Development Level

Tbio 21 | 11,651
Tdark 2 | 6,593
Tchem 1 | 1,388
Tclin 1 | 612

IMPC Phenotype

preweaning lethality, complete... 6 | 979
embryonic lethality prior to o... 5 | 239
embryonic lethality prior to t... 5 | 278
abnormal behavior 2 | 298
abnormal kidney morphology 1 | 65
abnormal seminal vesicle morph... 1 | 114
brachydactyly 1 | 19
cardiovascular system phenotyp... 1 | 36
decreased caudal vertebrae num... 1 | 53
decreased circulating bilirubi... 1 | 19
decreased hemoglobin content 1 | 68
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
decreased prepulse inhibition 1 | 82
decreased total body fat amoun... 1 | 207
hyperactivity 1 | 148
hypoactivity 1 | 132
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased heart rate variabili... 1 | 7
increased or absent threshold ... 1 | 101
short tibia 1 | 97
small adrenal glands 1 | 16
small lymph nodes 1 | 1
syndactyly 1 | 23
thrombocytosis 1 | 27

Disease

Carcinoma 14 | 11,493
ovarian cancer 13 | 8,520
ependymoma 11 | 4,679
psoriasis 11 | 6,694
astrocytic glioma 10 | 2,597
atypical teratoid / rhabdoid tumor 10 | 5,112
glioblastoma 10 | 5,792
medulloblastoma, large-cell 10 | 6,241
osteosarcoma 10 | 7,950
oligodendroglioma 9 | 2,850
Pick disease 7 | 1,894
primitive neuroectodermal tumor 7 | 3,035
adult high grade glioma 6 | 3,801
lung carcinoma 6 | 2,843
Astrocytoma, Pilocytic 5 | 3,081
Autosomal recessive predisposition 5 | 1,442
Breast cancer 5 | 3,578
Multiple myeloma 5 | 1,332
Osteopetrosis 5 | 43
group 3 medulloblastoma 5 | 4,104
Alzheimer's disease 4 | 658
Failure to gain weight 4 | 365
Pediatric failure to thrive 4 | 365
diabetes mellitus 4 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
subependymal giant cell astrocytoma 4 | 2,287
Anemia 3 | 365
Cutis Laxa 3 | 39
Epilepsy 3 | 792
Fetal Growth Retardation 3 | 189
Infant, Small for Gestational Age 3 | 176
Intrauterine retardation 3 | 176
Seizures 3 | 596
Short stature 3 | 531
dermatomyositis 3 | 966
lung cancer 3 | 4,740
malignant mesothelioma 3 | 3,232
pancreatic cancer 3 | 2,398
tuberculosis 3 | 2,010
Acromegaly 2 | 51
Alzheimer Disease 2 | 83
Anteverted nostril 2 | 191
Bipolar Disorder 2 | 666
Brachydactyly 2 | 156
Broad flat nasal bridge 2 | 236
Byzanthine arch palate 2 | 194
Cancer 2 | 2,499
Coarse hair 2 | 31
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Frontal bossing 2 | 157
Gaucher disease type 1 2 | 180
Gingival Hyperplasia 2 | 34
Gingival Hypertrophy 2 | 34
Gingival Overgrowth 2 | 36
Growth delay 2 | 114
Growth failure 2 | 114
Growth retardation 2 | 115
Hernia, Inguinal 2 | 89
Hyperandrogenism 2 | 34
Hyperinsulinism 2 | 133
Hypoglycemia 2 | 152
Hypothyroidism 2 | 122
Kidney disease 2 | 430
Late tooth eruption 2 | 61
Liver Cirrhosis, Experimental 2 | 769
Long philtrum 2 | 137
Low Birth Weights 2 | 69
Motor delay 2 | 147
Nasal bridge wide 2 | 236
Nephrocalcinosis 2 | 35
Neuropathy 2 | 261
No development of motor milestones 2 | 147
Osteoporosis 2 | 363
Parkinson Disease 2 | 64
Parkinson's disease 2 | 392
Polycystic ovary syndrome 2 | 360
Poor growth 2 | 114
Recurrent respiratory infections 2 | 141
Sensorineural Hearing Loss (disorder) 2 | 284
Sensorineural hearing loss 2 | 106
Short nose 2 | 132
Small for gestational age (disorder) 2 | 69
Small nose 2 | 132
Umbilical hernia 2 | 93
Very poor growth 2 | 114
Waldenstrons macroglobulinemia 2 | 765
breast carcinoma 2 | 1,638
chronic rhinosinusitis 2 | 512
cystic fibrosis 2 | 1,696
hepatocellular carcinoma 2 | 547
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
medulloblastoma 2 | 720
pancreatic carcinoma 2 | 562
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
pediatric high grade glioma 2 | 1,064
pituitary cancer 2 | 1,972
primary pancreatic ductal adenocarcinoma 2 | 1,109
spina bifida 2 | 1,074
tuberculosis and treatment for 6 months 2 | 409

Tissue

Blood and immune system 25 | 16,909
Urinary Tract 25 | 16,678
Digestive Tract 24 | 17,369
Endocrine System 24 | 18,159
Female tissues 24 | 17,400
Male tissues 24 | 17,142
Nervous System 24 | 16,725
Respiratory system 24 | 16,393
Skin and soft tissues 24 | 17,230
Cardiovascular System 23 | 15,192
Liver and Pancreas 23 | 16,750

Target Family

Enzyme 23 | 4,145
Kinase 1 | 634
Non-IDG 1 | 12,091

Reactome Pathway

Insulin receptor recycling 25 | 25
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
V-type proton ATPase subunit B, kidney isoform ATP6V1B1 Tchem Enzyme -1.71459 43.7 251
V-type proton ATPase subunit D ATP6V1D Tbio Enzyme -1.48812 30.2 69
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.46402 298.9 76
V-type proton ATPase 16 kDa proteolipid subunit ATP6V0C Tbio Enzyme -1.87899 78.9 72
V-type proton ATPase 116 kDa subunit a isoform 1 ATP6V0A1 Tbio Enzyme -1.40105 25.1 63
V-type proton ATPase subunit d 2 ATP6V0D2 Tbio Enzyme -1.17065 12.0 74
V-type proton ATPase 116 kDa subunit a isoform 3 TCIRG1 Tbio Enzyme -1.92345 93.5 63
V-type proton ATPase subunit H ATP6V1H Tbio Enzyme -1.26664 18.3 119
Insulin INS Tbio Non-IDG -5.17849 146933.7 2197
V-type proton ATPase subunit e 2 ATP6V0E2 Tdark Enzyme 0.18 0.40 24