Development Level

Tchem 5 | 1,598
Tbio 1 | 11,445

IMPC Phenotype

abnormal cornea morphology 1 | 31
abnormal skin condition 1 | 6
decreased circulating amylase ... 1 | 28
decreased circulating sodium l... 1 | 22
decreased mean corpuscular hem... 1 | 31
decreased thermal nociceptive ... 1 | 2
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased leukocyte cell numbe... 1 | 47
increased thermal nociceptive ... 1 | 9
preweaning lethality, incomple... 1 | 499

Disease

Cancer 6 | 2,499
Carcinoma 4 | 11,493
Immunologic Deficiency Syndromes 4 | 113
glioblastoma 4 | 5,792
Brain Ischemia 3 | 110
Heat Stroke 3 | 13
Mantle cell lymphoma 3 | 23
Multiple myeloma 3 | 1,332
astrocytoma 3 | 1,146
lung cancer 3 | 4,740
oligodendroglioma 3 | 2,850
ovarian cancer 3 | 8,520
Agammaglobulinemia 2 | 34
Anemia, Hemolytic 2 | 55
Anus, Imperforate 2 | 46
Arthritis 2 | 290
Asthma 2 | 385
Autoimmune thrombocytopenia 2 | 22
Brachycephaly 2 | 88
Breast Neoplasms 2 | 445
Broad cranium shape 2 | 88
Bronchiectasis 2 | 64
Cell Transformation, Neoplastic 2 | 97
Chronic otitis media 2 | 52
Colonic Neoplasms 2 | 142
Common variable immunodeficiency 2 | 101
Decreased antibody level in blood 2 | 35
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diabetes Mellitus, Type 2 2 | 142
Dystrophia unguium 2 | 53
Ectodermal dysplasia, hypohidrotic, with immune deficiency 2 | 2
Elevated hepatic transaminases 2 | 81
Frontal bossing 2 | 157
Hepatic enzyme increased 2 | 81
Highly variable severity 2 | 157
Hypertension 2 | 396
Hypodontia 2 | 81
Hypogammaglobulinemia 2 | 35
Hypohidrotic ectodermal dysplasia with immunodeficiency 2 | 2
Idiopathic thrombocytopenia 2 | 22
Immune thrombocytopenic purpura 2 | 24
Infantile onset 2 | 238
Inflammatory bowel disease 2 | 151
Kidney Failure, Chronic 2 | 46
Liver Cirrhosis, Experimental 2 | 769
Liver Dysfunction 2 | 99
Liver enzymes abnormal 2 | 81
Liver function test increased 2 | 81
Liver function tests abnormal finding 2 | 81
Lymphadenopathy 2 | 62
Lymphopenia 2 | 67
Mammary Neoplasms 2 | 425
Neoplastic Cell Transformation 2 | 89
Pneumonia 2 | 174
Purpura 2 | 43
Recurrent bronchitis 2 | 23
Recurrent respiratory infections 2 | 141
Rheumatoid arthritis 2 | 1,191
Schizophrenia 2 | 1,160
Sparse hair 2 | 59
Splenomegaly 2 | 190
Subclinical abnormal liver function tests 2 | 81
Thin, sparse hair 2 | 59
Transaminases increased 2 | 81
Variable expressivity 2 | 157
Wide skull shape 2 | 88
colon cancer 2 | 1,478
diabetes mellitus 2 | 1,728
ear infection chronic 2 | 52
ependymoma 2 | 4,679
osteosarcoma 2 | 7,950
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
psoriasis 2 | 6,694
tuberculosis 2 | 2,010
ATYPICAL MYCOBACTERIOSIS, FAMILIAL, X-LINKED 1 (disorder) 1 | 1
Abnormal pigmentation 1 | 25
Accessory nipple 1 | 11
Accessory rib 1 | 10
Acquired deformity of finger 1 | 3
Congenital hypoplasia of breast 1 | 25
Ectodermal Dysplasia, Anhidrotic, with Immunodeficiency, Osteopetrosis, and Lymphedema 1 | 1
Fine hair 1 | 42
Hyperkeratosis 1 | 50
Hypoplasia of nipple 1 | 16
Hypoplastic fingernails 1 | 11
INVASIVE PNEUMOCOCCAL DISEASE, RECURRENT ISOLATED, 2 (disorder) 1 | 1
Immunodeficiency without anhidrotic ectodermal dysplasia 1 | 1
Increased IgM levels 1 | 16
Increased susceptibility to bacterial infections 1 | 42
Irregular hyperpigmentation 1 | 33
Kyphoscoliosis deformity of spine 1 | 60
Onset of lymphedema around puberty 1 | 21
Peg-shaped incisors 1 | 6
Pointed incisor 1 | 6
Recurrent bacterial infection 1 | 42
Recurrent mycobacterium avium complex infections 1 | 2
Ridged nails 1 | 14
Warts 1 | 10
X- linked recessive 1 | 110
hypopigmented skin patch 1 | 59

Tissue

Blood and immune system 6 | 16,909
Cardiovascular System 6 | 15,192
Digestive Tract 6 | 17,369
Endocrine System 6 | 18,159
Female tissues 6 | 17,400
Liver and Pancreas 6 | 16,750
Male tissues 6 | 17,142
Nervous System 6 | 16,725
Respiratory system 6 | 16,393
Skin and soft tissues 6 | 17,230
Urinary Tract 6 | 16,678

Target Family

Transcription Factor 3 | 1,400
Kinase 2 | 634
Non-IDG 1 | 12,091

Reactome Pathway

IkBA variant leads to EDA-ID 6 | 6
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
Nuclear factor NF-kappa-B p100 subunit NFKB2 Tchem Transcription Factor -2.29577 191.3 637
NF-kappa-B inhibitor alpha NFKBIA Tchem Non-IDG -3.34987 1979.8 1300
Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB Tchem Kinase -2.93125 790.1 1824
Transcription factor p65 RELA Tchem Transcription Factor -3.00328 988.5 2215
Nuclear factor NF-kappa-B p105 subunit NFKB1 Tchem Transcription Factor -2.74349 505.0 1762