Development Level

Tbio 34 | 11,445
Tchem 7 | 1,598
Tclin 2 | 613
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, incomple... 4 | 499
abnormal seminal vesicle morph... 2 | 114
decreased circulating potassiu... 2 | 20
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
abnormal behavior 1 | 298
abnormal coat-hair pigmentatio... 1 | 64
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal heart morphology 1 | 162
abnormal incisor morphology 1 | 4
abnormal joint morphology 1 | 23
abnormal mandible morphology 1 | 2
abnormal sensory capabilities-... 1 | 8
abnormal snout morphology 1 | 23
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
absent pinna reflex 1 | 23
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating creatini... 1 | 39
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating lipase l... 1 | 3
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
edema 1 | 59
enlarged heart 1 | 210
enlarged seminal vesicle 1 | 10
hydrometra 1 | 53
hyperactivity 1 | 148
hypoactivity 1 | 132
increased bone mineral density 1 | 72
increased circulating fructosa... 1 | 13
increased circulating potassiu... 1 | 29
increased lean body mass 1 | 172
increased monocyte cell number 1 | 63
increased total body fat amoun... 1 | 134
microphthalmia 1 | 26
preweaning lethality, complete... 1 | 979
short tibia 1 | 97
small superior vagus ganglion 1 | 74

Disease

Carcinoma 32 | 11,493
ovarian cancer 18 | 8,520
osteosarcoma 17 | 7,950
psoriasis 17 | 6,694
Autosomal recessive predisposition 16 | 1,442
lung cancer 15 | 4,740
ependymoma 13 | 4,679
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
Intellectual disability 12 | 1,016
glioblastoma 12 | 5,792
interstitial cystitis 12 | 2,312
medulloblastoma, large-cell 12 | 6,241
tuberculosis 12 | 2,010
Breast cancer 11 | 3,578
malignant mesothelioma 11 | 3,232
invasive ductal carcinoma 10 | 2,951
lung carcinoma 10 | 2,843
Dull intelligence 9 | 645
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Muscle hypotonia 9 | 571
Poor school performance 9 | 645
adult high grade glioma 9 | 3,801
group 3 medulloblastoma 9 | 4,104
nephrosclerosis 9 | 333
non-small cell lung cancer 9 | 2,890
cystic fibrosis 8 | 1,696
ductal carcinoma in situ 8 | 1,745
oligodendroglioma 8 | 2,850
primitive neuroectodermal tumor 8 | 3,035
Astrocytoma, Pilocytic 7 | 3,081
Cognitive delay 7 | 608
Epilepsy 7 | 792
Global developmental delay 7 | 608
Liver Cirrhosis, Experimental 7 | 769
Mental and motor retardation 7 | 608
atypical teratoid / rhabdoid tumor 7 | 5,112
cutaneous lupus erythematosus 7 | 1,057
subependymal giant cell astrocytoma 7 | 2,287
Cancer 6 | 2,499
Seizures 6 | 596
Tyrosinemia 6 | 10
active Crohn's disease 6 | 922
astrocytic glioma 6 | 2,597
breast carcinoma 6 | 1,638
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
ulcerative colitis 6 | 1,819
Major Depressive Disorder 5 | 301
Maple syrup urine disease 5 | 24
Metabolic acidosis 5 | 90
Muscle Hypertonia 5 | 88
Schizophrenia 5 | 1,160
Unipolar Depression 5 | 250
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
lung adenocarcinoma 5 | 2,716
Atopic dermatitis 4 | 952
Bipolar Disorder 4 | 666
Endometriosis 4 | 540
Pellagra 4 | 26
active ulcerative colitis 4 | 764
adrenocortical carcinoma 4 | 1,428
pituitary cancer 4 | 1,972
primary Sjogren syndrome 4 | 735
Abnormal urinary amino-acid findings 3 | 38
Alkaptonuria 3 | 4
Aminoaciduria 3 | 38
Chronic obstructive pulmonary disease 3 | 184
Dermatitis, Allergic Contact 3 | 67
Dystonia 3 | 164
Dystonic disease 3 | 106
Electroencephalogram abnormal 3 | 101
Failure to gain weight 3 | 365
Growth delay 3 | 114
Growth failure 3 | 114
Growth retardation 3 | 115
Hepatomegaly 3 | 285
Hyperphenylalaninaemia 3 | 5
Hypertyrosinemia 3 | 3
Hypoglycemia 3 | 152
Irritation - emotion 3 | 68
Orotic aciduria 3 | 18
Pediatric failure to thrive 3 | 365
Phenylketonuria 3 | 20
Polycystic ovary syndrome 3 | 360
Poor growth 3 | 114
Primary hyperoxaluria 3 | 15
Small head 3 | 374
Tremor 3 | 113
Tyrosinemias 3 | 3
Very poor growth 3 | 114
head and neck cancer and chronic obstructive pulmonary disease 3 | 239
non primary Sjogren syndrome sicca 3 | 891
uncontrolled asthma 3 | 56
Hypertension 2 | 396
Psychotic Disorders 2 | 151
Schizoaffective Disorder 2 | 55
medulloblastoma 2 | 720
pediatric high grade glioma 2 | 1,064

Tissue

Blood and immune system 45 | 16,909
Endocrine System 45 | 18,159
Liver and Pancreas 45 | 16,750
Digestive Tract 44 | 17,369
Female tissues 44 | 17,400
Nervous System 44 | 16,725
Urinary Tract 44 | 16,678
Male tissues 41 | 17,142
Respiratory system 41 | 16,393
Skin and soft tissues 41 | 17,230
Cardiovascular System 39 | 15,192

Target Family

Enzyme 41 | 4,145
Transporter 4 | 473

Reactome Pathway

Histidine, lysine, phenylalani... 45 | 45
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
L-amino-acid oxidase IL4I1 Tbio Enzyme -2.79074 622.3 53
Formimidoyltransferase-cyclodeaminase FTCD Tbio Enzyme -2.23276 170.0 418
Large neutral amino acids transporter small subunit 1 SLC7A5 Tbio Transporter -1.90516 156.1 254
Carnosine synthase 1 CARNS1 Tbio Enzyme -0.64427 4.21 70
Ketimine reductase mu-crystallin CRYM Tbio Enzyme -1.70644 52.5 199
Fumarylacetoacetase FAH Tbio Enzyme -2.39887 253.3 196
Histamine N-methyltransferase HNMT Tchem Enzyme -2.88300 757.5 234
Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 Tbio Enzyme -3.14670 1303.9 150
Maleylacetoacetate isomerase GSTZ1 Tbio Enzyme -1.99892 99.5 150
5-phosphohydroxy-L-lysine phospho-lyase PHYKPL Tdark Enzyme -0.61979 4.65 106