Development Level

Tbio 794 | 11,651
Tchem 207 | 1,388
Tdark 126 | 6,593
Tclin 49 | 612

Collection

RFA-RM-18-021 10 | 328
Kinase: IDG Consortium (Target... 6 | 125
GPCR: IDG Consortium (Targets) 2 | 126
Ion Channel: IDG Consortium (T... 2 | 99
GPCR: IDG Consortium (Complete... 1 | 25
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 62 | 979
preweaning lethality, incomple... 31 | 499
embryonic lethality prior to t... 24 | 278
embryonic lethality prior to o... 18 | 239
abnormal behavior 15 | 298
decreased vertical activity 14 | 208
short tibia 12 | 97
decreased bone mineral content 11 | 151
abnormal bone structure 10 | 187
abnormal seminal vesicle morph... 10 | 114
abnormal embryo size 9 | 220
decreased bone mineral density 9 | 126
decreased mean corpuscular vol... 9 | 79
abnormal retina morphology 8 | 71
cataract 8 | 92
decreased total body fat amoun... 8 | 207
hypoactivity 8 | 132
increased bone mineral content 8 | 108
increased lean body mass 8 | 172
decreased circulating choleste... 7 | 93
enlarged heart 7 | 210
hyperactivity 7 | 148
increased bone mineral density 7 | 72
increased circulating alkaline... 7 | 122
increased mean corpuscular vol... 7 | 92
increased monocyte cell number 7 | 63
increased neutrophil cell numb... 7 | 46
small superior vagus ganglion 7 | 74
abnormal lens morphology 6 | 81
decreased caudal vertebrae num... 6 | 53
decreased circulating bilirubi... 6 | 19
decreased circulating creatini... 6 | 39
decreased circulating glucose ... 6 | 126
decreased circulating insulin ... 6 | 76
decreased lymphocyte cell numb... 6 | 83
decreased mean corpuscular hem... 6 | 50
embryonic growth retardation 6 | 106
increased leukocyte cell numbe... 6 | 47
increased total body fat amoun... 6 | 134
male infertility 6 | 123
thrombocytopenia 6 | 56
abnormal coat-hair pigmentatio... 5 | 64
abnormal heart morphology 5 | 162
decreased body weight 5 | 161
decreased circulating HDL chol... 5 | 68
decreased circulating fructosa... 5 | 30
decreased circulating serum al... 5 | 82
decreased lean body mass 5 | 135
enlarged lymph nodes 5 | 37
increased circulating sodium l... 5 | 71
increased or absent threshold ... 5 | 101
abnormal cornea morphology 4 | 31
abnormal kidney morphology 4 | 65
cardiovascular system phenotyp... 4 | 36
decreased circulating phosphat... 4 | 27
decreased circulating sodium l... 4 | 22
decreased circulating triglyce... 4 | 79
decreased fasted circulating g... 4 | 65
decreased hemoglobin content 4 | 68
decreased prepulse inhibition 4 | 82
increased blood urea nitrogen ... 4 | 48
increased circulating creatini... 4 | 38
increased circulating free fat... 4 | 20
increased hemoglobin content 4 | 45
increased mean corpuscular hem... 4 | 96
increased spleen weight 4 | 10
small testis 4 | 58
abnormal coat appearance 3 | 31
abnormal testis morphology 3 | 43
decreased circulating amylase ... 3 | 28
decreased circulating iron lev... 3 | 32
decreased circulating total pr... 3 | 49
decreased erythrocyte cell num... 3 | 62
decreased grip strength 3 | 116
decreased heart left ventricle... 3 | 28
decreased hematocrit 3 | 46
decreased neutrophil cell numb... 3 | 42
edema 3 | 59
enlarged spleen 3 | 41
impaired glucose tolerance 3 | 75
increased circulating calcium ... 3 | 34
increased circulating glucose ... 3 | 24
increased circulating potassiu... 3 | 29
increased circulating total pr... 3 | 28
increased circulating triglyce... 3 | 42
increased erythrocyte cell num... 3 | 39
increased mean platelet volume 3 | 45
increased red blood cell distr... 3 | 34
increased startle reflex 3 | 112
prenatal lethality prior to he... 3 | 87
small adrenal glands 3 | 16
abnormal epididymis morphology 2 | 42
abnormal gait 2 | 69
abnormal lung morphology 2 | 26
abnormal retinal vasculature m... 2 | 27
decreased circulating potassiu... 2 | 20
enlarged urinary bladder 2 | 8
increased circulating chloride... 2 | 41
increased circulating phosphat... 2 | 26
increased hematocrit 2 | 46

