Development Level

Tbio 2 | 10,625
Tchem 2 | 1,890

IMPC Phenotype

decreased mean corpuscular vol... 1 | 50
increased body weight 1 | 42

Disease

Inflammatory bowel disease 2 | 142
Influenza 2 | 142
Melioidosis 2 | 11
Meningitis 2 | 46
Pneumonia 2 | 133
Prostatic Neoplasms 2 | 471
astrocytoma 2 | 1,493
glioblastoma 2 | 5,572
lung cancer 2 | 4,473
malignant mesothelioma 2 | 3,163
pediatric high grade glioma 2 | 2,712
pilocytic astrocytoma 2 | 3,086
psoriasis 2 | 6,685
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 1,563
Adenosine deaminase deficiency 1 | 3
Arthritis 1 | 248
Asthma 1 | 349
Bronchiolitis 1 | 9
Brucellosis 1 | 24
Cancer 1 | 2,346
Connective tissue disease 1 | 59
Diffuse large B-cell lymphoma 1 | 42
Hypersensitivity reaction type II disease 1 | 235
Hypoxia-Ischemia, Brain 1 | 5
IRAK4 deficiency 1 | 1
Immune system cancer 1 | 38
Immunodeficiency due to interleukin-1 receptor-associated kinase-4 deficiency 1 | 1
Inflammation 1 | 109
Invasive Pneumococcal Disease, Recurrent Isolated, 1 1 | 2
Job's syndrome 1 | 4
Keratitis 1 | 42
LEGIONNAIRE DISEASE, SUSCEPTIBILITY TO 1 | 1
Legionnaires' disease 1 | 20
Lupus Erythematosus, Systemic 1 | 73
Lupus erythematosus 1 | 80
Lymphoid leukemia 1 | 69
Lymphoma, Follicular 1 | 20
MYD88 deficiency 1 | 1
Macroglobulinemia 1 | 17
Malaria 1 | 140
Multiple Sclerosis 1 | 498
Neoplasm Invasiveness 1 | 127
Neoplastic Cell Transformation 1 | 81
Nephritis 1 | 63
Peritonitis 1 | 37
Recurrent isolated invasive pneumococcal disease 1 1 | 1
Reperfusion Injury 1 | 84
SYSTEMIC LUPUS ERYTHEMATOSUS, RESISTANCE TO, 1 1 | 1
Systemic lupus erythematosus 1 1 | 1
Theileriasis 1 | 13
Tularemia 1 | 22
Typhoid fever 1 | 22
Vascular disease 1 | 281
WM1 1 | 1
Waldenstrom Macroglobulinemia 1 | 1
adult high grade glioma 1 | 2,148
cutaneous lupus erythematosus 1 | 1,056
cystic fibrosis 1 | 1,670
group 3 medulloblastoma 1 | 2,254
interstitial cystitis 1 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 1 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 1 | 3,289
juvenile dermatomyositis 1 | 1,189
lung carcinoma 1 | 2,844
mucosa-associated lymphoid tissue lymphoma 1 | 480
osteosarcoma 1 | 7,933
ovarian cancer 1 | 8,491
pancreatic cancer 1 | 2,300
pancreatic carcinoma 1 | 567
pituitary cancer 1 | 1,972
primitive neuroectodermal tumor 1 | 3,031
systemic lupus erythematosus 1 | 172
ulcerative colitis 1 | 2,087

Tissue

Blood and immune system 4 | 17,994
Cardiovascular System 4 | 17,957
Digestive Tract 4 | 18,472
Endocrine System 4 | 18,511
Female tissues 4 | 18,646
Liver and Pancreas 4 | 18,135
Male tissues 4 | 17,968
Nervous System 4 | 18,560
Respiratory system 4 | 17,483
Skin and soft tissues 4 | 18,114
Urinary Tract 4 | 18,443

Target Family

Non-IDG 3 | 11,969
Kinase 1 | 634

Reactome Pathway

IRAK4 deficiency (TLR5) 4 | 4
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Toll-like receptor 10 TLR10 Tbio Non-IDG -1.75724 56.1 295
Toll-like receptor 5 TLR5 Tchem Non-IDG -2.75432 581.0 635
Myeloid differentiation primary response protein MyD88 MYD88 Tbio Non-IDG -3.22244 1606.1 561
Interleukin-1 receptor-associated kinase 4 IRAK4 Tchem Kinase -2.24767 182.4 530