Development Level

Tbio 40 | 10,625
Tchem 7 | 1,890
Tdark 7 | 7,003
Tclin 1 | 602

IMPC Phenotype

preweaning lethality, complete... 6 | 633
embryonic lethality prior to t... 3 | 187
abnormal bone mineralization 2 | 55
decreased body weight 2 | 174
decreased lean body mass 2 | 195
decreased total body fat amoun... 2 | 186
embryonic lethality prior to o... 2 | 148
short tibia 2 | 82
abnormal bone structure 1 | 131
abnormal gait 1 | 51
abnormal kidney morphology 1 | 30
abnormal seminal vesicle morph... 1 | 47
absent vibrissae 1 | 14
decreased IgG1 level 1 | 4
decreased T cell number 1 | 31
decreased body length 1 | 108
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating choleste... 1 | 85
decreased circulating glucose ... 1 | 121
decreased circulating glycerol... 1 | 19
decreased circulating insulin ... 1 | 75
decreased circulating triglyce... 1 | 83
decreased effector memory CD4-... 1 | 6
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 19
decreased mean corpuscular vol... 1 | 50
decreased spleen weight 1 | 13
decreased threshold for audito... 1 | 32
enlarged heart 1 | 111
hyperactivity 1 | 108
increased circulating HDL chol... 1 | 63
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased grip strength 1 | 83
increased heart weight 1 | 37
increased lean body mass 1 | 107
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
increased sacral vertebrae num... 1 | 62
increased total body fat amoun... 1 | 57
prenatal lethality prior to he... 1 | 64
preweaning lethality, incomple... 1 | 260
vertebral fusion 1 | 23

Disease

ovarian cancer 37 | 8,491
osteosarcoma 33 | 7,933
glioblastoma 26 | 5,572
psoriasis 22 | 6,685
pancreatic ductal adenocarcinoma liver metastasis 21 | 1,795
medulloblastoma, large-cell 19 | 6,234
lung cancer 17 | 4,473
atypical teratoid / rhabdoid tumor 16 | 4,369
Multiple myeloma 15 | 1,327
pediatric high grade glioma 14 | 2,712
diabetes mellitus 13 | 1,663
lung adenocarcinoma 12 | 2,714
non-small cell lung cancer 12 | 2,798
Breast cancer 11 | 3,098
astrocytoma 11 | 1,493
ependymoma 11 | 2,514
acute quadriplegic myopathy 10 | 1,157
group 3 medulloblastoma 10 | 2,254
lung carcinoma 10 | 2,844
pancreatic cancer 10 | 2,300
pilocytic astrocytoma 10 | 3,086
invasive ductal carcinoma 9 | 2,950
subependymal giant cell astrocytoma 9 | 2,287
active Crohn's disease 8 | 918
tuberculosis 8 | 1,563
group 4 medulloblastoma 7 | 1,875
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,289
juvenile dermatomyositis 7 | 1,189
pituitary cancer 7 | 1,972
primitive neuroectodermal tumor 7 | 3,031
Cancer 6 | 2,346
Neurodegenerative disease 6 | 383
Pick disease 6 | 1,893
malignant mesothelioma 6 | 3,163
posterior fossa group B ependymoma 6 | 1,530
Rheumatoid Arthritis 5 | 1,170
adult high grade glioma 5 | 2,148
astrocytic glioma 5 | 2,241
dermatomyositis 5 | 966
non primary Sjogren syndrome sicca 5 | 840
oligodendroglioma 5 | 2,849
Alzheimer's disease 4 | 644
colon cancer 4 | 1,475
interstitial cystitis 4 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,956
primary pancreatic ductal adenocarcinoma 4 | 1,271
spina bifida 4 | 1,064
Carcinoma 3 | 2,147
Cardiomyopathy 3 | 110
Epilepsy 3 | 346
Myopathy 3 | 128
Obesity 3 | 616
Polycystic Ovary Syndrome 3 | 334
Waldenstrons macroglobulinemia 3 | 764
adrenocortical carcinoma 3 | 1,427
atypical teratoid/rhabdoid tumor 3 | 1,095
breast carcinoma 3 | 1,614
hepatocellular carcinoma 3 | 550
medulloblastoma 3 | 1,524
pancreatic carcinoma 3 | 567
posterior fossa group A ependymoma 3 | 1,511
sonic hedgehog group medulloblastoma 3 | 1,482
ulcerative colitis 3 | 2,087
AMYOTROPHIC LATERAL SCLEROSIS 1 2 | 49
Amyotrophic lateral sclerosis type 1 2 | 22
Amyotrophic lateral sclerosis type 8 2 | 9
Atherosclerosis 2 | 275
Atrial Fibrillation 2 | 110
Barrett's esophagus 2 | 185
Bipolar Disorder 2 | 266
COPD 2 | 116
Cardiomyopathy, Dilated 2 | 47
Charcot-Marie-Tooth disease 2 | 74
Craniofacial Abnormalities 2 | 147
Dengue hemorrhagic fever 2 | 4
Duchenne muscular dystrophy 2 | 602
Essential Hypertension 2 | 82
Fatty liver disease 2 | 86
Gastroenteritis 2 | 46
Liver carcinoma 2 | 217
Neuropathy 2 | 210
Parkinson's disease 2 | 364
Prostatic Neoplasms 2 | 471
SPINOCEREBELLAR ATAXIA 17 2 | 9
Squamous cell carcinoma of esophagus 2 | 82
Type 2 diabetes mellitus 2 | 192
Vascular disease 2 | 281
X-linked cerebral adrenoleukodystrophy 2 | 115
acute myeloid leukemia 2 | 785
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
esophageal adenocarcinoma 2 | 737
gastric cancer 2 | 436
gastric carcinoma 2 | 832
mucosa-associated lymphoid tissue lymphoma 2 | 480
progressive supranuclear palsy 2 | 674
sarcoidosis 2 | 368
systemic lupus erythematosus 2 | 172
tuberculosis and treatment for 6 months 2 | 686
Cardiomyopathy, Familial Idiopathic 1 | 2

