Development Level

Tbio 9 | 11,445
Tchem 2 | 1,598
Tclin 1 | 613

IMPC Phenotype

decreased erythrocyte cell num... 1 | 62
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
male infertility 1 | 123
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499

Disease

glioblastoma 9 | 5,792
medulloblastoma, large-cell 9 | 6,241
atypical teratoid / rhabdoid tumor 8 | 5,112
osteosarcoma 8 | 7,950
Carcinoma 7 | 11,493
malignant mesothelioma 7 | 3,232
group 3 medulloblastoma 6 | 4,104
primitive neuroectodermal tumor 6 | 3,035
psoriasis 6 | 6,694
lung cancer 5 | 4,740
non-small cell lung cancer 5 | 2,890
ovarian cancer 5 | 8,520
Cancer 4 | 2,499
lung adenocarcinoma 4 | 2,716
Dull intelligence 3 | 645
Intellectual disability 3 | 1,016
Kidney cancer 3 | 2,613
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Poor school performance 3 | 645
adrenocortical carcinoma 3 | 1,428
adult high grade glioma 3 | 3,801
colon cancer 3 | 1,478
Abnormality of metabolism/homeostasis 2 | 134
Atopic dermatitis 2 | 952
Breast cancer 2 | 3,578
Cognitive delay 2 | 608
Endometriosis 2 | 540
Epilepsy 2 | 792
Global developmental delay 2 | 608
Hematologic Neoplasms 2 | 22
Leukemia 2 | 104
Lung Neoplasms 2 | 232
Mental and motor retardation 2 | 608
Multiple myeloma 2 | 1,332
Muscle hypotonia 2 | 571
Orbital separation excessive 2 | 244
Rheumatoid arthritis 2 | 1,191
Seizures 2 | 596
Waldenstrons macroglobulinemia 2 | 765
astrocytic glioma 2 | 2,597
dermatomyositis 2 | 966
ependymoma 2 | 4,679
group 4 medulloblastoma 2 | 1,855
invasive ductal carcinoma 2 | 2,951
oligodendroglioma 2 | 2,850
pediatric high grade glioma 2 | 1,064
primary Sjogren syndrome 2 | 735
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis and treatment for 6 months 2 | 409
Abnormal vision 1 | 52
Acute lymphoid leukemia 1 | 25
Acute myeloid leukemia, disease 1 | 30
Adrenal Gland Neoplasms 1 | 11
Age related macular degeneration 1 | 72
Animal Mammary Neoplasms 1 | 136
Basal cell carcinoma 1 | 54
Brachydactyly 1 | 156
Breast Neoplasms 1 | 445
Carcinoma, Basal Cell 1 | 28
Carcinoma, Non-Small-Cell Lung 1 | 107
Carcinoma, Small Cell 1 | 9
Cloudy cornea 1 | 33
Convex nasal bridge 1 | 57
Corneal stromal opacities 1 | 33
Delayed myelination 1 | 22
Esophageal Squamous Cell Carcinoma 1 | 77
Gastrointestinal Stromal Tumors 1 | 48
Gross motor development delay 1 | 21
Hepatitis C 1 | 94
Hypotrichosis 8 1 | 6
Infectious disease of lung 1 | 29
Inverted V-shaped upper lip 1 | 19
Liver Neoplasms, Experimental 1 | 59
Malignant tumor of ovary 1 | 25
Mammary Neoplasms, Animal 1 | 136
Mammary Neoplasms, Experimental 1 | 154
Metastatic Breast Carcinoma 1 | 21
Multiple pulmonary infections 1 | 29
Ocular cancer 1 | 7
Open mouth 1 | 45
Prominent nasal bridge 1 | 57
Recurrent pneumonia 1 | 29
Recurrent pulmonary infections 1 | 29
Retinal Neoplasms 1 | 3
Retinoblastoma 1 | 19
Sezary Syndrome 1 | 27
Small cell carcinoma of lung 1 | 45
Somatic mutation 1 | 61
Squamous cell carcinoma of esophagus 1 | 77
Stevens-Johnson syndrome 1 | 92
Syndactyly of fingers 1 | 48
Tented mouth 1 | 19
Tented upper lip 1 | 19
Transitional cell carcinoma of bladder 1 | 17
Urethral Stricture 1 | 18
Usher syndrome type 1C 1 | 3
Uterine fibroid 1 | 28
non-small cell lung carcinoma 1 | 317

Tissue

Blood and immune system 12 | 16,909
Cardiovascular System 12 | 15,192
Digestive Tract 12 | 17,369
Endocrine System 12 | 18,159
Female tissues 12 | 17,400
Liver and Pancreas 12 | 16,750
Male tissues 12 | 17,142
Nervous System 12 | 16,725
Respiratory system 12 | 16,393
Skin and soft tissues 12 | 17,230
Urinary Tract 12 | 16,678

Target Family

Enzyme 9 | 4,145
Transcription Factor 2 | 1,400
Non-IDG 1 | 12,091

Reactome Pathway

Inhibition of replication init... 12 | 12
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA primase large subunit PRIM2 Tbio Enzyme 0.00000 89
Retinoblastoma-associated protein RB1 Tchem Non-IDG -3.07052 1137.4 2150
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform PPP2R1B Tbio Enzyme -1.20793 16.9 203
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta PPP2R3B Tbio Enzyme -1.28190 19.5 142
DNA primase small subunit PRIM1 Tbio Enzyme -0.87865 7.80 138
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform PPP2CB Tbio Enzyme -1.13726 11.3 290
DNA polymerase alpha catalytic subunit POLA1 Tclin Enzyme -2.40809 246.5 129
DNA polymerase alpha subunit B POLA2 Tbio Enzyme -0.54940 3.76 182
Transcription factor Dp-1 TFDP1 Tbio Transcription Factor -1.60201 42.3 256
Transcription factor Dp-2 TFDP2 Tbio Transcription Factor -0.71407 4.94 153