Development Level

Tbio 1,409 | 10,625
Tchem 409 | 1,890
Tdark 237 | 7,003
Tclin 129 | 602

Collection

Eligible Kinase Proteins 8 | 134
Eligible Ion Channel Proteins 2 | 117
Eligible non-olfactory GPCR Proteins 2 | 143

IMPC Term

preweaning lethality, complete... 80 | 633
preweaning lethality, incomple... 37 | 260
decreased lean body mass 32 | 195
decreased total body fat amoun... 30 | 186
embryonic lethality prior to t... 30 | 187
abnormal behavior 26 | 226
decreased bone mineral content 26 | 157
decreased body weight 22 | 174
decreased grip strength 20 | 123
embryonic lethality prior to o... 18 | 148
abnormal embryo size 17 | 112
increased mean corpuscular hem... 17 | 93
abnormal bone structure 16 | 131
abnormal retina morphology 16 | 100
decreased body length 16 | 108
enlarged heart 16 | 111
decreased bone mineral density 15 | 126
increased lean body mass 14 | 107
increased mean corpuscular vol... 14 | 91
increased or absent threshold ... 14 | 128
short tibia 14 | 82
abnormal lens morphology 13 | 73
decreased circulating triglyce... 13 | 83
increased bone mineral content 13 | 92
decreased circulating HDL chol... 12 | 77
decreased circulating choleste... 12 | 85
decreased circulating glucose ... 12 | 121
decreased heart weight 11 | 44
hypoactivity 11 | 89
increased circulating alkaline... 11 | 119
increased grip strength 11 | 83
male infertility 11 | 62
thrombocytopenia 11 | 46
abnormal seminal vesicle morph... 10 | 47
decreased circulating alanine ... 10 | 53
hyperactivity 10 | 108
increased bone mineral density 10 | 52
increased leukocyte cell numbe... 10 | 37
abnormal retinal pigmentation 9 | 61
decreased circulating insulin ... 9 | 75
decreased circulating serum al... 9 | 79
decreased lumbar vertebrae num... 9 | 62
decreased mean corpuscular vol... 9 | 50
increased circulating HDL chol... 9 | 63
decreased circulating LDL chol... 8 | 37
decreased circulating fructosa... 8 | 31
decreased erythrocyte cell num... 8 | 43
increased circulating choleste... 8 | 53
decreased circulating aspartat... 7 | 27
decreased prepulse inhibition 7 | 52
decreased startle reflex 7 | 48
enlarged lymph nodes 7 | 27
increased exploration in new e... 7 | 56
increased total body fat amoun... 7 | 57
abnormal coat/hair pigmentatio... 6 | 54
abnormal neural tube closure 6 | 37
abnormal sleep behavior 6 | 63
decreased NK T cell number 6 | 28
decreased caudal vertebrae num... 6 | 49
decreased circulating creatini... 6 | 31
decreased circulating free fat... 6 | 39
decreased circulating sodium l... 6 | 18
decreased fasted circulating g... 6 | 49
decreased hemoglobin content 6 | 53
decreased mean corpuscular hem... 6 | 34
decreased neutrophil cell numb... 6 | 37
impaired glucose tolerance 6 | 52
improved glucose tolerance 6 | 56
increased blood urea nitrogen ... 6 | 44
increased hematocrit 6 | 36
increased hemoglobin content 6 | 45
increased startle reflex 6 | 38
abnormal bone mineralization 5 | 55
abnormal forebrain development 5 | 18
abnormal gait 5 | 51
abnormal hindbrain development 5 | 24
abnormal midbrain development 5 | 22
cardiovascular system phenotyp... 5 | 35
cataract 5 | 26
decreased CD4-positive, CD25-p... 5 | 24
decreased blood urea nitrogen ... 5 | 31
decreased circulating bilirubi... 5 | 14
decreased circulating chloride... 5 | 32
decreased hematocrit 5 | 25
decreased monocyte cell number 5 | 28
decreased rib number 5 | 59
decreased threshold for audito... 5 | 32
enlarged spleen 5 | 26
female infertility 5 | 34
immune system phenotype 5 | 17
increased body weight 5 | 42
increased circulating calcium ... 5 | 32
increased circulating sodium l... 5 | 71
increased circulating total pr... 5 | 20
increased effector memory CD8-... 5 | 14
increased fasted circulating g... 5 | 68
increased sacral vertebrae num... 5 | 62
small testis 5 | 37
increased circulating chloride... 4 | 43
increased circulating potassiu... 4 | 31

