Development Level

Tbio 92 | 11,445
Tchem 14 | 1,598
Tdark 5 | 6,588
Tclin 4 | 613

IMPC Phenotype

preweaning lethality, complete... 14 | 979
embryonic lethality prior to o... 9 | 239
embryonic lethality prior to t... 7 | 278
abnormal embryo size 3 | 220
abnormal embryo turning 3 | 31
preweaning lethality, incomple... 3 | 499
abnormal blood vessel morpholo... 2 | 5
abnormal eye morphology 2 | 68
abnormal heart morphology 2 | 162
abnormal pharyngeal arch morph... 2 | 8
corneal opacity 2 | 32
decreased circulating glucose ... 2 | 126
embryonic growth retardation 2 | 106
increased circulating choleste... 2 | 66
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
abnormal bone structure 1 | 187
abnormal chorioallantoic fusio... 1 | 8
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal embryo development 1 | 7
abnormal eye size 1 | 7
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal kidney morphology 1 | 65
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal placement of pupils 1 | 6
abnormal retinal inner nuclear... 1 | 8
abnormal seminal vesicle morph... 1 | 114
abnormal somite shape 1 | 5
abnormal spinal cord morpholog... 1 | 9
abnormal spleen morphology 1 | 55
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased heart rate variabili... 1 | 13
decreased lean body mass 1 | 135
decreased red blood cell distr... 1 | 41
decreased total retina thickne... 1 | 17
decreased vertical activity 1 | 208
enlarged heart 1 | 210
female infertility 1 | 60
hyperactivity 1 | 148
hypoactivity 1 | 132
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 36
increased mean platelet volume 1 | 45
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
male infertility 1 | 123
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
thrombocytosis 1 | 27

Disease

ovarian cancer 74 | 8,520
Carcinoma 70 | 11,493
osteosarcoma 61 | 7,950
Cancer 50 | 2,499
Breast cancer 48 | 3,578
lung cancer 48 | 4,740
psoriasis 48 | 6,694
group 3 medulloblastoma 46 | 4,104
malignant mesothelioma 41 | 3,232
glioblastoma 40 | 5,792
medulloblastoma, large-cell 40 | 6,241
non-small cell lung cancer 35 | 2,890
atypical teratoid / rhabdoid tumor 32 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 29 | 3,291
invasive ductal carcinoma 27 | 2,951
primitive neuroectodermal tumor 27 | 3,035
adult high grade glioma 24 | 3,801
ductal carcinoma in situ 23 | 1,745
ependymoma 23 | 4,679
lung adenocarcinoma 23 | 2,716
Fanconi anemia 22 | 56
colon cancer 22 | 1,478
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,989
Short stature 20 | 531
nasopharyngeal carcinoma 20 | 1,058
Autosomal recessive predisposition 18 | 1,442
Bloom syndrome 18 | 29
Breast Neoplasms 18 | 445
Mammary Neoplasms 18 | 425
breast carcinoma 17 | 1,638
Intellectual disability 16 | 1,016
Kidney cancer 15 | 2,613
Small head 15 | 374
adrenocortical carcinoma 15 | 1,428
Ataxia telangiectasia 14 | 34
Dull intelligence 13 | 645
Low intelligence 13 | 645
Mental Retardation 13 | 645
Mental deficiency 13 | 645
Nijmegen breakage syndrome 13 | 24
Poor school performance 13 | 645
Xeroderma pigmentosum 13 | 43
astrocytic glioma 13 | 2,597
oligodendroglioma 13 | 2,850
pancreatic cancer 13 | 2,398
non primary Sjogren syndrome sicca 12 | 891
Cognitive delay 11 | 608
Global developmental delay 11 | 608
Hereditary Breast and Ovarian Cancer Syndrome 11 | 14
Mental and motor retardation 11 | 608
diabetes mellitus 11 | 1,728
pituitary cancer 11 | 1,972
Anemia 10 | 365
Chromosome Breakage 10 | 36
Hypoplastic mandible condyle 10 | 275
Mandibular hypoplasia 10 | 275
Micrognathism 10 | 275
Schizophrenia 10 | 1,160
Seckel syndrome 10 | 34
Waldenstrons macroglobulinemia 10 | 765
lung carcinoma 10 | 2,843
Acquired scoliosis 9 | 281
Curvature of spine 9 | 282
Multiple myeloma 9 | 1,332
Werner syndrome 9 | 29
Astrocytoma, Pilocytic 8 | 3,081
Increased chromosomal breakage 8 | 27
Pick disease 8 | 1,894
subependymal giant cell astrocytoma 8 | 2,287
ulcerative colitis 8 | 1,819
Atopic dermatitis 7 | 952
Cockayne syndrome 7 | 60
Convex nasal ridge 7 | 37
Decreased platelet count 7 | 111
Fetal Growth Retardation 7 | 189
Infant, Small for Gestational Age 7 | 176
Intrauterine retardation 7 | 176
Malignant neoplasm of breast 7 | 15
Melanoma 7 | 711
Prostatic Neoplasms 7 | 495
Thrombocytopenia 7 | 197
Xeroderma pigmentosum group F 7 | 22
cystic fibrosis 7 | 1,696
Almond-shaped eyes 6 | 23
Cleft Palate 6 | 271
Colorectal Neoplasms 6 | 243
Cryptorchidism 6 | 296
Endometriosis 6 | 540
Esophageal atresia with or without tracheoesophageal fistula 6 | 21
Leukopenia 6 | 72
Ovarian Neoplasms 6 | 102
Photosensitivity of skin 6 | 51
Strabismus 6 | 270
Xeroderma pigmentosum group G 6 | 16
acute myeloid leukemia 6 | 783
cutaneous lupus erythematosus 6 | 1,057
esophageal atresia/tracheoesophageal fistula 6 | 22
hypopigmented skin patch 6 | 59
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
ovarian neoplasm 6 | 99

Tissue

Endocrine System 115 | 18,159
Blood and immune system 114 | 16,909
Digestive Tract 114 | 17,369
Female tissues 114 | 17,400
Male tissues 114 | 17,142
Nervous System 114 | 16,725
Respiratory system 114 | 16,393
Skin and soft tissues 114 | 17,230
Urinary Tract 114 | 16,678
Liver and Pancreas 113 | 16,750
Cardiovascular System 112 | 15,192

Target Family

Non-IDG 71 | 12,091
Enzyme 35 | 4,145
Kinase 4 | 634
Epigenetic 3 | 242
TF/Epigenetic 1 | 38
Transcription Factor 1 | 1,400

Reactome Pathway

Homology Directed Repair 115 | 115
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2B type 1-N HIST1H2BN Tbio Non-IDG -1.51422 30.2 60
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 48
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.17 0.33 21
DNA polymerase delta subunit 4 POLD4 Tbio Enzyme -0.84887 7.32 24
RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 RHNO1 Tbio Non-IDG -3.20363 1560.8 3
Serine/threonine-protein kinase ATR ATR Tchem Kinase -2.80362 549.6 376
DNA endonuclease RBBP8 RBBP8 Tbio Enzyme -2.17933 148.4 308
DNA topoisomerase 3-alpha TOP3A Tbio Enzyme -2.77897 560.7 45
TP53-binding protein 1 TP53BP1 Tbio Epigenetic -2.69485 464.8 577
Protein timeless homolog TIMELESS Tbio Non-IDG -2.76871 578.0 138