Development Level

Tbio 340 | 11,445
Tchem 28 | 1,598
Tclin 18 | 613
Tdark 18 | 6,588

IMPC Phenotype

preweaning lethality, complete... 37 | 979
embryonic lethality prior to o... 10 | 239
embryonic lethality prior to t... 9 | 278
preweaning lethality, incomple... 7 | 499
abnormal embryo size 6 | 220
hypoactivity 5 | 132
abnormal heart morphology 4 | 162
decreased vertical activity 4 | 208
enlarged heart 4 | 210
abnormal behavior 3 | 298
abnormal retina morphology 3 | 71
abnormal skin morphology 3 | 50
decreased caudal vertebrae num... 3 | 53
increased leukocyte cell numbe... 3 | 47
increased total body fat amoun... 3 | 134
prolonged QT interval 3 | 38
abnormal body wall morphology 2 | 9
abnormal bone structure 2 | 187
abnormal craniofacial morpholo... 2 | 33
abnormal kidney morphology 2 | 65
decreased bone mineral density 2 | 126
embryonic growth retardation 2 | 106
hydrometra 2 | 53
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased circulating free fat... 2 | 20
increased circulating potassiu... 2 | 29
increased erythrocyte cell num... 2 | 39
increased grip strength 2 | 41
increased or absent threshold ... 2 | 101
increased startle reflex 2 | 112
male infertility 2 | 123
prolonged ST segment 2 | 36
small superior vagus ganglion 2 | 74
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal cecum morphology 1 | 7
abnormal epididymis morphology 1 | 42
abnormal femur morphology 1 | 14
abnormal forebrain morphology 1 | 10
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal hindbrain morphology 1 | 10
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal placenta size 1 | 20
abnormal retinal inner nuclear... 1 | 8
abnormal seminal vesicle morph... 1 | 114
abnormal snout morphology 1 | 23
abnormal startle reflex 1 | 15
abnormal vibrissa morphology 1 | 25
absent pinna reflex 1 | 23
absent startle reflex 1 | 24
brachydactyly 1 | 19
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased T cell number 1 | 15
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating alkaline... 1 | 46
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased lean body mass 1 | 135
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
decreased total retina thickne... 1 | 17
edema 1 | 59
enlarged cecum 1 | 5
enlarged epididymis 1 | 31
enlarged spleen 1 | 41
female infertility 1 | 60
hemorrhage 1 | 23
improved glucose tolerance 1 | 79
increased CD4-positive, alpha ... 1 | 4
increased anti-nuclear antigen... 1 | 19
increased blood urea nitrogen ... 1 | 48
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating LDL chol... 1 | 13
increased circulating calcium ... 1 | 34
increased fasted circulating g... 1 | 76
increased heart rate 1 | 23
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
mammalian phenotype 1 | 17
prenatal lethality prior to he... 1 | 87
prolonged PR interval 1 | 15
protruding tongue 1 | 3
short tibia 1 | 97
shortened RR interval 1 | 17

