Development Level

Tbio 5 | 10,625
Tchem 2 | 1,890
Tdark 1 | 7,003

Disease

osteosarcoma 4 | 7,933
lung cancer 3 | 4,466
medulloblastoma, large-cell 3 | 6,234
ovarian cancer 3 | 8,484
Intellectual disability 2 | 573
adrenocortical carcinoma 2 | 1,427
astrocytoma 2 | 1,493
cystic fibrosis 2 | 1,665
invasive ductal carcinoma 2 | 2,950
non-small cell lung cancer 2 | 2,798
oligodendroglioma 2 | 2,849
pediatric high grade glioma 2 | 2,712
pilocytic astrocytoma 2 | 3,086
pituitary cancer 2 | 1,972
primitive neuroectodermal tumor 2 | 3,031
psoriasis 2 | 6,685
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 1,557
ASTHMA, SUSCEPTIBILITY TO (finding) 1 | 6
Allergic hypersensitivity disease 1 | 123
Arthus reaction 1 | 8
Asthma 1 | 349
Ataxia 1 | 15
Atrophic gastritis 1 | 4
Atypical lipomatous tumor 1 | 2
Autoimmune hepatitis 1 | 13
Breast cancer 1 | 3,094
Burkitt Lymphoma 1 | 19
Cancer 1 | 2,346
Contact Dermatitis 1 | 80
Cortical blindness 1 | 15
Developmental coordination disorder 1 | 8
Drug allergy 1 | 36
Duchenne muscular dystrophy 1 | 602
Endometriosis 1 | 535
Focal epilepsy 1 | 5
Gaucher disease type 3 1 | 76
Gilles de la Tourette syndrome 1 | 47
Glutamate formiminotransferase deficiency 1 | 1
Histidinemia 1 | 9
Kernicterus 1 | 12
Nicotine dependence 1 | 53
Orotic aciduria 1 | 16
Pelvic inflammatory disease 1 | 21
Pick disease 1 | 1,893
Polycystic Ovary Syndrome 1 | 332
Propionic acidemia 1 | 20
Rhinitis 1 | 46
Sigmoid colon cancer 1 | 3
Specific language impairment 1 | 31
Urocanase deficiency 1 | 1
Urticaria 1 | 53
active Crohn's disease 1 | 918
active ulcerative colitis 1 | 477
adult high grade glioma 1 | 2,148
atypical teratoid / rhabdoid tumor 1 | 4,369
atypical teratoid/rhabdoid tumor 1 | 1,095
autosomal dominant Emery-Dreifuss muscular dystrophy 1 | 499
beta-ketothiolase deficiency 1 | 13
cutaneous lupus erythematosus 1 | 1,056
ductal carcinoma in situ 1 | 1,745
facioscapulohumeral dystrophy 1 | 286
gastric cancer 1 | 430
gastric carcinoma 1 | 832
glioblastoma 1 | 5,572
glioblastoma multiforme 1 | 347
group 3 medulloblastoma 1 | 2,254
interstitial cystitis 1 | 2,299
interstitial lung disease 1 | 291
intraductal papillary-mucinous adenoma (IPMA) 1 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 1 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 1 | 3,289
juvenile dermatomyositis 1 | 1,189
lung adenocarcinoma 1 | 2,713
lung carcinoma 1 | 2,844
malignant mesothelioma 1 | 3,162
medulloblastoma 1 | 1,524
nephrosclerosis 1 | 329
non primary Sjogren syndrome sicca 1 | 840
pancreatic ductal adenocarcinoma liver metastasis 1 | 1,795
posterior fossa group A ependymoma 1 | 1,511
posterior fossa group B ependymoma 1 | 1,530
progressive supranuclear palsy 1 | 674

Tissue

Blood and immune system 8 | 17,995
Cardiovascular System 8 | 17,958
Digestive Tract 8 | 18,473
Endocrine System 8 | 18,512
Female tissues 8 | 18,647
Liver and Pancreas 8 | 18,136
Male tissues 8 | 17,969
Nervous System 8 | 18,561
Respiratory system 8 | 17,484
Skin and soft tissues 8 | 18,115
Urinary Tract 8 | 18,444

Target Family

Enzyme 8 | 4,146

Reactome Pathway

Histidine catabolism 8 | 8
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Formimidoyltransferase-cyclodeaminase FTCD Tbio Enzyme -2.18544 160.5 238
Histamine N-methyltransferase HNMT Tchem Enzyme -2.84387 712.7 213
Carnosine synthase 1 CARNS1 Tbio Enzyme -0.58263 3.67 61
Probable imidazolonepropionase AMDHD1 Tdark Enzyme -0.04792 1.65 35
Histidine decarboxylase HDC Tbio Enzyme -2.63324 457.4 163
Carnosine N-methyltransferase CARNMT1 Tbio Enzyme 0.18 0.86 71
Urocanate hydratase UROC1 Tbio Enzyme -1.01946 10.3 49
Histidine ammonia-lyase HAL Tchem Enzyme -1.96905 96.8 64