplastic mandible condyle 6 | 273
Increase in blood pressure 6 | 118
Leukocyte adhesion deficiency 6 | 16
Mandibular hypoplasia 6 | 273
Micrognathism 6 | 273
Neoplasm Metastasis 6 | 160
Nephrotic Syndrome 6 | 76
Osteoporosis 6 | 348
Rheumatoid arthritis 6 | 1,156
Short stature 6 | 514
Stomach Neoplasms 6 | 287
aldosterone-producing adenoma 6 | 646
astrocytoma 6 | 1,113
head and neck cancer 6 | 263
posterior fossa group A ependymoma 6 | 456

Tissue

Blood and immune system 64 | 16,909
Endocrine System 64 | 18,159
Female tissues 64 | 17,400
Digestive Tract 63 | 17,369
Liver and Pancreas 63 | 16,750
Respiratory system 63 | 16,393
Skin and soft tissues 63 | 17,230
Urinary Tract 63 | 16,678
Male tissues 62 | 17,142
Cardiovascular System 61 | 15,192
Nervous System 60 | 16,725

Target Family

Non-IDG 62 | 12,091
Enzyme 1 | 4,145
Kinase 1 | 634
Transcription Factor 1 | 1,400

Reactome Pathway

Integrin cell surface interact... 65 | 65
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Bone sialoprotein 2 IBSP Tbio Non-IDG -2.95483 756.8 261
Collagen alpha-3(IX) chain COL9A3 Tbio Non-IDG -1.35534 21.6 115
Integrin alpha-L ITGAL Tclin Non-IDG -2.90090 757.3 1407
Integrin alpha-X ITGAX Tbio Non-IDG -3.23986 1600.6 1515
Integrin alpha-D ITGAD Tbio Non-IDG -1.43504 29.6 63
Integrin alpha-2 ITGA2 Tbio Non-IDG -2.58423 335.9 895
Thrombospondin-1 THBS1 Tbio Non-IDG -3.06622 1281.6 504
Collagen alpha-1(XVIII) chain COL18A1 Tbio Non-IDG -3.18339 1561.4 433
Intercellular adhesion molecule 4 ICAM4 Tbio Non-IDG -1.43430 28.1 158
Fibronectin FN1 Tchem Non-IDG -3.09873 1208.8 1583