Development Level

Tbio 138 | 10,625
Tdark 12 | 7,003
Tchem 5 | 1,890

IMPC Phenotype

preweaning lethality, complete... 5 | 633
abnormal snout morphology 1 | 18
decreased caudal vertebrae num... 1 | 49
decreased circulating sodium l... 1 | 18
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
increased circulating free fat... 1 | 17
increased grip strength 1 | 83
male infertility 1 | 62

Disease

ovarian cancer 72 | 8,491
lung cancer 61 | 4,473
osteosarcoma 49 | 7,933
medulloblastoma, large-cell 46 | 6,234
Multiple myeloma 40 | 1,327
intraductal papillary-mucinous neoplasm (IPMN) 36 | 3,289
psoriasis 33 | 6,685
diabetes mellitus 32 | 1,663
glioblastoma 29 | 5,572
atypical teratoid / rhabdoid tumor 28 | 4,369
Waldenstrons macroglobulinemia 27 | 764
Diamond-Blackfan anemia 24 | 30
acute quadriplegic myopathy 22 | 1,157
sonic hedgehog group medulloblastoma 22 | 1,482
group 3 medulloblastoma 21 | 2,254
oligodendroglioma 20 | 2,849
pediatric high grade glioma 19 | 2,712
malignant mesothelioma 18 | 3,163
Breast cancer 17 | 3,098
dermatomyositis 16 | 966
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,988
primitive neuroectodermal tumor 15 | 3,031
Cancer 14 | 2,346
ependymoma 14 | 2,514
invasive ductal carcinoma 14 | 2,950
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,795
Anemia, Diamond-Blackfan 13 | 15
Carcinoma 13 | 2,147
acute myeloid leukemia 13 | 785
astrocytoma 13 | 1,493
lung adenocarcinoma 13 | 2,714
astrocytic glioma 12 | 2,241
colon cancer 12 | 1,475
cystic fibrosis 12 | 1,670
non-small cell lung cancer 12 | 2,798
pilocytic astrocytoma 12 | 3,086
subependymal giant cell astrocytoma 12 | 2,287
Pick disease 10 | 1,893
inflammatory breast cancer 10 | 404
juvenile dermatomyositis 10 | 1,189
breast carcinoma 9 | 1,614
pancreatic cancer 9 | 2,300
Disease Progression 8 | 125
Prostatic Neoplasms 8 | 471
Stomach Neoplasms 8 | 282
ulcerative colitis 8 | 2,087
Anemia 7 | 252
Mammary Neoplasms 7 | 410
Rheumatoid Arthritis 7 | 1,170
adult high grade glioma 7 | 2,148
atypical teratoid/rhabdoid tumor 7 | 1,095
group 4 medulloblastoma 7 | 1,875
medulloblastoma 7 | 1,524
mucosa-associated lymphoid tissue lymphoma 7 | 480
Duchenne muscular dystrophy 6 | 602
adrenocortical carcinoma 6 | 1,427
cutaneous lupus erythematosus 6 | 1,056
posterior fossa group A ependymoma 6 | 1,511
Amyotrophic Lateral Sclerosis 5 | 432
Influenza 5 | 142
glioblastoma multiforme 5 | 347
hereditary spastic paraplegia 5 | 313
lung carcinoma 5 | 2,844
nasopharyngeal carcinoma 5 | 1,056
primary pancreatic ductal adenocarcinoma 5 | 1,271
Animal Mammary Neoplasms 4 | 135
Atopic dermatitis 4 | 944
HIV Infections 4 | 99
IGA Glomerulonephritis 4 | 454
Mammary Neoplasms, Experimental 4 | 149
Neoplasm Invasiveness 4 | 127
Parkinson Disease 4 | 105
Weight Gain 4 | 87
active Crohn's disease 4 | 918
non primary Sjogren syndrome sicca 4 | 840
primary Sjogren syndrome 4 | 788
spina bifida 4 | 1,064
Alzheimer's disease 3 | 644
Atherosclerosis 3 | 275
Hypertension 3 | 293
Irregular astigmatism 3 | 11
Malaria 3 | 140
Mesenchymal chondrosarcoma 3 | 4
Mixed connective tissue disease 3 | 16
Multiple Sclerosis 3 | 498
Myocardial Ischemia 3 | 169
Osteoporosis 3 | 259
Polycystic Ovary Syndrome 3 | 334
Pure red-cell aplasia 3 | 4
aldosterone-producing adenoma 3 | 664
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 499
ductal carcinoma in situ 3 | 1,745
interstitial lung disease 3 | 292
pancreatic carcinoma 3 | 567
pituitary cancer 3 | 1,972
posterior fossa group B ependymoma 3 | 1,530
progressive supranuclear palsy 3 | 674
systemic lupus erythematosus 3 | 172
tuberculosis 3 | 1,563

Tissue

Blood and immune system 155 | 17,994
Cardiovascular System 155 | 17,957
Endocrine System 155 | 18,511
Female tissues 155 | 18,646
Liver and Pancreas 155 | 18,135
Male tissues 155 | 17,968
Nervous System 155 | 18,560
Digestive Tract 154 | 18,472
Respiratory system 154 | 17,483
Urinary Tract 154 | 18,443
Skin and soft tissues 152 | 18,114

Target Family

Non-IDG 138 | 11,969
Enzyme 15 | 4,146
Kinase 1 | 634
Transporter 1 | 473

Reactome Pathway

Influenza Infection 155 | 155
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.47495 286.5 135
40S ribosomal protein S19 RPS19 Tbio Non-IDG -3.12258 1305.7 243
DNA-directed RNA polymerases I, II, and III subunit RPABC3 POLR2H Tbio Enzyme -1.14104 13.5 159
DNA-directed RNA polymerase II subunit RPB11-a POLR2J Tbio Enzyme -1.42612 28.8 182
Calreticulin CALR Tbio Non-IDG -3.16449 1423.9 650
60S ribosomal protein L13a RPL13A Tbio Non-IDG -1.62587 63.2 46
40S ribosomal protein S7 RPS7 Tbio Non-IDG -1.83618 67.7 104
Nucleoporin p58/p45 NUP58 Tdark Non-IDG -0.63849 5.23 31
60S ribosomal protein L38 RPL38 Tdark Non-IDG -1.39373 24.2 45
DNA-directed RNA polymerases I, II, and III subunit RPABC4 POLR2K Tbio Enzyme -0.89072 7.36 47