Development Level

Tbio 30 | 11,651
Tchem 11 | 1,388
Tclin 8 | 612

IMPC Phenotype

preweaning lethality, complete... 7 | 979
embryonic lethality prior to t... 4 | 278
abnormal embryo size 3 | 220
abnormal bone structure 2 | 187
abnormal retinal vasculature m... 2 | 27
cataract 2 | 92
decreased body weight 2 | 161
decreased circulating creatini... 2 | 39
impaired pupillary reflex 2 | 26
increased circulating choleste... 2 | 66
abnormal body wall morphology 1 | 9
abnormal cornea morphology 1 | 31
abnormal lens morphology 1 | 81
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal tail morphology 1 | 25
absent startle reflex 1 | 24
cleft palate 1 | 8
corneal opacity 1 | 32
decreased bone mineral content 1 | 151
decreased circulating aspartat... 1 | 34
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased spleen weight 1 | 10
decreased threshold for audito... 1 | 26
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
fused cornea and lens 1 | 5
hemorrhage 1 | 23
impaired righting response 1 | 26
increased body length 1 | 32
increased circulating HDL chol... 1 | 80
increased circulating glucose ... 1 | 24
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
iris synechia 1 | 3
limb grasping 1 | 41
narrow eye opening 1 | 12
no spontaneous movement 1 | 1
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97

Disease

Cancer 33 | 2,499
Carcinoma 31 | 11,493
ovarian cancer 25 | 8,520
osteosarcoma 23 | 7,950
lung cancer 22 | 4,740
psoriasis 21 | 6,694
atypical teratoid / rhabdoid tumor 20 | 5,112
Breast cancer 19 | 3,578
invasive ductal carcinoma 19 | 2,951
medulloblastoma, large-cell 18 | 6,241
glioblastoma 17 | 5,792
Kidney cancer 16 | 2,613
breast carcinoma 16 | 1,638
non-small cell lung cancer 14 | 2,890
diabetes mellitus 13 | 1,728
ductal carcinoma in situ 13 | 1,745
ependymoma 13 | 4,679
malignant mesothelioma 13 | 3,232
Delayed bone age 12 | 136
Hypoplastic mandible condyle 12 | 275
Mandibular hypoplasia 12 | 275
Micrognathism 12 | 275
Orbital separation excessive 12 | 244
Short stature 12 | 531
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
Autosomal recessive predisposition 11 | 1,442
Breast Neoplasms 11 | 445
Carcinoma, Hepatocellular 11 | 228
Cryptorchidism 11 | 296
Downward slant of palpebral fissure 11 | 158
Liver carcinoma 11 | 240
Mammary Neoplasms 11 | 425
group 3 medulloblastoma 11 | 4,104
lung adenocarcinoma 11 | 2,716
Blepharoptosis 10 | 231
Cleft Palate 10 | 271
Frontal bossing 10 | 157
Intellectual disability 10 | 1,016
oligodendroglioma 10 | 2,850
Astrocytoma, Pilocytic 9 | 3,081
Byzanthine arch palate 9 | 194
Cleft Lip 9 | 141
Depressive disorder 9 | 409
Dull intelligence 9 | 645
High forehead 9 | 102
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Obesity 9 | 678
Poor school performance 9 | 645
Schizophrenia 9 | 1,160
Seizures 9 | 596
Tall forehead 9 | 102
Telecanthus 9 | 62
astrocytic glioma 9 | 2,597
group 4 medulloblastoma 9 | 1,855
Cognitive delay 8 | 608
Concave bridge of nose 8 | 195
Depressed nasal bridge 8 | 195
Depressed nasal root/bridge 8 | 195
Epilepsy 8 | 792
Exophthalmos 8 | 112
Generalized osteopenia 8 | 99
Global developmental delay 8 | 608
Low set ears 8 | 181
Melanocytic nevus 8 | 43
Mental and motor retardation 8 | 608
Muscle hypotonia 8 | 571
Noncancerous mole 8 | 28
Osteopenia 8 | 99
Polycystic ovary syndrome 8 | 360
Prominent eyes 8 | 96
Prominent globes 8 | 96
Protruding eyes 8 | 96
Strabismus 8 | 270
Wide spaced nipples 8 | 46
adult high grade glioma 8 | 3,801
interstitial cystitis 8 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
juvenile dermatomyositis 8 | 1,187
lung carcinoma 8 | 2,843
pituitary cancer 8 | 1,972
Acquired scoliosis 7 | 281
Big calvaria 7 | 147
Curvature of spine 7 | 282
Fetal Growth Retardation 7 | 189
Increased head circumference 7 | 147
Increased size of cranium 7 | 147
Increased size of skull 7 | 147
Infant, Small for Gestational Age 7 | 176
Intrauterine retardation 7 | 176
Isolated cases 7 | 72
Joint hyperflexibility 7 | 78
Pectus excavatum 7 | 100
Stomach Neoplasms 7 | 300
Ventricular Septal Defects 7 | 119
adrenocortical carcinoma 7 | 1,428
pancreatic cancer 7 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962

Tissue

Endocrine System 48 | 18,159
Digestive Tract 47 | 17,369
Nervous System 47 | 16,725
Female tissues 46 | 17,400
Male tissues 46 | 17,142
Skin and soft tissues 46 | 17,230
Urinary Tract 45 | 16,678
Blood and immune system 44 | 16,909
Liver and Pancreas 44 | 16,750
Respiratory system 43 | 16,393
Cardiovascular System 40 | 15,192

Target Family

Non-IDG 28 | 12,091
Kinase 12 | 634
Enzyme 9 | 4,145

Reactome Pathway

IGF1R signaling cascade 49 | 49
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Insulin receptor substrate 2 IRS2 Tbio Non-IDG -2.64133 414.7 227
Tribbles homolog 3 TRIB3 Tbio Kinase -1.93599 97.7 421
Phosphatidylinositol 3-kinase catalytic subunit type 3 PIK3C3 Tchem Kinase -2.33238 204.8 739
Fibroblast growth factor receptor substrate 2 FRS2 Tbio Non-IDG -2.37203 224.0 344
Fibroblast growth factor 22 FGF22 Tbio Non-IDG -1.15836 16.5 186
3-phosphoinositide-dependent protein kinase 1 PDPK1 Tchem Kinase -2.12025 204.9 608
Fibroblast growth factor 10 FGF10 Tbio Non-IDG -2.55166 363.0 320
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -3.02404 981.4 501
Tyrosine-protein phosphatase non-receptor type 11 PTPN11 Tchem Enzyme -3.11032 1400.0 1077
Insulin-like growth factor II IGF2 Tbio Non-IDG -3.65750 4465.3 457