Development Level

Tbio 138 | 10,625
Tdark 12 | 7,003
Tchem 5 | 1,890

IMPC Term

preweaning lethality, complete... 5 | 633
abnormal snout morphology 1 | 18
decreased caudal vertebrae num... 1 | 49
decreased circulating sodium l... 1 | 18
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
increased circulating free fat... 1 | 17
increased grip strength 1 | 83
male infertility 1 | 62

Disease

ovarian cancer 72 | 8,484
lung cancer 61 | 4,466
osteosarcoma 49 | 7,933
medulloblastoma, large-cell 46 | 6,234
Multiple myeloma 40 | 1,327
intraductal papillary-mucinous neoplasm (IPMN) 36 | 3,289
psoriasis 33 | 6,685
diabetes mellitus 32 | 1,663
glioblastoma 29 | 5,572
atypical teratoid / rhabdoid tumor 28 | 4,369
Waldenstrons macroglobulinemia 27 | 765
Diamond-Blackfan anemia 23 | 28
acute quadriplegic myopathy 22 | 1,157
sonic hedgehog group medulloblastoma 22 | 1,482
group 3 medulloblastoma 21 | 2,254
oligodendroglioma 20 | 2,849
pediatric high grade glioma 19 | 2,712
malignant mesothelioma 18 | 3,162
Breast cancer 17 | 3,094
dermatomyositis 16 | 933
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,988
primitive neuroectodermal tumor 15 | 3,031
Cancer 14 | 2,346
ependymoma 14 | 2,514
invasive ductal carcinoma 14 | 2,950
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,795
Anemia, Diamond-Blackfan 13 | 15
Carcinoma 13 | 2,147
acute myeloid leukemia 13 | 780
astrocytoma 13 | 1,493
lung adenocarcinoma 13 | 2,713
astrocytic glioma 12 | 2,241
colon cancer 12 | 1,475
cystic fibrosis 12 | 1,665
non-small cell lung cancer 12 | 2,798
pilocytic astrocytoma 12 | 3,086
subependymal giant cell astrocytoma 12 | 2,287
Pick disease 10 | 1,893
inflammatory breast cancer 10 | 404
juvenile dermatomyositis 10 | 1,189
breast carcinoma 9 | 1,614
pancreatic cancer 9 | 2,300
Disease Progression 8 | 125
Prostatic Neoplasms 8 | 471
Stomach Neoplasms 8 | 282
ulcerative colitis 8 | 2,087
Anemia 7 | 252
Mammary Neoplasms 7 | 410
Rheumatoid Arthritis 7 | 1,160
adult high grade glioma 7 | 2,148
atypical teratoid/rhabdoid tumor 7 | 1,095
group 4 medulloblastoma 7 | 1,875
medulloblastoma 7 | 1,524
mucosa-associated lymphoid tissue lymphoma 7 | 480
Duchenne muscular dystrophy 6 | 602
adrenocortical carcinoma 6 | 1,427
cutaneous lupus erythematosus 6 | 1,056
posterior fossa group A ependymoma 6 | 1,511
Amyotrophic Lateral Sclerosis 5 | 431
Influenza 5 | 142
glioblastoma multiforme 5 | 347
hereditary spastic paraplegia 5 | 313
lung carcinoma 5 | 2,844
nasopharyngeal carcinoma 5 | 1,056
primary pancreatic ductal adenocarcinoma 5 | 1,271
Animal Mammary Neoplasms 4 | 136
Atopic dermatitis 4 | 944
HIV Infections 4 | 100
IGA Glomerulonephritis 4 | 454
Mammary Neoplasms, Experimental 4 | 150
Neoplasm Invasiveness 4 | 127
Parkinson Disease 4 | 102
Weight Gain 4 | 87
active Crohn's disease 4 | 918
non primary Sjogren syndrome sicca 4 | 840
primary Sjogren syndrome 4 | 789
spina bifida 4 | 1,064
Alzheimer's disease 3 | 644
Atherosclerosis 3 | 275
Hypertension 3 | 287
Irregular astigmatism 3 | 11
Malaria 3 | 140
Mesenchymal chondrosarcoma 3 | 4
Mixed connective tissue disease 3 | 16
Multiple Sclerosis 3 | 498
Myocardial Ischemia 3 | 169
Osteoporosis 3 | 257
Polycystic Ovary Syndrome 3 | 332
Pure red-cell aplasia 3 | 4
aldosterone-producing adenoma 3 | 664
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 499
ductal carcinoma in situ 3 | 1,745
interstitial lung disease 3 | 291
pancreatic carcinoma 3 | 567
pituitary cancer 3 | 1,972
posterior fossa group B ependymoma 3 | 1,530
progressive supranuclear palsy 3 | 674
systemic lupus erythematosus 3 | 156
tuberculosis 3 | 1,557

Tissue

Blood and immune system 155 | 17,995
Cardiovascular System 155 | 17,958
Endocrine System 155 | 18,512
Female tissues 155 | 18,647
Liver and Pancreas 155 | 18,136
Male tissues 155 | 17,969
Nervous System 155 | 18,561
Digestive Tract 154 | 18,473
Respiratory system 154 | 17,484
Urinary Tract 154 | 18,444
Skin and soft tissues 152 | 18,115

Target Family

Non-IDG 138 | 11,971
Enzyme 15 | 4,146
Kinase 1 | 634
Transporter 1 | 473

Reactome Pathway

Influenza Infection 155 | 155
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
Nuclear pore complex protein Nup98-Nup96 NUP98 Tbio Enzyme -2.21148 186.3 172
DNA-directed RNA polymerase II subunit RPB7 POLR2G Tbio Enzyme -1.74939 59.4 153
60S ribosomal protein L7a RPL7A Tbio Non-IDG -1.66015 45.9 60
60S ribosomal protein L18 RPL18 Tbio Non-IDG -1.73537 50.7 134
Nucleoporin p58/p45 NUP58 Tdark Non-IDG -0.70757 5.23 31
60S ribosomal protein L38 RPL38 Tdark Non-IDG -1.39563 24.2 45
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
40S ribosomal protein S4, Y isoform 1 RPS4Y1 Tbio Non-IDG -1.22796 15.4 118