Development Level

Tbio 121 | 10,625
Tdark 11 | 7,003
Tchem 4 | 1,890

IMPC Term

preweaning lethality, complete... 5 | 633
abnormal snout morphology 1 | 18
decreased caudal vertebrae num... 1 | 49
decreased circulating sodium l... 1 | 18
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
increased circulating free fat... 1 | 17
increased grip strength 1 | 83
male infertility 1 | 62

Disease

ovarian cancer 58 | 8,484
lung cancer 56 | 4,466
osteosarcoma 39 | 7,933
medulloblastoma, large-cell 38 | 6,234
Multiple myeloma 33 | 1,327
intraductal papillary-mucinous neoplasm (IPMN) 32 | 3,289
diabetes mellitus 30 | 1,663
Diamond-Blackfan anemia 23 | 28
atypical teratoid / rhabdoid tumor 22 | 4,369
glioblastoma 22 | 5,572
psoriasis 22 | 6,685
Waldenstrons macroglobulinemia 21 | 765
group 3 medulloblastoma 20 | 2,254
sonic hedgehog group medulloblastoma 20 | 1,482
oligodendroglioma 16 | 2,849
acute quadriplegic myopathy 15 | 1,157
pediatric high grade glioma 15 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,988
malignant mesothelioma 14 | 3,162
primitive neuroectodermal tumor 14 | 3,031
Anemia, Diamond-Blackfan 13 | 15
Breast cancer 12 | 3,094
invasive ductal carcinoma 12 | 2,950
Carcinoma 11 | 2,147
acute myeloid leukemia 11 | 780
astrocytoma 11 | 1,493
colon cancer 11 | 1,475
dermatomyositis 11 | 933
non-small cell lung cancer 11 | 2,798
astrocytic glioma 9 | 2,241
cystic fibrosis 9 | 1,665
ependymoma 9 | 2,514
lung adenocarcinoma 9 | 2,713
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,795
subependymal giant cell astrocytoma 9 | 2,287
Disease Progression 8 | 125
Stomach Neoplasms 8 | 282
pilocytic astrocytoma 8 | 3,086
Anemia 7 | 252
Cancer 7 | 2,346
Mammary Neoplasms 7 | 410
Pick disease 7 | 1,893
Rheumatoid Arthritis 7 | 1,160
adult high grade glioma 7 | 2,148
inflammatory breast cancer 7 | 404
atypical teratoid/rhabdoid tumor 6 | 1,095
breast carcinoma 6 | 1,614
mucosa-associated lymphoid tissue lymphoma 6 | 480
Prostatic Neoplasms 5 | 471
juvenile dermatomyositis 5 | 1,189
pancreatic cancer 5 | 2,300
ulcerative colitis 5 | 2,087
Parkinson Disease 4 | 102
Weight Gain 4 | 87
adrenocortical carcinoma 4 | 1,427
cutaneous lupus erythematosus 4 | 1,056
glioblastoma multiforme 4 | 347
medulloblastoma 4 | 1,524
posterior fossa group A ependymoma 4 | 1,511
Amyotrophic Lateral Sclerosis 3 | 431
Animal Mammary Neoplasms 3 | 136
Atopic dermatitis 3 | 944
Duchenne muscular dystrophy 3 | 602
Irregular astigmatism 3 | 11
Mammary Neoplasms, Experimental 3 | 150
Mesenchymal chondrosarcoma 3 | 4
Mixed connective tissue disease 3 | 16
Polycystic Ovary Syndrome 3 | 332
Pure red-cell aplasia 3 | 4
ductal carcinoma in situ 3 | 1,745
group 4 medulloblastoma 3 | 1,875
hereditary spastic paraplegia 3 | 313
interstitial lung disease 3 | 291
lung carcinoma 3 | 2,844
nasopharyngeal carcinoma 3 | 1,056
non primary Sjogren syndrome sicca 3 | 840
pancreatic carcinoma 3 | 567
posterior fossa group B ependymoma 3 | 1,530
primary pancreatic ductal adenocarcinoma 3 | 1,271
spina bifida 3 | 1,064
Anoxia 2 | 33
Atherosclerosis 2 | 275
Cockayne syndrome 2 | 54
Eumycotic mycetoma 2 | 3
Feingold syndrome 2 | 14
HIV Infections 2 | 100
Hypertension 2 | 287
Leukemia 2 | 88
Neurodegenerative disease 2 | 383
Osteoporosis 2 | 257
Shwachman-Diamond syndrome 2 | 16
Turner syndrome 2 | 31
active Crohn's disease 2 | 918
aldosterone-producing adenoma 2 | 664
cystic fibrosis and chronic rhinosinusitis 2 | 213
hepatocellular carcinoma 2 | 532
non diabetic and post-ischemic heart failure 2 | 200
pituitary cancer 2 | 1,972
progressive supranuclear palsy 2 | 674

Tissue

Blood and immune system 136 | 17,995
Cardiovascular System 136 | 17,958
Endocrine System 136 | 18,512
Female tissues 136 | 18,647
Liver and Pancreas 136 | 18,136
Male tissues 136 | 17,969
Nervous System 136 | 18,561
Digestive Tract 135 | 18,473
Respiratory system 135 | 17,484
Urinary Tract 135 | 18,444
Skin and soft tissues 133 | 18,115

Target Family

Non-IDG 122 | 11,971
Enzyme 14 | 4,146

Reactome Pathway

Influenza Viral RNA Transcript... 136 | 136
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
Nuclear pore complex protein Nup98-Nup96 NUP98 Tbio Enzyme -2.21148 186.3 172
DNA-directed RNA polymerase II subunit RPB7 POLR2G Tbio Enzyme -1.74939 59.4 153
60S ribosomal protein L7a RPL7A Tbio Non-IDG -1.66015 45.9 60
60S ribosomal protein L18 RPL18 Tbio Non-IDG -1.73537 50.7 134
Nucleoporin p58/p45 NUP58 Tdark Non-IDG -0.70757 5.23 31
60S ribosomal protein L38 RPL38 Tdark Non-IDG -1.39563 24.2 45
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
40S ribosomal protein S4, Y isoform 1 RPS4Y1 Tbio Non-IDG -1.22796 15.4 118
60S ribosomal protein L8 RPL8 Tbio Non-IDG -1.56871 36.4 182