Development Level

Tbio 19 | 10,625
Tdark 4 | 7,003
Tchem 2 | 1,890
Tclin 1 | 602

IMPC Term

embryonic lethality prior to o... 5 | 148
embryonic lethality prior to t... 5 | 187
preweaning lethality, complete... 4 | 633
decreased mean corpuscular vol... 2 | 50
hypoactivity 2 | 89
abnormal kidney morphology 1 | 30
abnormal seminal vesicle morph... 1 | 47
cardiovascular system phenotyp... 1 | 35
decreased caudal vertebrae num... 1 | 49
decreased erythrocyte cell num... 1 | 43
decreased hemoglobin content 1 | 53
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular hem... 1 | 19
decreased mean platelet volume 1 | 12
decreased prepulse inhibition 1 | 52
decreased total body fat amoun... 1 | 186
increased mean corpuscular hem... 1 | 93
short tibia 1 | 82
small adrenal glands 1 | 15
small lymph nodes 1 | 1
thrombocytosis 1 | 23

Disease

ovarian cancer 14 | 8,484
psoriasis 11 | 6,685
glioblastoma 10 | 5,572
medulloblastoma, large-cell 10 | 6,234
osteosarcoma 10 | 7,933
atypical teratoid / rhabdoid tumor 9 | 4,369
ependymoma 9 | 2,514
oligodendroglioma 9 | 2,849
Pick disease 8 | 1,893
astrocytic glioma 7 | 2,241
primitive neuroectodermal tumor 7 | 3,031
Multiple myeloma 6 | 1,327
lung carcinoma 6 | 2,844
Breast cancer 5 | 3,094
Osteopetrosis 5 | 40
adult high grade glioma 5 | 2,148
astrocytoma 5 | 1,493
medulloblastoma 5 | 1,524
pilocytic astrocytoma 5 | 3,086
subependymal giant cell astrocytoma 5 | 2,287
Alzheimer's disease 4 | 644
diabetes mellitus 4 | 1,663
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,289
Cutis laxa 3 | 28
cystic fibrosis 3 | 1,665
dermatomyositis 3 | 933
invasive ductal carcinoma 3 | 2,950
lung cancer 3 | 4,466
malignant mesothelioma 3 | 3,162
pancreatic cancer 3 | 2,300
pediatric high grade glioma 3 | 2,712
sonic hedgehog group medulloblastoma 3 | 1,482
tuberculosis and treatment for 6 months 3 | 686
Acanthosis nigricans 2 | 14
Anemia 2 | 252
Bipolar Disorder 2 | 266
Cancer 2 | 2,346
Diabetes Mellitus, Non-Insulin-Dependent 2 | 157
Donohue Syndrome 2 | 6
Enlarged vestibular aqueduct 2 | 10
Gaucher disease type 1 2 | 171
Hyperandrogenism 2 | 32
Hyperglycemia 2 | 120
Hyperinsulinism 2 | 63
Hypersensitivity reaction type II disease 2 | 235
Hypokalemia 2 | 40
Impaired glucose tolerance 2 | 12
Insulin Resistance 2 | 48
Kidney disease 2 | 396
Lewy Body Disease 2 | 19
Metabolic acidosis 2 | 49
Obesity 2 | 616
Osteoporosis 2 | 257
Parkinson Disease 2 | 102
Parkinson's disease 2 | 364
Polycystic Ovary Syndrome 2 | 332
Sensorineural hearing loss 2 | 107
Waldenstrons macroglobulinemia 2 | 765
breast carcinoma 2 | 1,614
chronic rhinosinusitis 2 | 512
group 3 medulloblastoma 2 | 2,254
hepatocellular carcinoma 2 | 532
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,988
pancreatic carcinoma 2 | 567
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
pituitary cancer 2 | 1,972
primary Sjogren syndrome 2 | 789
primary pancreatic ductal adenocarcinoma 2 | 1,271
spina bifida 2 | 1,064
tuberculosis 2 | 1,557
Anovulation 1 | 20
Calcinosis 1 | 62
Coloboma 1 | 51
Diabetic Nephropathy 1 | 37
Diabetic Retinopathy 1 | 53
Diarrhea 1 | 155
Dumping syndrome 1 | 9
Duodenal ulcer 1 | 20
Eating disorder 1 | 24
Edema 1 | 38
Exocrine pancreatic insufficiency 1 | 21
Histoplasmosis 1 | 22
Hypertrichosis 1 | 23
Hypertriglyceridemia 1 | 18
Hypertrophic Cardiomyopathy 1 | 56
Hypokalemic periodic paralysis 1 | 13
Hypotension 1 | 53
Liver Failure, Acute 1 | 22
Obstructive sleep apnea 1 | 28
Osteopetrosis, Autosomal Recessive 1 1 | 2
Ovarian Cysts 1 | 34
Pancreatitis 1 | 97
Pigmented villonodular synovitis 1 | 9
Pulmonary emphysema 1 | 34
Retinal disease 1 | 16
Type 1 diabetes mellitus 1 | 101
Ventricular Dysfunction, Left 1 | 15
Wolfram syndrome 1 | 11
maturity-onset diabetes of the young 1 | 28

Tissue

Blood and immune system 26 | 17,995
Cardiovascular System 26 | 17,958
Digestive Tract 26 | 18,473
Male tissues 26 | 17,969
Nervous System 26 | 18,561
Skin and soft tissues 26 | 18,115
Urinary Tract 26 | 18,444
Endocrine System 25 | 18,512
Female tissues 25 | 18,647
Liver and Pancreas 25 | 18,136
Respiratory system 24 | 17,484

Target Family

Enzyme 24 | 4,146
Kinase 1 | 634
Non-IDG 1 | 11,971

Reactome Pathway

Insulin receptor recycling 26 | 26
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
V-type proton ATPase catalytic subunit A ATP6V1A Tbio Enzyme -1.80191 64.7 120
Insulin INS Tbio Non-IDG -5.14691 141255.4 1549
V-type proton ATPase 116 kDa subunit a isoform 1 ATP6V0A1 Tbio Enzyme -1.36455 23.7 59
V-type proton ATPase subunit e 2 ATP6V0E2 Tdark Enzyme 0.18 0.40 19
V-type proton ATPase subunit E 1 ATP6V1E1 Tbio Enzyme -0.98803 10.3 111
V-type proton ATPase subunit B, kidney isoform ATP6V1B1 Tchem Enzyme -1.64875 40.5 209
V-type proton ATPase 16 kDa proteolipid subunit ATP6V0C Tbio Enzyme -1.83494 72.6 59
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.41643 279.3 62
V-type proton ATPase subunit D ATP6V1D Tbio Enzyme -1.48833 30.2 59
V-type proton ATPase subunit H ATP6V1H Tbio Enzyme -1.18640 16.7 95