Development Level

Tbio 32 | 10,625
Tchem 8 | 1,890
Tdark 1 | 7,003

IMPC Term

preweaning lethality, complete... 7 | 633
embryonic lethality prior to o... 4 | 148
embryonic lethality prior to t... 4 | 187
abnormal behavioral response t... 1 | 52
abnormal blood vessel morpholo... 1 | 2
abnormal bone structure 1 | 131
cardiovascular system phenotyp... 1 | 35
decreased circulating glucose ... 1 | 121
decreased fasted circulating g... 1 | 49
decreased heart rate variabili... 1 | 11
hypoactivity 1 | 89
increased circulating sodium l... 1 | 71
increased exploration in new e... 1 | 56
increased heart weight 1 | 37
increased lean body mass 1 | 107
increased mean corpuscular vol... 1 | 91

Disease

ovarian cancer 29 | 8,484
osteosarcoma 24 | 7,933
malignant mesothelioma 23 | 3,162
Breast cancer 21 | 3,094
lung cancer 21 | 4,466
Cancer 20 | 2,346
psoriasis 18 | 6,685
medulloblastoma, large-cell 17 | 6,234
non-small cell lung cancer 17 | 2,798
glioblastoma 16 | 5,572
group 3 medulloblastoma 16 | 2,254
primitive neuroectodermal tumor 15 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,289
Fanconi's anemia 13 | 50
Mammary Neoplasms 13 | 410
colon cancer 12 | 1,475
nasopharyngeal carcinoma 12 | 1,056
Neoplastic Syndromes, Hereditary 11 | 48
atypical teratoid/rhabdoid tumor 11 | 1,095
ductal carcinoma in situ 11 | 1,745
invasive ductal carcinoma 11 | 2,950
Bloom syndrome 10 | 30
Hereditary Breast and Ovarian Cancer Syndrome 10 | 14
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,988
pediatric high grade glioma 10 | 2,712
Ataxia telangiectasia 9 | 31
Carcinoma 9 | 2,147
Nijmegen breakage syndrome 9 | 23
adrenocortical carcinoma 9 | 1,427
lung adenocarcinoma 8 | 2,713
Breast Cancer, Familial 7 | 12
Peripheral Neuropathy 7 | 303
Seckel syndrome 7 | 34
non primary Sjogren syndrome sicca 7 | 840
sonic hedgehog group medulloblastoma 7 | 1,482
Malignant neoplasm of breast 6 | 63
Werner syndrome 6 | 29
atypical teratoid / rhabdoid tumor 6 | 4,369
diabetes mellitus 6 | 1,663
ependymoma 6 | 2,514
oligodendroglioma 6 | 2,849
ovarian neoplasm 6 | 97
posterior fossa group A ependymoma 6 | 1,511
Anemia 5 | 252
Prostate cancer 5 | 172
astrocytic glioma 5 | 2,241
pituitary cancer 5 | 1,972
Chronic Lymphocytic Leukemia 4 | 242
Fanconi Anemia 4 | 19
Microcephaly 4 | 149
Pancreatic Neoplasm 4 | 79
Prostatic Neoplasms 4 | 471
Rothmund-Thomson syndrome 4 | 22
Waldenstrons macroglobulinemia 4 | 765
breast carcinoma 4 | 1,614
lung carcinoma 4 | 2,844
Aplastic anemia 3 | 18
Cockayne syndrome 3 | 54
Cowden disease 3 | 16
Hereditary breast ovarian cancer 3 | 6
Intellectual disability 3 | 573
Li-Fraumeni Syndrome 3 | 13
Lynch syndrome 3 | 33
Malignant neoplasm of ovary 3 | 13
Pancreatic carcinoma, familial 3 | 8
Pick disease 3 | 1,893
Prostate cancer, familial 3 | 13
Xeroderma pigmentosum 3 | 41
adult high grade glioma 3 | 2,148
astrocytoma 3 | 1,493
cutaneous lupus erythematosus 3 | 1,056
dermatomyositis 3 | 933
pancreatic cancer 3 | 2,300
tuberculosis and treatment for 6 months 3 | 686
ulcerative colitis 3 | 2,087
Adenoid Cystic Carcinoma 2 | 99
Alzheimer's disease 2 | 644
Asthma 2 | 349
Bipolar Disorder 2 | 266
Endometriosis 2 | 535
Head and Neck Neoplasms 2 | 23
IGA Glomerulonephritis 2 | 454
Lobular neoplasia 2 | 15
Malignant neoplasm of prostate 2 | 67
Mammary Neoplasms, Experimental 2 | 150
Melanoma 2 | 261
Multiple Sclerosis 2 | 498
Rheumatoid Arthritis 2 | 1,160
Stomach Neoplasms 2 | 282
acute myeloid leukemia 2 | 780
acute quadriplegic myopathy 2 | 1,157
cystic fibrosis 2 | 1,665
inflammatory breast cancer 2 | 404
interstitial cystitis 2 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,956
non-small cell lung carcinoma 2 | 413
pilocytic astrocytoma 2 | 3,086
progressive supranuclear palsy 2 | 674
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 1,557

Tissue

Blood and immune system 41 | 17,995
Cardiovascular System 41 | 17,958
Digestive Tract 41 | 18,473
Endocrine System 41 | 18,512
Female tissues 41 | 18,647
Liver and Pancreas 41 | 18,136
Male tissues 41 | 17,969
Nervous System 41 | 18,561
Respiratory system 41 | 17,484
Skin and soft tissues 41 | 18,115
Urinary Tract 41 | 18,444

Target Family

Non-IDG 31 | 11,971
Enzyme 6 | 4,146
Kinase 3 | 634
Epigenetic 1 | 242

Reactome Pathway

Homologous DNA Pairing and Str... 41 | 41
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.76828 59.7 468
Replication factor C subunit 3 RFC3 Tbio Non-IDG -1.28299 19.5 161
Replication factor C subunit 5 RFC5 Tbio Non-IDG -1.02728 11.1 64
Replication factor C subunit 2 RFC2 Tbio Non-IDG -1.34287 19.7 194
Replication protein A 14 kDa subunit RPA3 Tbio Non-IDG -1.80635 59.3 127
Replication factor C subunit 4 RFC4 Tbio Non-IDG -1.13105 13.0 167
Partner and localizer of BRCA2 PALB2 Tbio Non-IDG -2.07830 149.3 120
Cell cycle checkpoint control protein RAD9B RAD9B Tdark Non-IDG -0.05859 1.38 29
DNA replication ATP-dependent helicase/nuclease DNA2 DNA2 Tbio Enzyme -2.37310 239.3 81
Breast cancer type 2 susceptibility protein BRCA2 Tbio Non-IDG -3.42019 2495.6 219