Development Level

Tbio 46 | 11,445
Tdark 4 | 6,588
Tchem 3 | 1,598

IMPC Phenotype

decreased circulating serum al... 2 | 82
preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal eye morphology 1 | 68
cataract 1 | 92
decreased exploration in new e... 1 | 11
decreased lymphocyte cell numb... 1 | 83
decreased red blood cell distr... 1 | 41
decreased total body fat amoun... 1 | 207
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
hypoactivity 1 | 132
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating creatini... 1 | 38
increased circulating potassiu... 1 | 29
increased circulating triglyce... 1 | 42
increased lean body mass 1 | 172
increased neutrophil cell numb... 1 | 46
mydriasis 1 | 6
preweaning lethality, complete... 1 | 979
short tibia 1 | 97
small adrenal glands 1 | 16
small kidney 1 | 16
thrombocytosis 1 | 27

Disease

Carcinoma 42 | 11,493
psoriasis 33 | 6,694
ovarian cancer 29 | 8,520
glioblastoma 28 | 5,792
atypical teratoid / rhabdoid tumor 25 | 5,112
ependymoma 25 | 4,679
osteosarcoma 22 | 7,950
Astrocytoma, Pilocytic 21 | 3,081
medulloblastoma, large-cell 19 | 6,241
adult high grade glioma 17 | 3,801
group 3 medulloblastoma 15 | 4,104
malignant mesothelioma 15 | 3,232
primitive neuroectodermal tumor 15 | 3,035
Breast cancer 14 | 3,578
invasive ductal carcinoma 14 | 2,951
lung cancer 14 | 4,740
group 4 medulloblastoma 13 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
lung carcinoma 13 | 2,843
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
oligodendroglioma 12 | 2,850
Autosomal recessive predisposition 11 | 1,442
astrocytic glioma 11 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
non-small cell lung cancer 11 | 2,890
pancreatic cancer 11 | 2,398
pituitary cancer 11 | 1,972
subependymal giant cell astrocytoma 11 | 2,287
Cancer 10 | 2,499
interstitial cystitis 10 | 2,312
Coarse facial features 9 | 108
Intellectual disability 9 | 1,016
Short neck 9 | 140
Short stature 9 | 531
Thickened facial skin with coarse facial features 9 | 108
cystic fibrosis 9 | 1,696
ductal carcinoma in situ 9 | 1,745
lung adenocarcinoma 9 | 2,716
pediatric high grade glioma 9 | 1,064
Acquired scoliosis 8 | 281
Congenital deafness 8 | 185
Curvature of spine 8 | 282
Deafness 8 | 198
Dull intelligence 8 | 645
Hearing Loss, Partial 8 | 185
Hepatomegaly 8 | 285
Kidney cancer 8 | 2,613
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Poor school performance 8 | 645
Splenomegaly 8 | 190
breast carcinoma 8 | 1,638
cutaneous lupus erythematosus 8 | 1,057
hearing impairment 8 | 199
ulcerative colitis 8 | 1,819
Big calvaria 7 | 147
Cryptorchidism 7 | 296
Hernia, Inguinal 7 | 89
Increased head circumference 7 | 147
Increased size of cranium 7 | 147
Increased size of skull 7 | 147
Muscle hypotonia 7 | 571
Umbilical hernia 7 | 93
adrenocortical carcinoma 7 | 1,428
aldosterone-producing adenoma 7 | 665
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
Atopic dermatitis 6 | 952
Broad flat nasal bridge 6 | 236
Craniofacial Abnormalities 6 | 151
Duchenne muscular dystrophy 6 | 601
Hydrocephalus 6 | 152
Joint stiffness 6 | 84
Melanoma 6 | 711
Mucopolysaccharidosis 6 | 26
Multiple myeloma 6 | 1,332
Nasal bridge wide 6 | 236
Osteoporosis 6 | 363
Pick disease 6 | 1,894
Schizophrenia 6 | 1,160
colon cancer 6 | 1,478
diabetes mellitus 6 | 1,728
gastric carcinoma 6 | 807
sonic hedgehog group medulloblastoma 6 | 467
tuberculosis 6 | 2,010
Anteverted nostril 5 | 191
Concave bridge of nose 5 | 195
Congenital Epicanthus 5 | 177
Coxa valga 5 | 22
Depressed nasal bridge 5 | 195
Depressed nasal root/bridge 5 | 195
Hereditary spherocytosis type 3 5 | 14
Knee joint valgus deformity 5 | 56
Orbital separation excessive 5 | 244
Pfaundler-Hurler Syndrome 5 | 12
Simpson-Golabi-Behmel syndrome 5 | 19
astrocytoma 5 | 1,146
esophageal adenocarcinoma 5 | 737
non primary Sjogren syndrome sicca 5 | 891
spina bifida 5 | 1,074

Tissue

Digestive Tract 52 | 17,369
Endocrine System 52 | 18,159
Female tissues 52 | 17,400
Nervous System 52 | 16,725
Urinary Tract 52 | 16,678
Male tissues 51 | 17,142
Skin and soft tissues 50 | 17,230
Blood and immune system 49 | 16,909
Liver and Pancreas 49 | 16,750
Respiratory system 49 | 16,393
Cardiovascular System 44 | 15,192

Target Family

Enzyme 35 | 4,145
Non-IDG 17 | 12,091
Transporter 1 | 473

Reactome Pathway

Heparan sulfate/heparin (HS-GA... 53 | 53
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Xylosyltransferase 1 XYLT1 Tbio Enzyme -2.10436 129.4 88
Heparan sulfate glucosamine 3-O-sulfotransferase 4 HS3ST4 Tdark Enzyme -0.45852 2.98 18
Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 Tbio Enzyme -0.79764 6.35 32
Glypican-6 GPC6 Tbio Non-IDG -1.33560 21.9 125
Alpha-N-acetylglucosaminidase NAGLU Tbio Enzyme -2.18649 159.9 64
Heparan sulfate glucosamine 3-O-sulfotransferase 6 HS3ST6 Tdark Enzyme -0.31878 2.19 19
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 NDST3 Tbio Enzyme -0.66930 5.78 111
UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter SLC35D2 Tbio Transporter -1.58749 38.8 59
D-glucuronyl C5-epimerase GLCE Tbio Enzyme -1.19848 19.9 34
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 NDST1 Tbio Enzyme -1.91878 84.7 146