Development Level

Tbio 839 | 10,625
Tchem 314 | 1,890
Tdark 136 | 7,003
Tclin 87 | 602

Collection

Eligible Kinase Proteins 8 | 134
Eligible Ion Channel Proteins 2 | 117
Eligible non-olfactory GPCR Proteins 2 | 143

IMPC Term

preweaning lethality, complete... 50 | 633
embryonic lethality prior to t... 22 | 187
decreased total body fat amoun... 18 | 186
decreased body weight 16 | 174
decreased lean body mass 16 | 195
preweaning lethality, incomple... 16 | 260
decreased bone mineral content 13 | 157
abnormal behavior 12 | 226
abnormal retina morphology 12 | 100
embryonic lethality prior to o... 12 | 148
abnormal lens morphology 11 | 73
increased mean corpuscular hem... 11 | 93
abnormal bone structure 10 | 131
abnormal embryo size 10 | 112
decreased grip strength 10 | 123
enlarged heart 9 | 111
increased bone mineral content 9 | 92
abnormal retinal pigmentation 8 | 61
decreased circulating choleste... 8 | 85
decreased circulating glucose ... 8 | 121
decreased circulating insulin ... 8 | 75
decreased circulating triglyce... 8 | 83
decreased lumbar vertebrae num... 8 | 62
decreased mean corpuscular vol... 8 | 50
increased circulating alkaline... 8 | 119
short tibia 8 | 82
thrombocytopenia 8 | 46
decreased body length 7 | 108
decreased bone mineral density 7 | 126
decreased circulating HDL chol... 7 | 77
decreased circulating fructosa... 7 | 31
decreased circulating serum al... 7 | 79
hypoactivity 7 | 89
increased bone mineral density 7 | 52
increased leukocyte cell numbe... 7 | 37
increased mean corpuscular vol... 7 | 91
abnormal coat/hair pigmentatio... 6 | 54
abnormal seminal vesicle morph... 6 | 47
decreased circulating creatini... 6 | 31
decreased heart weight 6 | 44
increased lean body mass 6 | 107
male infertility 6 | 62
decreased circulating alanine ... 5 | 53
decreased circulating sodium l... 5 | 18
decreased prepulse inhibition 5 | 52
enlarged lymph nodes 5 | 27
hyperactivity 5 | 108
increased grip strength 5 | 83
increased sacral vertebrae num... 5 | 62
abnormal QRS complex 4 | 25
abnormal bone mineralization 4 | 55
abnormal cornea morphology 4 | 24
cardiovascular system phenotyp... 4 | 35
cataract 4 | 26
decreased NK T cell number 4 | 28
decreased blood urea nitrogen ... 4 | 31
decreased circulating LDL chol... 4 | 37
decreased circulating bilirubi... 4 | 14
decreased circulating total pr... 4 | 41
decreased erythrocyte cell num... 4 | 43
decreased fasted circulating g... 4 | 49
decreased mean corpuscular hem... 4 | 34
decreased neutrophil cell numb... 4 | 37
impaired pupillary reflex 4 | 14
increased blood urea nitrogen ... 4 | 44
increased body weight 4 | 42
increased circulating HDL chol... 4 | 63
increased circulating LDL chol... 4 | 15
increased circulating choleste... 4 | 53
increased circulating phosphat... 4 | 24
increased circulating sodium l... 4 | 71
increased circulating total pr... 4 | 20
increased exploration in new e... 4 | 56
increased hemoglobin content 4 | 45
increased or absent threshold ... 4 | 128
increased startle reflex 4 | 38
increased total body fat amoun... 4 | 57
abnormal heart morphology 3 | 51
abnormal neural tube closure 3 | 37
abnormal testis morphology 3 | 30
decreased caudal vertebrae num... 3 | 49
decreased circulating alkaline... 3 | 41
decreased circulating aspartat... 3 | 27
decreased eosinophil cell numb... 3 | 41
decreased threshold for audito... 3 | 32
enlarged spleen 3 | 26
increased circulating calcium ... 3 | 32
increased circulating free fat... 3 | 17
increased circulating potassiu... 3 | 31
increased circulating triglyce... 3 | 24
increased erythrocyte cell num... 3 | 26
increased fasted circulating g... 3 | 68
increased gamma-delta T cell n... 3 | 16
increased mean platelet volume 3 | 19
increased rib number 3 | 41
prenatal lethality prior to he... 3 | 64
small adrenal glands 3 | 15
small superior vagus ganglion 3 | 20
small testis 3 | 37
thrombocytosis 3 | 23

