Development Level

Tbio 57 | 10,625
Tchem 9 | 1,890
Tdark 6 | 7,003
Tclin 1 | 602

IMPC Term

preweaning lethality, complete... 6 | 633
decreased lean body mass 3 | 195
decreased bone mineral content 2 | 157
increased lean body mass 2 | 107
abnormal coping response 1 | 12
abnormal gait 1 | 51
decreased body length 1 | 108
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating aspartat... 1 | 27
decreased circulating calcium ... 1 | 33
decreased circulating chloride... 1 | 32
decreased circulating choleste... 1 | 85
decreased grip strength 1 | 123
decreased lactate dehydrogenas... 1 | 14
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
embryonic lethality prior to o... 1 | 148
enlarged lymph nodes 1 | 27
hyperactivity 1 | 108
increased circulating alkaline... 1 | 119

Disease

ovarian cancer 49 | 8,484
lung cancer 41 | 4,466
osteosarcoma 36 | 7,933
medulloblastoma, large-cell 34 | 6,234
glioblastoma 30 | 5,572
psoriasis 28 | 6,685
dermatomyositis 23 | 933
atypical teratoid / rhabdoid tumor 22 | 4,369
Cancer 20 | 2,346
group 3 medulloblastoma 20 | 2,254
pediatric high grade glioma 18 | 2,712
Multiple myeloma 17 | 1,327
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,289
Carcinoma 16 | 2,147
Breast cancer 14 | 3,094
ependymoma 14 | 2,514
pilocytic astrocytoma 14 | 3,086
malignant mesothelioma 13 | 3,162
oligodendroglioma 13 | 2,849
primitive neuroectodermal tumor 13 | 3,031
subependymal giant cell astrocytoma 13 | 2,287
Influenza 12 | 142
astrocytic glioma 12 | 2,241
non-small cell lung cancer 12 | 2,798
pancreatic cancer 12 | 2,300
invasive ductal carcinoma 11 | 2,950
juvenile dermatomyositis 11 | 1,189
Pick disease 10 | 1,893
Waldenstrons macroglobulinemia 10 | 765
cutaneous lupus erythematosus 10 | 1,056
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,988
lung carcinoma 10 | 2,844
astrocytoma 9 | 1,493
tuberculosis 9 | 1,557
Amyotrophic Lateral Sclerosis 8 | 431
group 4 medulloblastoma 8 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,956
lung adenocarcinoma 8 | 2,713
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
sonic hedgehog group medulloblastoma 8 | 1,482
ulcerative colitis 8 | 2,087
Atopic dermatitis 7 | 944
Multiple Sclerosis 7 | 498
Rheumatoid Arthritis 7 | 1,160
acute myeloid leukemia 7 | 780
breast carcinoma 7 | 1,614
cystic fibrosis 7 | 1,665
primary Sjogren syndrome 7 | 789
systemic lupus erythematosus 7 | 156
acute quadriplegic myopathy 6 | 1,157
diabetes mellitus 6 | 1,663
interstitial cystitis 6 | 2,299
Hepatitis C 5 | 90
adult high grade glioma 5 | 2,148
atypical teratoid/rhabdoid tumor 5 | 1,095
nasopharyngeal carcinoma 5 | 1,056
posterior fossa group A ependymoma 5 | 1,511
primary pancreatic ductal adenocarcinoma 5 | 1,271
progressive supranuclear palsy 5 | 674
Alzheimer's disease 4 | 644
colon cancer 4 | 1,475
ductal carcinoma in situ 4 | 1,745
hereditary spastic paraplegia 4 | 313
medulloblastoma 4 | 1,524
pancreatic carcinoma 4 | 567
spina bifida 4 | 1,064
Encephalitis 3 | 54
HIV Infections 3 | 100
Leukemia, Myelocytic, Acute 3 | 113
Lung disease 3 | 132
Myocardial Ischemia 3 | 169
Prostatic Neoplasms 3 | 471
Severe acute respiratory syndrome 3 | 26
Vascular disease 3 | 281
active Crohn's disease 3 | 918
adrenocortical carcinoma 3 | 1,427
aldosterone-producing adenoma 3 | 664
esophageal adenocarcinoma 3 | 737
gastric carcinoma 3 | 832
hepatocellular carcinoma 3 | 532
inflammatory breast cancer 3 | 404
pituitary cancer 3 | 1,972
posterior fossa group B ependymoma 3 | 1,530
Arthritis 2 | 248
Disease Progression 2 | 125
Down syndrome 2 | 548
Endometriosis 2 | 535
Gaucher disease type 1 2 | 171
Hypersensitivity reaction type II disease 2 | 235
Hypertension 2 | 287
IGA Glomerulonephritis 2 | 454
Leukemia 2 | 88
Melanoma 2 | 261
Muscle Weakness 2 | 92
Neoplasm Metastasis 2 | 138
Parkinson's disease 2 | 364
Stomach Neoplasms 2 | 282
non-small cell lung carcinoma 2 | 413
tuberculosis and treatment for 3 months 2 | 327
tuberculosis and treatment for 6 months 2 | 686

Tissue

Blood and immune system 73 | 17,995
Cardiovascular System 73 | 17,958
Endocrine System 73 | 18,512
Female tissues 73 | 18,647
Liver and Pancreas 73 | 18,136
Male tissues 73 | 17,969
Nervous System 73 | 18,561
Digestive Tract 72 | 18,473
Respiratory system 72 | 17,484
Skin and soft tissues 72 | 18,115
Urinary Tract 72 | 18,444

Target Family

Non-IDG 56 | 11,971
Enzyme 12 | 4,146
Kinase 3 | 634
Transcription Factor 2 | 1,400

Reactome Pathway

ISG15 antiviral mechanism 73 | 73
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
Nuclear pore complex protein Nup98-Nup96 NUP98 Tbio Enzyme -2.21148 186.3 172
Nucleoporin p58/p45 NUP58 Tdark Non-IDG -0.70757 5.23 31
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
Nucleoporin-like protein 2 NUPL2 Tbio Non-IDG -0.99049 10.1 66
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
Ubiquitin-conjugating enzyme E2 E1 UBE2E1 Tbio Non-IDG -1.18305 12.0 72
Eukaryotic initiation factor 4A-III EIF4A3 Tbio Non-IDG -2.21804 176.4 137
Ubiquitin-conjugating enzyme E2 N UBE2N Tchem Non-IDG -2.02460 99.0 237
Eukaryotic translation initiation factor 4 gamma 3 EIF4G3 Tbio Non-IDG -1.29547 17.0 113