Development Level

Tbio 43 | 11,651
Tdark 7 | 6,593
Tchem 5 | 1,388
Tclin 1 | 612

IMPC Phenotype

preweaning lethality, complete... 9 | 979
embryonic lethality prior to t... 4 | 278
decreased lean body mass 3 | 135
increased total body fat amoun... 3 | 134
decreased body weight 2 | 161
decreased circulating glucose ... 2 | 126
decreased red blood cell distr... 2 | 41
decreased total body fat amoun... 2 | 207
embryonic lethality prior to o... 2 | 239
increased circulating HDL chol... 2 | 80
increased lean body mass 2 | 172
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal gait 1 | 69
abnormal kidney morphology 1 | 65
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating glycerol... 1 | 16
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased spleen weight 1 | 10
enlarged heart 1 | 210
hyperactivity 1 | 148
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating triglyce... 1 | 42
increased grip strength 1 | 41
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
vertebral fusion 1 | 23

Disease

Carcinoma 39 | 11,493
ovarian cancer 37 | 8,520
osteosarcoma 33 | 7,950
glioblastoma 27 | 5,792
pancreatic ductal adenocarcinoma liver metastasis 22 | 1,962
psoriasis 22 | 6,694
medulloblastoma, large-cell 20 | 6,241
atypical teratoid / rhabdoid tumor 19 | 5,112
lung cancer 18 | 4,740
ependymoma 17 | 4,679
group 3 medulloblastoma 16 | 4,104
Multiple myeloma 15 | 1,332
adult high grade glioma 15 | 3,801
diabetes mellitus 13 | 1,728
Breast cancer 12 | 3,578
lung adenocarcinoma 12 | 2,716
non-small cell lung cancer 12 | 2,890
Astrocytoma, Pilocytic 10 | 3,081
acute quadriplegic myopathy 10 | 1,158
lung carcinoma 10 | 2,843
pancreatic cancer 10 | 2,398
Autosomal recessive predisposition 9 | 1,442
invasive ductal carcinoma 9 | 2,951
subependymal giant cell astrocytoma 9 | 2,287
tuberculosis 9 | 2,010
Kidney cancer 8 | 2,613
active Crohn's disease 8 | 922
astrocytoma 8 | 1,146
primitive neuroectodermal tumor 8 | 3,035
Pick disease 7 | 1,894
astrocytic glioma 7 | 2,597
group 4 medulloblastoma 7 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
juvenile dermatomyositis 7 | 1,187
malignant mesothelioma 7 | 3,232
pituitary cancer 7 | 1,972
Cancer 6 | 2,499
Neurodegenerative disease 6 | 414
Alzheimer's disease 5 | 658
Rheumatoid arthritis 5 | 1,191
dermatomyositis 5 | 966
non primary Sjogren syndrome sicca 5 | 891
oligodendroglioma 5 | 2,850
pediatric high grade glioma 5 | 1,064
Bipolar Disorder 4 | 666
Dysarthria 4 | 192
Epilepsy 4 | 792
Muscle hypotonia 4 | 571
Neurogenic Muscular Atrophy 4 | 139
Neurogenic muscle atrophy, especially in the lower limbs 4 | 139
Obesity 4 | 678
Skeletal muscle atrophy 4 | 139
Vascular disease 4 | 319
colon cancer 4 | 1,478
interstitial cystitis 4 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
muscle degeneration 4 | 139
spina bifida 4 | 1,074
Acquired flat foot 3 | 72
Blepharoptosis 3 | 231
Byzanthine arch palate 3 | 194
Cerebellar Ataxia 3 | 304
Cerebral atrophy 3 | 178
Degenerative brain disorder 3 | 100
Depressive disorder 3 | 409
Exostosis 3 | 15
Fetal Growth Retardation 3 | 189
Flatfoot 3 | 73
Impaired glucose tolerance 3 | 28
Infant, Small for Gestational Age 3 | 176
Intellectual disability 3 | 1,016
Intrauterine retardation 3 | 176
Motor delay 3 | 147
Muscle Cramp 3 | 55
Neuropathy 3 | 261
No development of motor milestones 3 | 147
Polycystic liver disease 3 | 16
Polycystic ovary syndrome 3 | 360
Sensorineural Hearing Loss (disorder) 3 | 284
Short stature 3 | 531
Supratentorial atrophy 3 | 94
Tremor 3 | 113
Waldenstrons macroglobulinemia 3 | 765
adrenocortical carcinoma 3 | 1,428
breast carcinoma 3 | 1,638
hepatocellular carcinoma 3 | 547
pancreatic carcinoma 3 | 562
posterior fossa group B ependymoma 3 | 416
primary pancreatic ductal adenocarcinoma 3 | 1,109
ulcerative colitis 3 | 1,819
Absent reflex 2 | 92
Absent tendon reflex 2 | 92
Bell Palsy 2 | 58
Difficulty walking 2 | 28
Distal limb muscle weakness due to peripheral neuropathy 2 | 62
Distal muscle weakness 2 | 62
Progressive disorder 2 | 142
Reflex, Deep Tendon, Absent 2 | 92
Retinal Degeneration 2 | 106

Tissue

Blood and immune system 56 | 16,909
Cardiovascular System 56 | 15,192
Digestive Tract 56 | 17,369
Endocrine System 56 | 18,159
Female tissues 56 | 17,400
Liver and Pancreas 56 | 16,750
Male tissues 56 | 17,142
Nervous System 56 | 16,725
Respiratory system 56 | 16,393
Skin and soft tissues 56 | 17,230
Urinary Tract 56 | 16,678

Target Family

Non-IDG 29 | 12,091
Enzyme 20 | 4,145
Transcription Factor 3 | 1,400
Epigenetic 2 | 242
Kinase 2 | 634

Reactome Pathway

IRE1alpha activates chaperones 56 | 56
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 17 ZBTB17 Tbio Transcription Factor -1.57508 40.4 92
Signal recognition particle receptor subunit beta SRPRB Tdark Non-IDG -0.45047 3.90 198
Talin-1 TLN1 Tbio Non-IDG -1.94109 90.0 426
Hypoxia up-regulated protein 1 HYOU1 Tbio Non-IDG -1.99998 112.6 246
WD repeat domain phosphoinositide-interacting protein 1 WIPI1 Tbio Non-IDG -1.64159 43.5 192
ATPase ASNA1 ASNA1 Tbio Enzyme -1.82276 75.9 253
Protein transport protein Sec31A SEC31A Tbio Non-IDG -1.18458 13.0 88
Prolactin regulatory element-binding protein PREB Tbio Transcription Factor -2.36585 221.7 63
Glycogen synthase kinase-3 alpha GSK3A Tclin Kinase -1.82880 53.1 840
ER lumen protein-retaining receptor 3 KDELR3 Tdark Non-IDG 0.40 0.12 65