Development Level

Tbio 1,480 | 11,651
Tchem 296 | 1,388
Tdark 217 | 6,593
Tclin 108 | 612

Collection

RFA-RM-18-021 10 | 328
Kinase: IDG Consortium (Target... 6 | 125
GPCR: IDG Consortium (Targets) 2 | 126
Ion Channel: IDG Consortium (T... 2 | 99
Kinase: IDG Consortium (Comple... 2 | 37
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 117 | 979
preweaning lethality, incomple... 63 | 499
embryonic lethality prior to t... 40 | 278
abnormal behavior 34 | 298
embryonic lethality prior to o... 29 | 239
decreased vertical activity 27 | 208
abnormal seminal vesicle morph... 26 | 114
decreased bone mineral content 26 | 151
enlarged heart 26 | 210
decreased total body fat amoun... 24 | 207
short tibia 23 | 97
abnormal embryo size 22 | 220
increased lean body mass 20 | 172
abnormal bone structure 19 | 187
abnormal heart morphology 19 | 162
male infertility 19 | 123
decreased bone mineral density 16 | 126
hypoactivity 16 | 132
increased mean corpuscular vol... 16 | 92
decreased body weight 15 | 161
decreased lean body mass 15 | 135
hyperactivity 15 | 148
increased monocyte cell number 15 | 63
increased or absent threshold ... 15 | 101
increased total body fat amoun... 15 | 134
increased bone mineral content 14 | 108
increased mean corpuscular hem... 14 | 96
abnormal retina morphology 13 | 71
decreased circulating choleste... 13 | 93
decreased circulating glucose ... 13 | 126
decreased lymphocyte cell numb... 13 | 83
decreased mean corpuscular vol... 13 | 79
increased circulating alkaline... 13 | 122
increased neutrophil cell numb... 13 | 46
cataract 12 | 92
embryonic growth retardation 12 | 106
increased bone mineral density 12 | 72
increased leukocyte cell numbe... 12 | 47
small superior vagus ganglion 12 | 74
decreased hemoglobin content 11 | 68
female infertility 11 | 60
thrombocytopenia 11 | 56
decreased circulating creatini... 10 | 39
decreased mean corpuscular hem... 10 | 50
abnormal sleep behavior 9 | 70
decreased caudal vertebrae num... 9 | 53
decreased circulating HDL chol... 9 | 68
decreased circulating insulin ... 9 | 76
decreased circulating triglyce... 9 | 79
decreased erythrocyte cell num... 9 | 62
decreased heart left ventricle... 9 | 28
decreased hematocrit 9 | 46
decreased prepulse inhibition 9 | 82
decreased startle reflex 9 | 75
enlarged lymph nodes 9 | 37
impaired glucose tolerance 9 | 75
abnormal lens morphology 8 | 81
decreased blood urea nitrogen ... 8 | 51
decreased grip strength 8 | 116
increased blood urea nitrogen ... 8 | 48
increased circulating creatini... 8 | 38
increased hematocrit 8 | 46
small testis 8 | 58
abnormal gait 7 | 69
abnormal skin morphology 7 | 50
cardiovascular system phenotyp... 7 | 36
decreased circulating bilirubi... 7 | 19
enlarged spleen 7 | 41
hydrometra 7 | 53
increased circulating choleste... 7 | 66
increased lymphocyte cell numb... 7 | 32
increased mean platelet volume 7 | 45
prenatal lethality prior to he... 7 | 87
abnormal coat-hair pigmentatio... 6 | 64
abnormal kidney morphology 6 | 65
abnormal spleen morphology 6 | 55
decreased body length 6 | 101
decreased circulating alanine ... 6 | 47
decreased circulating aspartat... 6 | 34
decreased circulating fructosa... 6 | 30
decreased circulating iron lev... 6 | 32
decreased circulating serum al... 6 | 82
decreased fasted circulating g... 6 | 65
decreased neutrophil cell numb... 6 | 42
improved glucose tolerance 6 | 79
increased circulating HDL chol... 6 | 80
increased circulating chloride... 6 | 41
increased circulating sodium l... 6 | 71
increased grip strength 6 | 41
increased startle reflex 6 | 112
abnormal epididymis morphology 5 | 42
decreased circulating LDL chol... 5 | 38
decreased circulating amylase ... 5 | 28
decreased circulating free fat... 5 | 31
decreased circulating total pr... 5 | 49
decreased red blood cell distr... 5 | 41
increased circulating free fat... 5 | 20
increased fasted circulating g... 5 | 76
increased hemoglobin content 5 | 45
prolonged QT interval 5 | 38

