Development Level

Tbio 8 | 11,445
Tchem 1 | 1,598

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal lens morphology 1 | 81
embryonic lethality prior to t... 1 | 278

Disease

Carcinoma 5 | 11,493
osteosarcoma 5 | 7,950
ovarian cancer 5 | 8,520
acute myeloid leukemia 4 | 783
glioblastoma 4 | 5,792
lung cancer 4 | 4,740
medulloblastoma, large-cell 4 | 6,241
atypical teratoid / rhabdoid tumor 3 | 5,112
Anemia 2 | 365
Cancer 2 | 2,499
Hypohidrotic ectodermal dysplasia 2 | 15
Hypoplastic mandible condyle 2 | 275
Mandibular hypoplasia 2 | 275
Micrognathism 2 | 275
Myofibrillar myopathy 1 2 | 6
Myofibrillar myopathy 3 2 | 5
Pick's disease 2 | 15
astrocytic glioma 2 | 2,597
dermatomyositis 2 | 966
group 4 medulloblastoma 2 | 1,855
juvenile dermatomyositis 2 | 1,187
primary pancreatic ductal adenocarcinoma 2 | 1,109
progressive supranuclear palsy 2 | 676
psoriasis 2 | 6,694
Abnormality of the metaphyses 1 | 48
Abnormally-shaped vertebrae 1 | 31
Acquired scoliosis 1 | 281
Advanced bone age 1 | 35
Agenesis of teeth 1 | 21
Alzheimer's disease 1 | 658
Anterior open-bite malocclusion 1 | 4
Aortic Valve Insufficiency 1 | 40
Aortic valve stenosis 1 | 28
Arthritis 1 | 290
Atrial Fibrillation 1 | 124
Attention deficit hyperactivity disorder 1 | 278
Autosomal dominant hypohidrotic ectodermal dysplasia syndrome (disorder) 1 | 3
Bicuspid aortic valve 1 | 16
Byzanthine arch palate 1 | 194
CPI 1 | 1
Cholestasis, Extrahepatic 1 | 25
Cleft Palate, Isolated, And Mental Retardation 1 | 2
Cleft Soft Palate 1 | 7
Cleft of hard palate 1 | 2
Cleft uvula 1 | 27
Conductive hearing loss 1 | 123
Congenital sensorineural hearing loss 1 | 12
Coronary artery disease 1 | 268
Curvature of spine 1 | 282
Deep overbite 1 | 4
Dental abnormalities 1 | 60
Dilatation of aorta 1 | 9
Disorder of eye 1 | 27
Downward slant of palpebral fissure 1 | 158
Epilepsy 1 | 792
Eye Abnormalities 1 | 35
Flexion contracture of proximal interphalangeal joint 1 | 75
Freckles 1 | 33
Frontometaphyseal dysplasia 1 | 2
Gastrointestinal system disease 1 | 54
Gaucher disease type 3 1 | 67
Gingival Hyperplasia 1 | 34
Gingival Hypertrophy 1 | 34
Gingival Overgrowth 1 | 36
Hamman-Rich syndrome 1 | 34
Hyperplasia of supraorbital margins 1 | 19
Hyperplasia of supraorbital ridge 1 | 19
Hypertrophy of supraorbital margins 1 | 19
Hypertrophy of supraorbital ridge 1 | 19
Hypoplasia of muscle 1 | 5
Joint stiffness 1 | 84
Long fingers 1 | 9
Mitral Regurgitation, Conductive Deafness, and Fusion of Cervical Vertebrae and of Carpal and Tarsal Bones 1 | 1
Mitral regurgitation, mild 1 | 32
Mitral valve insufficiency 1 | 49
Osteopetrosis 1 | 43
Osteoporosis 1 | 363
Overbite 1 | 4
Polycystic ovary syndrome 1 | 360
Posterior lingual occlusion of mandibular teeth 1 | 4
Profound Mental Retardation 1 | 31
Profound intellectual disabilities 1 | 31
Prominent supraorbital ridges 1 | 19
Reduced number of teeth 1 | 21
Seizures 1 | 596
Sensorineural Hearing Loss (disorder) 1 | 284
Short thumb terminal phalanx 1 | 5
Subaortic stenosis 1 | 9
Submucous cleft of hard palate 1 | 11
Synostosis of carpal bones 1 | 9
Tetralogy of Fallot 1 | 63
Tooth Abnormalities 1 | 69
Ulnar deviation of the fingers 1 | 21
Ventricular Septal Defects 1 | 119
acute quadriplegic myopathy 1 | 1,158
astrocytoma 1 | 1,146
lung adenocarcinoma 1 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 1 | 1,962
spina bifida 1 | 1,074
tuberculosis and treatment for 6 months 1 | 409

Tissue

Blood and immune system 9 | 16,909
Cardiovascular System 9 | 15,192
Digestive Tract 9 | 17,369
Endocrine System 9 | 18,159
Female tissues 9 | 17,400
Liver and Pancreas 9 | 16,750
Male tissues 9 | 17,142
Nervous System 9 | 16,725
Respiratory system 9 | 16,393
Skin and soft tissues 9 | 17,230
Urinary Tract 9 | 16,678

Target Family

Non-IDG 5 | 12,091
Enzyme 2 | 4,145
Kinase 2 | 634

Reactome Pathway

IRAK2 mediated activation of T... 9 | 9
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.12534 131.4 181
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG -1.66231 61.9 139
TNF receptor-associated factor 6 TRAF6 Tbio Non-IDG -2.74221 511.1 403
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TAB2 Tbio Enzyme -1.90517 75.2 151
Mitogen-activated protein kinase kinase kinase 7 MAP3K7 Tchem Kinase -1.46817 32.4 765
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 TAB1 Tbio Kinase -1.94861 84.9 478
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 TAB3 Tbio Enzyme -1.39954 24.6 207