Development Level

Tbio 140 | 11,445
Tdark 10 | 6,588
Tchem 4 | 1,598

IMPC Phenotype

preweaning lethality, complete... 8 | 979
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
abnormal heart morphology 1 | 162
abnormal snout morphology 1 | 23
decreased circulating sodium l... 1 | 22
decreased vertical activity 1 | 208
enlarged heart 1 | 210
increased circulating free fat... 1 | 20
increased grip strength 1 | 41
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
male infertility 1 | 123
prolonged QT interval 1 | 38

Disease

ovarian cancer 72 | 8,520
lung cancer 60 | 4,740
Carcinoma 56 | 11,493
osteosarcoma 49 | 7,950
medulloblastoma, large-cell 45 | 6,241
Multiple myeloma 40 | 1,332
intraductal papillary-mucinous neoplasm (IPMN) 36 | 3,291
atypical teratoid / rhabdoid tumor 33 | 5,112
psoriasis 33 | 6,694
diabetes mellitus 32 | 1,728
glioblastoma 31 | 5,792
group 3 medulloblastoma 30 | 4,104
Waldenstrons macroglobulinemia 27 | 765
Diamond-Blackfan anemia 25 | 31
Breast cancer 23 | 3,578
acute quadriplegic myopathy 22 | 1,158
oligodendroglioma 20 | 2,850
ependymoma 19 | 4,679
adult high grade glioma 18 | 3,801
malignant mesothelioma 18 | 3,232
dermatomyositis 16 | 966
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
primitive neuroectodermal tumor 15 | 3,035
Anemia 14 | 365
Cleft Palate 14 | 271
Delayed Puberty 14 | 97
astrocytic glioma 14 | 2,597
invasive ductal carcinoma 14 | 2,951
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
sonic hedgehog group medulloblastoma 14 | 467
Abnormality of the urinary system 13 | 21
Anemia, Diamond-Blackfan 13 | 16
Anemia, Macrocytic 13 | 18
Cancer 13 | 2,499
Cardiac Arrhythmia 13 | 103
Cardiac conduction abnormalities 13 | 78
Conduction disorder of the heart 13 | 79
EKG abnormalities 13 | 78
Electrocardiogram abnormal 13 | 81
Electrocardiogram change 13 | 78
Fatigue 13 | 182
Hand deformities 13 | 32
Intermittent migraine headaches 13 | 68
Kidney cancer 13 | 2,613
Migraine Disorders 13 | 76
Pallor 13 | 40
Uranostaphyloschisis 13 | 167
acute myeloid leukemia 13 | 783
genital abnormal 13 | 17
lung adenocarcinoma 13 | 2,716
reproductive system abnormality 13 | 17
Astrocytoma, Pilocytic 12 | 3,081
colon cancer 12 | 1,478
cystic fibrosis 12 | 1,696
non-small cell lung cancer 12 | 2,890
subependymal giant cell astrocytoma 12 | 2,287
astrocytoma 11 | 1,146
Pick disease 10 | 1,894
juvenile dermatomyositis 10 | 1,187
breast carcinoma 9 | 1,638
pancreatic cancer 9 | 2,398
Disease Progression 8 | 136
Stomach Neoplasms 8 | 300
group 4 medulloblastoma 8 | 1,855
pediatric high grade glioma 8 | 1,064
ulcerative colitis 8 | 1,819
Adenocarcinoma of lung 7 | 142
Breast Neoplasms 7 | 445
Disease Models, Animal 7 | 155
Mammary Neoplasms 7 | 425
Prostatic Neoplasms 7 | 495
mucosa-associated lymphoid tissue lymphoma 7 | 484
Amyotrophic lateral sclerosis 6 | 451
Duchenne muscular dystrophy 6 | 601
Rheumatoid arthritis 6 | 1,191
adrenocortical carcinoma 6 | 1,428
cutaneous lupus erythematosus 6 | 1,057
Autosomal recessive predisposition 5 | 1,442
Influenza 5 | 142
Reticulocytopenia 5 | 10
hereditary spastic paraplegia 5 | 318
inflammatory breast cancer 5 | 286
lung carcinoma 5 | 2,843
medulloblastoma 5 | 720
nasopharyngeal carcinoma 5 | 1,058
non primary Sjogren syndrome sicca 5 | 891
primary pancreatic ductal adenocarcinoma 5 | 1,109
tuberculosis 5 | 2,010
Animal Mammary Neoplasms 4 | 136
Atopic dermatitis 4 | 952
HIV Infections 4 | 102
Infantile onset 4 | 238
Mammary Neoplasms, Experimental 4 | 154
Neoplasm Invasiveness 4 | 161
Parkinson Disease 4 | 64
Schizophrenia 4 | 1,160
Short stature 4 | 531
active Crohn's disease 4 | 922
spina bifida 4 | 1,074

Tissue

Digestive Tract 151 | 17,369
Endocrine System 151 | 18,159
Blood and immune system 150 | 16,909
Female tissues 150 | 17,400
Liver and Pancreas 150 | 16,750
Male tissues 150 | 17,142
Respiratory system 150 | 16,393
Skin and soft tissues 150 | 17,230
Cardiovascular System 149 | 15,192
Nervous System 149 | 16,725
Urinary Tract 149 | 16,678

Target Family

Non-IDG 137 | 12,091
Enzyme 15 | 4,145
Kinase 1 | 634
Transporter 1 | 473

Reactome Pathway

Influenza Infection 154 | 154
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Heat shock protein HSP 90-alpha HSP90AA1 Tchem Non-IDG -3.31859 4681.5 1057
Clathrin heavy chain 1 CLTC Tbio Non-IDG -1.66258 38.8 231
Calnexin CANX Tbio Non-IDG -2.87537 714.9 630
Exportin-1 XPO1 Tbio Non-IDG -3.14385 1273.6 200
Calreticulin CALR Tbio Non-IDG -3.19563 1544.2 778
DNA-directed RNA polymerase II subunit RPB1 POLR2A Tbio Enzyme -2.40028 236.4 437
Importin subunit beta-1 KPNB1 Tbio Non-IDG -1.63038 38.8 174
Transforming growth factor beta-1 TGFB1 Tchem Non-IDG -3.84680 5672.0 1222
GTP-binding nuclear protein Ran RAN Tbio Enzyme -2.54769 316.0 452
Nucleoprotein TPR TPR Tbio Non-IDG -2.11491 135.6 161