Disease

Carcinoma 1,228 | 11,493
ovarian cancer 1,054 | 8,520
osteosarcoma 1,019 | 7,950
psoriasis 917 | 6,694
glioblastoma 750 | 5,792
lung cancer 742 | 4,740
medulloblastoma, large-cell 669 | 6,241
Cancer 657 | 2,499
atypical teratoid / rhabdoid tumor 524 | 5,112
lung carcinoma 495 | 2,843
adult high grade glioma 471 | 3,801
ependymoma 464 | 4,679
tuberculosis 442 | 2,010
malignant mesothelioma 440 | 3,232
Breast cancer 438 | 3,578
Astrocytoma, Pilocytic 427 | 3,081
non-small cell lung cancer 420 | 2,890
interstitial cystitis 418 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 408 | 3,291
invasive ductal carcinoma 395 | 2,951
group 3 medulloblastoma 382 | 4,104
diabetes mellitus 367 | 1,728
subependymal giant cell astrocytoma 366 | 2,287
pancreatic cancer 360 | 2,398
ulcerative colitis 357 | 1,819
intraductal papillary-mucinous carcinoma (IPMC) 356 | 2,989
lung adenocarcinoma 352 | 2,716
intraductal papillary-mucinous adenoma (IPMA) 340 | 2,955
Rheumatoid arthritis 320 | 1,191
cutaneous lupus erythematosus 283 | 1,057
oligodendroglioma 279 | 2,850
primitive neuroectodermal tumor 276 | 3,035
Kidney cancer 275 | 2,613
Multiple myeloma 275 | 1,332
pancreatic ductal adenocarcinoma liver metastasis 267 | 1,962
juvenile dermatomyositis 257 | 1,187
astrocytic glioma 250 | 2,597
cystic fibrosis 249 | 1,696
dermatomyositis 244 | 966
Autosomal recessive predisposition 234 | 1,442
breast carcinoma 223 | 1,638
pituitary cancer 219 | 1,972
group 4 medulloblastoma 214 | 1,855
primary Sjogren syndrome 211 | 735
astrocytoma 210 | 1,146
Arthritis 191 | 290
Multiple Sclerosis 191 | 540
Pick disease 190 | 1,894
Liver Cirrhosis, Experimental 187 | 769
Schizophrenia 183 | 1,160
acute quadriplegic myopathy 180 | 1,158
ductal carcinoma in situ 180 | 1,745
colon cancer 179 | 1,478
Atopic dermatitis 170 | 952
Waldenstrons macroglobulinemia 170 | 765
Hypersensitivity reaction type II disease 168 | 253
active Crohn's disease 160 | 922
adrenocortical carcinoma 160 | 1,428
Asthma 158 | 385
primary pancreatic ductal adenocarcinoma 152 | 1,109
mucosa-associated lymphoid tissue lymphoma 149 | 484
Kidney disease 148 | 430
esophageal adenocarcinoma 143 | 737
active ulcerative colitis 137 | 764
nasopharyngeal carcinoma 135 | 1,058
pediatric high grade glioma 123 | 1,064
Duchenne muscular dystrophy 120 | 601
spina bifida 119 | 1,074
gastric carcinoma 117 | 807
Anemia 111 | 365
non primary Sjogren syndrome sicca 109 | 891
Ankylosing spondylitis 108 | 140
Melanoma 106 | 711
Obesity 105 | 678
Alzheimer's disease 104 | 658
Bipolar Disorder 104 | 666
Human immunodeficiency virus infectious disease 104 | 138
acute myeloid leukemia 104 | 783
periodontitis 104 | 293
Vascular disease 103 | 319
Intellectual disability 100 | 1,016
Dermatitis 99 | 157
Hypertension 99 | 396
Prostatic Neoplasms 99 | 495
hepatocellular carcinoma 99 | 547
sarcoidosis 99 | 370
Inflammatory bowel disease 95 | 151
Systemic lupus erythematosus 93 | 194
Acquired immunodeficiency syndrome 92 | 197
Liver disease 92 | 237
Lung disease 90 | 142
Pneumonia 90 | 174
pancreatic carcinoma 90 | 562
Atherosclerosis 89 | 291
Epilepsy 88 | 792
Seizures 88 | 596
Breast Neoplasms 87 | 445
Mammary Neoplasms 84 | 425
Crohn's disease 83 | 321
Juvenile rheumatoid arthritis 83 | 111

Tissue

Endocrine System 1,848 | 18,159
Digestive Tract 1,842 | 17,369
Skin and soft tissues 1,833 | 17,230
Blood and immune system 1,831 | 16,909
Female tissues 1,824 | 17,400
Male tissues 1,814 | 17,142
Liver and Pancreas 1,810 | 16,750
Urinary Tract 1,808 | 16,678
Respiratory system 1,789 | 16,393
Nervous System 1,732 | 16,725
Cardiovascular System 1,692 | 15,192

Target Family

Non-IDG 1,377 | 12,091
Enzyme 507 | 4,145
Kinase 108 | 634
Transcription Factor 54 | 1,400
GPCR 18 | 408
Ion Channel 16 | 344
Transporter 13 | 473
Epigenetic 5 | 242
Nuclear Receptor 2 | 48
TF/Epigenetic 1 | 38

Reactome Pathway

Immune System 2,101 | 2,101
Signal Transduction 2,657 | 2,657
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Interleukin-9 IL9 Tbio Non-IDG -2.50811 334.4 459
Myosin-2 MYH2 Tbio Non-IDG -2.14128 114.9 63
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
Tyrosine-protein phosphatase non-receptor type 5 PTPN5 Tchem Enzyme -1.85420 70.8 225
Myeloperoxidase MPO Tchem Enzyme -3.51470 3209.3 1255
Cytoplasmic FMR1-interacting protein 1 CYFIP1 Tbio Non-IDG -1.46134 28.5 64
HLA class I histocompatibility antigen, A-25 alpha chain HLA-A Tbio Non-IDG -2.41667 4123.8 0
CMRF35-like molecule 9 CD300LG Tdark Non-IDG -0.92828 10.3 49
Tyrosine-protein kinase ZAP-70 ZAP70 Tchem Kinase -2.91589 798.2 1515