Development Level

Tbio 161 | 10,625
Tdark 68 | 7,003
Tchem 12 | 1,890
Tclin 11 | 602

IMPC Term

abnormal pelvic girdle bone mo... 1 | 11
abnormal retinal pigmentation 1 | 61
abnormal rib morphology 1 | 28
abnormal seminal vesicle morph... 1 | 47
abnormal sleep behavior 1 | 63
decreased circulating calcium ... 1 | 33
decreased circulating glucose ... 1 | 121
decreased circulating magnesiu... 1 | 11
decreased monocyte cell number 1 | 28
decreased threshold for audito... 1 | 32
enlarged epididymis 1 | 27
enlarged heart 1 | 111
hyperactivity 1 | 108
increased circulating sodium l... 1 | 71
increased eosinophil cell numb... 1 | 9
increased grip strength 1 | 83
increased mean corpuscular vol... 1 | 91
increased rib number 1 | 41
increased spleen weight 1 | 3
increased vertical activity 1 | 18

Disease

Cancer 113 | 2,346
psoriasis 110 | 6,685
Ankylosing spondylitis 76 | 138
diabetes mellitus 75 | 1,663
osteosarcoma 75 | 7,933
Hypersensitivity reaction type II disease 69 | 235
Arthritis 63 | 248
Acquired immunodeficiency syndrome 61 | 164
Uveitis 59 | 103
Behcet's disease 58 | 74
Juvenile rheumatoid arthritis 56 | 104
lung cancer 53 | 4,466
Psoriatic arthritis 51 | 83
interstitial cystitis 51 | 2,299
lung carcinoma 50 | 2,844
Rheumatoid Arthritis 49 | 1,160
cutaneous lupus erythematosus 49 | 1,056
Multiple Sclerosis 39 | 498
Takayasu's arteritis 38 | 52
Stevens-Johnson syndrome 37 | 78
tuberculosis 37 | 1,557
glioblastoma 36 | 5,572
ovarian cancer 36 | 8,484
Congenital adrenal hyperplasia 35 | 74
Retinal vasculitis 35 | 36
ulcerative colitis 35 | 2,087
non-small cell lung cancer 34 | 2,798
Kidney disease 32 | 396
Anemia 29 | 252
invasive ductal carcinoma 28 | 2,950
lung adenocarcinoma 28 | 2,713
primary Sjogren syndrome 28 | 789
Liver disease 26 | 219
Leprosy 25 | 77
Primary immunodeficiency disease 25 | 52
Skin disease 25 | 65
pilocytic astrocytoma 25 | 3,086
Hemochromatosis 23 | 55
Human immunodeficiency virus infectious disease 23 | 92
medulloblastoma, large-cell 23 | 6,234
Hepatitis B 22 | 103
subependymal giant cell astrocytoma 20 | 2,287
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,988
periodontitis 18 | 269
adult high grade glioma 16 | 2,148
malignant mesothelioma 16 | 3,162
pre-eclampsia 16 | 67
Multiple myeloma 15 | 1,327
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,956
mucosa-associated lymphoid tissue lymphoma 15 | 480
pancreatic cancer 15 | 2,300
posterior fossa group A ependymoma 15 | 1,511
atypical teratoid / rhabdoid tumor 14 | 4,369
juvenile dermatomyositis 14 | 1,189
pediatric high grade glioma 14 | 2,712
astrocytoma 13 | 1,493
chronic lymphosyte leukemia 13 | 232
dermatomyositis 13 | 933
group 4 medulloblastoma 12 | 1,875
head and neck cancer and chronic obstructive pulmonary disease 12 | 237
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,289
tuberculosis and treatment for 6 months 11 | 686
Asthma 10 | 349
breast carcinoma 10 | 1,614
ductal carcinoma in situ 10 | 1,745
Breast cancer 9 | 3,094
IGA Glomerulonephritis 9 | 454
Inflammatory bowel disease 9 | 142
Lung disease 9 | 132
colon cancer 9 | 1,475
primary pancreatic ductal adenocarcinoma 9 | 1,271
Crohn's disease 8 | 304
Duchenne muscular dystrophy 8 | 602
Thrombocytopenia 8 | 105
gastric carcinoma 8 | 832
nasopharyngeal carcinoma 8 | 1,056
pituitary cancer 8 | 1,972
sarcoidosis 8 | 358
Atherosclerosis 7 | 275
Carcinoma 7 | 2,147
Coronary artery disease 7 | 240
Malaria 7 | 140
active Crohn's disease 7 | 918
Allergic hypersensitivity disease 6 | 123
Cerebrovascular disease 6 | 231
Dermatitis 6 | 107
Hypertension 6 | 287
Leukemia 6 | 88
Lymphoma 6 | 56
Severe Combined Immunodeficiency 6 | 46
acute myeloid leukemia 6 | 780
cystic fibrosis 6 | 1,665
esophageal adenocarcinoma 6 | 737
primitive neuroectodermal tumor 6 | 3,031
Down syndrome 5 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 499
ependymoma 5 | 2,514
inflammatory breast cancer 5 | 404
pancreatic carcinoma 5 | 567
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795

Tissue

Blood and immune system 168 | 17,995
Digestive Tract 165 | 18,473
Female tissues 164 | 18,647
Respiratory system 163 | 17,484
Liver and Pancreas 162 | 18,136
Urinary Tract 162 | 18,444
Nervous System 161 | 18,561
Cardiovascular System 160 | 17,958
Endocrine System 160 | 18,512
Skin and soft tissues 158 | 18,115
Male tissues 156 | 17,969

Target Family

Non-IDG 251 | 11,971
Enzyme 1 | 4,146

Reactome Pathway

Immunoregulatory interactions ... 252 | 252
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

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