Development Level

Tbio 2 | 10,625
Tchem 2 | 1,890

IMPC Term

decreased mean corpuscular vol... 1 | 50
increased body weight 1 | 42

Disease

Inflammatory bowel disease 2 | 142
Influenza 2 | 142
Melioidosis 2 | 11
Meningitis 2 | 46
Pneumonia 2 | 133
Prostatic Neoplasms 2 | 471
astrocytoma 2 | 1,493
glioblastoma 2 | 5,572
lung cancer 2 | 4,466
malignant mesothelioma 2 | 3,162
pediatric high grade glioma 2 | 2,712
pilocytic astrocytoma 2 | 3,086
psoriasis 2 | 6,685
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 1,557
Adenosine deaminase deficiency 1 | 3
Arthritis 1 | 248
Asthma 1 | 349
Bronchiolitis 1 | 9
Brucellosis 1 | 24
Cancer 1 | 2,346
Connective tissue disease 1 | 59
Diffuse large B-cell lymphoma 1 | 41
Hypersensitivity reaction type II disease 1 | 235
Hypoxia-Ischemia, Brain 1 | 5
IRAK4 Deficiency 1 | 1
Immune system cancer 1 | 38
Inflammation 1 | 109
Invasive Pneumococcal Disease, Recurrent Isolated, 1 1 | 2
Job's syndrome 1 | 4
Keratitis 1 | 42
LEGIONNAIRE DISEASE, SUSCEPTIBILITY TO 1 | 1
Legionnaires' disease 1 | 20
Lupus Erythematosus, Systemic 1 | 73
Lupus erythematosus 1 | 80
Lymphoid leukemia 1 | 69
Lymphoma, Follicular 1 | 20
MYD88 Deficiency 1 | 1
Macroglobulinemia 1 | 17
Malaria 1 | 140
Multiple Sclerosis 1 | 498
Neoplasm Invasiveness 1 | 127
Neoplastic Cell Transformation 1 | 81
Nephritis 1 | 29
Peritonitis 1 | 37
Reperfusion Injury 1 | 84
SYSTEMIC LUPUS ERYTHEMATOSUS, RESISTANCE TO, 1 1 | 1
Theileriasis 1 | 13
Tularemia 1 | 22
Typhoid fever 1 | 22
Vascular disease 1 | 281
Waldenstrom Macroglobulinemia 1 | 1
adult high grade glioma 1 | 2,148
cutaneous lupus erythematosus 1 | 1,056
cystic fibrosis 1 | 1,665
group 3 medulloblastoma 1 | 2,254
interstitial cystitis 1 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 1 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 1 | 3,289
juvenile dermatomyositis 1 | 1,189
lung carcinoma 1 | 2,844
mucosa-associated lymphoid tissue lymphoma 1 | 480
osteosarcoma 1 | 7,933
ovarian cancer 1 | 8,484
pancreatic cancer 1 | 2,300
pancreatic carcinoma 1 | 567
pituitary cancer 1 | 1,972
primitive neuroectodermal tumor 1 | 3,031
systemic lupus erythematosus 1 | 156
ulcerative colitis 1 | 2,087

Tissue

Blood and immune system 4 | 17,995
Cardiovascular System 4 | 17,958
Digestive Tract 4 | 18,473
Endocrine System 4 | 18,512
Female tissues 4 | 18,647
Liver and Pancreas 4 | 18,136
Male tissues 4 | 17,969
Nervous System 4 | 18,561
Respiratory system 4 | 17,484
Skin and soft tissues 4 | 18,115
Urinary Tract 4 | 18,444

Target Family

Non-IDG 3 | 11,971
Kinase 1 | 634

Reactome Pathway

IRAK4 deficiency (TLR5) 4 | 4
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myeloid differentiation primary response protein MyD88 MYD88 Tbio Non-IDG -3.17898 1606.1 561
Toll-like receptor 10 TLR10 Tbio Non-IDG -1.72726 56.1 295
Interleukin-1 receptor-associated kinase 4 IRAK4 Tchem Kinase -2.21875 182.4 530
Toll-like receptor 5 TLR5 Tchem Non-IDG -2.71212 581.0 635