Development Level

Tbio 6 | 11,445
Tchem 1 | 1,598

IMPC Phenotype

abnormal cranium morphology 1 | 36
abnormal retina morphology 1 | 71
decreased circulating serum al... 1 | 82
decreased spleen weight 1 | 10
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged kidney 1 | 14
increased circulating alkaline... 1 | 122
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
short tibia 1 | 97

Disease

Carcinoma 7 | 11,493
ovarian cancer 6 | 8,520
osteosarcoma 5 | 7,950
Astrocytoma, Pilocytic 4 | 3,081
adult high grade glioma 4 | 3,801
ependymoma 4 | 4,679
glioblastoma 4 | 5,792
group 4 medulloblastoma 4 | 1,855
lung carcinoma 4 | 2,843
medulloblastoma, large-cell 4 | 6,241
Cancer 3 | 2,499
Familial hypocalciuric hypercalcemia 3 | 20
Intellectual disability 3 | 1,016
Kidney cancer 3 | 2,613
Melanoma 3 | 711
Pick disease 3 | 1,894
Skin cancer 3 | 469
astrocytic glioma 3 | 2,597
atypical teratoid / rhabdoid tumor 3 | 5,112
cystic fibrosis 3 | 1,696
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
lung cancer 3 | 4,740
oligodendroglioma 3 | 2,850
subependymal giant cell astrocytoma 3 | 2,287
3p- syndrome 2 | 21
Breast cancer 2 | 3,578
Carcinoma, Hepatocellular 2 | 228
Liver carcinoma 2 | 240
Multiple myeloma 2 | 1,332
Schizophrenia 2 | 1,160
gastric carcinoma 2 | 807
group 3 medulloblastoma 2 | 4,104
interstitial cystitis 2 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
non primary Sjogren syndrome sicca 2 | 891
pancreatic cancer 2 | 2,398
pituitary cancer 2 | 1,972
primary pancreatic ductal adenocarcinoma 2 | 1,109
primitive neuroectodermal tumor 2 | 3,035
psoriasis 2 | 6,694
tuberculosis 2 | 2,010
Adenocarcinoma 1 | 122
Adrenal Gland Neoplasms 1 | 11
Alzheimer's disease 1 | 658
Animal Mammary Neoplasms 1 | 136
Atopic dermatitis 1 | 952
Autistic Disorder 1 | 364
Cardiomyopathy, Dilated 1 | 83
Cardiovascular system disease 1 | 246
Cell Transformation, Neoplastic 1 | 97
Depressive disorder 1 | 409
Dyslexia 1 | 43
Endometriosis 1 | 540
HIV Infections 1 | 102
Heart disease 1 | 306
Heart failure 1 | 162
Impotence 1 | 42
Large intestine cancer 1 | 126
Liver cancer 1 | 604
Liver diseases 1 | 87
Lung Neoplasms 1 | 232
Mammary Neoplasms, Animal 1 | 136
Mammary Neoplasms, Experimental 1 | 154
Mental Depression 1 | 333
Necrosis 1 | 53
Neoplasm Metastasis 1 | 168
Neoplastic Cell Transformation 1 | 89
Neurodevelopmental Disorders 1 | 70
Pilocytic astrocytoma 1 | 56
Retinitis pigmentosa 47 1 | 4
Small Cell Lung Carcinoma 1 | 41
Small cell carcinoma of lung 1 | 45
Specific language impairment 1 | 34
Ventricular Dysfunction, Left 1 | 22
Vesicoureteral reflux 1 | 32
Waldenstrons macroglobulinemia 1 | 765
Wiskott-Aldrich syndrome 1 | 30
active Crohn's disease 1 | 922
adrenocortical carcinoma 1 | 1,428
atypical teratoid/rhabdoid tumor 1 | 357
breast carcinoma 1 | 1,638
chorea-acanthocytosis 1 | 12
colon cancer 1 | 1,478
diabetes mellitus 1 | 1,728
fibroadenoma 1 | 559
gastric cancer 1 | 459
hepatocellular carcinoma 1 | 547
invasive ductal carcinoma 1 | 2,951
lung adenocarcinoma 1 | 2,716
medulloblastoma 1 | 720
mucosa-associated lymphoid tissue lymphoma 1 | 484
nasopharyngeal carcinoma 1 | 1,058
non-small cell lung cancer 1 | 2,890
pediatric high grade glioma 1 | 1,064
progressive supranuclear palsy 1 | 676
sarcoidosis 1 | 370
severe Alzheimer's disease 1 | 47
ulcerative colitis 1 | 1,819
urothelial carcinoma 1 | 318

Tissue

Blood and immune system 6 | 16,909
Cardiovascular System 6 | 15,192
Digestive Tract 6 | 17,369
Endocrine System 6 | 18,159
Female tissues 6 | 17,400
Liver and Pancreas 6 | 16,750
Male tissues 6 | 17,142
Nervous System 6 | 16,725
Respiratory system 6 | 16,393
Skin and soft tissues 6 | 17,230
Urinary Tract 6 | 16,678

Target Family

Enzyme 5 | 4,145
Non-IDG 2 | 12,091

Reactome Pathway

Inactivation of CDC42 and RAC1 7 | 7
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
SLIT-ROBO Rho GTPase-activating protein 2 SRGAP2 Tbio Enzyme -1.09985 24.7 0
Cell division control protein 42 homolog CDC42 Tchem Enzyme -3.37283 2188.5 380
SLIT-ROBO Rho GTPase-activating protein 1 SRGAP1 Tbio Enzyme -0.99760 9.60 170
SLIT-ROBO Rho GTPase-activating protein 3 SRGAP3 Tbio Enzyme -1.70089 58.5 76
Roundabout homolog 1 ROBO1 Tbio Non-IDG -2.15518 129.8 261
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.94674 87.1 452
Slit homolog 2 protein SLIT2 Tbio Non-IDG -2.01765 104.0 215