Tissue

Blood and immune system 55 | 17,994
Cardiovascular System 55 | 17,957
Digestive Tract 55 | 18,472
Endocrine System 55 | 18,511
Female tissues 55 | 18,646
Liver and Pancreas 55 | 18,135
Male tissues 55 | 17,968
Nervous System 55 | 18,560
Respiratory system 55 | 17,483
Skin and soft tissues 55 | 18,114
Urinary Tract 55 | 18,443

Target Family

Non-IDG 29 | 11,969
Enzyme 19 | 4,146
Transcription Factor 3 | 1,400
Epigenetic 2 | 242
Kinase 2 | 634

Reactome Pathway

IRE1alpha activates chaperones 55 | 55
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
WD repeat domain phosphoinositide-interacting protein 1 WIPI1 Tbio Non-IDG -1.58031 37.0 174
ATPase ASNA1 ASNA1 Tbio Enzyme -1.80082 72.3 207
Stress-associated endoplasmic reticulum protein 1 SERP1 Tbio Non-IDG -1.31775 29.5 75
Protein transport protein Sec31A SEC31A Tbio Non-IDG -1.15789 12.4 72
Zinc finger and BTB domain-containing protein 17 ZBTB17 Tbio Transcription Factor -1.49849 31.0 70
Serine/threonine-protein kinase/endoribonuclease IRE1 ERN1 Tchem Kinase -2.40076 210.9 439
Golgi SNAP receptor complex member 2 GOSR2 Tbio Non-IDG -1.31339 15.8 74
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 CTDSP2 Tbio Enzyme -1.72953 50.2 165
Alpha-adducin ADD1 Tbio Enzyme -2.44049 275.9 522
Protein transport protein Sec61 subunit beta SEC61B Tbio Non-IDG -0.16023 1.18 115