Development Level

Tbio 33 | 11,178
Tchem 7 | 1,885
Tdark 1 | 6,569

IMPC Phenotype

preweaning lethality, complete... 9 | 979
embryonic lethality prior to t... 7 | 278
embryonic lethality prior to o... 6 | 239
abnormal blood vessel morpholo... 2 | 5
abnormal embryo size 2 | 220
abnormal embryo turning 2 | 31
decreased circulating glucose ... 2 | 126
abnormal bone structure 1 | 187
abnormal chorioallantoic fusio... 1 | 8
abnormal embryo development 1 | 7
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pharyngeal arch morph... 1 | 8
abnormal somite shape 1 | 5
abnormal spinal cord morpholog... 1 | 9
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
cardiovascular system phenotyp... 1 | 36
decreased fasted circulating g... 1 | 65
decreased heart rate variabili... 1 | 13
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
hypoactivity 1 | 132
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased heart weight 1 | 62
increased mean corpuscular vol... 1 | 92
pale yolk sac 1 | 25
pallor 1 | 34

Disease

ovarian cancer 29 | 8,297
Carcinoma 28 | 11,192
osteosarcoma 23 | 7,766
Breast cancer 21 | 3,469
group 3 medulloblastoma 21 | 4,002
lung cancer 21 | 4,607
malignant mesothelioma 21 | 3,135
Cancer 19 | 2,388
psoriasis 18 | 6,514
medulloblastoma, large-cell 16 | 6,086
non-small cell lung cancer 16 | 2,799
atypical teratoid / rhabdoid tumor 15 | 4,971
glioblastoma 15 | 5,635
primitive neuroectodermal tumor 14 | 2,957
Fanconi anemia 13 | 56
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,204
Short stature 12 | 514
colon cancer 12 | 1,428
Breast Neoplasms 11 | 423
Mammary Neoplasms 11 | 403
Small head 11 | 366
adult high grade glioma 11 | 3,701
ependymoma 11 | 4,559
invasive ductal carcinoma 11 | 2,867
nasopharyngeal carcinoma 11 | 1,024
Autosomal recessive predisposition 10 | 1,407
Dull intelligence 10 | 634
Hereditary Breast and Ovarian Cancer Syndrome 10 | 13
Intellectual disability 10 | 998
Low intelligence 10 | 634
Mental Retardation 10 | 634
Mental deficiency 10 | 634
Poor school performance 10 | 634
ductal carcinoma in situ 10 | 1,686
Ataxia telangiectasia 9 | 33
Bloom syndrome 9 | 29
adrenocortical carcinoma 9 | 1,385
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,902
Nijmegen breakage syndrome 7 | 23
lung adenocarcinoma 7 | 2,627
Chromosome Breakage 6 | 35
Increased chromosomal breakage 6 | 27
Kidney cancer 6 | 2,548
Malignant neoplasm of breast 6 | 14
Seckel syndrome 6 | 34
non primary Sjogren syndrome sicca 6 | 861
Acquired scoliosis 5 | 274
Cognitive delay 5 | 596
Convex nasal ridge 5 | 36
Curvature of spine 5 | 275
Decreased platelet count 5 | 110
Global developmental delay 5 | 596
Hypoplastic mandible condyle 5 | 273
Mandibular hypoplasia 5 | 273
Mental and motor retardation 5 | 596
Micrognathism 5 | 273
Narrow face 5 | 54
Thin face 5 | 54
Thrombocytopenia 5 | 193
Werner syndrome 5 | 29
Xeroderma pigmentosum 5 | 42
astrocytic glioma 5 | 2,530
diabetes mellitus 5 | 1,683
oligodendroglioma 5 | 2,768
pituitary cancer 5 | 1,915
Almond-shaped eyes 4 | 23
Anemia 4 | 353
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 3 4 | 8
Bilateral fifth finger clinodactyly 4 | 109
Curvature of little finger 4 | 109
Esophageal atresia with or without tracheoesophageal fistula 4 | 20
Fetal Growth Retardation 4 | 186
Hyperplasia of nose 4 | 22
Hypertrophy of nose 4 | 22
Infant, Small for Gestational Age 4 | 174
Intrauterine retardation 4 | 174
Irregular hyperpigmentation 4 | 33
Large nose 4 | 22
Leukopenia 4 | 72
Microcephaly 4 | 166
Ovarian Neoplasms 4 | 96
Prostate cancer 4 | 164
Pyridoxine-responsive sideroblastic anemia 4 | 17
Radial aplasia/hypoplasia 4 | 27
Rothmund-Thomson syndrome 4 | 19
Short palpebral fissure 4 | 37
Waldenstrons macroglobulinemia 4 | 742
breast carcinoma 4 | 1,589
esophageal atresia/tracheoesophageal fistula 4 | 21
hypopigmented skin patch 4 | 59
lung carcinoma 4 | 2,755
ovarian neoplasm 4 | 93
Astrocytoma, Pilocytic 3 | 3,006
Bipolar Disorder 3 | 646
Chronic Lymphocytic Leukemia 3 | 254
Prostatic Neoplasms 3 | 472
Schizophrenia 3 | 1,136
cutaneous lupus erythematosus 3 | 1,016
dermatomyositis 3 | 941
pancreatic cancer 3 | 2,322

Tissue

Blood and immune system 41 | 16,909
Cardiovascular System 41 | 15,192
Digestive Tract 41 | 17,369
Endocrine System 41 | 18,159
Female tissues 41 | 17,400
Liver and Pancreas 41 | 16,750
Male tissues 41 | 17,142
Nervous System 41 | 16,725
Respiratory system 41 | 16,393
Skin and soft tissues 41 | 17,230
Urinary Tract 41 | 16,678

Target Family

Non-IDG 32 | 12,091
Enzyme 6 | 4,145
Kinase 2 | 634
Epigenetic 1 | 242

Reactome Pathway

Homologous DNA Pairing and Str... 41 | 41
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase ATR ATR Tchem Kinase -2.80362 549.6 376
RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 RHNO1 Tbio Non-IDG -3.20363 1560.8 3
DNA endonuclease RBBP8 RBBP8 Tbio Enzyme -2.17933 148.4 308
DNA repair protein XRCC3 XRCC3 Tbio Non-IDG -2.50791 314.0 414
DNA topoisomerase 3-alpha TOP3A Tbio Enzyme -2.77897 560.7 45
Replication protein A 14 kDa subunit RPA3 Tbio Non-IDG -1.85941 67.1 171
Replication factor C subunit 2 RFC2 Tbio Non-IDG -1.36589 20.3 293
Replication factor C subunit 3 RFC3 Tbio Non-IDG -1.30866 19.7 176
Exonuclease 1 EXO1 Tbio Enzyme -2.64302 437.0 263
Breast cancer type 2 susceptibility protein BRCA2 Tbio Non-IDG -3.46139 2647.6 209