Development Level

Tbio 156 | 10,625
Tchem 83 | 1,890
Tclin 44 | 602
Tdark 7 | 7,003

Collection

Eligible Kinase Proteins 3 | 134

IMPC Term

preweaning lethality, complete... 15 | 633
decreased body weight 10 | 174
decreased total body fat amoun... 7 | 186
decreased circulating choleste... 6 | 85
enlarged heart 6 | 111
abnormal bone structure 5 | 131
decreased circulating HDL chol... 5 | 77
decreased circulating LDL chol... 5 | 37
decreased lean body mass 5 | 195
embryonic lethality prior to t... 5 | 187
decreased bone mineral content 4 | 157
decreased circulating alanine ... 4 | 53
decreased grip strength 4 | 123
decreased lumbar vertebrae num... 4 | 62
abnormal behavior 3 | 226
abnormal embryo size 3 | 112
decreased body length 3 | 108
decreased circulating triglyce... 3 | 83
decreased kidney weight 3 | 7
increased mean corpuscular hem... 3 | 93
thrombocytopenia 3 | 46
abnormal bone mineralization 2 | 55
abnormal coat/hair pigmentatio... 2 | 54
abnormal lens morphology 2 | 73
abnormal retina morphology 2 | 100
abnormal retinal pigmentation 2 | 61
abnormal retinal vasculature m... 2 | 15
abnormal rib morphology 2 | 28
abnormal seminal vesicle morph... 2 | 47
cataract 2 | 26
decreased circulating aspartat... 2 | 27
decreased circulating creatini... 2 | 31
decreased circulating glucose ... 2 | 121
decreased circulating serum al... 2 | 79
decreased circulating sodium l... 2 | 18
decreased circulating total pr... 2 | 41
decreased fasted circulating g... 2 | 49
decreased heart weight 2 | 44
decreased lactate dehydrogenas... 2 | 14
decreased mean corpuscular hem... 2 | 19
decreased mean corpuscular vol... 2 | 50
decreased neutrophil cell numb... 2 | 37
decreased rib number 2 | 59
decreased spleen weight 2 | 13
decreased thoracic vertebrae n... 2 | 7
embryonic lethality prior to o... 2 | 148
enlarged spleen 2 | 26
immune system phenotype 2 | 17
impaired glucose tolerance 2 | 52
impaired pupillary reflex 2 | 14
increased circulating HDL chol... 2 | 63
increased circulating LDL chol... 2 | 15
increased circulating alkaline... 2 | 119
increased circulating phosphat... 2 | 24
increased exploration in new e... 2 | 56
increased lean body mass 2 | 107
increased or absent threshold ... 2 | 128
increased startle reflex 2 | 38
limb grasping 2 | 35
male infertility 2 | 62
preweaning lethality, incomple... 2 | 260
abnormal body wall morphology 1 | 7
abnormal cornea morphology 1 | 24
abnormal gait 1 | 51
abnormal head morphology 1 | 10
abnormal locomotor activation 1 | 26
abnormal neural tube closure 1 | 37
abnormal respiratory quotient 1 | 9
abnormal spleen morphology 1 | 36
absent pinna reflex 1 | 21
corneal opacity 1 | 25
decreased T cell number 1 | 31
decreased blood urea nitrogen ... 1 | 31
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating calcium ... 1 | 33
decreased circulating chloride... 1 | 32
decreased circulating iron lev... 1 | 25
decreased circulating magnesiu... 1 | 11
decreased circulating potassiu... 1 | 17
decreased effector memory CD8-... 1 | 24
decreased hemoglobin content 1 | 53
decreased mean corpuscular hem... 1 | 34
female infertility 1 | 34
impaired righting response 1 | 19
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased bone mineral density 1 | 52
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 53
increased circulating fructosa... 1 | 11
increased grip strength 1 | 83
increased mean corpuscular vol... 1 | 91
increased mean platelet volume 1 | 19
increased sacral vertebrae num... 1 | 62
prenatal lethality prior to he... 1 | 64
short tibia 1 | 82
thrombocytosis 1 | 23
tremors 1 | 34
vertebral fusion 1 | 23