Disease

ovarian cancer 1,098 | 8,484
osteosarcoma 1,090 | 7,933
psoriasis 953 | 6,685
glioblastoma 769 | 5,572
lung cancer 748 | 4,466
medulloblastoma, large-cell 729 | 6,234
Cancer 655 | 2,346
lung carcinoma 516 | 2,844
atypical teratoid / rhabdoid tumor 496 | 4,369
pilocytic astrocytoma 468 | 3,086
malignant mesothelioma 445 | 3,162
interstitial cystitis 440 | 2,299
ulcerative colitis 439 | 2,087
intraductal papillary-mucinous neoplasm (IPMN) 436 | 3,289
non-small cell lung cancer 432 | 2,798
invasive ductal carcinoma 430 | 2,950
Breast cancer 400 | 3,094
subependymal giant cell astrocytoma 396 | 2,287
intraductal papillary-mucinous carcinoma (IPMC) 378 | 2,988
lung adenocarcinoma 377 | 2,713
pancreatic cancer 375 | 2,300
intraductal papillary-mucinous adenoma (IPMA) 369 | 2,956
tuberculosis 369 | 1,557
diabetes mellitus 368 | 1,663
pediatric high grade glioma 368 | 2,712
oligodendroglioma 319 | 2,849
Rheumatoid Arthritis 310 | 1,160
primitive neuroectodermal tumor 301 | 3,031
cutaneous lupus erythematosus 289 | 1,056
ependymoma 279 | 2,514
Multiple myeloma 271 | 1,327
astrocytoma 271 | 1,493
adult high grade glioma 270 | 2,148
juvenile dermatomyositis 264 | 1,189
Carcinoma 263 | 2,147
cystic fibrosis 255 | 1,665
group 4 medulloblastoma 249 | 1,875
pituitary cancer 242 | 1,972
astrocytic glioma 233 | 2,241
pancreatic ductal adenocarcinoma liver metastasis 233 | 1,795
breast carcinoma 232 | 1,614
group 3 medulloblastoma 229 | 2,254
primary Sjogren syndrome 226 | 789
posterior fossa group A ependymoma 217 | 1,511
Pick disease 213 | 1,893
dermatomyositis 206 | 933
ductal carcinoma in situ 199 | 1,745
colon cancer 198 | 1,475
primary pancreatic ductal adenocarcinoma 194 | 1,271
Multiple Sclerosis 185 | 498
acute quadriplegic myopathy 182 | 1,157
medulloblastoma 173 | 1,524
Arthritis 171 | 248
adrenocortical carcinoma 171 | 1,427
Atopic dermatitis 166 | 944
Waldenstrons macroglobulinemia 165 | 765
active Crohn's disease 165 | 918
Hypersensitivity reaction type II disease 160 | 235
mucosa-associated lymphoid tissue lymphoma 156 | 480
Asthma 153 | 349
esophageal adenocarcinoma 150 | 737
Kidney disease 144 | 396
gastric carcinoma 141 | 832
nasopharyngeal carcinoma 137 | 1,056
spina bifida 134 | 1,064
IGA Glomerulonephritis 132 | 454
sonic hedgehog group medulloblastoma 127 | 1,482
Duchenne muscular dystrophy 124 | 602
posterior fossa group B ependymoma 120 | 1,530
atypical teratoid/rhabdoid tumor 117 | 1,095
Alzheimer's disease 115 | 644
acute myeloid leukemia 108 | 780
Ankylosing spondylitis 107 | 138
Prostatic Neoplasms 105 | 471
tuberculosis and treatment for 6 months 104 | 686
Vascular disease 103 | 281
periodontitis 103 | 269
pancreatic carcinoma 102 | 567
Obesity 101 | 616
hepatocellular carcinoma 99 | 532
non primary Sjogren syndrome sicca 99 | 840
Mammary Neoplasms 98 | 410
Acquired immunodeficiency syndrome 92 | 164
sarcoidosis 90 | 358
Atherosclerosis 89 | 275
Anemia 88 | 252
Lung disease 88 | 132
Liver disease 86 | 219
Inflammatory bowel disease 85 | 142
non-small cell lung carcinoma 85 | 413
Crohn's disease 83 | 304
Down syndrome 82 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 82 | 499
Endometriosis 81 | 535
head and neck cancer and chronic obstructive pulmonary disease 81 | 237
Juvenile rheumatoid arthritis 77 | 104
Parkinson's disease 77 | 364
Uveitis 77 | 103
gastric cancer 75 | 430
inflammatory breast cancer 75 | 404

Tissue

Nervous System 2,053 | 18,561
Digestive Tract 2,050 | 18,473
Female tissues 2,049 | 18,647
Urinary Tract 2,044 | 18,444
Blood and immune system 2,040 | 17,995
Endocrine System 2,037 | 18,512
Liver and Pancreas 2,029 | 18,136
Cardiovascular System 2,019 | 17,958
Skin and soft tissues 2,014 | 18,115
Male tissues 2,001 | 17,969
Respiratory system 1,994 | 17,484

Target Family

Non-IDG 1,406 | 11,971
Enzyme 523 | 4,146
Kinase 143 | 634
Transcription Factor 53 | 1,400
Ion Channel 20 | 341
GPCR 18 | 406
Transporter 12 | 473
Epigenetic 5 | 242
Nuclear Receptor 3 | 48
TF/Epigenetic 1 | 38

Reactome Pathway

Immune System 2,184 | 2,184
Signal Transduction 2,516 | 2,516
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Immunoglobulin kappa variable 3-11 IGKV3-11 Tdark Non-IDG 0.00000 0
T-cell receptor beta chain V region CTL-L17 TCRB Tdark Non-IDG 0.00000 0
T-cell receptor alpha chain V region CTL-L17 TCRA Tdark Non-IDG 0.00000 0
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961