Disease

ovarian cancer 223 | 8,520
Carcinoma 210 | 11,493
osteosarcoma 154 | 7,950
lung cancer 146 | 4,740
psoriasis 125 | 6,694
medulloblastoma, large-cell 116 | 6,241
glioblastoma 114 | 5,792
Multiple myeloma 101 | 1,332
Cancer 95 | 2,499
atypical teratoid / rhabdoid tumor 90 | 5,112
diabetes mellitus 82 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 77 | 3,291
ependymoma 72 | 4,679
group 3 medulloblastoma 71 | 4,104
Breast cancer 69 | 3,578
adult high grade glioma 69 | 3,801
malignant mesothelioma 67 | 3,232
oligodendroglioma 62 | 2,850
Waldenstrons macroglobulinemia 59 | 765
tuberculosis 55 | 2,010
primitive neuroectodermal tumor 54 | 3,035
Astrocytoma, Pilocytic 52 | 3,081
subependymal giant cell astrocytoma 51 | 2,287
non-small cell lung cancer 49 | 2,890
invasive ductal carcinoma 48 | 2,951
astrocytic glioma 45 | 2,597
Kidney cancer 43 | 2,613
Pick disease 43 | 1,894
acute quadriplegic myopathy 43 | 1,158
dermatomyositis 42 | 966
intraductal papillary-mucinous carcinoma (IPMC) 42 | 2,989
Anemia 39 | 365
intraductal papillary-mucinous adenoma (IPMA) 39 | 2,955
lung adenocarcinoma 38 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 36 | 1,962
astrocytoma 35 | 1,146
pancreatic cancer 35 | 2,398
ulcerative colitis 35 | 1,819
lung carcinoma 34 | 2,843
interstitial cystitis 31 | 2,312
Hypersensitivity reaction type II disease 30 | 253
Kidney disease 30 | 430
Multiple Sclerosis 30 | 540
breast carcinoma 30 | 1,638
juvenile dermatomyositis 30 | 1,187
Acquired immunodeficiency syndrome 29 | 197
acute myeloid leukemia 28 | 783
group 4 medulloblastoma 28 | 1,855
Arthritis 26 | 290
Liver disease 26 | 237
colon cancer 26 | 1,478
Diamond-Blackfan anemia 25 | 31
cystic fibrosis 25 | 1,696
Ankylosing spondylitis 24 | 140
Hepatitis B 24 | 108
Schizophrenia 24 | 1,160
HIV Infections 23 | 102
Primary immunodeficiency disease 23 | 54
Rheumatoid arthritis 23 | 1,191
Hemochromatosis 22 | 54
Herpes zoster 22 | 68
Intellectual disability 22 | 1,016
Juvenile rheumatoid arthritis 22 | 111
Skin disease 22 | 66
Uveitis 22 | 103
pediatric high grade glioma 22 | 1,064
Autosomal recessive predisposition 21 | 1,442
Behcet's disease 21 | 89
Birdshot chorioretinopathy 21 | 23
Leprosy 21 | 73
primary pancreatic ductal adenocarcinoma 21 | 1,109
pituitary cancer 20 | 1,972
primary Sjogren syndrome 20 | 735
sonic hedgehog group medulloblastoma 19 | 467
Cockayne syndrome 18 | 60
Stomach Neoplasms 18 | 300
cutaneous lupus erythematosus 18 | 1,057
Cleft Palate 17 | 271
Cognitive delay 17 | 608
Global developmental delay 17 | 608
Mental and motor retardation 17 | 608
Breast Neoplasms 16 | 445
Fatigue 16 | 182
adrenocortical carcinoma 16 | 1,428
ductal carcinoma in situ 16 | 1,745
medulloblastoma 16 | 720
non primary Sjogren syndrome sicca 16 | 891
Delayed Puberty 15 | 97
Uranostaphyloschisis 15 | 167
hepatocellular carcinoma 15 | 547
Dull intelligence 14 | 645
Low intelligence 14 | 645
Mammary Neoplasms 14 | 425
Mental Retardation 14 | 645
Mental deficiency 14 | 645
Osteoporosis 14 | 363
Poor school performance 14 | 645
spina bifida 14 | 1,074
Prostatic Neoplasms 13 | 495
progressive supranuclear palsy 13 | 676

Tissue

Endocrine System 375 | 18,159
Digestive Tract 374 | 17,369
Female tissues 373 | 17,400
Blood and immune system 372 | 16,909
Male tissues 372 | 17,142
Skin and soft tissues 372 | 17,230
Urinary Tract 372 | 16,678
Liver and Pancreas 371 | 16,750
Nervous System 371 | 16,725
Respiratory system 371 | 16,393
Cardiovascular System 365 | 15,192

Target Family

Non-IDG 289 | 12,091
Enzyme 88 | 4,145
Kinase 17 | 634
Epigenetic 3 | 242
Transporter 3 | 473
GPCR 2 | 408
Transcription Factor 2 | 1,400

Reactome Pathway

Infectious disease 404 | 404
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.02901 103.9 190
40S ribosomal protein S19 RPS19 Tbio Non-IDG -3.14746 1380.8 267
60S ribosomal protein L36 RPL36 Tbio Non-IDG -1.62928 39.9 123
RNA polymerase II subunit A C-terminal domain phosphatase CTDP1 Tbio Enzyme -1.88697 80.7 113
Proteasome activator complex subunit 4 PSME4 Tdark Non-IDG -1.60128 39.3 43
Endophilin-A2 SH3GL1 Tbio Non-IDG -2.15479 134.2 257
FACT complex subunit SPT16 SUPT16H Tbio Enzyme -1.85453 70.7 324
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Negative elongation factor B NELFB Tbio Non-IDG -1.16040 16.4 158
Nucleoporin NDC1 NDC1 Tbio Non-IDG -0.66901 4.57 46