Disease

ovarian cancer 164 | 8,484
osteosarcoma 151 | 7,933
glioblastoma 122 | 5,572
Cancer 119 | 2,346
medulloblastoma, large-cell 118 | 6,234
psoriasis 118 | 6,685
lung cancer 105 | 4,466
atypical teratoid / rhabdoid tumor 84 | 4,369
Breast cancer 72 | 3,094
Carcinoma 68 | 2,147
malignant mesothelioma 66 | 3,162
pilocytic astrocytoma 66 | 3,086
oligodendroglioma 65 | 2,849
ependymoma 64 | 2,514
invasive ductal carcinoma 62 | 2,950
intraductal papillary-mucinous neoplasm (IPMN) 61 | 3,289
pediatric high grade glioma 57 | 2,712
lung adenocarcinoma 55 | 2,713
astrocytic glioma 53 | 2,241
non-small cell lung cancer 52 | 2,798
subependymal giant cell astrocytoma 52 | 2,287
interstitial cystitis 51 | 2,299
lung carcinoma 51 | 2,844
Multiple myeloma 49 | 1,327
intraductal papillary-mucinous adenoma (IPMA) 47 | 2,956
primitive neuroectodermal tumor 46 | 3,031
pancreatic cancer 45 | 2,300
ulcerative colitis 44 | 2,087
diabetes mellitus 43 | 1,663
intraductal papillary-mucinous carcinoma (IPMC) 42 | 2,988
pancreatic ductal adenocarcinoma liver metastasis 37 | 1,795
pituitary cancer 37 | 1,972
Pick disease 36 | 1,893
medulloblastoma 36 | 1,524
tuberculosis 36 | 1,557
astrocytoma 35 | 1,493
breast carcinoma 35 | 1,614
cystic fibrosis 35 | 1,665
ductal carcinoma in situ 35 | 1,745
group 4 medulloblastoma 35 | 1,875
group 3 medulloblastoma 34 | 2,254
adult high grade glioma 32 | 2,148
Rheumatoid Arthritis 31 | 1,160
colon cancer 29 | 1,475
Mammary Neoplasms 28 | 410
primary pancreatic ductal adenocarcinoma 26 | 1,271
adrenocortical carcinoma 24 | 1,427
juvenile dermatomyositis 24 | 1,189
Liver carcinoma 22 | 217
Parkinson's disease 22 | 364
Schizophrenia 22 | 501
Waldenstrons macroglobulinemia 22 | 765
posterior fossa group B ependymoma 22 | 1,530
dermatomyositis 21 | 933
Intellectual disability 20 | 573
Obesity 20 | 616
non-small cell lung carcinoma 20 | 413
spina bifida 20 | 1,064
Autistic Disorder 19 | 320
Lung Neoplasms 19 | 171
Renal Cell Carcinoma 19 | 199
cutaneous lupus erythematosus 19 | 1,056
gastric carcinoma 19 | 832
Alzheimer's disease 18 | 644
HIV Infections 18 | 100
Stomach Neoplasms 18 | 282
non primary Sjogren syndrome sicca 18 | 840
Polycystic Ovary Syndrome 17 | 332
Prostatic Neoplasms 17 | 471
atypical teratoid/rhabdoid tumor 17 | 1,095
esophageal adenocarcinoma 17 | 737
sonic hedgehog group medulloblastoma 17 | 1,482
Asthma 16 | 349
Vascular disease 16 | 281
posterior fossa group A ependymoma 16 | 1,511
Mammary Neoplasms, Experimental 15 | 150
Neoplasm Invasiveness 15 | 127
Noonan Syndrome 15 | 33
Osteoporosis 15 | 257
pancreatic carcinoma 15 | 567
Anemia 14 | 252
Animal Mammary Neoplasms 14 | 136
Heart disease 14 | 279
Peripheral Neuropathy 14 | 303
Squamous cell carcinoma 14 | 94
fibroadenoma 14 | 557
primary Sjogren syndrome 14 | 789
tuberculosis and treatment for 6 months 14 | 686
Adenoma 13 | 165
Kidney disease 13 | 396
Myocardial Ischemia 13 | 169
autosomal dominant Emery-Dreifuss muscular dystrophy 13 | 499
Atherosclerosis 12 | 275
Atopic dermatitis 12 | 944
Down syndrome 12 | 548
Melanoma 12 | 261
Multiple Sclerosis 12 | 498
Thrombocytopenia 12 | 105
acute myeloid leukemia 12 | 780
hepatocellular carcinoma 12 | 532

Tissue

Female tissues 290 | 18,647
Nervous System 290 | 18,561
Digestive Tract 289 | 18,473
Endocrine System 289 | 18,512
Liver and Pancreas 288 | 18,136
Urinary Tract 288 | 18,444
Blood and immune system 287 | 17,995
Skin and soft tissues 285 | 18,115
Cardiovascular System 284 | 17,958
Male tissues 283 | 17,969
Respiratory system 279 | 17,484

Target Family

Non-IDG 141 | 11,971
Enzyme 88 | 4,146
Kinase 56 | 634
Ion Channel 5 | 341

Reactome Pathway

IGF1R signaling cascade 290 | 290
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
Fibroblast growth factor 5 FGF5 Tbio Non-IDG -2.00731 99.9 143
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Fibrinogen alpha chain FGA Tbio Non-IDG -2.84597 716.2 457
STE20-related kinase adapter protein alpha STRADA Tbio Kinase -1.42357 23.3 215
Beta-arrestin-1 ARRB1 Tchem Non-IDG -2.54226 366.3 416
Interleukin-2 receptor subunit beta IL2RB Tclin Non-IDG -2.08442 120.9 537
Beta-klotho KLB Tbio Enzyme -1.89423 69.9 47