Disease

osteosarcoma 682 | 7,933
ovarian cancer 681 | 8,484
psoriasis 587 | 6,685
glioblastoma 476 | 5,572
lung cancer 466 | 4,466
Cancer 454 | 2,346
medulloblastoma, large-cell 443 | 6,234
lung carcinoma 319 | 2,844
atypical teratoid / rhabdoid tumor 304 | 4,369
pilocytic astrocytoma 295 | 3,086
malignant mesothelioma 282 | 3,162
non-small cell lung cancer 275 | 2,798
intraductal papillary-mucinous neoplasm (IPMN) 271 | 3,289
interstitial cystitis 266 | 2,299
subependymal giant cell astrocytoma 265 | 2,287
ulcerative colitis 264 | 2,087
invasive ductal carcinoma 263 | 2,950
diabetes mellitus 259 | 1,663
lung adenocarcinoma 252 | 2,713
Breast cancer 250 | 3,094
intraductal papillary-mucinous adenoma (IPMA) 238 | 2,956
pediatric high grade glioma 238 | 2,712
intraductal papillary-mucinous carcinoma (IPMC) 236 | 2,988
tuberculosis 233 | 1,557
pancreatic cancer 232 | 2,300
oligodendroglioma 205 | 2,849
Rheumatoid Arthritis 189 | 1,160
ependymoma 189 | 2,514
Multiple myeloma 184 | 1,327
Carcinoma 183 | 2,147
primitive neuroectodermal tumor 180 | 3,031
astrocytoma 178 | 1,493
cutaneous lupus erythematosus 166 | 1,056
cystic fibrosis 158 | 1,665
juvenile dermatomyositis 157 | 1,189
pancreatic ductal adenocarcinoma liver metastasis 153 | 1,795
astrocytic glioma 152 | 2,241
pituitary cancer 148 | 1,972
group 4 medulloblastoma 144 | 1,875
adult high grade glioma 139 | 2,148
dermatomyositis 134 | 933
Pick disease 133 | 1,893
group 3 medulloblastoma 133 | 2,254
breast carcinoma 130 | 1,614
primary pancreatic ductal adenocarcinoma 129 | 1,271
Arthritis 124 | 248
Waldenstrons macroglobulinemia 122 | 765
acute quadriplegic myopathy 121 | 1,157
colon cancer 119 | 1,475
ductal carcinoma in situ 119 | 1,745
posterior fossa group A ependymoma 119 | 1,511
medulloblastoma 117 | 1,524
mucosa-associated lymphoid tissue lymphoma 115 | 480
primary Sjogren syndrome 115 | 789
Kidney disease 100 | 396
Hypersensitivity reaction type II disease 99 | 235
adrenocortical carcinoma 97 | 1,427
esophageal adenocarcinoma 95 | 737
gastric carcinoma 93 | 832
Atopic dermatitis 91 | 944
IGA Glomerulonephritis 90 | 454
Multiple Sclerosis 87 | 498
Alzheimer's disease 85 | 644
active Crohn's disease 83 | 918
Asthma 80 | 349
Duchenne muscular dystrophy 80 | 602
Ankylosing spondylitis 79 | 138
atypical teratoid/rhabdoid tumor 79 | 1,095
nasopharyngeal carcinoma 76 | 1,056
spina bifida 76 | 1,064
Vascular disease 75 | 281
Acquired immunodeficiency syndrome 74 | 164
sonic hedgehog group medulloblastoma 74 | 1,482
periodontitis 71 | 269
Prostatic Neoplasms 70 | 471
Anemia 69 | 252
pancreatic carcinoma 69 | 567
Obesity 68 | 616
non primary Sjogren syndrome sicca 68 | 840
posterior fossa group B ependymoma 68 | 1,530
Mammary Neoplasms 65 | 410
acute myeloid leukemia 65 | 780
Juvenile rheumatoid arthritis 63 | 104
Uveitis 63 | 103
tuberculosis and treatment for 6 months 61 | 686
hepatocellular carcinoma 60 | 532
Behcet's disease 57 | 74
Liver disease 55 | 219
Atherosclerosis 54 | 275
Down syndrome 53 | 548
Parkinson's disease 53 | 364
gastric cancer 53 | 430
non-small cell lung carcinoma 53 | 413
Psoriatic arthritis 52 | 83
Schizophrenia 52 | 501
Lung disease 51 | 132
autosomal dominant Emery-Dreifuss muscular dystrophy 51 | 499
Intellectual disability 49 | 573
chronic lymphosyte leukemia 49 | 232
head and neck cancer and chronic obstructive pulmonary disease 49 | 237

Tissue

Digestive Tract 1,273 | 18,473
Nervous System 1,272 | 18,561
Female tissues 1,270 | 18,647
Urinary Tract 1,267 | 18,444
Blood and immune system 1,262 | 17,995
Endocrine System 1,261 | 18,512
Liver and Pancreas 1,256 | 18,136
Cardiovascular System 1,249 | 17,958
Skin and soft tissues 1,246 | 18,115
Male tissues 1,238 | 17,969
Respiratory system 1,235 | 17,484

Target Family

Non-IDG 801 | 11,971
Enzyme 374 | 4,146
Kinase 129 | 634
Transcription Factor 26 | 1,400
Ion Channel 18 | 341
GPCR 13 | 406
Transporter 12 | 473
Epigenetic 2 | 242
Nuclear Receptor 1 | 48

Reactome Pathway

Innate Immune System 1,376 | 1,376
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Immunoglobulin kappa variable 3-11 IGKV3-11 Tdark Non-IDG 0.00000 0
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Antileukoproteinase SLPI Tbio Enzyme -2.56514 434.2 290