Development Level

Tbio 9 | 11,651
Tchem 2 | 1,388
Tclin 1 | 612

IMPC Phenotype

decreased erythrocyte cell num... 1 | 62
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
male infertility 1 | 123
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499

Disease

glioblastoma 9 | 5,792
medulloblastoma, large-cell 9 | 6,241
atypical teratoid / rhabdoid tumor 8 | 5,112
osteosarcoma 8 | 7,950
Carcinoma 7 | 11,493
malignant mesothelioma 7 | 3,232
group 3 medulloblastoma 6 | 4,104
primitive neuroectodermal tumor 6 | 3,035
psoriasis 6 | 6,694
lung cancer 5 | 4,740
non-small cell lung cancer 5 | 2,890
ovarian cancer 5 | 8,520
Cancer 4 | 2,499
lung adenocarcinoma 4 | 2,716
Dull intelligence 3 | 645
Intellectual disability 3 | 1,016
Kidney cancer 3 | 2,613
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Poor school performance 3 | 645
adrenocortical carcinoma 3 | 1,428
adult high grade glioma 3 | 3,801
colon cancer 3 | 1,478
Abnormality of metabolism/homeostasis 2 | 134
Atopic dermatitis 2 | 952
Breast cancer 2 | 3,578
Cognitive delay 2 | 608
Endometriosis 2 | 540
Epilepsy 2 | 792
Global developmental delay 2 | 608
Hematologic Neoplasms 2 | 22
Leukemia 2 | 104
Lung Neoplasms 2 | 232
Mental and motor retardation 2 | 608
Multiple myeloma 2 | 1,332
Muscle hypotonia 2 | 571
Orbital separation excessive 2 | 244
Rheumatoid arthritis 2 | 1,191
Seizures 2 | 596
Waldenstrons macroglobulinemia 2 | 765
astrocytic glioma 2 | 2,597
dermatomyositis 2 | 966
ependymoma 2 | 4,679
group 4 medulloblastoma 2 | 1,855
invasive ductal carcinoma 2 | 2,951
oligodendroglioma 2 | 2,850
pediatric high grade glioma 2 | 1,064
primary Sjogren syndrome 2 | 735
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis and treatment for 6 months 2 | 409
Abnormal vision 1 | 52
Acute lymphoid leukemia 1 | 25
Acute myeloid leukemia, disease 1 | 30
Adrenal Gland Neoplasms 1 | 11
Age related macular degeneration 1 | 72
Animal Mammary Neoplasms 1 | 136
Basal cell carcinoma 1 | 54
Brachydactyly 1 | 156
Breast Neoplasms 1 | 445
Carcinoma, Basal Cell 1 | 28
Carcinoma, Non-Small-Cell Lung 1 | 107
Carcinoma, Small Cell 1 | 9
Cloudy cornea 1 | 33
Convex nasal bridge 1 | 57
Corneal stromal opacities 1 | 33
Delayed myelination 1 | 22
Esophageal Squamous Cell Carcinoma 1 | 77
Gastrointestinal Stromal Tumors 1 | 48
Gross motor development delay 1 | 21
Hepatitis C 1 | 94
Hypotrichosis 8 1 | 6
Infectious disease of lung 1 | 29
Inverted V-shaped upper lip 1 | 19
Liver Neoplasms, Experimental 1 | 59
Malignant tumor of ovary 1 | 25
Mammary Neoplasms, Animal 1 | 136
Mammary Neoplasms, Experimental 1 | 154
Metastatic Breast Carcinoma 1 | 21
Multiple pulmonary infections 1 | 29
Ocular cancer 1 | 7
Open mouth 1 | 45
Prominent nasal bridge 1 | 57
Recurrent pneumonia 1 | 29
Recurrent pulmonary infections 1 | 29
Retinal Neoplasms 1 | 3
Retinoblastoma 1 | 19
Sezary Syndrome 1 | 27
Small cell carcinoma of lung 1 | 45
Somatic mutation 1 | 61
Squamous cell carcinoma of esophagus 1 | 77
Stevens-Johnson syndrome 1 | 92
Syndactyly of fingers 1 | 48
Tented mouth 1 | 19
Tented upper lip 1 | 19
Transitional cell carcinoma of bladder 1 | 17
Urethral Stricture 1 | 18
Usher syndrome type 1C 1 | 3
Uterine fibroid 1 | 28
non-small cell lung carcinoma 1 | 317

Tissue

Blood and immune system 12 | 16,909
Cardiovascular System 12 | 15,192
Digestive Tract 12 | 17,369
Endocrine System 12 | 18,159
Female tissues 12 | 17,400
Liver and Pancreas 12 | 16,750
Male tissues 12 | 17,142
Nervous System 12 | 16,725
Respiratory system 12 | 16,393
Skin and soft tissues 12 | 17,230
Urinary Tract 12 | 16,678

Target Family

Enzyme 9 | 4,145
Transcription Factor 2 | 1,400
Non-IDG 1 | 12,091

Reactome Pathway

Inhibition of replication init... 12 | 12
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform PPP2R1B Tbio Enzyme -1.20793 16.9 203
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta PPP2R3B Tbio Enzyme -1.28190 19.5 142
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform PPP2CB Tbio Enzyme -1.13726 11.3 290
DNA primase small subunit PRIM1 Tbio Enzyme -0.87865 7.80 138
DNA polymerase alpha catalytic subunit POLA1 Tclin Enzyme -2.40809 246.5 129
DNA polymerase alpha subunit B POLA2 Tbio Enzyme -0.54940 3.76 182
Transcription factor Dp-1 TFDP1 Tbio Transcription Factor -1.60201 42.3 256
Transcription factor Dp-2 TFDP2 Tbio Transcription Factor -0.71407 4.94 153
DNA primase large subunit PRIM2 Tbio Enzyme 0.00000 89
Retinoblastoma-associated protein RB1 Tchem Non-IDG -3.07052 1137.4 2150