Development Level

Tbio 6 | 11,651
Tchem 1 | 1,388

Disease

Carcinoma 6 | 11,493
Intellectual disability 3 | 1,016
lung cancer 3 | 4,740
medulloblastoma, large-cell 3 | 6,241
osteosarcoma 3 | 7,950
Astrocytoma, Pilocytic 2 | 3,081
Liver Cirrhosis, Experimental 2 | 769
adult high grade glioma 2 | 3,801
astrocytoma 2 | 1,146
cystic fibrosis 2 | 1,696
ependymoma 2 | 4,679
glioblastoma 2 | 5,792
group 3 medulloblastoma 2 | 4,104
invasive ductal carcinoma 2 | 2,951
non-small cell lung cancer 2 | 2,890
oligodendroglioma 2 | 2,850
ovarian cancer 2 | 8,520
pituitary cancer 2 | 1,972
primitive neuroectodermal tumor 2 | 3,035
psoriasis 2 | 6,694
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 2,010
Abnormal urinary amino-acid findings 1 | 38
Alcoholic Intoxication, Chronic 1 | 289
Allergic hypersensitivity disease 1 | 126
Amelogenesis imperfecta type 1B 1 | 4
Amelogenesis imperfecta type 1E 1 | 3
Aminoaciduria 1 | 38
Anemia, Megaloblastic 1 | 16
Arthus reaction 1 | 7
Asthma 1 | 385
Asthma, susceptibility to 1 | 11
Ataxia 1 | 15
Autoimmune hepatitis 1 | 11
Autosomal recessive predisposition 1 | 1,442
Breast cancer 1 | 3,578
Burkitt Lymphoma 1 | 20
Cancer 1 | 2,499
Contact Dermatitis 1 | 81
Cortical blindness 1 | 16
Drug Hypersensitivity 1 | 34
Drug allergy 1 | 36
Duchenne muscular dystrophy 1 | 601
Dull intelligence 1 | 645
Endometriosis 1 | 540
Gaucher disease type 3 1 | 67
Gilles de la Tourette syndrome 1 | 47
Glutamate formiminotransferase deficiency 1 | 1
Growth delay 1 | 114
Growth failure 1 | 114
Growth retardation 1 | 115
Hepatomegaly 1 | 285
Histidinemia 1 | 9
Hypersegmentation of neutrophil nuclei 1 | 1
Kernicterus 1 | 11
Kidney cancer 1 | 2,613
Low intelligence 1 | 645
MENTAL RETARDATION, AUTOSOMAL RECESSIVE 51 1 | 1
Mental Retardation 1 | 645
Mental deficiency 1 | 645
Orotic aciduria 1 | 18
Pick disease 1 | 1,894
Polycystic ovary syndrome 1 | 360
Poor growth 1 | 114
Poor school performance 1 | 645
Positive ferric chloride test 1 | 1
Propionic acidemia 1 | 16
Rhinitis 1 | 55
Sigmoid colon cancer 1 | 4
Specific language impairment 1 | 34
Tourette Syndrome 1 | 4
Urocanase deficiency 1 | 1
Urocanic aciduria 1 | 1
Urticaria 1 | 67
Very poor growth 1 | 114
active Crohn's disease 1 | 922
active ulcerative colitis 1 | 764
adrenocortical carcinoma 1 | 1,428
atypical teratoid / rhabdoid tumor 1 | 5,112
atypical teratoid/rhabdoid tumor 1 | 357
autosomal dominant Emery-Dreifuss muscular dystrophy 1 | 510
beta-ketothiolase deficiency 1 | 13
cutaneous lupus erythematosus 1 | 1,057
ductal carcinoma in situ 1 | 1,745
facioscapulohumeral dystrophy 1 | 288
gastric cancer 1 | 459
gastric carcinoma 1 | 807
interstitial cystitis 1 | 2,312
interstitial lung disease 1 | 298
intraductal papillary-mucinous neoplasm (IPMN) 1 | 3,291
juvenile dermatomyositis 1 | 1,187
lung adenocarcinoma 1 | 2,716
lung carcinoma 1 | 2,843
malignant mesothelioma 1 | 3,232
nephrosclerosis 1 | 333
non primary Sjogren syndrome sicca 1 | 891
pancreatic ductal adenocarcinoma liver metastasis 1 | 1,962
pediatric high grade glioma 1 | 1,064
progressive supranuclear palsy 1 | 676

Tissue

Blood and immune system 7 | 16,909
Endocrine System 7 | 18,159
Female tissues 7 | 17,400
Liver and Pancreas 7 | 16,750
Nervous System 7 | 16,725
Cardiovascular System 6 | 15,192
Digestive Tract 6 | 17,369
Male tissues 6 | 17,142
Skin and soft tissues 6 | 17,230
Urinary Tract 6 | 16,678
Respiratory system 5 | 16,393

Target Family

Enzyme 7 | 4,145

Reactome Pathway

Histidine catabolism 7 | 7
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carnosine N-methyltransferase CARNMT1 Tbio Enzyme -0.42597 1.92 80
Histidine decarboxylase HDC Tbio Enzyme -2.65393 472.2 175
Formimidoyltransferase-cyclodeaminase FTCD Tbio Enzyme -2.23276 170.0 418
Carnosine synthase 1 CARNS1 Tbio Enzyme -0.64427 4.21 70
Histamine N-methyltransferase HNMT Tchem Enzyme -2.88300 757.5 234
Urocanate hydratase UROC1 Tbio Enzyme -1.01946 10.3 60
Histidine ammonia-lyase HAL Tbio Enzyme -2.01531 102.1 85