Disease

Carcinoma 646 | 11,493
ovarian cancer 572 | 8,520
osteosarcoma 544 | 7,950
psoriasis 490 | 6,694
lung cancer 405 | 4,740
glioblastoma 397 | 5,792
Cancer 384 | 2,499
medulloblastoma, large-cell 337 | 6,241
lung carcinoma 273 | 2,843
atypical teratoid / rhabdoid tumor 268 | 5,112
tuberculosis 244 | 2,010
non-small cell lung cancer 241 | 2,890
ependymoma 238 | 4,679
Breast cancer 234 | 3,578
diabetes mellitus 228 | 1,728
malignant mesothelioma 228 | 3,232
Astrocytoma, Pilocytic 227 | 3,081
adult high grade glioma 224 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 220 | 3,291
subependymal giant cell astrocytoma 216 | 2,287
interstitial cystitis 214 | 2,312
lung adenocarcinoma 207 | 2,716
invasive ductal carcinoma 202 | 2,951
pancreatic cancer 196 | 2,398
intraductal papillary-mucinous carcinoma (IPMC) 193 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 192 | 2,955
ulcerative colitis 187 | 1,819
group 3 medulloblastoma 184 | 4,104
Multiple myeloma 170 | 1,332
Rheumatoid arthritis 160 | 1,191
dermatomyositis 160 | 966
pancreatic ductal adenocarcinoma liver metastasis 156 | 1,962
Kidney cancer 153 | 2,613
oligodendroglioma 144 | 2,850
cutaneous lupus erythematosus 143 | 1,057
Autosomal recessive predisposition 141 | 1,442
juvenile dermatomyositis 140 | 1,187
primitive neuroectodermal tumor 133 | 3,035
cystic fibrosis 131 | 1,696
astrocytoma 127 | 1,146
astrocytic glioma 125 | 2,597
Arthritis 124 | 290
Waldenstrons macroglobulinemia 114 | 765
group 4 medulloblastoma 111 | 1,855
pituitary cancer 111 | 1,972
Liver Cirrhosis, Experimental 109 | 769
mucosa-associated lymphoid tissue lymphoma 107 | 484
acute quadriplegic myopathy 106 | 1,158
breast carcinoma 104 | 1,638
Pick disease 99 | 1,894
primary Sjogren syndrome 96 | 735
Kidney disease 95 | 430
Schizophrenia 94 | 1,160
primary pancreatic ductal adenocarcinoma 94 | 1,109
colon cancer 92 | 1,478
Hypersensitivity reaction type II disease 91 | 253
ductal carcinoma in situ 85 | 1,745
Atopic dermatitis 84 | 952
esophageal adenocarcinoma 84 | 737
Multiple Sclerosis 82 | 540
Ankylosing spondylitis 80 | 140
adrenocortical carcinoma 76 | 1,428
active Crohn's disease 74 | 922
Duchenne muscular dystrophy 72 | 601
Human immunodeficiency virus infectious disease 72 | 138
Alzheimer's disease 71 | 658
Behcet's disease 71 | 89
Anemia 70 | 365
Asthma 70 | 385
active ulcerative colitis 70 | 764
Acquired immunodeficiency syndrome 69 | 197
periodontitis 69 | 293
Intellectual disability 68 | 1,016
pediatric high grade glioma 67 | 1,064
gastric carcinoma 65 | 807
Melanoma 64 | 711
nasopharyngeal carcinoma 64 | 1,058
Uveitis 63 | 103
Juvenile rheumatoid arthritis 62 | 111
Seizures 62 | 596
Stevens-Johnson syndrome 61 | 92
non primary Sjogren syndrome sicca 61 | 891
Epilepsy 60 | 792
Vascular disease 60 | 319
Herpes zoster 59 | 68
acute myeloid leukemia 57 | 783
Dermatitis 56 | 157
Liver disease 56 | 237
hepatocellular carcinoma 56 | 547
Bipolar Disorder 55 | 666
Obesity 55 | 678
Psoriatic arthritis 54 | 86
Dull intelligence 53 | 645
Low intelligence 53 | 645
Mental Retardation 53 | 645
Mental deficiency 53 | 645
Poor school performance 53 | 645
spina bifida 53 | 1,074
pancreatic carcinoma 52 | 562
Muscle hypotonia 50 | 571

Tissue

Endocrine System 972 | 18,159
Digestive Tract 969 | 17,369
Skin and soft tissues 966 | 17,230
Blood and immune system 962 | 16,909
Male tissues 961 | 17,142
Female tissues 960 | 17,400
Liver and Pancreas 951 | 16,750
Urinary Tract 948 | 16,678
Respiratory system 937 | 16,393
Nervous System 912 | 16,725
Cardiovascular System 892 | 15,192

Target Family

Non-IDG 705 | 12,091
Enzyme 328 | 4,145
Kinase 80 | 634
Transcription Factor 22 | 1,400
Ion Channel 14 | 344
GPCR 13 | 408
Transporter 12 | 473
Epigenetic 2 | 242

Reactome Pathway

Innate Immune System 1,176 | 1,176
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myosin-2 MYH2 Tbio Non-IDG -2.14128 114.9 63
Myeloperoxidase MPO Tchem Enzyme -3.51470 3209.3 1255
Cytoplasmic FMR1-interacting protein 1 CYFIP1 Tbio Non-IDG -1.46134 28.5 64
HLA class I histocompatibility antigen, A-25 alpha chain HLA-A Tbio Non-IDG -2.41667 4123.8 0
HLA class I histocompatibility antigen, B-51 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 0
T-cell surface glycoprotein CD3 zeta chain CD247 Tbio Non-IDG -2.61157 386.3 882
C4b-binding protein alpha chain C4BPA Tbio Non-IDG -2.43425 244.7 172